CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mycophenolic acid
Accession: CHEBI:168396
browse the term
Definition: A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.
Synonyms: exact_synonym: (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
related_synonym: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid; Formula=C17H20O6; InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+; InChIKey=HPNSFSBZBAHARI-RUDMXATFSA-N; Mycophenolate; Mycophenolsaeure; SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O; acide mycophenolique; acido micofenolico; acidum mycophenolicum
alt_id: CHEBI:43973
xref: CAS:24280-93-1; DrugBank:DB01024; Drug_Central:1860; KEGG:D05096
xref_mesh: MESH:D009173
xref: PDBeChem:MOA; PMID:11272311; PMID:15470161; PMID:16629948; PMID:16640327; PMID:17482154; PMID:17498396; PMID:18194117; PMID:18611107; PMID:18996104; PMID:19689217; Patent:US4753935; Reaxys:318158; Wikipedia:Mycophenolic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:62932
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Abcf1
ATP binding cassette subfamily F member 1
increases expression
ISO
Mycophenolic Acid results in increased expression of ABCF1 mRNA
CTD
PMID:19818335
NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
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Adm
adrenomedullin
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein]
CTD
PMID:15063164
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Agt
angiotensinogen
decreases expression
EXP
Mycophenolic Acid results in decreased expression of AGT protein alternative form
CTD
PMID:15213268
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Aif1
allograft inflammatory factor 1
decreases expression multiple interactions
EXP
Mycophenolic Acid results in decreased expression of AIF1 mRNA [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA
CTD
PMID:10688038
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Aimp1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
increases expression
ISO
Mycophenolic Acid results in increased expression of AIMP1 mRNA
CTD
PMID:19818335
NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
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Akt1
AKT serine/threonine kinase 1
increases expression
ISO
Mycophenolic Acid results in increased expression of AKT1 protein
CTD
PMID:21396949
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
affects binding
ISO
Mycophenolic Acid binds to ALB protein
CTD
PMID:26892221
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Ar
androgen receptor
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atf1
activating transcription factor 1
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein]
CTD
PMID:20302854
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Mycophenolic Acid results in increased expression of BAK1 protein
CTD
PMID:16505121
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein
CTD
PMID:21396949
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone]; schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of BCL2 protein]
CTD
PMID:16505121 PMID:21396949 PMID:35321622
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp1
caspase 1
increases expression
ISO
Mycophenolic Acid results in increased expression of CASP1 mRNA
CTD
PMID:19818335
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO
Mycophenolic Acid results in increased activity of CASP3 protein [Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased cleavage of CASP3 protein]
CTD
PMID:16059982 PMID:16505121 PMID:21396949 PMID:35321622
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl19
C-C motif chemokine ligand 19
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL19 mRNA
CTD
PMID:19818335
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
CTD
PMID:17624267
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CCL20 mRNA Mycophenolic Acid results in increased expression of CCL20 mRNA
CTD
PMID:19818335
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl22
C-C motif chemokine ligand 22
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL22 mRNA
CTD
PMID:19818335
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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Ccl25
C-C motif chemokine ligand 25
increases expression
ISO
Mycophenolic Acid results in increased expression of CCL25 mRNA
CTD
PMID:19818335
NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Mycophenolic Acid results in decreased expression of CCL4 mRNA
CTD
PMID:19818335
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccl5
C-C motif chemokine ligand 5
multiple interactions decreases expression
EXP
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA Mycophenolic Acid results in decreased expression of CCL5 mRNA
CTD
PMID:10688038
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccl7
C-C motif chemokine ligand 7
decreases expression
ISO
Mycophenolic Acid results in decreased expression of CCL7 mRNA
CTD
PMID:19818335
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccl9
C-C motif chemokine ligand 9
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CCL6 mRNA Mycophenolic Acid results in increased expression of CCL6 mRNA
CTD
PMID:19818335
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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Ccr10
C-C motif chemokine receptor 10
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR10 mRNA
CTD
PMID:19818335
NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988
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Ccr2
C-C motif chemokine receptor 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR2 mRNA
CTD
PMID:19818335
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Ccr3
C-C motif chemokine receptor 3
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR3 mRNA
CTD
PMID:19818335
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Ccr6
C-C motif chemokine receptor 6
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR6 mRNA
CTD
PMID:19818335
NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
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Ccr9
C-C motif chemokine receptor 9
increases expression
ISO
Mycophenolic Acid results in increased expression of CCR9 mRNA
CTD
PMID:19818335
NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969
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Cd40lg
CD40 ligand
increases expression
ISO
Mycophenolic Acid results in increased expression of CD40LG mRNA
CTD
PMID:19818335
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
CTD
PMID:12193749
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein]
CTD
PMID:20302854
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
ISO
Mycophenolic Acid results in increased expression of CX3CL1 mRNA
CTD
PMID:19818335
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl12
C-X-C motif chemokine ligand 12
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCL12 mRNA
CTD
PMID:19818335
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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Cxcl2
C-X-C motif chemokine ligand 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCL2 protein
CTD
PMID:19818335
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CXCL1 mRNA Mycophenolic Acid results in increased expression of CXCL1 mRNA
CTD
PMID:19818335
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cxcl6
C-X-C motif chemokine ligand 6
decreases expression increases expression
ISO
Mycophenolic Acid results in decreased expression of CXCL5 mRNA Mycophenolic Acid results in increased expression of CXCL5 mRNA
CTD
PMID:19818335
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Cxcr2
C-X-C motif chemokine receptor 2
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR2 mRNA
CTD
PMID:19818335
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cxcr3
C-X-C motif chemokine receptor 3
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR3 mRNA
CTD
PMID:19818335
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Cxcr5
C-X-C motif chemokine receptor 5
increases expression
ISO
Mycophenolic Acid results in increased expression of CXCR5 mRNA
CTD
PMID:19818335
NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
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Cycs
cytochrome c, somatic
increases secretion
ISO
Mycophenolic Acid results in increased secretion of CYCS protein
CTD
PMID:16505121
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
Mycophenolic Acid results in increased expression of CYP1A1 mRNA Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD
PMID:25929522
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
CTD
PMID:25929522
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases methylation
ISO
CYP2C8 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases methylation
ISO
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183 PMID:25455453
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases methylation
ISO
CYP3A5 protein results in increased methylation of Mycophenolic Acid
CTD
PMID:15570183
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Des
desmin
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein]
CTD
PMID:17624267
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Esr1
estrogen receptor 1
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of ESR2 protein
CTD
PMID:25752796
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Mycophenolic Acid results in increased expression of FOS mRNA
CTD
PMID:12730611
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein]
CTD
PMID:20302854
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
Mycophenolic Acid results in decreased expression of HSPA5 mRNA
CTD
PMID:24356939
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Ifng
interferon gamma
decreases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of IFNG mRNA [Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD
PMID:11562063 PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL10 mRNA
CTD
PMID:11562063
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il10ra
interleukin 10 receptor subunit alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of IL10RA mRNA
CTD
PMID:19818335
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
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Il10rb
interleukin 10 receptor subunit beta
increases expression
ISO
Mycophenolic Acid results in increased expression of IL10RB mRNA
CTD
PMID:19818335
NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074
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Il11
interleukin 11
increases expression
ISO
Mycophenolic Acid results in increased expression of IL11 mRNA
CTD
PMID:19818335
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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Il12rb2
interleukin 12 receptor subunit beta 2
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL12RB2 mRNA
CTD
PMID:11562063
NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289
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Il13
interleukin 13
increases expression
ISO
Mycophenolic Acid results in increased expression of IL13 mRNA
CTD
PMID:19818335
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il15
interleukin 15
increases expression
ISO
Mycophenolic Acid results in increased expression of IL15 mRNA
CTD
PMID:19818335
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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Il16
interleukin 16
increases expression
ISO
Mycophenolic Acid results in increased expression of IL16 mRNA
CTD
PMID:19818335
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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Il18
interleukin 18
decreases expression
ISO
Mycophenolic Acid results in decreased expression of IL18 mRNA
CTD
PMID:19818335
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1r1
interleukin 1 receptor type 1
increases expression
ISO
Mycophenolic Acid results in increased expression of IL1R1 mRNA
CTD
PMID:19818335
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Il1r2
interleukin 1 receptor type 2
increases expression
ISO
Mycophenolic Acid results in increased expression of IL1R2 mRNA
CTD
PMID:19818335
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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Il2
interleukin 2
multiple interactions decreases expression
ISO EXP
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] Mycophenolic Acid results in decreased expression of IL2 mRNA
CTD
PMID:11562063 PMID:12193749 PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il2rb
interleukin 2 receptor subunit beta
increases expression
ISO
Mycophenolic Acid results in increased expression of IL2RB mRNA
CTD
PMID:19818335
NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
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Il2rg
interleukin 2 receptor subunit gamma
increases expression
ISO
Mycophenolic Acid results in increased expression of IL2RG mRNA
CTD
PMID:19818335
NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823
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Il3
interleukin 3
increases expression
ISO
Mycophenolic Acid results in increased expression of IL3 mRNA
CTD
PMID:19818335
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Il4
interleukin 4
decreases expression
EXP
Mycophenolic Acid results in decreased expression of IL4 mRNA
CTD
PMID:11562063
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5ra
interleukin 5 receptor subunit alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of IL5RA mRNA
CTD
PMID:19818335
NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
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Il6
interleukin 6
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6 protein
CTD
PMID:11981085
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6RA mRNA
CTD
PMID:19818335
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
Mycophenolic Acid results in increased expression of IL6ST mRNA
CTD
PMID:19818335
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Impdh2
inosine monophosphate dehydrogenase 2
increases expression
EXP
Mycophenolic Acid results in increased expression of IMPDH2 mRNA
CTD
PMID:11145582
NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
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Itgam
integrin subunit alpha M
increases expression
ISO
Mycophenolic Acid results in increased expression of ITGAM mRNA
CTD
PMID:19818335
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Klrk1
killer cell lectin like receptor K1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of KLRK1
CTD
PMID:20736080
NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
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Krcc1
lysine-rich coiled-coil 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of KRCC1 mRNA
CTD
PMID:24356939
NCBI chr 4:103,261,642...103,274,672
Ensembl chr 4:103,261,536...103,277,156
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Lrrc37a
leucine rich repeat containing 37A
decreases expression
ISO
Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA
CTD
PMID:24356939
NCBI chr10:88,395,837...88,433,519
Ensembl chr10:88,396,663...88,433,323
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Lta
lymphotoxin alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of LTA mRNA
CTD
PMID:19818335
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Ltb
lymphotoxin beta
increases expression
ISO
Mycophenolic Acid results in increased expression of LTB mRNA
CTD
PMID:19818335
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein
CTD
PMID:15604220
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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Mapk1
mitogen activated protein kinase 1
multiple interactions decreases expression increases phosphorylation
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK1 protein] Mycophenolic Acid results in decreased expression of MAPK1 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions decreases expression increases phosphorylation
ISO
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK3 protein] Mycophenolic Acid results in decreased expression of MAPK3 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation decreases expression
ISO EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; schizandrin A inhibits the reaction [Mycophenolic Acid results in increased phosphorylation of MAPK8 protein] Mycophenolic Acid results in decreased expression of MAPK8 protein modified form
CTD
PMID:20302854 PMID:35321622
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions decreases expression
ISO EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] Mycophenolic Acid results in decreased expression of MAPK9 protein modified form
CTD
PMID:20302854
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapt
microtubule-associated protein tau
decreases expression
ISO
Mycophenolic Acid results in decreased expression of MAPT protein
CTD
PMID:16930453
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mif
macrophage migration inhibitory factor
increases expression
ISO
Mycophenolic Acid results in increased expression of MIF mRNA
CTD
PMID:19818335
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 Ensembl chr 4:12,790,902...12,799,504
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Nanos1
nanos C2HC-type zinc finger 1
increases expression
ISO
Mycophenolic Acid results in increased expression of NANOS1 mRNA
CTD
PMID:24356939
NCBI chr 1:259,897,663...259,901,561
Ensembl chr 1:259,897,939...259,898,730
G
Ncr1
natural cytotoxicity triggering receptor 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR1
CTD
PMID:20736080
NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558
G
Ncr2
natural cytotoxicity triggering receptor 2
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR2
CTD
PMID:20736080
NCBI chr 9:12,777,195...12,828,437
G
Ncr3
natural cytotoxicity triggering receptor 3
decreases expression
ISO
Mycophenolic Acid results in decreased expression of NCR3
CTD
PMID:20736080
NCBI chr20:3,637,242...3,643,748
Ensembl chr20:3,638,240...3,643,799
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO
Mycophenolic Acid results in increased activity of NR1I2 protein [Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Ocln
occludin
multiple interactions decreases expression
ISO
schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of OCLN protein]
CTD
PMID:35321622
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Pdcd4
programmed cell death 4
increases expression
ISO
Mycophenolic Acid results in increased expression of PDCD4 mRNA
CTD
PMID:24356939
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pgr
progesterone receptor
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Prkca
protein kinase C, alpha
increases expression
ISO
Mycophenolic Acid results in increased expression of PRKCA protein
CTD
PMID:21396949
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Rac1
Rac family small GTPase 1
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species]
CTD
PMID:17950325
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of RELA protein modified form Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD
PMID:20302854
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rgs2
regulator of G-protein signaling 2
increases expression
ISO
Mycophenolic Acid results in increased expression of RGS2 mRNA
CTD
PMID:24356939
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rps6
ribosomal protein S6
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein
CTD
PMID:15604220
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
Mycophenolic Acid results in decreased expression of SLC7A11 mRNA
CTD
PMID:24356939
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Spmip11
sperm microtubule inner protein 11
multiple interactions
EXP
Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]
CTD
PMID:17624267
NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485
G
Spp1
secreted phosphoprotein 1
increases expression
ISO
Mycophenolic Acid results in increased expression of SPP1 mRNA
CTD
PMID:19818335
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Stat5a
signal transducer and activator of transcription 5A
multiple interactions
ISO
[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein
CTD
PMID:15604220
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
G
Tgfb1
transforming growth factor, beta 1
decreases expression
EXP
Mycophenolic Acid results in decreased expression of TGFB1 mRNA
CTD
PMID:11562063
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Mycophenolic Acid binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Tjp1
tight junction protein 1
decreases expression multiple interactions
ISO
Mycophenolic Acid results in decreased expression of TJP1 protein schizandrin A inhibits the reaction [Mycophenolic Acid results in decreased expression of TJP1 protein]
CTD
PMID:35321622
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tnf
tumor necrosis factor
decreases expression increases expression multiple interactions
EXP ISO
Mycophenolic Acid results in decreased expression of TNF mRNA Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
CTD
PMID:11562063 PMID:11912253 PMID:19818335
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
ISO
Mycophenolic Acid results in increased expression of TNFRSF1A mRNA
CTD
PMID:19818335
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf1b
TNF receptor superfamily member 1B
increases expression
ISO
Mycophenolic Acid results in increased expression of TNFRSF1B mRNA
CTD
PMID:19818335
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Tp53
tumor protein p53
affects activity
ISO
Mycophenolic Acid affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tspoap1
TSPO associated protein 1
decreases expression
ISO
Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA
CTD
PMID:24356939
NCBI chr10:72,554,220...72,586,402
Ensembl chr10:72,560,980...72,586,412
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation multiple interactions affects metabolic processing
ISO
UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid 4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid
CTD
PMID:18498916 PMID:18816295 PMID:31742356
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney]
RGD
PMID:17624267
RGD:38596322
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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