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G |
Cat |
catalase |
decreases activity increases activity multiple interactions |
ISO EXP |
cumene hydroperoxide results in decreased activity of CAT protein cumene hydroperoxide results in increased activity of CAT protein Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein] |
CTD |
PMID:12065085 PMID:12423650 PMID:16928893 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
affects oxidation |
EXP |
CYP2B1 protein affects the oxidation of cumene hydroperoxide |
CTD |
PMID:17478480 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
affects oxidation |
EXP |
CYP2B6 protein affects the oxidation of cumene hydroperoxide |
CTD |
PMID:17478480 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
affects oxidation |
ISO |
CYP2C19 protein affects the oxidation of cumene hydroperoxide |
CTD |
PMID:17478480 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
affects oxidation |
ISO |
CYP2C8 protein affects the oxidation of cumene hydroperoxide |
CTD |
PMID:17478480 |
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G |
Cyp2d1 |
cytochrome P450, family 2, subfamily d, polypeptide 1 |
affects oxidation |
EXP |
CYP2D1 protein affects the oxidation of cumene hydroperoxide |
CTD |
PMID:17478480 |
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NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084
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G |
Cyp2s1 |
cytochrome P450, family 2, subfamily s, polypeptide 1 |
multiple interactions |
ISO |
[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin |
CTD |
PMID:19713358 |
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NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
multiple interactions decreases expression |
EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein] cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein |
CTD |
PMID:16469450 PMID:17510559 PMID:19447174 |
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NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
multiple interactions |
ISO |
cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein |
CTD |
PMID:12717419 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
EXP |
cumene hydroperoxide results in increased activity of G6PD protein |
CTD |
PMID:16928893 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of GAPDH protein |
CTD |
PMID:11295360 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of GCLC mRNA |
CTD |
PMID:30547568 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of GCLM mRNA |
CTD |
PMID:30547568 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases response to substance increases metabolic processing increases reduction |
ISO |
GPX1 protein results in decreased susceptibility to cumene hydroperoxide GPX1 protein results in increased metabolism of cumene hydroperoxide GPX1 protein results in increased reduction of cumene hydroperoxide |
CTD |
PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
increases reduction |
ISO |
GPX2 protein results in increased reduction of cumene hydroperoxide |
CTD |
PMID:8428933 |
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NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases response to substance |
ISO |
GPX4 results in decreased susceptibility to cumene hydroperoxide |
CTD |
PMID:18206984 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
EXP |
cumene hydroperoxide results in decreased activity of GSR protein |
CTD |
PMID:16928893 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
increases metabolic processing |
ISO |
GSTA1 protein results in increased metabolism of cumene hydroperoxide |
CTD |
PMID:1985777 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases metabolic processing increases metabolic processing |
ISO |
GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide GSTA2 protein results in increased metabolism of cumene hydroperoxide |
CTD |
PMID:3138230 PMID:15077012 PMID:15128049 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases response to substance affects metabolic processing |
EXP |
GSTA3 protein results in decreased susceptibility to cumene hydroperoxide GSTA3 protein affects the metabolism of cumene hydroperoxide |
CTD |
PMID:1740415 PMID:2768223 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
decreases metabolic processing increases metabolic processing |
ISO |
GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide |
CTD |
PMID:15247628 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases metabolic processing |
ISO |
GSTP1 protein results in increased metabolism of cumene hydroperoxide |
CTD |
PMID:2747627 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt1 |
glutathione S-transferase theta 1 |
affects oxidation affects metabolic processing |
ISO |
GSTT1 protein affects the oxidation of cumene hydroperoxide GSTT1 protein affects the metabolism of cumene hydroperoxide |
CTD |
PMID:9854036 PMID:19664997 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gstt2 |
glutathione S-transferase theta 2 |
affects metabolic processing |
EXP |
GSTT2 protein affects the metabolism of cumene hydroperoxide |
CTD |
PMID:2114406 |
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NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects metabolic processing |
ISO |
GSTZ1 protein affects the metabolism of cumene hydroperoxide |
CTD |
PMID:9396740 |
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NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
Gusb |
glucuronidase, beta |
multiple interactions decreases uptake increases secretion |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] |
CTD |
PMID:19135433 |
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of HMOX1 mRNA |
CTD |
PMID:30547568 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of HSPB1 protein |
CTD |
PMID:11295360 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Idh1 |
isocitrate dehydrogenase (NADP(+)) 1 |
increases activity |
EXP |
cumene hydroperoxide results in increased activity of IDH1 protein |
CTD |
PMID:16928893 |
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NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases secretion |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein] |
CTD |
PMID:19135433 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] |
CTD |
PMID:19608619 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mb |
myoglobin |
affects metabolic processing |
ISO |
MB protein mutant form affects the metabolism of cumene hydroperoxide |
CTD |
PMID:8855949 |
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NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases response to substance |
EXP |
MGST1 results in decreased susceptibility to cumene hydroperoxide |
CTD |
PMID:17306223 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein |
CTD |
PMID:14972014 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases response to substance affects response to substance multiple interactions |
ISO |
NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide [NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to cumene hydroperoxide Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide] [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] |
CTD |
PMID:19303893 PMID:19608619 PMID:20932822 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] |
CTD |
PMID:19135433 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of NQO1 mRNA |
CTD |
PMID:30547568 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Odc1 |
ornithine decarboxylase 1 |
increases activity multiple interactions |
ISO |
cumene hydroperoxide results in increased activity of ODC1 protein Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein] |
CTD |
PMID:12065085 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Ppia |
peptidylprolyl isomerase A |
decreases response to substance |
EXP |
PPIA protein results in decreased susceptibility to cumene hydroperoxide |
CTD |
PMID:17011206 |
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NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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G |
Prdx1 |
peroxiredoxin 1 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of PRDX1 protein |
CTD |
PMID:11295360 |
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NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of PRDX2 protein |
CTD |
PMID:11295360 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Prdx6 |
peroxiredoxin 6 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of PRDX6 protein |
CTD |
PMID:11295360 |
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NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
cumene hydroperoxide results in increased expression of PTGS2 protein [cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein] |
CTD |
PMID:14972014 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Sord |
sorbitol dehydrogenase |
increases activity |
EXP |
cumene hydroperoxide results in increased activity of SORD protein |
CTD |
PMID:16928893 |
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NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
cumene hydroperoxide results in increased expression of TGFB1 mRNA |
CTD |
PMID:8148055 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein] |
CTD |
PMID:19135433 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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