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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mycophenolate mofetil
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Accession:CHEBI:8764 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
 related_synonym: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate;   Cellcept;   Formula=C23H31NO7;   InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+;   InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N;   MMF;   RS 61443;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(=O)OCCN1CCOCC1;   mycophenolic acid morpholinoethyl ester
 xref: CAS:128794-94-5;   DrugBank:DB00688;   Drug_Central:1859;   HMDB:HMDB0014826;   KEGG:C07908;   KEGG:D00752
 xref_mesh: MESH:C063008
 xref: PMID:11099793;   PMID:11490743;   PMID:15572389;   PMID:15992049;   PMID:16979992;   PMID:19858585;   PMID:21180633;   PMID:21710356;   PMID:22081165;   PMID:22294686;   PMID:22310598;   PMID:22417996;   PMID:22460418;   PMID:22560143;   PMID:8826401;   PMID:9274835;   Reaxys:7500599;   Wikipedia:Mycophenolate_mofetil

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mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        antimicrobial agent 17376
          mycophenolic acid 109
            mycophenolate mofetil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        monocarboxylic acid 17604
                                          fatty acid 16009
                                            unsaturated fatty acid 950
                                              monounsaturated fatty acid 449
                                                hexenoic acid 109
                                                  hex-4-enoic acid 109
                                                    mycophenolic acid 109
                                                      mycophenolate mofetil 1
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