Nanos1 (nanos C2HC-type zinc finger 1) - Rat Genome Database

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Gene: Nanos1 (nanos C2HC-type zinc finger 1) Rattus norvegicus
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Symbol: Nanos1
Name: nanos C2HC-type zinc finger 1
RGD ID: 1308194
Description: Predicted to enable enzyme activator activity and mRNA binding activity. Predicted to be involved in epithelial cell migration; oogenesis; and post-transcriptional regulation of gene expression. Predicted to act upstream of or within several processes, including cerebellar neuron development; regulation of cell growth; and tissue homeostasis. Predicted to be located in cytoplasm. Predicted to be active in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Orthologous to human NANOS1 (nanos C2HC-type zinc finger 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365494; nanos homolog 1; nanos homolog 1 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,883,713 - 269,887,611 (+)NCBIGRCr8
mRatBN7.21259,897,663 - 259,901,561 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,897,939 - 259,898,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,104,260 - 268,108,173 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,810,285 - 274,814,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,464,604 - 267,468,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,134,676 - 282,140,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,134,981 - 282,135,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,473,193 - 289,478,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,364,669 - 267,365,460 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,575,753 - 267,576,545 (+)NCBI
Celera1255,538,425 - 255,544,121 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12690449   PMID:17047063   PMID:18223680   PMID:19168546   PMID:24736845   PMID:25100735   PMID:26609159   PMID:37058523  


Genomics

Comparative Map Data
Nanos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,883,713 - 269,887,611 (+)NCBIGRCr8
mRatBN7.21259,897,663 - 259,901,561 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,897,939 - 259,898,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,104,260 - 268,108,173 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,810,285 - 274,814,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,464,604 - 267,468,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,134,676 - 282,140,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,134,981 - 282,135,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,473,193 - 289,478,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,364,669 - 267,365,460 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,575,753 - 267,576,545 (+)NCBI
Celera1255,538,425 - 255,544,121 (+)NCBICelera
Cytogenetic Map1q55NCBI
NANOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,029,714 - 119,033,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,029,714 - 119,033,730 (+)EnsemblGRCh38hg38GRCh38
GRCh3710120,789,226 - 120,793,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,779,218 - 120,783,844 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410120,779,217 - 120,783,844NCBI
Celera10114,519,831 - 114,524,459 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,419,071 - 114,422,892 (+)NCBIHuRef
CHM1_110121,073,565 - 121,078,193 (+)NCBICHM1_1
T2T-CHM13v2.010119,925,128 - 119,929,140 (+)NCBIT2T-CHM13v2.0
Nanos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,744,425 - 60,748,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,744,425 - 60,748,352 (+)EnsemblGRCm39 Ensembl
GRCm381960,755,987 - 60,759,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,755,987 - 60,759,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv371960,831,890 - 60,835,817 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,810,650 - 60,814,577 (+)NCBIMGSCv36mm8
Celera1962,965,287 - 62,969,184 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Nanos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,538,242 - 23,539,051 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,538,224 - 23,540,039 (+)NCBIChiLan1.0ChiLan1.0
NANOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,891,105 - 130,892,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,896,469 - 130,898,314 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010115,603,040 - 115,607,245 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NANOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,285,422 - 29,287,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,427,699 - 29,428,585 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,816,403 - 29,817,305 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,816,403 - 29,817,305 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,370,510 - 29,371,386 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,390,262 - 29,391,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,584,430 - 29,585,323 (+)NCBIUU_Cfam_GSD_1.0
NANOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14128,962,375 - 128,963,229 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114128,962,311 - 128,964,207 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,493,274 - 140,495,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NANOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,823,590 - 111,825,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604873,088,083 - 73,091,031 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,737,735 - 27,738,568 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473727,736,167 - 27,738,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nanos1
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000036203
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1259647732260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1258843780260122809Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43
Low 81 168 111 60 111 207 37 104 49
Below cutoff 3 45 48 25 9 25 17 25 71 41 8 15

Sequence


Ensembl Acc Id: ENSRNOT00000036203   ⟹   ENSRNOP00000033820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1259,897,939 - 259,898,730 (+)Ensembl
Rnor_6.0 Ensembl1282,134,981 - 282,135,772 (+)Ensembl
RefSeq Acc Id: NM_001400932   ⟹   NP_001387861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,883,713 - 269,887,611 (+)NCBI
mRatBN7.21259,897,663 - 259,901,561 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387861 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033820.2
Ensembl Acc Id: ENSRNOP00000033820   ⟸   ENSRNOT00000036203
RefSeq Acc Id: NP_001387861   ⟸   NM_001400932
- UniProtKB: D4A1F8 (UniProtKB/TrEMBL)
Protein Domains
Nanos-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1F8-F1-model_v2 AlphaFold D4A1F8 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691026
Promoter ID:EPDNEW_R1545
Type:single initiation site
Name:Nanos1_1
Description:nanos C2HC-type zinc finger 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,134,897 - 282,134,957EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308194 AgrOrtholog
BioCyc Gene G2FUF-55226 BioCyc
Ensembl Genes ENSRNOG00000025060 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036203.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.60.30 UniProtKB/TrEMBL
InterPro Nanos_sf UniProtKB/TrEMBL
  Znf_Nanos UniProtKB/TrEMBL
  Znf_nanos-typ UniProtKB/TrEMBL
NCBI Gene 365494 ENTREZGENE
PANTHER NANOS HOMOLOG 1 UniProtKB/TrEMBL
  Znf_Nanos UniProtKB/TrEMBL
Pfam zf-nanos UniProtKB/TrEMBL
PhenoGen Nanos1 PhenoGen
PROSITE ZF_NANOS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025060 RatGTEx
UniProt D4A1F8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-10 Nanos1  nanos C2HC-type zinc finger 1  Nanos1  nanos homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nanos1  nanos homolog 1 (Drosophila)   Nanos1_predicted  nanos homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nanos1_predicted  nanos homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED