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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flurbiprofen
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Accession:CHEBI:5130 term browser browse the term
Definition:A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Synonyms:exact_synonym: 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid
 related_synonym: (+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid;   2-(2-fluorobiphenyl-4-yl)propanoic acid;   2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid;   3-fluoro-4-phenylhydratropic acid;   Ansaid;   Formula=C15H13FO2;   InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18);   InChIKey=SYTBZMRGLBWNTM-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1
 xref: Beilstein:2054451;   CAS:5104-49-4;   DrugBank:DB00712;   Drug_Central:1219;   KEGG:D00330;   LINCS:LSM-5174
 xref_mesh: MESH:D005480
 xref: PMID:12859660;   PMID:17562170;   PMID:19588427;   PMID:27746736;   PMID:27832658;   PMID:28147361;   PMID:28166217;   PMID:28298171;   PMID:28402193;   Wikipedia:Flurbiprofen


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Flurbiprofen results in decreased expression of ACTA1 mRNA CTD PMID:16949054 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 decreases expression ISO Flurbiprofen results in decreased expression of AKR1B7 mRNA CTD PMID:16949054 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flurbiprofen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:19010312 PMID:21187079 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; Flurbiprofen results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:16949054 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Flurbiprofen binds to ALB protein CTD PMID:9353694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Flurbiprofen results in decreased expression of ALDH7A1 mRNA CTD PMID:16949054 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Flurbiprofen results in increased expression of ANP32A mRNA CTD PMID:16949054 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Anxa1 annexin A1 increases expression ISO Flurbiprofen results in increased expression of ANXA1 mRNA CTD PMID:16949054 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa3 annexin A3 increases expression ISO Flurbiprofen results in increased expression of ANXA3 mRNA CTD PMID:16949054 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Apod apolipoprotein D increases expression ISO Flurbiprofen results in increased expression of APOD mRNA CTD PMID:16949054 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Apof apolipoprotein F increases expression ISO Flurbiprofen results in increased expression of APOF mRNA CTD PMID:16949054 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
JBrowse link
G App amyloid beta precursor protein affects cleavage
decreases secretion
multiple interactions
ISO
EXP
Flurbiprofen affects the cleavage of APP protein
Flurbiprofen results in decreased secretion of APP protein
alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein]
Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium]
CTD PMID:14690522 PMID:17292621 PMID:18648507 PMID:19659691 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arg1 arginase 1 decreases expression ISO Flurbiprofen results in decreased expression of ARG1 mRNA CTD PMID:16949054 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases activity EXP Flurbiprofen results in decreased activity of ASIC1 protein CTD PMID:11588175 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Flurbiprofen results in increased expression of BIRC5 mRNA CTD PMID:16949054 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Flurbiprofen results in increased expression of BNIP3 mRNA CTD PMID:16949054 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein] CTD PMID:8581270 PMID:11166334 PMID:12044622 PMID:12791437 PMID:14991081 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Flurbiprofen results in decreased expression of CCNB1 protein CTD PMID:11687965 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Flurbiprofen results in increased expression of CEACAM1 mRNA CTD PMID:16949054 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Flurbiprofen results in decreased expression of CES3 mRNA CTD PMID:16949054 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Flurbiprofen results in increased expression of CITED2 mRNA CTD PMID:16949054 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression ISO Flurbiprofen results in increased expression of CMAS mRNA CTD PMID:16949054 NCBI chr 4:176,994,129...177,012,445
Ensembl chr 4:176,994,129...177,012,444
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression ISO Flurbiprofen results in increased expression of CMPK2 mRNA CTD PMID:16949054 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 decreases expression ISO Flurbiprofen results in decreased expression of CRISP1 mRNA CTD PMID:16949054 NCBI chr 9:24,356,577...24,383,679
Ensembl chr 9:24,356,579...24,383,679
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of CYP17A1 protein CTD PMID:31184881 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Flurbiprofen results in decreased expression of CYP24A1 mRNA CTD PMID:16949054 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression ISO Flurbiprofen results in increased expression of CYP2F2 mRNA CTD PMID:16949054 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Defb1 defensin beta 1 decreases expression ISO Flurbiprofen results in decreased expression of DEFB1 mRNA CTD PMID:16949054 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Egf epidermal growth factor increases expression ISO Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Flurbiprofen results in increased phosphorylation of EIF4E protein
MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]
CTD PMID:18056468 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression
ISO ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Flurbiprofen results in increased expression of ELAVL1 protein
CTD PMID:18056468 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Eln elastin decreases expression ISO Flurbiprofen results in decreased expression of ELN mRNA CTD PMID:16949054 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression ISO Flurbiprofen results in decreased expression of ENPP2 mRNA CTD PMID:16949054 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Flurbiprofen results in decreased activity of FAAH protein CTD PMID:12751821 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Folr1 folate receptor alpha decreases expression ISO Flurbiprofen results in decreased expression of FOLR1 mRNA CTD PMID:16949054 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]]
Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]
CTD PMID:10864209 PMID:11164833 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
CTD PMID:21097678 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Flurbiprofen results in decreased expression of GPX3 mRNA CTD PMID:16949054 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO Flurbiprofen results in increased expression of GSTO1 mRNA CTD PMID:16949054 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein] CTD PMID:6696821 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Flurbiprofen results in increased expression of HELLS mRNA CTD PMID:16949054 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases degradation
increases expression
multiple interactions
increases activity
ISO Flurbiprofen results in decreased degradation of HPGD protein
Flurbiprofen results in increased expression of HPGD mRNA
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein
Flurbiprofen results in increased activity of HPGD protein
CTD PMID:19501039 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO Flurbiprofen results in increased expression of HSD11B2 mRNA CTD PMID:16949054 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Flurbiprofen results in increased expression of ICAM1 protein CTD PMID:16020654 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Flurbiprofen results in increased expression of IFIT2 mRNA CTD PMID:16949054 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifng interferon gamma multiple interactions ISO Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein] CTD PMID:19659691 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]; Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]
CTD PMID:11112151 PMID:12517972 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Flurbiprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO Flurbiprofen results in decreased expression of KCNN4 mRNA CTD PMID:16949054 NCBI chr 1:81,227,855...81,245,986
Ensembl chr 1:81,230,612...81,245,996
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]] CTD PMID:11166334 PMID:12791437 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lgals3 galectin 3 increases expression ISO Flurbiprofen results in increased expression of LGALS3 mRNA CTD PMID:16949054 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lgals9 galectin 9 decreases expression ISO Flurbiprofen results in decreased expression of LGALS9 mRNA CTD PMID:16949054 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Testosterone] CTD PMID:31184881 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Flurbiprofen results in decreased expression of LHCGR mRNA; Flurbiprofen results in decreased expression of LHCGR protein CTD PMID:31184881 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Flurbiprofen results in increased expression of LMO7 mRNA CTD PMID:16949054 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G Lto1 LTO1 maturation factor of ABCE1 decreases expression ISO Flurbiprofen results in decreased expression of LTO1 mRNA CTD PMID:16949054 NCBI chr 1:218,075,995...218,082,700
Ensembl chr 1:218,076,116...218,080,824
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:19501039 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:130,121,678...130,129,199
Ensembl chr 7:130,121,687...130,128,604
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 PMID:21097678 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Flurbiprofen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:19501039 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Flurbiprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO [[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
Flurbiprofen results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msmb microseminoprotein, beta increases expression ISO Flurbiprofen results in increased expression of MSMB mRNA CTD PMID:16949054 NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11099482 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO Flurbiprofen results in increased expression of NFKBIZ mRNA CTD PMID:16949054 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; Flurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Flurbiprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]
Flurbiprofen results in increased expression of NGFR mRNA; Flurbiprofen results in increased expression of NGFR protein
CTD PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Flurbiprofen results in increased expression of NOS2 mRNA
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:8528547 PMID:11405284 PMID:16944022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity ISO Flurbiprofen results in increased activity of NQO1 protein CTD PMID:8572925 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Flurbiprofen results in increased expression of PAPSS2 mRNA CTD PMID:16949054 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression ISO Flurbiprofen results in decreased expression of PCP4 mRNA CTD PMID:16949054 NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Flurbiprofen results in increased expression of PDZK1 mRNA CTD PMID:16949054 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Penk proenkephalin decreases expression ISO Flurbiprofen results in decreased expression of PENK mRNA CTD PMID:16949054 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Flurbiprofen results in increased expression of PIK3C3 mRNA CTD PMID:16949054 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA] CTD PMID:15878913 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression
ISO [Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein; Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]; AKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]; HRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA] CTD PMID:16949054 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP
Flurbiprofen results in decreased activity of PTGS1 protein CTD PMID:9233713 PMID:9258749 PMID:18848576 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
decreases degradation
increases expression
decreases expression
EXP
ISO
Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Zymosan results in increased expression of PTGS2 protein]
Flurbiprofen results in decreased activity of PTGS2 protein
Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]
Flurbiprofen results in decreased degradation of PTGS2 protein; Flurbiprofen results in decreased degradation of PTGS2 protein mutant form
Flurbiprofen results in decreased activity of PTGS2 protein; Flurbiprofen results in decreased activity of PTGS2 protein mutant form
Flurbiprofen results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen results in increased expression of PTGS2 mRNA; Flurbiprofen results in increased expression of PTGS2 protein
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Flurbiprofen inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Flurbiprofen promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Flurbiprofen results in increased expression of and results in increased activity of PTGS2 protein
Flurbiprofen results in decreased expression of PTGS2 mRNA
CTD PMID:9099957 PMID:9258749 PMID:9321948 PMID:10594327 PMID:11095985 PMID:11099482 PMID:11112151 PMID:11405284 PMID:11687965 PMID:12517972 PMID:15878913 PMID:16949054 PMID:18848576 PMID:19758985 PMID:22245433 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Flurbiprofen inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Flurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Flurbiprofen inhibits the reaction [Zymosan results in increased localization of and results in increased activity of RELA protein]
CTD PMID:11099482 PMID:11291649 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhog ras homolog family member G increases expression ISO Flurbiprofen results in increased expression of RHOG mRNA CTD PMID:16949054 NCBI chr 1:167,336,147...167,347,720
Ensembl chr 1:167,335,248...167,347,671
JBrowse link
G Rhou ras homolog family member U increases expression ISO Flurbiprofen results in increased expression of RHOU mRNA CTD PMID:16949054 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Flurbiprofen inhibits the reaction [alitretinoin binds to RXRA protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sell selectin L decreases expression ISO Flurbiprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression ISO Flurbiprofen results in decreased expression of SMOC2 mRNA CTD PMID:16949054 NCBI chr 1:56,242,289...56,374,106
Ensembl chr 1:56,242,346...56,374,120
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Flurbiprofen results in increased expression of SOX2 mRNA CTD PMID:16949054 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Flurbiprofen results in decreased expression of SRD5A1 mRNA; Flurbiprofen results in decreased expression of SRD5A1 protein CTD PMID:31184881 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Flurbiprofen results in increased expression of TGOLN2 mRNA CTD PMID:16949054 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Flurbiprofen inhibits the reaction [Arachidonic Acid results in decreased expression of THRSP mRNA] CTD PMID:10357836 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Flurbiprofen results in increased expression of TIMP1 protein
[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein; [Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA
CTD PMID:19501039 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Flurbiprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]
CTD PMID:10903797 PMID:19659691 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
decreases response to substance
increases expression
ISO Flurbiprofen results in increased abundance of and results in increased phosphorylation of TP53 protein
TP53 protein results in increased susceptibility to Flurbiprofen
TP53 protein mutant form results in decreased susceptibility to Flurbiprofen
Flurbiprofen results in increased expression of TP53 protein
CTD PMID:11687965 PMID:15710360 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO Flurbiprofen results in decreased expression of TWIST1 mRNA CTD PMID:16949054 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Flurbiprofen results in increased expression of TYMS mRNA CTD PMID:16949054 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 PMID:15843492 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Flurbiprofen CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 NCBI chr14:22,597,103...22,619,968 JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein
CTD PMID:12716482 PMID:16491094 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:12716482 PMID:16491094 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          antimicrobial food preservative 11695
            biphenyl 177
              flurbiprofen 108
                (R)-flurbiprofen 0
                (S)-flurbiprofen 0
                nitroflurbiprofen 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        monocarboxylic acid 17475
                                          fatty acid 15994
                                            saturated fatty acid 15967
                                              propionic acid 3671
                                                flurbiprofen 108
                                                  (R)-flurbiprofen 0
                                                  (S)-flurbiprofen 0
                                                  nitroflurbiprofen 7
paths to the root