|
G |
Acta1 |
actin, alpha 1, skeletal muscle |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ACTA1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
|
|
G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of AKR1B7 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
|
|
G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity |
ISO |
Flurbiprofen results in decreased activity of AKR1C2 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
multiple interactions decreases activity |
ISO |
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol |
CTD |
PMID:19010312 PMID:21187079 |
|
NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein |
CTD |
PMID:16949054 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
|
|
G |
Alb |
albumin |
affects binding |
ISO |
Flurbiprofen binds to ALB protein |
CTD |
PMID:9353694 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
|
|
G |
Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ALDH7A1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
|
|
G |
Anp32a |
acidic nuclear phosphoprotein 32 family member A |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANP32A mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
|
|
G |
Anxa1 |
annexin A1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANXA1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
|
|
G |
Anxa3 |
annexin A3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of ANXA3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
|
|
G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Flurbiprofen results in increased expression of APOD mRNA |
CTD |
PMID:16949054 |
|
NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
|
|
G |
Apof |
apolipoprotein F |
increases expression |
ISO |
Flurbiprofen results in increased expression of APOF mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
|
|
G |
App |
amyloid beta precursor protein |
affects cleavage decreases secretion multiple interactions |
ISO EXP |
Flurbiprofen affects the cleavage of APP protein Flurbiprofen results in decreased secretion of APP protein alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium] |
CTD |
PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
|
|
G |
Arg1 |
arginase 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ARG1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
|
|
G |
Asic1 |
acid sensing ion channel subunit 1 |
decreases activity |
EXP |
Flurbiprofen results in decreased activity of ASIC1 protein |
CTD |
PMID:11588175 |
|
NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
ISO |
Flurbiprofen results in increased expression of BIRC5 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
|
|
G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of BNIP3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
|
|
G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] |
CTD |
PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 |
|
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
|
|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CCNB1 protein |
CTD |
PMID:11687965 |
|
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
|
|
G |
Ceacam1 |
CEA cell adhesion molecule 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CEACAM1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
|
|
G |
Ces3a |
carboxylesterase 3a |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CES3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:37,070,705...37,079,411
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CITED2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
|
|
G |
Cmas |
cytidine monophosphate N-acetylneuraminic acid synthetase |
increases expression |
ISO |
Flurbiprofen results in increased expression of CMAS mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444
|
|
G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CMPK2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
|
|
G |
Crisp1 |
cysteine-rich secretory protein 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CRISP1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 9:24,356,577...24,383,679
Ensembl chr 9:24,356,579...24,383,679
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO EXP |
Flurbiprofen results in decreased activity of CYP17A1 protein |
CTD |
PMID:31184881 |
|
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
|
|
G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of CYP24A1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
|
|
G |
Cyp2f4 |
cytochrome P450, family 2, subfamily f, polypeptide 4 |
increases expression |
ISO |
Flurbiprofen results in increased expression of CYP2F2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
|
|
G |
Defb1 |
defensin beta 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of DEFB1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
|
|
G |
Egf |
epidermal growth factor |
increases expression |
ISO |
Flurbiprofen results in increased expression of EGF mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 2:68,820,616...68,895,537
|
|
G |
Eif4e |
eukaryotic translation initiation factor 4E |
increases phosphorylation multiple interactions |
ISO |
Flurbiprofen results in increased phosphorylation of EIF4E protein MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] |
CTD |
PMID:18056468 |
|
NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
|
|
G |
Elavl1 |
ELAV like RNA binding protein 1 |
multiple interactions increases expression |
ISO |
ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA] Flurbiprofen results in increased expression of ELAVL1 protein |
CTD |
PMID:18056468 |
|
NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
|
|
G |
Eln |
elastin |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ELN mRNA |
CTD |
PMID:16949054 |
|
NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
|
|
G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of ENPP2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
|
|
G |
Faah |
fatty acid amide hydrolase |
decreases activity |
EXP |
Flurbiprofen results in decreased activity of FAAH protein |
CTD |
PMID:12751821 |
|
NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
|
|
G |
Folr1 |
folate receptor alpha |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of FOLR1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP ISO |
Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]] Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA] |
CTD |
PMID:10864209 PMID:11164833 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
|
|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression multiple interactions |
ISO |
Flurbiprofen results in increased expression of GDF15 protein 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein] |
CTD |
PMID:21097678 |
|
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
|
|
G |
Gpx3 |
glutathione peroxidase 3 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of GPX3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
|
|
G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of GSTO1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
|
|
G |
Gusb |
glucuronidase, beta |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] |
CTD |
PMID:6696821 |
|
NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
|
|
G |
Hells |
helicase, lymphoid specific |
increases expression |
ISO |
Flurbiprofen results in increased expression of HELLS mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183 Ensembl chr 1:257,766,691...257,949,183
|
|
G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
decreases degradation increases expression multiple interactions increases activity |
ISO |
Flurbiprofen results in decreased degradation of HPGD protein Flurbiprofen results in increased expression of HPGD mRNA [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein Flurbiprofen results in increased activity of HPGD protein |
CTD |
PMID:19501039 |
|
NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] |
CTD |
PMID:16949054 |
|
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of HSD11B2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
EXP |
Flurbiprofen results in increased expression of ICAM1 protein |
CTD |
PMID:16020654 |
|
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
|
|
G |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of IFIT2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] |
CTD |
PMID:19659691 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] |
CTD |
PMID:10903797 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
|
|
G |
Il11 |
interleukin 11 |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] |
CTD |
PMID:12110441 |
|
NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA] Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein] |
CTD |
PMID:11112151 PMID:12517972 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:10903797 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Kcnn4 |
potassium calcium-activated channel subfamily N member 4 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of KCNN4 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
|
|
G |
Kng2 |
kininogen 2 |
multiple interactions |
EXP |
Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] |
CTD |
PMID:11166334 PMID:12791437 |
|
NCBI chr11:81,509,185...81,516,759
|
|
G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of LGALS3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
|
|
G |
Lgals9 |
galectin 9 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of LGALS9 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
|
|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] |
CTD |
PMID:31184881 |
|
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
|
|
G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
decreases expression |
EXP |
Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein |
CTD |
PMID:31184881 |
|
NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
|
|
G |
Lmo7 |
LIM domain 7 |
increases expression |
ISO |
Flurbiprofen results in increased expression of LMO7 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
|
|
G |
Lto1 |
LTO1 maturation factor of ABCE1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of LTO1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:218,075,995...218,082,700
Ensembl chr 1:218,076,116...218,080,824
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein |
CTD |
PMID:19501039 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
|
|
G |
Mapk11 |
mitogen-activated protein kinase 11 |
multiple interactions |
ISO |
MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
|
NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] |
CTD |
PMID:18056468 PMID:21097678 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein |
CTD |
PMID:19501039 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
|
G |
Mapkapk2 |
MAPK activated protein kinase 2 |
multiple interactions |
ISO |
Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
|
NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
|
|
G |
Mapkapk3 |
MAPK activated protein kinase 3 |
multiple interactions |
ISO |
MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] |
CTD |
PMID:18056468 |
|
NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA Flurbiprofen results in decreased expression of MMP9 mRNA |
CTD |
PMID:19501039 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
|
|
G |
Msmb |
microseminoprotein, beta |
increases expression |
ISO |
Flurbiprofen results in increased expression of MSMB mRNA |
CTD |
PMID:16949054 |
|
NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:11099482 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
|
|
G |
Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
Flurbiprofen results in increased expression of NFKBIZ mRNA |
CTD |
PMID:16949054 |
|
NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
|
|
G |
Ngfr |
nerve growth factor receptor |
multiple interactions increases expression |
ISO |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein] Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein |
CTD |
PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 |
|
NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
EXP ISO |
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] Flurbiprofen results in increased expression of NOS2 mRNA Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:8528547 PMID:11405284 PMID:16944022 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
ISO |
Flurbiprofen results in increased activity of NQO1 protein |
CTD |
PMID:8572925 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
G |
Papss2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PAPSS2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
|
|
G |
Pcp4 |
Purkinje cell protein 4 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of PCP4 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229
|
|
G |
Pdzk1 |
PDZ domain containing 1 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PDZK1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
|
|
G |
Penk |
proenkephalin |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of PENK mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
|
|
G |
Pik3c3 |
phosphatidylinositol 3-kinase, catalytic subunit type 3 |
increases expression |
ISO |
Flurbiprofen results in increased expression of PIK3C3 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
|
|
G |
Pla2g4a |
phospholipase A2 group IVA |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:15878913 |
|
NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
|
|
G |
Psca |
prostate stem cell antigen |
multiple interactions increases expression |
ISO |
[Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] |
CTD |
PMID:16949054 |
|
NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
ISO EXP |
Flurbiprofen results in decreased activity of PTGS1 protein |
CTD |
PMID:9233713 PMID:9258749 PMID:18848576 |
|
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity decreases degradation increases expression decreases expression |
EXP ISO |
Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein] Flurbiprofen results in decreased activity of PTGS2 protein Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein Flurbiprofen results in decreased expression of PTGS2 mRNA |
CTD |
PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 PMID:11099482 PMID:11112151 PMID:11405284 PMID:11687965 PMID:12517972 PMID:15878913 PMID:16949054 PMID:18848576 PMID:19758985 PMID:22245433 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein] |
CTD |
PMID:11099482 PMID:11291649 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Rhog |
ras homolog family member G |
increases expression |
ISO |
Flurbiprofen results in increased expression of RHOG mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:167,336,147...167,347,720
Ensembl chr 1:167,335,248...167,347,671
|
|
G |
Rhou |
ras homolog family member U |
increases expression |
ISO |
Flurbiprofen results in increased expression of RHOU mRNA |
CTD |
PMID:16949054 |
|
NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
|
|
G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] |
CTD |
PMID:19659691 |
|
NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
|
|
G |
Sell |
selectin L |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
|
NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
|
|
G |
Smoc2 |
SPARC related modular calcium binding 2 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of SMOC2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 1:56,242,289...56,374,106
Ensembl chr 1:56,242,346...56,374,120
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of SOX2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
|
|
G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
decreases expression |
EXP |
Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein |
CTD |
PMID:31184881 |
|
NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
|
|
G |
Tgoln2 |
trans-golgi network protein 2 |
increases expression |
ISO |
Flurbiprofen results in increased expression of TGOLN2 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
|
|
G |
Thrsp |
thyroid hormone responsive |
multiple interactions |
ISO |
Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] |
CTD |
PMID:10357836 |
|
NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Flurbiprofen results in increased expression of TIMP1 protein [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA |
CTD |
PMID:19501039 |
|
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] |
CTD |
PMID:10903797 PMID:19659691 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases response to substance decreases response to substance increases expression |
ISO |
Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein TP53 protein results in increased susceptibility to Flurbiprofen TP53 protein mutant form results in decreased susceptibility to Flurbiprofen Flurbiprofen results in increased expression of TP53 protein |
CTD |
PMID:11687965 PMID:15710360 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
|
|
G |
Twist1 |
twist family bHLH transcription factor 1 |
decreases expression |
ISO |
Flurbiprofen results in decreased expression of TWIST1 mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
|
|
G |
Tyms |
thymidylate synthetase |
increases expression |
ISO |
Flurbiprofen results in increased expression of TYMS mRNA |
CTD |
PMID:16949054 |
|
NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
|
NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15117964 PMID:15843492 |
|
NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
|
NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases glucuronidation |
ISO |
UGT1A6 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
|
NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt1a8 |
UDP glucuronosyltransferase family 1 member A8 |
increases glucuronidation |
ISO |
UGT1A8 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15117964 |
|
NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
|
NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
|
|
G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:8302279 |
|
NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
|
|
G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases glucuronidation |
ISO |
UGT2B7 protein results in increased glucuronidation of Flurbiprofen |
CTD |
PMID:15843492 |
|
NCBI chr14:22,597,103...22,619,968
|
|
|
G |
Casp1 |
caspase 1 |
decreases expression |
ISO |
nitroflurbiprofen results in decreased expression of CASP1 mRNA |
CTD |
PMID:15081244 |
|
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
|
|
G |
Cth |
cystathionine gamma-lyase |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] |
CTD |
PMID:16491094 |
|
NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:16491094 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:16491094 |
|
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
|
|
G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
nitroflurbiprofen results in decreased expression of NOS2 mRNA nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:8528547 PMID:15081244 PMID:16491094 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases activity |
ISO EXP |
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein] nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] nitroflurbiprofen results in decreased activity of RELA protein |
CTD |
PMID:12716482 PMID:16491094 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein] nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:12716482 PMID:16491094 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|