CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: farnesane
Accession: CHEBI:36756
browse the term
Definition: A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10.
Synonyms: exact_synonym: 2,6,10-trimethyldodecane
related_synonym: Farnesan; Formula=C15H32; InChI=1S/C15H32/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h13-15H,6-12H2,1-5H3; InChIKey=YFHFHLSMISYUAQ-UHFFFAOYSA-N; SMILES=CCC(C)CCCC(C)CCCC(C)C
xref: Beilstein:1719672; CAS:3891-98-3; LIPID_MAPS_instance:LMPR0103010000; MetaCyc:CPD-8764; Patent:US2008098645; Patent:US7399323; Reaxys:1719672
G
Akr1b10
aldo-keto reductase family 1, member B10
increases reduction
ISO
AKR1B10 protein results in increased reduction of farnesal
CTD
PMID:21187079
NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
G
Akr1c18
aldo-keto reductase family 1, member C18
increases reduction
ISO
AKR1C3 protein results in increased reduction of farnesal
CTD
PMID:21187079
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
G
Akr1c21
aldo-keto reductase family 1, member C21
increases expression
ISO
farnesal results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
farnesal results in increased expression of GCLC mRNA
CTD
PMID:20491607
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
G
Mt2
metallothionein 2
increases expression
ISO
farnesal results in increased expression of MT2A mRNA
CTD
PMID:20491607
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
G
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA
CTD
PMID:30611723
NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161
G
Acaa2
acetyl-CoA acyltransferase 2
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA Farnesol analog results in increased expression of ACAA2 mRNA
CTD
PMID:30611723
NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
G
Acadm
acyl-Coenzyme A dehydrogenase, medium chain
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADM mRNA
CTD
PMID:30611723
NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
G
Acads
acyl-Coenzyme A dehydrogenase, short chain
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADS mRNA Farnesol analog results in increased expression of ACADS mRNA
CTD
PMID:30611723
NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
G
Acat1
acetyl-Coenzyme A acetyltransferase 1
increases expression
ISO
Farnesol analog results in increased expression of ACAT1 mRNA
CTD
PMID:30611723
NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
G
Acat2
acetyl-Coenzyme A acetyltransferase 2
increases expression
ISO
Farnesol analog results in increased expression of ACAT2 mRNA
CTD
PMID:30611723
NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
G
Acot1
acyl-CoA thioesterase 1
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT1 mRNA
CTD
PMID:30611723
NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145
G
Acot12
acyl-CoA thioesterase 12
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA Farnesol analog results in increased expression of ACOT12 mRNA
CTD
PMID:30611723
NCBI chr13:91,889,635...91,934,271
Ensembl chr13:91,889,631...91,934,267
G
Acot6
acyl-CoA thioesterase 6
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA
CTD
PMID:30611723
NCBI chr12:84,147,538...84,158,128
Ensembl chr12:84,147,428...84,158,123
G
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA
CTD
PMID:30611723
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
G
Acox2
acyl-Coenzyme A oxidase 2, branched chain
increases expression decreases expression
ISO
Farnesol analog results in increased expression of ACOX2 mRNA Farnesol analog results in decreased expression of ACOX2 mRNA
CTD
PMID:30611723
NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262
G
Acsl4
acyl-CoA synthetase long-chain family member 4
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA
CTD
PMID:30611723
NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
G
Acsl5
acyl-CoA synthetase long-chain family member 5
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA
CTD
PMID:30611723
NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
G
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA
CTD
PMID:30611723
NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423
G
Akr1b10
aldo-keto reductase family 1, member B10
increases chemical synthesis
ISO
AKR1B10 protein results in increased chemical synthesis of Farnesol
CTD
PMID:21187079
NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
G
Akr1c18
aldo-keto reductase family 1, member C18
increases chemical synthesis multiple interactions
ISO
AKR1C3 protein results in increased chemical synthesis of Farnesol [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol
CTD
PMID:21187079
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
G
Akr1c20
aldo-keto reductase family 1, member C20
increases expression
ISO
Farnesol results in increased expression of AKR1C1 mRNA
CTD
PMID:30806763
NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
G
Apoa5
apolipoprotein A-V
increases expression multiple interactions
ISO
Farnesol analog results in increased expression of APOA5 mRNA [Farnesol analog co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
CTD
PMID:30611723
NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217
G
Apoc4
apolipoprotein C-IV
decreases expression
ISO
Farnesol analog results in decreased expression of APOC4 mRNA
CTD
PMID:30611723
NCBI chr 7:19,412,009...19,415,385
Ensembl chr 7:19,412,008...19,415,404
G
Atf3
activating transcription factor 3
increases expression
ISO
Farnesol results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Farnesol results in increased expression of BAK1 protein
CTD
PMID:12530055
NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
G
Casp3
caspase 3
increases activity decreases activity
ISO
Farnesol results in increased activity of CASP3 protein Farnesol results in decreased activity of CASP3 protein
CTD
PMID:10733934 PMID:21453689
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Cat
catalase
increases expression multiple interactions
ISO EXP
Farnesol results in increased expression of CAT protein Farnesol inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] Farnesol inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
CTD
PMID:18793622 PMID:21453689 PMID:37458150
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Ccl4
C-C motif chemokine ligand 4
increases secretion
ISO
Farnesol results in increased secretion of CCL4 protein
CTD
PMID:30806763
NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
G
Ccna2
cyclin A2
decreases expression
ISO
Farnesol results in decreased expression of CCNA2 protein
CTD
PMID:17138864
NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
G
Ccnb1
cyclin B1
decreases expression
ISO
Farnesol results in decreased expression of CCNB1 protein
CTD
PMID:17138864
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
G
Cdk2
cyclin dependent kinase 2
decreases expression multiple interactions
ISO
Farnesol results in decreased expression of CDK2 protein Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
G
Cdkn1a
cyclin dependent kinase inhibitor 1A
increases response to substance increases expression multiple interactions
ISO
CDKN1A protein results in increased susceptibility to Farnesol Farnesol results in increased expression of CDKN1A protein Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
G
Cdkn1b
cyclin dependent kinase inhibitor 1B
increases expression increases response to substance multiple interactions
ISO
Farnesol results in increased expression of CDKN1B protein CDKN1B protein results in increased susceptibility to Farnesol Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
G
Cox10
heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
decreases expression
ISO
Farnesol analog results in decreased expression of COX10 mRNA
CTD
PMID:30611723
NCBI chr11:63,853,453...63,970,298
Ensembl chr11:63,853,453...63,970,294
G
Cpt1a
carnitine palmitoyltransferase 1a, liver
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CPT1A mRNA
CTD
PMID:30611723
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression increases secretion
ISO
Farnesol results in increased expression of CXCL8 mRNA Farnesol results in increased secretion of CXCL8 protein
CTD
PMID:27965148 PMID:30806763
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases activity
ISO
Farnesol results in increased activity of CYP19A1 protein
CTD
PMID:15840382
NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity increases expression
ISO
Farnesol results in increased activity of CYP1A1 protein Farnesol results in increased expression of CYP1A1 mRNA
CTD
PMID:15840382 PMID:30806763
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity multiple interactions
ISO
Farnesol results in increased activity of CYP1A2 protein Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP1A2 mRNA]
CTD
PMID:15840382 PMID:30611723
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
G
Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
increases activity
ISO
Farnesol results in increased activity of CYP2A1 protein
CTD
PMID:15840382
NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809
G
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
increases activity
ISO
Farnesol results in increased activity of CYP2A3 protein
CTD
PMID:15840382
NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513
G
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2B6 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP2B6 mRNA] Farnesol analog results in increased expression of CYP2B6 mRNA; Farnesol results in increased expression of CYP2B6 mRNA
CTD
PMID:30611723
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
G
Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
increases activity
ISO
Farnesol results in increased activity of CYP2B2 protein
CTD
PMID:15840382
NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
G
Cyp2c52-ps
cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene
increases activity
ISO
Farnesol results in increased activity of CYP2C11 protein
CTD
PMID:15840382
NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases activity decreases expression multiple interactions
ISO
Farnesol results in increased activity of CYP2E1 protein Farnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNA [Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]
CTD
PMID:15840382 PMID:30611723
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
G
Cyp4a12b
cytochrome P450, family 4, subfamily a, polypeptide 12B
increases activity
ISO
Farnesol results in increased activity of CYP4A1 protein
CTD
PMID:15840382
NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
G
Decr1
2,4-dienoyl CoA reductase 1, mitochondrial
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA
CTD
PMID:30611723
NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
G
Dgat1
diacylglycerol O-acyltransferase 1
decreases expression
ISO
Farnesol analog results in decreased expression of DGAT1 mRNA
CTD
PMID:30611723
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
G
Dgat2
diacylglycerol O-acyltransferase 2
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of DGAT2 mRNA
CTD
PMID:30611723
NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Farnesol results in increased expression of DNAJB4 mRNA
CTD
PMID:27965148
NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
G
Ech1
enoyl coenzyme A hydratase 1, peroxisomal
increases expression
ISO
Farnesol analog results in increased expression of ECH1 mRNA
CTD
PMID:30611723
NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
G
Egf
epidermal growth factor
multiple interactions
ISO
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein]
CTD
PMID:24587105
NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
G
Elovl6
ELOVL fatty acid elongase 6
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ELOVL6 mRNA
CTD
PMID:30611723
NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144
G
Fabp1
fatty acid binding protein 1, liver
increases expression
ISO
Farnesol analog results in increased expression of FABP1 mRNA
CTD
PMID:30611723
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
G
Fabp4
fatty acid binding protein 4, adipocyte
increases expression
ISO
Farnesol results in increased expression of FABP4 mRNA
CTD
PMID:30806763
NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
G
Fasn
fatty acid synthase
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of FASN mRNA
CTD
PMID:30611723
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
ISO
Farnesol analog results in increased expression of FDFT1 mRNA
CTD
PMID:30611723
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
G
Fnta
farnesyltransferase, CAAX box, alpha
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of FNTA mRNA
CTD
PMID:30611723
NCBI chr 8:26,488,716...26,505,638
Ensembl chr 8:26,488,750...26,505,678
G
Fntb
farnesyltransferase, CAAX box, beta
decreases expression
ISO
Farnesol analog results in decreased expression of FNTB mRNA
CTD
PMID:30611723
NCBI chr12:76,884,014...76,968,188
Ensembl chr12:76,812,363...76,968,186
G
Gpat4
glycerol-3-phosphate acyltransferase 4
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of GPAT4 mRNA
CTD
PMID:30611723
NCBI chr 8:23,661,281...23,698,469
Ensembl chr 8:23,661,281...23,698,362
G
Gpt
glutamic pyruvic transaminase, soluble
multiple interactions
EXP
Farnesol inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD
PMID:37458150
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
G
Gsr
glutathione reductase
increases activity multiple interactions increases expression
ISO EXP
Farnesol results in increased activity of GSR protein Farnesol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] Farnesol results in increased expression of GSR protein
CTD
PMID:15840382 PMID:21453689 PMID:37458150
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHA mRNA Farnesol analog results in increased expression of HADHA mRNA
CTD
PMID:30611723
NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA Farnesol analog results in increased expression of HADHB mRNA
CTD
PMID:30611723
NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591
G
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
multiple interactions increases expression decreases activity
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA Farnesol results in increased expression of HMGCR protein Farnesol results in decreased activity of HMGCR protein
CTD
PMID:12477733 PMID:16332721 PMID:30611723
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
G
Hmox1
heme oxygenase 1
increases expression
ISO
Farnesol results in increased expression of HMOX1 mRNA
CTD
PMID:30806763
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
G
Hras
Harvey rat sarcoma virus oncogene
multiple interactions
ISO
Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]
CTD
PMID:12477733
NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
Farnesol results in increased expression of ICAM1 mRNA
CTD
PMID:30806763
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
G
Ikbkb
inhibitor of kappaB kinase beta
multiple interactions
EXP
Farnesol inhibits the reaction [Acetaminophen results in increased expression of IKBKB mRNA]
CTD
PMID:37458150
NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
G
Il16
interleukin 16
increases secretion
ISO
Farnesol results in increased secretion of IL16 protein
CTD
PMID:30806763
NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
G
Il1a
interleukin 1 alpha
increases expression
ISO
Farnesol results in increased expression of IL1A mRNA
CTD
PMID:30806763
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Il1b
interleukin 1 beta
multiple interactions
EXP ISO
Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL1B protein] Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
CTD
PMID:20304105 PMID:37458150
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il1r2
interleukin 1 receptor, type II
increases expression
ISO
Farnesol results in increased expression of IL1R2 mRNA
CTD
PMID:30806763
NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
G
Il6
interleukin 6
multiple interactions
EXP
Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]
CTD
PMID:37458150
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Ins2
insulin II
multiple interactions
ISO
Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein]
CTD
PMID:24587105
NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
G
Lipc
lipase, hepatic
increases expression
ISO
Farnesol analog results in increased expression of LIPC mRNA
CTD
PMID:30611723
NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
G
Lpin1
lipin 1
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of LPIN1 mRNA
CTD
PMID:30611723
NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967
G
Lpin3
lipin 3
decreases expression
ISO
Farnesol analog results in decreased expression of LPIN3 mRNA
CTD
PMID:30611723
NCBI chr 2:160,722,590...160,747,920
Ensembl chr 2:160,722,590...160,747,922
G
Mlxipl
MLX interacting protein-like
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA
CTD
PMID:30611723
NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236
G
Mmp3
matrix metallopeptidase 3
increases expression
ISO
Farnesol results in increased expression of MMP3 mRNA
CTD
PMID:30806763
NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
G
Mvk
mevalonate kinase
multiple interactions decreases activity
ISO
Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] Farnesol results in decreased activity of MVK protein
CTD
PMID:9392419 PMID:20304105
NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
G
Myl9
myosin, light polypeptide 9, regulatory
multiple interactions
ISO
Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]
CTD
PMID:24587105
NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
increases activity
ISO
Farnesol results in increased activity of NQO1 protein
CTD
PMID:15840382
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression multiple interactions
ISO
Farnesol analog results in decreased expression of NR0B2 mRNA [Farnesol analog co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA
CTD
PMID:30611723
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions decreases expression
ISO
Farnesol binds to and results in increased activity of NR1H4 protein Farnesol analog results in decreased expression of NR1H4 mRNA
CTD
PMID:15491415 PMID:30611723
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
G
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
multiple interactions decreases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PCK1 mRNA Farnesol analog results in decreased expression of PCK1 mRNA
CTD
PMID:30611723
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
G
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
increases expression
ISO
Farnesol analog results in increased expression of PDSS1 mRNA
CTD
PMID:30611723
NCBI chr 2:22,784,393...22,830,273
Ensembl chr 2:22,785,534...22,830,278
G
Plin2
perilipin 2
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA Farnesol analog results in increased expression of PLIN2 mRNA
CTD
PMID:30611723
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARA mRNA; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
CTD
PMID:11779144 PMID:30611723
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
G
Pparg
peroxisome proliferator activated receptor gamma
multiple interactions increases expression
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARG mRNA Farnesol analog results in increased expression of PPARG mRNA
CTD
PMID:30611723
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
G
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
multiple interactions
ISO
Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]
CTD
PMID:22343369
NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
G
Rabggta
Rab geranylgeranyl transferase, a subunit
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA
CTD
PMID:30611723
NCBI chr14:55,953,321...55,959,720
Ensembl chr14:55,952,873...55,959,720
G
Rabggtb
Rab geranylgeranyl transferase, b subunit
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA
CTD
PMID:30611723
NCBI chr 3:153,612,926...153,618,603
Ensembl chr 3:153,612,924...153,618,646
G
Rac1
Rac family small GTPase 1
multiple interactions
ISO
Farnasol inhibits the reaction [Ropivacaine decreases activity of RAC1 protein in esophageal carcinoma cells]
RGD
PMID:29777701
RGD:155230817
NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
G
Rhoa
ras homolog family member A
multiple interactions
ISO
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein] Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]
CTD
PMID:9398081 PMID:24587105
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
G
Rhoc
ras homolog family member C
multiple interactions
ISO
Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein]
CTD
PMID:24587105
NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775
G
Rxra
retinoid X receptor alpha
multiple interactions
ISO
Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
CTD
PMID:11779144
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
G
Scd2
stearoyl-Coenzyme A desaturase 2
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD mRNA
CTD
PMID:30611723
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
G
Scd3
stearoyl-coenzyme A desaturase 3
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD5 mRNA
CTD
PMID:30611723
NCBI chr19:44,191,727...44,232,455
Ensembl chr19:44,191,708...44,232,455
G
Serpinb3d
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
increases expression
ISO
Farnesol results in increased expression of SERPINB3 mRNA
CTD
PMID:30806763
NCBI chr 1:107,005,893...107,011,210
Ensembl chr 1:107,005,897...107,011,236
G
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA
CTD
PMID:30611723
NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840
G
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
multiple interactions
ISO
[Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC27A1 mRNA
CTD
PMID:30611723
NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946
G
Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
increases expression
ISO
Farnesol analog results in increased expression of SLC27A2 mRNA
CTD
PMID:30611723
NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
increases expression
ISO
Farnesol results in increased expression of SLC7A11 mRNA
CTD
PMID:30806763
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
G
Tnf
tumor necrosis factor
multiple interactions increases expression
ISO EXP
Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]] Farnesol inhibits the reaction [Acetaminophen results in increased expression of TNF protein] Farnesol results in increased expression of TNF mRNA
CTD
PMID:22343369 PMID:30806763 PMID:37458150
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
G
Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
increases glucuronidation
ISO
UGT1A4 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719
G
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
increases glucuronidation
ISO
UGT1A6 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
G
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
G
Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
increases glucuronidation
ISO
UGT2B7 protein results in increased glucuronidation of Farnesol
CTD
PMID:15320866
NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
juvenile hormone III binds to and results in increased activity of NR1H4 protein
CTD
PMID:15491415
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
G
Rxra
retinoid X receptor alpha
multiple interactions
ISO EXP
Methoprene binds to and results in increased activity of RXRA protein
CTD
PMID:16731579
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
G
Rxrb
retinoid X receptor beta
multiple interactions
ISO
Methoprene binds to and results in increased activity of RXRB protein
CTD
PMID:12970175
NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373
G
Ucp1
uncoupling protein 1 (mitochondrial, proton carrier)
increases expression
EXP
Methoprene results in increased expression of UCP1 mRNA
CTD
PMID:10600643
NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081
G
Agt
angiotensinogen
multiple interactions
ISO
[nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33212213
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
CTD
PMID:33212213
NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
G
Bax
BCL2-associated X protein
increases expression
ISO
nerolidol results in increased expression of BAX mRNA
CTD
PMID:35357761
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
G
Bcl2
B cell leukemia/lymphoma 2
decreases expression
ISO
nerolidol results in decreased expression of BCL2 mRNA
CTD
PMID:35357761
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Casp3
caspase 3
increases expression
ISO
nerolidol results in increased expression of CASP3 mRNA
CTD
PMID:35357761
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Cat
catalase
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]
CTD
PMID:33212213
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Ccnd1
cyclin D1
decreases expression
ISO
nerolidol results in decreased expression of CCND1 mRNA
CTD
PMID:35357761
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
G
Gpx4
glutathione peroxidase 4
multiple interactions
ISO
[nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein
CTD
PMID:33212213
NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
G
Il6
interleukin 6
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]
CTD
PMID:33212213
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
CTD
PMID:33212213
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33212213
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
nerolidol results in increased expression of and results in increased phosphorylation of MAPK8 mRNA
CTD
PMID:35357761
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
G
Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]
CTD
PMID:33212213
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
G
Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]
CTD
PMID:33212213
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]
CTD
PMID:33212213
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD
PMID:33212213
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
G
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]
CTD
PMID:33212213
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
G
Sod2
superoxide dismutase 2, mitochondrial
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]
CTD
PMID:33212213
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
CTD
PMID:33212213
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
G
Tlr4
toll-like receptor 4
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]
CTD
PMID:33212213
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
G
Tnf
tumor necrosis factor
multiple interactions
ISO
nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]
CTD
PMID:33212213
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all