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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flurbiprofen
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Accession:CHEBI:5130 term browser browse the term
Definition:A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Synonyms:exact_synonym: 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid
 related_synonym: (+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid;   2-(2-fluorobiphenyl-4-yl)propanoic acid;   2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid;   3-fluoro-4-phenylhydratropic acid;   Ansaid;   Formula=C15H13FO2;   InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18);   InChIKey=SYTBZMRGLBWNTM-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1
 xref: Beilstein:2054451;   CAS:5104-49-4;   DrugBank:DB00712;   Drug_Central:1219;   KEGG:D00330;   LINCS:LSM-5174
 xref_mesh: MESH:D005480
 xref: PMID:12859660;   PMID:17562170;   PMID:19588427;   PMID:27746736;   PMID:27832658;   PMID:28147361;   PMID:28166217;   PMID:28298171;   PMID:28402193;   Wikipedia:Flurbiprofen


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Flurbiprofen results in decreased expression of ACTA1 mRNA CTD PMID:16949054 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 decreases expression ISO Flurbiprofen results in decreased expression of AKR1B7 mRNA CTD PMID:16949054 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flurbiprofen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:19010312 PMID:21187079 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:16949054 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding ISO Flurbiprofen binds to ALB protein CTD PMID:9353694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Flurbiprofen results in decreased expression of ALDH7A1 mRNA CTD PMID:16949054 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Flurbiprofen results in increased expression of ANP32A mRNA CTD PMID:16949054
G Anxa1 annexin A1 increases expression ISO Flurbiprofen results in increased expression of ANXA1 mRNA CTD PMID:16949054 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa3 annexin A3 increases expression ISO Flurbiprofen results in increased expression of ANXA3 mRNA CTD PMID:16949054 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Apod apolipoprotein D increases expression ISO Flurbiprofen results in increased expression of APOD mRNA CTD PMID:16949054 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Apof apolipoprotein F increases expression ISO Flurbiprofen results in increased expression of APOF mRNA CTD PMID:16949054 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
JBrowse link
G App amyloid beta precursor protein affects cleavage
decreases secretion
multiple interactions
ISO
EXP
Flurbiprofen affects the cleavage of APP protein
Flurbiprofen results in decreased secretion of APP protein
alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein]
Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium]
CTD PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arg1 arginase 1 decreases expression ISO Flurbiprofen results in decreased expression of ARG1 mRNA CTD PMID:16949054 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases activity EXP Flurbiprofen results in decreased activity of ASIC1 protein CTD PMID:11588175 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Flurbiprofen results in increased expression of BIRC5 mRNA CTD PMID:16949054 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Flurbiprofen results in increased expression of BNIP3 mRNA CTD PMID:16949054 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] CTD PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Flurbiprofen results in decreased expression of CCNB1 protein CTD PMID:11687965 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Flurbiprofen results in increased expression of CEACAM1 mRNA CTD PMID:16949054 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Flurbiprofen results in decreased expression of CES3 mRNA CTD PMID:16949054 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Flurbiprofen results in increased expression of CITED2 mRNA CTD PMID:16949054 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression ISO Flurbiprofen results in increased expression of CMAS mRNA CTD PMID:16949054 NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression ISO Flurbiprofen results in increased expression of CMPK2 mRNA CTD PMID:16949054 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 decreases expression ISO Flurbiprofen results in decreased expression of CRISP1 mRNA CTD PMID:16949054 NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of CYP17A1 protein CTD PMID:31184881 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Flurbiprofen results in decreased expression of CYP24A1 mRNA CTD PMID:16949054 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
affects hydrolysis
increases hydrolysis
affects hydroxylation
increases metabolic processing
affects binding
increases hydroxylation
affects metabolic processing
ISO 3',4'-dimethoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 3-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 4'-methoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 5-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 6,7-dihydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 7-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; acacetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; alpha-naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Apigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Benzbromarone inhibits the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]; Benzbromarone promotes the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]; beta-Naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; chrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Dapsone promotes the reaction [CYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen]; Dapsone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; flavanone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; flavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Fluconazole affects the reaction [CYP2C9 gene polymorphism affects the metabolism of Flurbiprofen]; galangin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Genistein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; naringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; naringin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Quercetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]
CYP2C9 gene polymorphism affects the hydrolysis of Flurbiprofen
CYP2C9 protein results in increased hydrolysis of Flurbiprofen
CYP2C9 protein affects the hydroxylation of Flurbiprofen
CYP2C9 protein results in increased metabolism of Flurbiprofen
Flurbiprofen binds to CYP2C9 protein
CYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen; CYP2C9 protein results in increased hydroxylation of Flurbiprofen
CTD PMID:9698079 PMID:11901091 PMID:15130760 PMID:15955872 PMID:18378563 More... NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression ISO Flurbiprofen results in increased expression of CYP2F2 mRNA CTD PMID:16949054 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Defb1 defensin beta 1 decreases expression ISO Flurbiprofen results in decreased expression of DEFB1 mRNA CTD PMID:16949054 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
JBrowse link
G Egf epidermal growth factor increases expression ISO Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Flurbiprofen results in increased phosphorylation of EIF4E protein
MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]
CTD PMID:18056468 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression
ISO ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Flurbiprofen results in increased expression of ELAVL1 protein
CTD PMID:18056468 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Eln elastin decreases expression ISO Flurbiprofen results in decreased expression of ELN mRNA CTD PMID:16949054 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO Flurbiprofen results in decreased expression of ENPP2 mRNA CTD PMID:16949054 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Flurbiprofen results in decreased activity of FAAH protein CTD PMID:12751821 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Folr1 folate receptor alpha decreases expression ISO Flurbiprofen results in decreased expression of FOLR1 mRNA CTD PMID:16949054 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]]
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]
CTD PMID:10864209 PMID:11164833 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
CTD PMID:21097678 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Flurbiprofen results in decreased expression of GPX3 mRNA CTD PMID:16949054 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO Flurbiprofen results in increased expression of GSTO1 mRNA CTD PMID:16949054 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Flurbiprofen results in increased expression of HELLS mRNA CTD PMID:16949054 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases degradation
increases expression
multiple interactions
increases activity
ISO Flurbiprofen results in decreased degradation of HPGD protein
Flurbiprofen results in increased expression of HPGD mRNA
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein
Flurbiprofen results in increased activity of HPGD protein
CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO Flurbiprofen results in increased expression of HSD11B2 mRNA CTD PMID:16949054 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Flurbiprofen results in increased expression of ICAM1 protein CTD PMID:16020654 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Flurbiprofen results in increased expression of IFIT2 mRNA CTD PMID:16949054 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ifng interferon gamma multiple interactions ISO Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] CTD PMID:19659691 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]
CTD PMID:11112151 PMID:12517972 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO Flurbiprofen results in decreased expression of KCNN4 mRNA CTD PMID:16949054 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] CTD PMID:11166334 PMID:12791437 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lgals3 galectin 3 increases expression ISO Flurbiprofen results in increased expression of LGALS3 mRNA CTD PMID:16949054 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lgals9 galectin 9 decreases expression ISO Flurbiprofen results in decreased expression of LGALS9 mRNA CTD PMID:16949054 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] CTD PMID:31184881 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein CTD PMID:31184881 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Flurbiprofen results in increased expression of LMO7 mRNA CTD PMID:16949054 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lto1 LTO1 maturation factor of ABCE1 decreases expression ISO Flurbiprofen results in decreased expression of LTO1 mRNA CTD PMID:16949054 NCBI chr 1:200,074,247...200,080,951
Ensembl chr 1:200,074,253...200,088,061
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:19501039 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 PMID:21097678 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:19501039 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
Flurbiprofen results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msmb microseminoprotein, beta increases expression ISO Flurbiprofen results in increased expression of MSMB mRNA CTD PMID:16949054 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11099482 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Flurbiprofen results in increased expression of NFKBIZ mRNA CTD PMID:16949054 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein
CTD PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Flurbiprofen results in increased expression of NOS2 mRNA
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:8528547 PMID:11405284 PMID:16944022 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity ISO Flurbiprofen results in increased activity of NQO1 protein CTD PMID:8572925 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Flurbiprofen results in increased expression of PAPSS2 mRNA CTD PMID:16949054 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression ISO Flurbiprofen results in decreased expression of PCP4 mRNA CTD PMID:16949054 NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Flurbiprofen results in increased expression of PDZK1 mRNA CTD PMID:16949054 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
JBrowse link
G Penk proenkephalin decreases expression ISO Flurbiprofen results in decreased expression of PENK mRNA CTD PMID:16949054 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Flurbiprofen results in increased expression of PIK3C3 mRNA CTD PMID:16949054 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] CTD PMID:15878913 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression
ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of PTGS1 protein CTD PMID:9233713 PMID:9258749 PMID:18848576 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
decreases degradation
increases expression
decreases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein]
Flurbiprofen results in decreased activity of PTGS2 protein
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]
Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form
Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein
Flurbiprofen results in decreased expression of PTGS2 mRNA
CTD PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein]
CTD PMID:11099482 PMID:11291649 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Rhog ras homolog family member G increases expression ISO Flurbiprofen results in increased expression of RHOG mRNA CTD PMID:16949054 NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
JBrowse link
G Rhou ras homolog family member U increases expression ISO Flurbiprofen results in increased expression of RHOU mRNA CTD PMID:16949054 NCBI chr19:51,641,408...51,651,249 JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sell selectin L decreases expression ISO Flurbiprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression ISO Flurbiprofen results in decreased expression of SMOC2 mRNA CTD PMID:16949054 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Flurbiprofen results in increased expression of SOX2 mRNA CTD PMID:16949054 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein CTD PMID:31184881 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Flurbiprofen results in increased expression of TGOLN2 mRNA CTD PMID:16949054 NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] CTD PMID:10357836 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of TIMP1 protein
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]
CTD PMID:10903797 PMID:19659691 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases response to substance
increases expression
ISO Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein
TP53 protein results in increased susceptibility to Flurbiprofen
TP53 protein mutant form results in decreased susceptibility to Flurbiprofen
Flurbiprofen results in increased expression of TP53 protein
CTD PMID:11687965 PMID:15710360 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Flurbiprofen results in decreased expression of TWIST1 mRNA CTD PMID:16949054 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Flurbiprofen results in increased expression of TYMS mRNA CTD PMID:16949054 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 PMID:15843492 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein
CTD PMID:12716482 PMID:16491094 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:12716482 PMID:16491094 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antimicrobial food preservative 11833
            biphenyl 197
              flurbiprofen 109
                (R)-flurbiprofen 0
                (S)-flurbiprofen 0
                nitroflurbiprofen 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            saturated fatty acid 15986
                                              propionic acid 3690
                                                flurbiprofen 109
                                                  (R)-flurbiprofen 0
                                                  (S)-flurbiprofen 0
                                                  nitroflurbiprofen 7
paths to the root