Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:5130
Term: flurbiprofen
Definition: A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID: MESH:D005480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionISORGD:7309816480464CTDFlurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]PMID:12517972
Il1bmultiple interactionsISORGD:7309816480464CTDFlurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]PMID:11112151 PMID:12517972
Go Back to source page   Continue to Ontology report