CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mycophenolic acid
Accession: CHEBI:168396
browse the term
Definition: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Synonyms: exact_synonym: (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
related_synonym: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid; Formula=C17H20O6; InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+; InChIKey=HPNSFSBZBAHARI-RUDMXATFSA-N; Mycophenolate; Mycophenolsaeure; SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O; acide mycophenolique; acido micofenolico; acidum mycophenolicum
alt_id: CHEBI:43973
xref: CAS:24280-93-1; DrugBank:DB01024; Drug_Central:1860; KEGG:D05096
xref_mesh: MESH:D009173
xref: PDBeChem:MOA; PMID:11272311; PMID:15470161; PMID:16629948; PMID:16640327; PMID:17482154; PMID:17498396; PMID:18194117; PMID:18611107; PMID:18996104; PMID:19689217; Patent:US4753935; Reaxys:318158; Wikipedia:Mycophenolic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:62932
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Abcf1
ATP binding cassette subfamily F member 1
increases expression
ISO
Mycophenolic Acid results in increased expression of ABCF1 mRNA
CTD
PMID:19818335
NCBI chr20:2,807,315...2,820,240
Ensembl chr20:2,807,106...2,820,240
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Adm
adrenomedullin
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein]
CTD
PMID:15063164
NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371
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Agt
angiotensinogen
decreases expression
EXP
Mycophenolic Acid results in decreased expression of AGT protein alternative form
CTD
PMID:15213268
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
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Aif1
allograft inflammatory factor 1
decreases expression multiple interactions
EXP
Mycophenolic Acid results in decreased expression of AIF1 mRNA [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA
CTD
PMID:10688038
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
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Aimp1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
increases expression
ISO
Mycophenolic Acid results in increased expression of AIMP1 mRNA
CTD
PMID:19818335
NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994
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Akt1
AKT serine/threonine kinase 1
increases expression
ISO
Mycophenolic Acid results in increased expression of AKT1 protein
CTD
PMID:21396949
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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Alb
albumin
affects binding
ISO
Mycophenolic Acid binds to ALB protein
CTD
PMID:26892221
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
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Ar
androgen receptor
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
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Atf1
activating transcription factor 1
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein]
CTD
PMID:20302854
NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Mycophenolic Acid results in increased expression of BAK1 protein
CTD
PMID:16505121
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein
CTD
PMID:21396949
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein]
CTD
PMID:16505121 PMID:21396949 PMID:35321622
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp1
caspase 1
increases expression
ISO
Mycophenolic Acid results in increased expression of CASP1 mRNA
CTD
PMID:19818335
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
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Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO
Mycophenolic Acid results in increased activity of CASP3 protein [Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein]
CTD
PMID:16059982 PMID:16505121 PMID:21396949 PMID:35321622
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Ccl19
C-C motif chemokine ligand 19
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL19 mRNA
CTD
PMID:19818335
NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
CTD
PMID:17624267
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
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Ccl20
C-C motif chemokine ligand 20
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CCL20 mRNA Mycophenolic Acid results in increased expression of CCL20 mRNA
CTD
PMID:19818335
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
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Ccl22
C-C motif chemokine ligand 22
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL22 mRNA
CTD
PMID:19818335
NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359
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Ccl25
C-C motif chemokine ligand 25
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL25 mRNA
CTD
PMID:19818335
NCBI chr12:7,505,231...7,514,402
Ensembl chr12:7,505,235...7,514,385
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Mycophenolic Acid results in decreased expression of CCL4 mRNA
CTD
PMID:19818335
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
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Ccl5
C-C motif chemokine ligand 5
multiple interactions decreases expression
EXP
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA Mycophenolic Acid results in decreased expression of CCL5 mRNA
CTD
PMID:10688038
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
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Ccl7
C-C motif chemokine ligand 7
decreases expression
ISO
Mycophenolic Acid results in decreased expression of CCL7 mRNA
CTD
PMID:19818335
NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947
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Ccl9
C-C motif chemokine ligand 9
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CCL6 mRNA Mycophenolic Acid results in increased expression of CCL6 mRNA
CTD
PMID:19818335
NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877
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Ccr10
C-C motif chemokine receptor 10
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR10 mRNA
CTD
PMID:19818335
NCBI chr10:86,608,836...86,611,273
Ensembl chr10:86,608,836...86,611,273
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Ccr2
C-C motif chemokine receptor 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR2 mRNA
CTD
PMID:19818335
NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059
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Ccr3
C-C motif chemokine receptor 3
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR3 mRNA
CTD
PMID:19818335
NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593
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Ccr6
C-C motif chemokine receptor 6
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR6 mRNA
CTD
PMID:19818335
NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059
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Ccr9
C-C motif chemokine receptor 9
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR9 mRNA
CTD
PMID:19818335
NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:132,273,544...132,287,883
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Cd40lg
CD40 ligand
increases expression
ISO
Mycophenolic Acid results in increased expression of CD40LG mRNA
CTD
PMID:19818335
NCBI chr X:140,164,341...140,176,057
Ensembl chr X:140,164,302...140,176,475
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
CTD
PMID:12193749
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein]
CTD
PMID:20302854
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
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Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
ISO
Mycophenolic Acid results in increased expression of CX3CL1 mRNA
CTD
PMID:19818335
NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
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Cxcl12
C-X-C motif chemokine ligand 12
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCL12 mRNA
CTD
PMID:19818335
NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
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Cxcl2
C-X-C motif chemokine ligand 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCL2 protein
CTD
PMID:19818335
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CXCL1 mRNA Mycophenolic Acid results in increased expression of CXCL1 mRNA
CTD
PMID:19818335
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
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Cxcl6
C-X-C motif chemokine ligand 6
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CXCL5 mRNA Mycophenolic Acid results in increased expression of CXCL5 mRNA
CTD
PMID:19818335
NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417
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Cxcr2
C-X-C motif chemokine receptor 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR2 mRNA
CTD
PMID:19818335
NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602
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Cxcr3
C-X-C motif chemokine receptor 3
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR3 mRNA
CTD
PMID:19818335
NCBI chr X:70,884,293...70,886,944
Ensembl chr X:70,883,958...70,886,871
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Cxcr5
C-X-C motif chemokine receptor 5
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR5 mRNA
CTD
PMID:19818335
NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:53,740,197...53,754,816
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Cycs
cytochrome c, somatic
increases secretion
ISO
Mycophenolic Acid results in increased secretion of CYCS protein
CTD
PMID:16505121
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
Mycophenolic Acid results in increased expression of CYP1A1 mRNA Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD
PMID:25929522
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
CTD
PMID:25929522
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases methylation
ISO
CYP2C8 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases methylation
ISO
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183 PMID:25455453
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases methylation
ISO
CYP3A5 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183
NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
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Des
desmin
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein]
CTD
PMID:17624267
NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
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Esr1
estrogen receptor 1
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
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Esr2
estrogen receptor 2
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of ESR2 protein
CTD
PMID:25752796
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Mycophenolic Acid results in increased expression of FOS mRNA
CTD
PMID:12730611
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein]
CTD
PMID:20302854
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
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Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
Mycophenolic Acid results in decreased expression of HSPA5 mRNA
CTD
PMID:24356939
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
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Ifng
interferon gamma
decreases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of IFNG mRNA [Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD
PMID:11562063 PMID:29594315
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il10
interleukin 10
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL10 mRNA
CTD
PMID:11562063
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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Il10ra
interleukin 10 receptor subunit alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of IL10RA mRNA
CTD
PMID:19818335
NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028
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Il10rb
interleukin 10 receptor subunit beta
increases expression
ISO
Mycophenolic Acid results in increased expression of IL10RB mRNA
CTD
PMID:19818335
NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053
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Il11
interleukin 11
increases expression
ISO
Mycophenolic Acid results in increased expression of IL11 mRNA
CTD
PMID:19818335
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915
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Il12rb2
interleukin 12 receptor subunit beta 2
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL12RB2 mRNA
CTD
PMID:11562063
NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937
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Il13
interleukin 13
increases expression
ISO
Mycophenolic Acid results in increased expression of IL13 mRNA
CTD
PMID:19818335
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
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Il15
interleukin 15
increases expression
ISO
Mycophenolic Acid results in increased expression of IL15 mRNA
CTD
PMID:19818335
NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348
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Il16
interleukin 16
increases expression
ISO
Mycophenolic Acid results in increased expression of IL16 mRNA
CTD
PMID:19818335
NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023
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Il18
interleukin 18
decreases expression
ISO
Mycophenolic Acid results in decreased expression of IL18 mRNA
CTD
PMID:19818335
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
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Il1r1
interleukin 1 receptor type 1
increases expression
ISO
Mycophenolic Acid results in increased expression of IL1R1 mRNA
CTD
PMID:19818335
NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579
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Il1r2
interleukin 1 receptor type 2
increases expression
ISO
Mycophenolic Acid results in increased expression of IL1R2 mRNA
CTD
PMID:19818335
NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374
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Il2
interleukin 2
multiple interactions decreases expression
ISO EXP
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] Mycophenolic Acid results in decreased expression of IL2 mRNA
CTD
PMID:11562063 PMID:12193749 PMID:29594315
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Il2rb
interleukin 2 receptor subunit beta
increases expression
ISO
Mycophenolic Acid results in increased expression of IL2RB mRNA
CTD
PMID:19818335
NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537
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Il2rg
interleukin 2 receptor subunit gamma
increases expression
ISO
Mycophenolic Acid results in increased expression of IL2RG mRNA
CTD
PMID:19818335
NCBI chr X:70,435,340...70,439,052
Ensembl chr X:70,435,343...70,439,161
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Il3
interleukin 3
increases expression
ISO
Mycophenolic Acid results in increased expression of IL3 mRNA
CTD
PMID:19818335
NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810
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Il4
interleukin 4
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL4 mRNA
CTD
PMID:11562063
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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Il5ra
interleukin 5 receptor subunit alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of IL5RA mRNA
CTD
PMID:19818335
NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943
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Il6
interleukin 6
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6 protein
CTD
PMID:11981085
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Il6r
interleukin 6 receptor
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6RA mRNA
CTD
PMID:19818335
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6ST mRNA
CTD
PMID:19818335
NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182
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Impdh2
inosine monophosphate dehydrogenase 2
increases expression
EXP
Mycophenolic Acid results in increased expression of IMPDH2 mRNA
CTD
PMID:11145582
NCBI chr 8:118,135,204...118,139,892
Ensembl chr 8:118,135,262...118,139,873
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Itgam
integrin subunit alpha M
increases expression
ISO
Mycophenolic Acid results in increased expression of ITGAM mRNA
CTD
PMID:19818335
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
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Klrk1
killer cell lectin like receptor K1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of KLRK1
CTD
PMID:20736080
NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382
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Krcc1
lysine-rich coiled-coil 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of KRCC1 mRNA
CTD
PMID:24356939
NCBI chr 4:104,819,958...104,832,987
Ensembl chr 4:104,819,190...104,855,484
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Lrrc37a
leucine rich repeat containing 37A
decreases expression
ISO
Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA
CTD
PMID:24356939
NCBI chr10:88,896,517...88,933,472
Ensembl chr10:88,896,703...88,933,361
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Lta
lymphotoxin alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of LTA mRNA
CTD
PMID:19818335
NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533
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Ltb
lymphotoxin beta
increases expression
ISO
Mycophenolic Acid results in increased expression of LTB mRNA
CTD
PMID:19818335
NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein
CTD
PMID:15604220
NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461
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Mapk1
mitogen activated protein kinase 1
multiple interactions decreases expression increases phosphorylation
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein] Mycophenolic Acid results in decreased expression of MAPK1 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
multiple interactions decreases expression increases phosphorylation
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein] Mycophenolic Acid results in decreased expression of MAPK3 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation decreases expression
ISO EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein] Mycophenolic Acid results in decreased expression of MAPK8 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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Mapk9
mitogen-activated protein kinase 9
multiple interactions decreases expression
ISO EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] Mycophenolic Acid results in decreased expression of MAPK9 protein modified form
CTD
PMID:20302854
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
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Mapt
microtubule-associated protein tau
decreases expression
ISO
Mycophenolic Acid results in decreased expression of MAPT protein
CTD
PMID:16930453
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
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Mif
macrophage migration inhibitory factor
increases expression
ISO
Mycophenolic Acid results in increased expression of MIF mRNA
CTD
PMID:19818335
NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121 Ensembl chr20:134,041,774...134,042,121
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Nanos1
nanos C2HC-type zinc finger 1
increases expression
ISO
Mycophenolic Acid results in increased expression of NANOS1 mRNA
CTD
PMID:24356939
NCBI chr 1:269,883,713...269,887,611
Ensembl chr 1:269,883,536...269,895,417
G
Ncr1
natural cytotoxicity triggering receptor 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR1
CTD
PMID:20736080
NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:78,659,262...78,703,273
G
Ncr2
natural cytotoxicity triggering receptor 2
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR2
CTD
PMID:20736080
NCBI chr 9:20,274,057...20,324,708
G
Ncr3
natural cytotoxicity triggering receptor 3
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR3
CTD
PMID:20736080
NCBI chr20:3,642,912...3,648,425
Ensembl chr20:3,642,912...3,644,188
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO
Mycophenolic Acid results in increased activity of NR1I2 protein [Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:25455453
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
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Ocln
occludin
multiple interactions decreases expression
ISO
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein]
CTD
PMID:35321622
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
G
Pdcd4
programmed cell death 4
increases expression
ISO
Mycophenolic Acid results in increased expression of PDCD4 mRNA
CTD
PMID:24356939
NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
G
Pgr
progesterone receptor
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
G
Prkca
protein kinase C, alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of PRKCA protein
CTD
PMID:21396949
NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
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Rac1
Rac family small GTPase 1
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species]
CTD
PMID:17950325
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of RELA protein modified form Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD
PMID:20302854
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Rgs2
regulator of G-protein signaling 2
increases expression
ISO
Mycophenolic Acid results in increased expression of RGS2 mRNA
CTD
PMID:24356939
NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697
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Rps6
ribosomal protein S6
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein
CTD
PMID:15604220
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
Mycophenolic Acid results in decreased expression of SLC7A11 mRNA
CTD
PMID:24356939
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
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Spmip11
sperm microtubule inner protein 11
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]
CTD
PMID:17624267
NCBI chr 7:131,599,977...131,621,508
Ensembl chr 7:131,599,973...131,621,506
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Mycophenolic Acid results in increased expression of SPP1 mRNA
CTD
PMID:19818335
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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Stat5a
signal transducer and activator of transcription 5A
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein
CTD
PMID:15604220
NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
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Tgfb1
transforming growth factor, beta 1
decreases expression
EXP
Mycophenolic Acid results in decreased expression of TGFB1 mRNA
CTD
PMID:11562063
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
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Tjp1
tight junction protein 1
decreases expression multiple interactions
ISO
Mycophenolic Acid results in decreased expression of TJP1 protein schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein]
CTD
PMID:35321622
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
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Tnf
tumor necrosis factor
decreases expression increases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of TNF mRNA Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
CTD
PMID:11562063 PMID:11912253 PMID:19818335
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
ISO
Mycophenolic Acid results in increased expression of TNFRSF1A mRNA
CTD
PMID:19818335
NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
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Tnfrsf1b
TNF receptor superfamily member 1B
increases expression
ISO
Mycophenolic Acid results in increased expression of TNFRSF1B mRNA
CTD
PMID:19818335
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411
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Tp53
tumor protein p53
affects activity
ISO
Mycophenolic Acid affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
G
Tspoap1
TSPO associated protein 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA
CTD
PMID:24356939
NCBI chr10:73,053,414...73,083,640
Ensembl chr10:73,058,354...73,083,640
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation multiple interactions affects metabolic processing
ISO
UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid 4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid
CTD
PMID:18498916 PMID:18816295 PMID:31742356
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
G
Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney]
RGD
PMID:17624267
RGD:38596322
NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521
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