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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cumene hydroperoxide
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Accession:CHEBI:78673 term browser browse the term
Definition:A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group.
Synonyms:related_synonym: 1-Methyl-1-phenylethyl hydroperoxide;   7-Cumyl hydroperoxide;   CHP;   Cumenyl hydroperoxide;   Cumolhydroperoxid;   Cumyl hydroperoxide;   Formula=C9H12O2;   Hydroperoxyde de cumene;   Hydroperoxyde de cumyle;   InChI=1S/C9H12O2/c1-9(2,11-10)8-6-4-3-5-7-8/h3-7,10H,1-2H3;   InChIKey=YQHLDYVWEZKEOX-UHFFFAOYSA-N;   Isopropylbenzene hydroperoxide;   SMILES=CC(C)(OO)c1ccccc1;   alpha,alpha-Dimethylbenzyl hydroperoxide;   alpha-Cumene hydroperoxide;   alpha-Cumyl hydroperoxide
 xref: CAS:80-15-9
 xref_mesh: MESH:C007164
 xref: MetaCyc:CPD0-1449;   PMID:23357941;   PMID:23707950;   PMID:23767299;   PMID:24073228;   PMID:24492382;   PMID:26985019;   Reaxys:1908117;   Wikipedia:Cumene_hydroperoxide


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cumene hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
increases activity
multiple interactions
ISO
EXP
cumene hydroperoxide results in decreased activity of CAT protein
cumene hydroperoxide results in increased activity of CAT protein
Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]
CTD PMID:12065085 PMID:12423650 PMID:16928893 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects oxidation EXP CYP2B1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects oxidation EXP CYP2B6 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects oxidation ISO CYP2C19 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects oxidation ISO CYP2C8 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects oxidation EXP CYP2D1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin CTD PMID:19713358 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
decreases expression
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]
cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein
CTD PMID:16469450 PMID:17510559 PMID:19447174 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein CTD PMID:12717419 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of G6PD protein CTD PMID:16928893 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cumene hydroperoxide results in increased expression of GAPDH protein CTD PMID:11295360 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLM mRNA CTD PMID:30547568 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance
increases metabolic processing
increases reduction
ISO GPX1 protein results in decreased susceptibility to cumene hydroperoxide
GPX1 protein results in increased metabolism of cumene hydroperoxide
GPX1 protein results in increased reduction of cumene hydroperoxide
CTD PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of cumene hydroperoxide CTD PMID:8428933 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 results in decreased susceptibility to cumene hydroperoxide CTD PMID:18206984 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP cumene hydroperoxide results in decreased activity of GSR protein CTD PMID:16928893 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases metabolic processing
affects metabolic processing
decreases response to substance
ISO
EXP
GSTA1 protein results in increased metabolism of cumene hydroperoxide
GSTA3 protein affects the metabolism of cumene hydroperoxide
GSTA3 protein results in decreased susceptibility to cumene hydroperoxide
CTD PMID:1740415 PMID:1985777 PMID:2768223 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases metabolic processing
increases metabolic processing
ISO GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTA2 protein results in increased metabolism of cumene hydroperoxide
CTD PMID:3138230 PMID:15077012 PMID:15128049 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases glutathionylation ISO GSTA3 protein results in increased glutathionylation of cumene hydroperoxide CTD PMID:21876218 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide
CTD PMID:15247628 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide
CTD PMID:15247628 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases metabolic processing ISO GSTP1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:2747627 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects oxidation
affects metabolic processing
ISO GSTT1 protein affects the oxidation of cumene hydroperoxide
GSTT1 protein affects the metabolism of cumene hydroperoxide
CTD PMID:9854036 PMID:19664997 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects metabolic processing EXP GSTT2 protein affects the metabolism of cumene hydroperoxide CTD PMID:2114406 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing ISO GSTZ1 protein affects the metabolism of cumene hydroperoxide CTD PMID:9396740 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases uptake
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cumene hydroperoxide results in increased expression of HMOX1 mRNA CTD PMID:30547568 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO cumene hydroperoxide results in increased expression of HSPB1 protein CTD PMID:11295360 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases activity EXP cumene hydroperoxide results in increased activity of IDH1 protein CTD PMID:16928893 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein] CTD PMID:19135433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mb myoglobin affects metabolic processing ISO MB protein mutant form affects the metabolism of cumene hydroperoxide CTD PMID:8855949 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases response to substance EXP MGST1 results in decreased susceptibility to cumene hydroperoxide CTD PMID:17306223 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein CTD PMID:14972014 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases response to substance
affects response to substance
multiple interactions
ISO NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to cumene hydroperoxide
Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]
CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] CTD PMID:19135433 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO cumene hydroperoxide results in increased expression of NQO1 mRNA CTD PMID:30547568 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions
ISO cumene hydroperoxide results in increased activity of ODC1 protein
Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]
CTD PMID:12065085 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ppia peptidylprolyl isomerase A decreases response to substance EXP PPIA protein results in decreased susceptibility to cumene hydroperoxide CTD PMID:17011206 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO cumene hydroperoxide results in increased expression of PRDX1 protein CTD PMID:11295360 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO cumene hydroperoxide results in increased expression of PRDX2 protein CTD PMID:11295360 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO cumene hydroperoxide results in increased expression of PRDX6 protein CTD PMID:11295360 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO cumene hydroperoxide results in increased expression of PTGS2 protein
[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]
CTD PMID:14972014 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sord sorbitol dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of SORD protein CTD PMID:16928893 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO cumene hydroperoxide results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein] CTD PMID:19135433 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        oxidising agent 9920
          cumene hydroperoxide 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19429
                        hydrogen molecular entity 19423
                          hydrides 18758
                            organic hydride 18356
                              organic fundamental parent 18356
                                hydrocarbon 18075
                                  cyclic hydrocarbon 17090
                                    monocyclic hydrocarbon 5811
                                      annulene 5637
                                        aromatic annulene 5637
                                          benzene 5637
                                            alkylbenzene 3360
                                              cumene 101
                                                cumene hydroperoxide 47
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