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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:enilconazole
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Accession:CHEBI:81927 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.
Synonyms:exact_synonym: rac-1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
 related_synonym: (+-)-1-(beta-(Allyloxy)-2,4-dichlorophenethyl)-imidazole;   (RS)-enilconazole;   1-[2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl]-1H-imidazole;   Allyl-1-(2,4-dichlorophenyl)-2-imidazol-1-ylethyl ether;   Chloramizol;   Formula=C14H14Cl2N2O;   Imazalil;   R 23,979;   R 23979;   chloramizole;   enilconazol;   enilconazolum;   rac-enilconazole;   racemic enilconazole
 xref: CAS:35554-44-0;   HMDB:HMDB0031794;   KEGG:C18739;   KEGG:D03997
 xref_mesh: MESH:C017435
 xref: PMID:23813824;   PMID:23952944;   PMID:24039133;   PMID:24123539;   PMID:24334985;   Pesticides:imazalil;   Reaxys:545683;   Wikipedia:Enilconazole


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enilconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO enilconazole results in decreased expression of ABCB11 mRNA CTD PMID:29451352 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO enilconazole results in decreased expression of ABCC2 mRNA CTD PMID:29451352 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression
multiple interactions
increases expression		 ISO
EXP		 enilconazole results in decreased expression of ABCC3 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA
enilconazole results in increased expression of ABCC3 mRNA		 CTD PMID:29451352 PMID:33426623 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO enilconazole results in decreased expression of ABCD3 mRNA CTD PMID:30853599 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO enilconazole results in decreased expression of ACOX1 mRNA CTD PMID:32201337 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adk adenosine kinase increases expression ISO enilconazole results in increased expression of ADK mRNA CTD PMID:32201337 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
increases expression		 ISO
EXP		 enilconazole results in decreased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA
enilconazole results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA		 CTD PMID:32201337 PMID:33426623 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression
multiple interactions		 ISO enilconazole results in decreased expression of ALDH2 mRNA
[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein		 CTD PMID:32201337 PMID:34830855 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ano1 anoctamin 1 decreases expression ISO enilconazole results in decreased expression of ANO1 mRNA CTD PMID:29106682 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Anxa10 annexin A10 increases expression ISO enilconazole results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
affects binding		 ISO Dihydrotestosterone inhibits the reaction [enilconazole results in increased activity of AR protein]; enilconazole inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; enilconazole inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]
enilconazole results in decreased expression of AR mRNA
enilconazole binds to AR protein		 CTD PMID:15064155 PMID:18324785 PMID:21310686 PMID:30853599 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arg1 arginase 1 decreases expression ISO enilconazole results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO enilconazole results in increased expression of ATP8B1 mRNA CTD PMID:32201337 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396 		JBrowse link
G Cat catalase increases expression ISO enilconazole results in increased expression of CAT mRNA CTD PMID:29451352 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO enilconazole results in increased expression of CCL5 mRNA CTD PMID:32201337 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
decreases expression		 ISO [enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein
enilconazole results in decreased expression of CES2 mRNA		 CTD PMID:32201337 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cftr CF transmembrane conductance regulator affects binding
decreases expression		 ISO enilconazole binds to CFTR protein
enilconazole results in decreased expression of CFTR mRNA; enilconazole results in decreased expression of CFTR protein		 CTD PMID:29106682 PMID:32814239 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO enilconazole results in increased expression of COMT protein CTD PMID:32201337 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects expression ISO enilconazole affects the expression of CYP11A1 mRNA CTD PMID:30853599 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO enilconazole results in increased expression of CYP17A1 mRNA CTD PMID:30853599 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
affects secretion		 ISO enilconazole results in decreased activity of CYP19A1 protein
enilconazole affects the secretion of CYP19A1 mRNA		 CTD PMID:10806373 PMID:15554355 PMID:26141389 PMID:30853599 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions		 ISO enilconazole results in increased activity of CYP1A1 protein
enilconazole results in increased expression of CYP1A1 mRNA; enilconazole results in increased expression of CYP1A1 protein
enilconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:19070657 PMID:21762035 PMID:32194361 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
multiple interactions		 ISO enilconazole affects the expression of CYP1A2 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA		 CTD PMID:32201337 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO enilconazole results in increased expression of CYP1B1 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein		 CTD PMID:32201337 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO enilconazole results in increased expression of CYP27A1 mRNA CTD PMID:32814239 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions		 EXP enilconazole results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B2 mRNA		 CTD PMID:33426623 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
affects expression		 ISO [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
enilconazole results in increased expression of CYP2B10
enilconazole affects the expression of CYP2B6 mRNA		 CTD PMID:27853109 PMID:32201337 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO enilconazole results in decreased expression of CYP2C19 mRNA; enilconazole results in decreased expression of CYP2C19 protein CTD PMID:32194361 PMID:32201337 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression		 ISO [clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
enilconazole results in decreased expression of CYP2E1 mRNA		 CTD PMID:32201337 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects expression
decreases activity
multiple interactions
increases expression		 ISO enilconazole affects the expression of CYP3A4 mRNA
enilconazole results in decreased activity of CYP3A4 protein
[Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA
enilconazole results in increased expression of CYP3A4 protein		 CTD PMID:21762035 PMID:25028461 PMID:32201337 PMID:34273450 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression		 EXP [enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A23-3A1 mRNA
enilconazole results in increased expression of CYP3A23-3A1 mRNA		 CTD PMID:33426623 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions		 ISO enilconazole results in increased expression of CYP3A5 mRNA; enilconazole results in increased expression of CYP3A5 protein
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein		 CTD PMID:32201337 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO enilconazole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO
EXP		 enilconazole results in decreased expression of CYP7A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA
enilconazole results in decreased expression of CYP7A1 mRNA; enilconazole results in decreased expression of CYP7A1 protein		 CTD PMID:29451352 PMID:32194361 PMID:32201337 PMID:32814239 PMID:33426623 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO enilconazole results in decreased expression of CYP7B1 mRNA CTD PMID:32201337 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO enilconazole results in increased expression of CYP8B1 mRNA CTD PMID:32814239 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dnm1 dynamin 1 decreases expression ISO enilconazole results in decreased expression of DNM1 mRNA CTD PMID:32201337 NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538 		JBrowse link
G Eln elastin decreases expression
multiple interactions		 EXP enilconazole results in decreased expression of ELN mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA		 CTD PMID:33426623 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO enilconazole binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 decreases expression
multiple interactions		 ISO enilconazole results in decreased expression of ESR2 mRNA
enilconazole binds to and results in increased activity of ESR2 protein		 CTD PMID:30853599 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fabp6 fatty acid binding protein 6 decreases expression ISO enilconazole results in decreased expression of FABP6 mRNA CTD PMID:32814239 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO enilconazole results in increased expression of FAS mRNA CTD PMID:32201337 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression
increases expression		 ISO enilconazole results in decreased expression of FGF15 mRNA
enilconazole results in increased expression of FGF15 mRNA		 CTD PMID:29451352 PMID:32814239 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO enilconazole results in decreased expression of G6PC1 mRNA CTD PMID:32194361 PMID:32201337 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO enilconazole results in increased expression of GPX1 mRNA CTD PMID:29451352 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO enilconazole results in decreased expression of GPX2 mRNA CTD PMID:29451352 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO enilconazole results in increased expression of GSR mRNA CTD PMID:29451352 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase decreases expression ISO enilconazole results in decreased expression of GSS mRNA CTD PMID:29451352 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression ISO enilconazole results in decreased expression of HAAO mRNA CTD PMID:32201337 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression ISO enilconazole affects the expression of HMGCR mRNA CTD PMID:30853599 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression ISO enilconazole affects the expression of HMGCS1 mRNA CTD PMID:30853599 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 decreases expression ISO enilconazole results in decreased expression of HSD17B13 mRNA CTD PMID:30853599 NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression ISO enilconazole affects the expression of HSD3B1 mRNA CTD PMID:30853599 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Ifng interferon gamma increases expression ISO enilconazole results in increased expression of IFNG mRNA CTD PMID:27393971 PMID:32814239 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression		 ISO enilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
enilconazole results in increased expression of IL17A mRNA		 CTD PMID:22289359 PMID:32814239 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO enilconazole results in increased expression of IL1A mRNA CTD PMID:32814239 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO enilconazole results in increased expression of IL1B mRNA CTD PMID:27393971 PMID:32814239 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO enilconazole results in increased expression of IL6 mRNA CTD PMID:27393971 PMID:32201337 PMID:32814239 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO enilconazole results in increased expression of JUN mRNA CTD PMID:32201337 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Khk ketohexokinase decreases expression ISO enilconazole results in decreased expression of KHK mRNA CTD PMID:32201337 NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717 		JBrowse link
G Klf4 KLF transcription factor 4 affects expression
decreases expression		 ISO enilconazole affects the expression of KLF4 mRNA
enilconazole results in decreased expression of KLF4 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Ky kyphoscoliosis peptidase multiple interactions
decreases expression		 EXP [enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA
enilconazole results in decreased expression of KY mRNA		 CTD PMID:33426623 NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO enilconazole results in increased expression of LCN2 CTD PMID:27393971 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP enilconazole results in decreased expression of LHB protein CTD PMID:36410587 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO enilconazole results in increased expression of LPL mRNA CTD PMID:32201337 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D decreases expression ISO enilconazole results in decreased expression of LY6D mRNA CTD PMID:32201337 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO enilconazole results in increased expression of MAPK8 mRNA CTD PMID:32201337 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Megf11 multiple EGF-like-domains 11 multiple interactions
decreases expression		 EXP [enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA
enilconazole results in decreased expression of MEGF11 mRNA		 CTD PMID:33426623 NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061 		JBrowse link
G Mep1b meprin A subunit beta affects expression
decreases expression		 ISO enilconazole affects the expression of MEP1B mRNA
enilconazole results in decreased expression of MEP1B mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840 		JBrowse link
G Mlxipl MLX interacting protein-like decreases expression ISO enilconazole results in decreased expression of MLXIPL mRNA CTD PMID:32201337 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases expression		 EXP [enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA
enilconazole results in increased expression of MME mRNA		 CTD PMID:33426623 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO enilconazole results in decreased expression of MTTP mRNA CTD PMID:32201337 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Muc1 mucin 1, cell surface associated affects expression
decreases expression		 ISO enilconazole affects the expression of MUC1 mRNA
enilconazole results in decreased expression of MUC1 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming affects expression
decreases expression		 ISO enilconazole affects the expression of MUC2 mRNA
enilconazole results in decreased expression of MUC2 mRNA		 CTD PMID:29106682 PMID:32814239 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc3 mucin 3 decreases expression ISO enilconazole results in decreased expression of MUC17 mRNA CTD PMID:32814239 NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression		 ISO [clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA
enilconazole results in decreased expression of NR0B2 mRNA		 CTD PMID:32201337 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
increases expression		 ISO enilconazole results in decreased expression of NR1H4 mRNA
enilconazole results in increased expression of NR1H4 mRNA		 CTD PMID:29451352 PMID:32814239 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein; enilconazole binds to and results in increased activity of NR1I2 protein; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
enilconazole results in increased activity of NR1I2 protein		 CTD PMID:16565514 PMID:17438109 PMID:21115097 PMID:25028461 PMID:29973476 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects response to substance		 ISO enilconazole binds to and results in increased activity of NR1I3 protein; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]
NR1I3 protein affects the susceptibility to enilconazole		 CTD PMID:18832183 PMID:27853109 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression ISO enilconazole results in decreased expression of PDK4 mRNA CTD PMID:32201337 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression ISO enilconazole results in decreased expression of PNPLA3 mRNA CTD PMID:32201337 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO enilconazole binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO enilconazole results in decreased expression of PPARGC1A mRNA CTD PMID:32201337 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [enilconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO enilconazole results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarg retinoic acid receptor, gamma increases activity ISO enilconazole results in increased activity of RARG protein CTD PMID:20143881 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Retnlb resistin like beta affects expression ISO enilconazole affects the expression of RETNLB mRNA CTD PMID:29106682 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368 		JBrowse link
G Rgcc regulator of cell cycle increases expression ISO enilconazole results in increased expression of RGCC mRNA CTD PMID:32201337 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141 		JBrowse link
G Rora RAR-related orphan receptor A multiple interactions ISO enilconazole binds to and results in decreased activity of RORA protein CTD PMID:22289359 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO enilconazole results in decreased expression of SCD mRNA CTD PMID:32201337 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO enilconazole results in decreased expression of SLC10A1 mRNA CTD PMID:29451352 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression ISO enilconazole results in increased expression of SLC10A2 mRNA CTD PMID:32814239 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO enilconazole results in decreased expression of SLC12A2 mRNA; enilconazole results in decreased expression of SLC12A2 protein CTD PMID:29106682 PMID:32814239 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression ISO enilconazole results in decreased expression of SLC22A5 mRNA; enilconazole results in decreased expression of SLC22A5 protein CTD PMID:36150497 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 decreases expression ISO enilconazole results in decreased expression of SLC26A3 mRNA; enilconazole results in decreased expression of SLC26A3 protein CTD PMID:29106682 PMID:32814239 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 decreases expression ISO enilconazole results in decreased expression of SLC26A6 mRNA; enilconazole results in decreased expression of SLC26A6 protein CTD PMID:29106682 PMID:32814239 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions EXP [enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA CTD PMID:33426623 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 decreases expression ISO enilconazole results in decreased expression of SLC9A3 mRNA CTD PMID:29106682 PMID:32814239 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO enilconazole results in increased expression of SLCO4A1 mRNA CTD PMID:32201337 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO enilconazole results in increased expression of SOD1 mRNA CTD PMID:29451352 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO enilconazole results in decreased expression of SOD2 mRNA CTD PMID:29451352 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Star steroidogenic acute regulatory protein affects expression
decreases expression		 ISO
EXP		 enilconazole affects the expression of STAR mRNA
enilconazole results in decreased expression of STAR mRNA		 CTD PMID:30853599 PMID:36410587 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression ISO enilconazole results in decreased expression of SULT1B1 mRNA CTD PMID:32201337 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases expression ISO enilconazole results in increased expression of SULT1C2 mRNA CTD PMID:32201337 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO enilconazole results in decreased expression of TFF3 mRNA CTD PMID:32201337 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO enilconazole binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO enilconazole results in increased expression of TNF mRNA CTD PMID:27393971 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO enilconazole results in decreased expression of UGT2B7 mRNA CTD PMID:32201337 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      chemical substance 14405
        mixture 13722
          racemate 12097
            enilconazole 109
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  heteroarene 17135
                                    monocyclic heteroarene 14869
                                      azole 14371
                                        diazole 10481
                                          imidazoles 9884
                                            1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole 109
                                              (S)-enilconazole 109
                                                enilconazole 109
paths to the root