Gene Chemical Interaction Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3889
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tp53
Name:	tumor protein p53

Acc ID:	CHEBI:5130
Term:	flurbiprofen
Definition:	A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID:	MESH:D005480

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tp53	decreases response to substance	ISO	RGD:70502	6480464	CTD	TP53 protein mutant form results in decreased susceptibility to Flurbiprofen	PMID:15710360
Tp53	increases expression	ISO	RGD:70502	6480464	CTD	Flurbiprofen results in increased expression of TP53 protein	PMID:11687965
Tp53	increases response to substance	ISO	RGD:70502	6480464	CTD	TP53 protein results in increased susceptibility to Flurbiprofen	PMID:15710360
Tp53	multiple interactions	ISO	RGD:70502	6480464	CTD	Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein	PMID:15710360

Go Back to source page

Continue to Ontology report