Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mycophenolate mofetil
go back to main search page
Accession:CHEBI:8764 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
 related_synonym: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate;   Cellcept;   Formula=C23H31NO7;   InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+;   InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N;   MMF;   RS 61443;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(=O)OCCN1CCOCC1;   mycophenolic acid morpholinoethyl ester
 xref: CAS:128794-94-5;   DrugBank:DB00688;   Drug_Central:1859;   HMDB:HMDB0014826;   KEGG:C07908;   KEGG:D00752
 xref_mesh: MESH:C063008
 xref: PMID:11099793;   PMID:11490743;   PMID:15572389;   PMID:15992049;   PMID:16979992;   PMID:19858585;   PMID:21180633;   PMID:21710356;   PMID:22081165;   PMID:22294686;   PMID:22310598;   PMID:22417996;   PMID:22460418;   PMID:22560143;   PMID:8826401;   PMID:9274835;   Reaxys:7500599;   Wikipedia:Mycophenolate_mofetil


show annotations for term's descendants           Sort by:
 
mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        antimicrobial agent 17369
          mycophenolic acid 108
            mycophenolate mofetil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        monocarboxylic acid 17594
                                          fatty acid 16001
                                            unsaturated fatty acid 950
                                              monounsaturated fatty acid 450
                                                hexenoic acid 108
                                                  hex-4-enoic acid 108
                                                    mycophenolic acid 108
                                                      mycophenolate mofetil 1
paths to the root