Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cumene
go back to main search page
Accession:CHEBI:34656 term browser browse the term
Definition:An alkylbenzene that is benzene carrying an isopropyl group.
Synonyms:related_synonym: (propan-2-yl)benzene;   1-Methylethyl-Benzene;   2-Phenylpropane;   Formula=C9H12;   InChI=1S/C9H12/c1-8(2)9-6-4-3-5-7-9/h3-8H,1-2H3;   InChIKey=RWGFKTVRMDUZSP-UHFFFAOYSA-N;   Isopropylbenzene;   SMILES=CC(C)c1ccccc1
 xref: Beilstein:1236613;   CAS:98-82-8;   HMDB:HMDB0034029;   KEGG:C14396
 xref_mesh: MESH:C015763
 xref: MetaCyc:CPD0-2360;   PMID:19340095;   PMID:24441387;   Patent:KR20140001929;   Reaxys:1236613;   Wikipedia:Cumene



show annotations for term's descendants           Sort by:
cumene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap12 A-kinase anchoring protein 12 decreases expression ISO cumene results in decreased expression of AKAP12 mRNA CTD PMID:18648096 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Areg amphiregulin multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of AREG mRNA CTD PMID:18648096 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Cadm1 cell adhesion molecule 1 decreases expression ISO cumene results in decreased expression of CADM1 mRNA CTD PMID:18648096 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
JBrowse link
G Cav1 caveolin 1 decreases expression ISO cumene results in decreased expression of CAV1 mRNA CTD PMID:18648096 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CCN1 mRNA CTD PMID:18648096 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of CCND1 mRNA CTD PMID:18648096 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh5 cadherin 5 decreases expression ISO cumene results in decreased expression of CDH5 mRNA CTD PMID:18648096 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression ISO cumene results in decreased expression of CDKN2D mRNA CTD PMID:18648096 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CEBPD mRNA CTD PMID:18648096 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CKS1B mRNA CTD PMID:18648096 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO cumene results in increased expression of CLU mRNA
KRAS gene mutant form promotes the reaction [cumene results in increased expression of CLU mRNA]
CTD PMID:18648096 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DLC1 mRNA CTD PMID:18648096 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO cumene results in decreased expression of DUSP1 mRNA CTD PMID:18648096 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp14 dual specificity phosphatase 14 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP14 mRNA CTD PMID:18648096 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
JBrowse link
G Dusp3 dual specificity phosphatase 3 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP3 mRNA CTD PMID:18648096 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression ISO cumene results in decreased expression of DUSP4 mRNA CTD PMID:18648096 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENO1 mRNA CTD PMID:18648096 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENPP2 mRNA CTD PMID:18648096 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of EPCAM mRNA CTD PMID:18648096 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Ereg epiregulin multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of EREG mRNA CTD PMID:18648096 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression
increases expression
ISO cumene results in decreased expression of ETS1 mRNA
cumene results in increased expression of ETS1 mRNA
CTD PMID:18648096 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases expression ISO cumene results in decreased expression of FHL1 mRNA CTD PMID:18648096 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of GPER1 mRNA CTD PMID:18648096 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO cumene results in decreased expression of GPX3 mRNA CTD PMID:18648096 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsn gelsolin decreases expression ISO cumene results in decreased expression of GSN mRNA CTD PMID:18648096 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects localization
decreases activity
ISO cumene affects the localization of GSTP1 protein
cumene results in decreased activity of GSTP1 protein
CTD PMID:18409811 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of IGFBP4 mRNA CTD PMID:18648096 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Klf5 KLF transcription factor 5 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA CTD PMID:18648096 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CCN1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of CEBPD mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of CKS1B mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DLC1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP14 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP3 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENO1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENPP2 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of EPCAM mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of GPER1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of IGFBP4 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT18 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT8 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of LASP1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of MMP14 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of RACK1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of RB1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SDC1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SLC2A1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SOD3 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SRD5A1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of AREG mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of CCND1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of EREG mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of LAMTOR2 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein; [cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of PTGES mRNA; KRAS gene mutant form promotes the reaction [cumene results in increased expression of CLU mRNA] CTD PMID:18648096 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt18 keratin 18 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT18 mRNA CTD PMID:18648096 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt8 keratin 8 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT8 mRNA CTD PMID:18648096 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of LAMTOR2 mRNA CTD PMID:18648096 NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013
JBrowse link
G Lasp1 LIM and SH3 protein 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of LASP1 mRNA CTD PMID:18648096 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292
JBrowse link
G Lims2 LIM zinc finger domain containing 2 decreases expression ISO cumene results in decreased expression of LIMS2 mRNA CTD PMID:18648096 NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137
JBrowse link
G Loxl1 lysyl oxidase-like 1 decreases expression ISO cumene results in decreased expression of LOXL1 mRNA CTD PMID:18648096 NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein CTD PMID:18648096 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA CTD PMID:18648096 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of MMP14 mRNA CTD PMID:18648096 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Pdzd2 PDZ domain containing 2 decreases expression ISO cumene results in decreased expression of PDZD2 mRNA CTD PMID:18648096 NCBI chr 2:61,384,614...61,770,516
Ensembl chr 2:61,386,381...61,770,524
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of PTGES mRNA CTD PMID:18648096 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO cumene results in decreased expression of PTPRD mRNA CTD PMID:18648096 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of RACK1 mRNA CTD PMID:18648096 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of RB1 mRNA CTD PMID:18648096 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs decreases expression ISO cumene results in decreased expression of RECK mRNA CTD PMID:18648096 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SDC1 mRNA CTD PMID:18648096 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SLC2A1 mRNA CTD PMID:18648096 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SOD3 mRNA CTD PMID:18648096 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SRD5A1 mRNA CTD PMID:18648096 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA CTD PMID:18648096 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
2-isopropylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxrb retinoid X receptor beta increases activity ISO 2-isopropylphenol results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
2-phenylpropan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta multiple interactions ISO 2-phenyl-2-propanol binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
4-isopropylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4-isopropylphenol inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:27561732 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases glutathionylation ISO CYP2C8 protein results in increased glutathionylation of 4-isopropylphenol CTD PMID:23470418
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of 4-isopropylphenol CTD PMID:23470418 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
ISO 4-isopropylphenol binds to and results in increased activity of ESRRG protein; 4-isopropylphenol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]
4-isopropylphenol binds to ESRRG protein
CTD PMID:27486708 PMID:31127318 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO 4-isopropylphenol binds to and results in increased activity of OR5D18 protein CTD PMID:21142015 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858
JBrowse link
cumene hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
increases activity
multiple interactions
ISO
EXP
cumene hydroperoxide results in decreased activity of CAT protein
cumene hydroperoxide results in increased activity of CAT protein
Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]
CTD PMID:12065085 PMID:12423650 PMID:16928893 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects oxidation EXP CYP2B1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects oxidation EXP CYP2B6 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects oxidation ISO CYP2C19 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects oxidation ISO CYP2C8 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects oxidation EXP CYP2D1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin CTD PMID:19713358 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
decreases expression
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]
cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein
CTD PMID:16469450 PMID:17510559 PMID:19447174 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein CTD PMID:12717419 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of G6PD protein CTD PMID:16928893 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cumene hydroperoxide results in increased expression of GAPDH protein CTD PMID:11295360 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLM mRNA CTD PMID:30547568 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance
increases reduction
increases metabolic processing
ISO GPX1 protein results in decreased susceptibility to cumene hydroperoxide
GPX1 protein results in increased reduction of cumene hydroperoxide
GPX1 protein results in increased metabolism of cumene hydroperoxide
CTD PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of cumene hydroperoxide CTD PMID:8428933 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 results in decreased susceptibility to cumene hydroperoxide CTD PMID:18206984 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP cumene hydroperoxide results in decreased activity of GSR protein CTD PMID:16928893 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases metabolic processing ISO GSTA1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:1985777 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases metabolic processing
increases metabolic processing
ISO GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTA2 protein results in increased metabolism of cumene hydroperoxide
CTD PMID:3138230 PMID:15077012 PMID:15128049 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance
affects metabolic processing
EXP GSTA3 protein results in decreased susceptibility to cumene hydroperoxide
GSTA3 protein affects the metabolism of cumene hydroperoxide
CTD PMID:1740415 PMID:2768223 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide
CTD PMID:15247628 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases metabolic processing ISO GSTP1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:2747627 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects oxidation
affects metabolic processing
ISO GSTT1 protein affects the oxidation of cumene hydroperoxide
GSTT1 protein affects the metabolism of cumene hydroperoxide
CTD PMID:9854036 PMID:19664997 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gstt2 glutathione S-transferase theta 2 affects metabolic processing EXP GSTT2 protein affects the metabolism of cumene hydroperoxide CTD PMID:2114406 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing ISO GSTZ1 protein affects the metabolism of cumene hydroperoxide CTD PMID:9396740 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Gusb glucuronidase, beta multiple interactions
increases secretion
decreases uptake
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cumene hydroperoxide results in increased expression of HMOX1 mRNA CTD PMID:30547568 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO cumene hydroperoxide results in increased expression of HSPB1 protein CTD PMID:11295360 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases activity EXP cumene hydroperoxide results in increased activity of IDH1 protein CTD PMID:16928893 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein] CTD PMID:19135433 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mb myoglobin affects metabolic processing ISO MB protein mutant form affects the metabolism of cumene hydroperoxide CTD PMID:8855949 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases response to substance EXP MGST1 results in decreased susceptibility to cumene hydroperoxide CTD PMID:17306223 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein CTD PMID:14972014 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases response to substance
multiple interactions
affects response to substance
ISO NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]
Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to cumene hydroperoxide
CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] CTD PMID:19135433 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO cumene hydroperoxide results in increased expression of NQO1 mRNA CTD PMID:30547568 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions
ISO cumene hydroperoxide results in increased activity of ODC1 protein
Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]
CTD PMID:12065085 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ppia peptidylprolyl isomerase A decreases response to substance EXP PPIA protein results in decreased susceptibility to cumene hydroperoxide CTD PMID:17011206 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO cumene hydroperoxide results in increased expression of PRDX1 protein CTD PMID:11295360 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO cumene hydroperoxide results in increased expression of PRDX2 protein CTD PMID:11295360 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO cumene hydroperoxide results in increased expression of PRDX6 protein CTD PMID:11295360 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO cumene hydroperoxide results in increased expression of PTGS2 protein
[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]
CTD PMID:14972014 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sord sorbitol dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of SORD protein CTD PMID:16928893 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO cumene hydroperoxide results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein] CTD PMID:19135433 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
isoprocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO isoprocarb metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      chemical role 19460
        environmental contaminant 18857
          benzene 5798
            alkylbenzene 3515
              cumene 101
                2-isopropylphenol + 2
                2-phenyl-1,2-propanediol 0
                2-phenylpropan-2-ol 1
                4-isopropylphenol + 5
                cumene hydroperoxide 46
                cuminaldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            organic hydride 18693
                              organic fundamental parent 18693
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    monocyclic hydrocarbon 6146
                                      annulene 5798
                                        aromatic annulene 5798
                                          benzene 5798
                                            alkylbenzene 3515
                                              cumene 101
                                                2-isopropylphenol + 2
                                                2-phenyl-1,2-propanediol 0
                                                2-phenylpropan-2-ol 1
                                                4-isopropylphenol + 5
                                                cumene hydroperoxide 46
                                                cuminaldehyde 0
paths to the root