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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:5130
Term: flurbiprofen
Definition: A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID: MESH:D005480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53decreases response to substanceISORGD:705026480464CTDTP53 protein mutant form results in decreased susceptibility to FlurbiprofenPMID:15710360
Tp53increases expressionISORGD:705026480464CTDFlurbiprofen results in increased expression of TP53 proteinPMID:11687965
Tp53increases response to substanceISORGD:705026480464CTDTP53 protein results in increased susceptibility to FlurbiprofenPMID:15710360
Tp53multiple interactionsISORGD:705026480464CTDFlurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 proteinPMID:15710360
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