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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mycophenolate mofetil
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Accession:CHEBI:8764 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
 related_synonym: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate;   Cellcept;   Formula=C23H31NO7;   InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+;   InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N;   MMF;   RS 61443;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(=O)OCCN1CCOCC1;   mycophenolic acid morpholinoethyl ester
 xref: CAS:128794-94-5;   DrugBank:DB00688;   Drug_Central:1859;   HMDB:HMDB0014826;   KEGG:C07908;   KEGG:D00752
 xref_mesh: MESH:C063008
 xref: PMID:11099793;   PMID:11490743;   PMID:15572389;   PMID:15992049;   PMID:16979992;   PMID:19858585;   PMID:21180633;   PMID:21710356;   PMID:22081165;   PMID:22294686;   PMID:22310598;   PMID:22417996;   PMID:22460418;   PMID:22560143;   PMID:8826401;   PMID:9274835;   Reaxys:7500599;   Wikipedia:Mycophenolate_mofetil

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mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          mycophenolic acid 109
            mycophenolate mofetil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          fatty acid 16480
                                            unsaturated fatty acid 956
                                              monounsaturated fatty acid 452
                                                hexenoic acid 109
                                                  hex-4-enoic acid 109
                                                    mycophenolic acid 109
                                                      mycophenolate mofetil 1
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