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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mycophenolic acid
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Accession:CHEBI:168396 term browser browse the term
Definition:A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
 related_synonym: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid;   Formula=C17H20O6;   InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+;   InChIKey=HPNSFSBZBAHARI-RUDMXATFSA-N;   Mycophenolate;   Mycophenolsaeure;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O;   acide mycophenolique;   acido micofenolico;   acidum mycophenolicum
 alt_id: CHEBI:43973
 xref: CAS:24280-93-1;   DrugBank:DB01024;   Drug_Central:1860;   KEGG:D05096
 xref_mesh: MESH:D009173
 xref: PDBeChem:MOA;   PMID:11272311;   PMID:15470161;   PMID:16629948;   PMID:16640327;   PMID:17482154;   PMID:17498396;   PMID:18194117;   PMID:18611107;   PMID:18996104;   PMID:19689217;   Patent:US4753935;   Reaxys:318158;   Wikipedia:Mycophenolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62932



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mycophenolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO Mycophenolic Acid results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr20:2,807,315...2,820,240
Ensembl chr20:2,807,106...2,820,240
JBrowse link
G Adm adrenomedullin multiple interactions EXP Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15063164 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371
JBrowse link
G Agt angiotensinogen decreases expression EXP Mycophenolic Acid results in decreased expression of AGT protein alternative form CTD PMID:15213268 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression
multiple interactions
EXP Mycophenolic Acid results in decreased expression of AIF1 mRNA
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA
CTD PMID:10688038 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Mycophenolic Acid results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO Mycophenolic Acid results in increased expression of AKT1 protein CTD PMID:21396949 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin affects binding ISO Mycophenolic Acid binds to ALB protein CTD PMID:26892221 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Ar androgen receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] CTD PMID:20302854 NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mycophenolic Acid results in increased expression of BAK1 protein CTD PMID:16505121 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein] CTD PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp1 caspase 1 increases expression ISO Mycophenolic Acid results in increased expression of CASP1 mRNA CTD PMID:19818335 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO Mycophenolic Acid results in increased activity of CASP3 protein
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein]
CTD PMID:16059982 PMID:16505121 PMID:21396949 PMID:35321622 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO Mycophenolic Acid results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:17624267 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CCL20 mRNA
Mycophenolic Acid results in increased expression of CCL20 mRNA
CTD PMID:19818335 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Mycophenolic Acid results in increased expression of CCL22 mRNA CTD PMID:19818335 NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO Mycophenolic Acid results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr12:7,505,231...7,514,402
Ensembl chr12:7,505,235...7,514,385
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
EXP [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA
Mycophenolic Acid results in decreased expression of CCL5 mRNA
CTD PMID:10688038 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CCL6 mRNA
Mycophenolic Acid results in increased expression of CCL6 mRNA
CTD PMID:19818335 NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO Mycophenolic Acid results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr10:86,608,836...86,611,273
Ensembl chr10:86,608,836...86,611,273
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO Mycophenolic Acid results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression ISO Mycophenolic Acid results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:132,273,544...132,287,883
JBrowse link
G Cd40lg CD40 ligand increases expression ISO Mycophenolic Acid results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] CTD PMID:12193749 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] CTD PMID:20302854 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO Mycophenolic Acid results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Mycophenolic Acid results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CXCL1 mRNA
Mycophenolic Acid results in increased expression of CXCL1 mRNA
CTD PMID:19818335 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CXCL5 mRNA
Mycophenolic Acid results in increased expression of CXCL5 mRNA
CTD PMID:19818335 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO Mycophenolic Acid results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:53,740,197...53,754,816
JBrowse link
G Cycs cytochrome c, somatic increases secretion ISO Mycophenolic Acid results in increased secretion of CYCS protein CTD PMID:16505121 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Mycophenolic Acid results in increased expression of CYP1A1 mRNA
Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:25929522 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:25929522 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases methylation ISO CYP2C8 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases methylation
ISO [Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased methylation of Mycophenolic Acid
CTD PMID:15570183 PMID:25455453 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases methylation ISO CYP3A5 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Des desmin multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mycophenolic Acid results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] CTD PMID:20302854 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Mycophenolic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24356939 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
EXP
ISO
Mycophenolic Acid results in decreased expression of IFNG mRNA
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD PMID:11562063 PMID:29594315 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il10 interleukin 10 decreases expression EXP Mycophenolic Acid results in decreased expression of IL10 mRNA CTD PMID:11562063 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028
JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053
JBrowse link
G Il11 interleukin 11 increases expression ISO Mycophenolic Acid results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 decreases expression EXP Mycophenolic Acid results in decreased expression of IL12RB2 mRNA CTD PMID:11562063 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937
JBrowse link
G Il13 interleukin 13 increases expression ISO Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il15 interleukin 15 increases expression ISO Mycophenolic Acid results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348
JBrowse link
G Il16 interleukin 16 increases expression ISO Mycophenolic Acid results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023
JBrowse link
G Il18 interleukin 18 decreases expression ISO Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO Mycophenolic Acid results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Mycophenolic Acid results in increased expression of IL1R2 mRNA CTD PMID:19818335 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO
EXP
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
Mycophenolic Acid results in decreased expression of IL2 mRNA
CTD PMID:11562063 PMID:12193749 PMID:29594315 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Mycophenolic Acid results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161
JBrowse link
G Il3 interleukin 3 increases expression ISO Mycophenolic Acid results in increased expression of IL3 mRNA CTD PMID:19818335 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810
JBrowse link
G Il4 interleukin 4 decreases expression EXP Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943
JBrowse link
G Il6 interleukin 6 increases expression ISO Mycophenolic Acid results in increased expression of IL6 protein CTD PMID:11981085 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Mycophenolic Acid results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression EXP Mycophenolic Acid results in increased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:118,135,204...118,139,892
Ensembl chr 8:118,135,262...118,139,873
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Mycophenolic Acid results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Mycophenolic Acid results in decreased expression of KLRK1 CTD PMID:20736080 NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382
JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Mycophenolic Acid results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 4:104,819,958...104,832,987
Ensembl chr 4:104,819,190...104,855,484
JBrowse link
G Lrrc37a leucine rich repeat containing 37A decreases expression ISO Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA CTD PMID:24356939 NCBI chr10:88,896,517...88,933,472
Ensembl chr10:88,896,703...88,933,361
JBrowse link
G Lta lymphotoxin alpha increases expression ISO Mycophenolic Acid results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533
JBrowse link
G Ltb lymphotoxin beta increases expression ISO Mycophenolic Acid results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
increases phosphorylation
ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein]
Mycophenolic Acid results in decreased expression of MAPK1 protein modified form
CTD PMID:20302854 PMID:35321622 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression
increases phosphorylation
ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein]
Mycophenolic Acid results in decreased expression of MAPK3 protein modified form
CTD PMID:20302854 PMID:35321622 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
decreases expression
ISO
EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein]
Mycophenolic Acid results in decreased expression of MAPK8 protein modified form
CTD PMID:20302854 PMID:35321622 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression
ISO
EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
Mycophenolic Acid results in decreased expression of MAPK9 protein modified form
CTD PMID:20302854 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mycophenolic Acid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO Mycophenolic Acid results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121
JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Mycophenolic Acid results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr 1:269,883,713...269,887,611
Ensembl chr 1:269,883,536...269,895,417
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR1 CTD PMID:20736080 NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:78,659,262...78,703,273
JBrowse link
G Ncr2 natural cytotoxicity triggering receptor 2 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR2 CTD PMID:20736080 NCBI chr 9:20,274,057...20,324,708 JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR3 CTD PMID:20736080 NCBI chr20:3,642,912...3,648,425
Ensembl chr20:3,642,912...3,644,188
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Mycophenolic Acid results in increased activity of NR1I2 protein
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Ocln occludin multiple interactions
decreases expression
ISO schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein] CTD PMID:35321622 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mycophenolic Acid results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Prkca protein kinase C, alpha increases expression ISO Mycophenolic Acid results in increased expression of PRKCA protein CTD PMID:21396949 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:17950325 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
EXP
ISO
Mycophenolic Acid results in decreased expression of RELA protein modified form
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD PMID:20302854 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Mycophenolic Acid results in increased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein CTD PMID:15604220 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Mycophenolic Acid results in decreased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr 7:131,599,977...131,621,508
Ensembl chr 7:131,599,973...131,621,506
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein CTD PMID:15604220 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Mycophenolic Acid results in decreased expression of TGFB1 mRNA CTD PMID:11562063 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO Mycophenolic Acid results in decreased expression of TJP1 protein
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein]
CTD PMID:35321622 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
EXP
ISO
Mycophenolic Acid results in decreased expression of TNF mRNA
Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
CTD PMID:11562063 PMID:11912253 PMID:19818335 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Mycophenolic Acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tspoap1 TSPO associated protein 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA CTD PMID:24356939 NCBI chr10:73,053,414...73,083,640
Ensembl chr10:73,058,354...73,083,640
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
affects metabolic processing
ISO UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid
4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide
UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid
CTD PMID:18498916 PMID:18816295 PMID:31742356 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          mycophenolic acid 114
            mycophenolate mofetil 1
            mycophenolic acid O-acyl-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      monocarboxylic acid 18309
                                        fatty acid 17010
                                          unsaturated fatty acid 1711
                                            monounsaturated fatty acid 634
                                              hexenoic acid 114
                                                hex-4-enoic acid 114
                                                  mycophenolic acid 114
                                                    mycophenolate mofetil 1
                                                    mycophenolic acid O-acyl-glucuronide 0
paths to the root