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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:silibinin
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Accession:CHEBI:9144 term browser browse the term
Definition:A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
 related_synonym: Flavobin;   Formula=C25H22O10;   InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1;   InChIKey=SEBFKMXJBCUCAI-HKTJVKLFSA-N;   Karsil;   SMILES=[H][C@@]1(Oc2cc(ccc2O[C@@H]1CO)[C@@]1([H])Oc2cc(O)cc(O)c2C(=O)[C@@H]1O)c1ccc(O)c(OC)c1;   Silibinine;   Silybin;   Silymarin;   silibinina;   silibininum
 xref: CAS:22888-70-6;   HMDB:HMDB0030583;   KEGG:C07610;   KEGG:D08515;   KNApSAcK:C00001003
 xref_mesh: MESH:C440975
 xref: PMID:22086675;   PMID:22555054;   PMID:22899727;   PMID:23073223;   PMID:23357565;   PMID:23402882;   Patent:CN102727484;   Reaxys:1632852;   Wikipedia:Silibinin


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silibinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP Silybin results in increased expression of ABCA1 protein CTD PMID:26729088 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Silybin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; Silybin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] CTD PMID:34217736 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions ISO Silybin affects the localization of and affects the activity of ABCB11 protein CTD PMID:15763547 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 ISO
EXP		 Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]
Silybin results in increased phosphorylation of ACACA protein		 CTD PMID:25294820 PMID:25559859 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACLY ATP citrate lyase decreases phosphorylation EXP Silybin results in decreased phosphorylation of ACLY protein CTD PMID:25294820 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in increased expression of ACP5 protein] CTD PMID:36087815 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression ISO silymarin (silibinin) increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats RGD PMID:26115886 RGD:25330099 NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674 		JBrowse link
G AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 multiple interactions ISO Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA] CTD PMID:28619387 NCBI chr21:43,865,223...43,987,592
Ensembl chr21:43,865,223...43,987,592 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Silybin results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of AKT1 protein] CTD PMID:25559859 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein] CTD PMID:36087815 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G AMACR alpha-methylacyl-CoA racemase decreases expression EXP Silybin results in decreased expression of AMACR protein CTD PMID:25294820 NCBI chr 5:33,986,165...34,008,050
Ensembl chr 5:33,986,165...34,008,104 		JBrowse link
G APOA5 apolipoprotein A5 multiple interactions ISO Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA] CTD PMID:28619387 NCBI chr11:116,789,367...116,792,420
Ensembl chr11:116,789,367...116,792,420 		JBrowse link
G ASL argininosuccinate lyase multiple interactions ISO Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein] CTD PMID:28619387 NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697 		JBrowse link
G ATM ATM serine/threonine kinase multiple interactions EXP Silybin results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16777994 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in increased expression of BAX protein]; Silybin inhibits the reaction [Ethanol results in increased expression of BAX protein]; Silybin inhibits the reaction [Mitomycin affects the localization of BAX protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]] CTD PMID:19834285 PMID:35158046 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP Silybin results in decreased expression of BCL2 mRNA
[Silybin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of BCL2 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; Silybin inhibits the reaction [Mitomycin affects the expression of BCL2]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]		 CTD PMID:19834285 PMID:21969006 PMID:35158046 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
affects localization
increases cleavage		 EXP benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of BID protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of BID protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein]
Silybin affects the localization of BID protein modified form		 CTD PMID:16777994 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP [Silybin co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA CTD PMID:21969006 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CA9 carbonic anhydrase 9 multiple interactions
decreases expression		 EXP Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of CA9 mRNA] CTD PMID:21969006 NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159 		JBrowse link
G CASP2 caspase 2 multiple interactions EXP benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; Silybin results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:16777994 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases expression		 EXP Arsenic Trioxide promotes the reaction [Silybin results in increased activity of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Silybin inhibits the reaction [Acetaldehyde results in increased cleavage of CASP3 protein]; Silybin inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; Silybin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; Silybin results in increased cleavage of and results in increased activity of CASP3 protein
Silybin results in increased expression of CASP3 mRNA		 CTD PMID:16777994 PMID:21969006 PMID:35158046 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]; Silybin results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16777994 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Silybin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16777994 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO Silybin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Silybin inhibits the reaction [Arsenic results in decreased activity of CAT protein] CTD PMID:22229868 PMID:35752206 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCNA1 cyclin A1 decreases expression EXP Silybin results in decreased expression of CCNA1 protein CTD PMID:18435416 NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870 		JBrowse link
G CCNA2 cyclin A2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNA2 protein] CTD PMID:25559859 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions
decreases expression		 EXP Silybin inhibits the reaction [Arsenic results in increased expression of CCNB1]
Silybin results in decreased expression of CCNB1 protein		 CTD PMID:18435416 PMID:25868784 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression		 EXP
ISO		 [Silybin co-treated with Arsenic] results in decreased expression of CCND1 protein
Silybin results in decreased expression of CCND1 protein
Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]		 CTD PMID:16788158 PMID:18435416 PMID:25559859 PMID:25868784 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND3 cyclin D3 multiple interactions
decreases expression		 EXP [Silybin co-treated with Arsenic] results in decreased expression of CCND3 protein
Silybin results in decreased expression of CCND3 protein		 CTD PMID:18435416 PMID:25868784 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Silybin results in decreased expression of CCNE1 protein CTD PMID:18435416 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDC25A cell division cycle 25A decreases expression EXP Silybin results in decreased expression of CDC25A protein CTD PMID:18435416 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417 		JBrowse link
G CDC25B cell division cycle 25B decreases expression EXP Silybin results in decreased expression of CDC25B protein CTD PMID:18435416 NCBI chr20:3,786,951...3,806,115
Ensembl chr20:3,786,772...3,806,121 		JBrowse link
G CDC25C cell division cycle 25C decreases expression EXP Silybin results in decreased expression of CDC25C protein CTD PMID:18435416 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions
decreases expression		 EXP Silybin inhibits the reaction [Arsenic results in increased expression of CDK1 protein]
Silybin results in decreased expression of CDK1 protein		 CTD PMID:18435416 PMID:25868784 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions
decreases expression		 EXP [Silybin co-treated with Arsenic] results in decreased expression of CDK2 protein
Silybin results in decreased expression of CDK2 protein		 CTD PMID:18435416 PMID:25868784 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions
decreases expression		 EXP [Silybin co-treated with Arsenic] results in decreased expression of CDK4 protein
Silybin results in decreased expression of CDK4 protein		 CTD PMID:18435416 PMID:25868784 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDK6 cyclin dependent kinase 6 multiple interactions EXP [Silybin co-treated with Arsenic] results in decreased expression of CDK6 protein CTD PMID:25868784 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases cleavage		 EXP [Silybin co-treated with Arsenic] results in increased expression of CDKN1A protein; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Silybin results in increased cleavage of CDKN1A protein] CTD PMID:16777994 PMID:25868784 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions
increases expression		 EXP
ISO		 [Silybin co-treated with Arsenic] results in increased expression of CDKN1B protein
Silybin results in increased expression of CDKN1B protein
Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]		 CTD PMID:18435416 PMID:25559859 PMID:25868784 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:25559859 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CHEK2 checkpoint kinase 2 increases phosphorylation
multiple interactions		 EXP Silybin results in increased phosphorylation of CHEK2 protein
Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]		 CTD PMID:16777994 PMID:18435416 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CTSB cathepsin B multiple interactions EXP [Arsenic Trioxide co-treated with Silybin] results in decreased expression of CTSB mRNA CTD PMID:21969006 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Silybin analog inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:23810508 PMID:33839235 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYB5A cytochrome b5 type A multiple interactions ISO Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA] CTD PMID:28619387 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Silybin inhibits the reaction [sodium arsenite results in increased expression of CYBB] CTD PMID:24062023 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity EXP Silybin results in decreased activity of CYP2C8 protein CTD PMID:28457856 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Silybin results in decreased activity of CYP2C9 protein CTD PMID:15155549 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
multiple interactions		 EXP Silybin results in decreased activity of CYP3A4 protein
Silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]		 CTD PMID:15155549 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP DDIT3 affects the reaction [Silybin results in increased expression of TNFRSF10B] CTD PMID:19939880 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA] CTD PMID:25559859 NCBI chr14:100,726,892...100,738,224
Ensembl chr14:100,725,705...100,738,224 		JBrowse link
G DNM1L dynamin 1 like multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in increased expression of DNM1L protein]; Silybin inhibits the reaction [Ethanol results in increased expression of DNM1L protein] CTD PMID:35158046 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
G EGR1 early growth response 1 multiple interactions
increases expression		 EXP EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]
Silybin results in increased expression of EGR1 protein		 CTD PMID:24440808 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP
ISO		 Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP
ISO		 Silybin results in increased activity of [ESR1 protein binds to ESR2 protein] CTD PMID:16076518 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FAAH fatty acid amide hydrolase multiple interactions
decreases activity		 ISO Silybin inhibits the reaction [FAAH protein results in increased metabolism of and results in decreased activity of anandamide]
Silybin results in decreased activity of FAAH protein		 CTD PMID:37245739 NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein] CTD PMID:25559859 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FASN fatty acid synthase decreases expression
multiple interactions		 EXP
ISO		 Silybin results in decreased expression of FASN protein
Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]		 CTD PMID:25294820 PMID:25559859 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions ISO Silybin inhibits the reaction [Urethane results in increased secretion of FGF2 protein] CTD PMID:16788158 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in decreased expression of FTH1 mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of FTH1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of FTH1 mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of FTH1 protein] CTD PMID:35595033 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Silybin inhibits the reaction [Arsenic results in decreased activity of G6PD protein] CTD PMID:22229868 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GDF15 growth differentiation factor 15 increases expression
multiple interactions		 EXP Silybin results in increased expression of GDF15 mRNA; Silybin results in increased expression of GDF15 protein
EGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [Silybin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [Silybin results in increased expression of GDF15 protein]		 CTD PMID:24440808 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO
EXP		 Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]
Silybin inhibits the reaction [Acetaldehyde results in increased activity of GPT protein]; Silybin inhibits the reaction [Ethanol results in increased activity of and results in increased secretion of GPT protein]		 CTD PMID:28619387 PMID:35158046 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Silybin inhibits the reaction [Arsenic results in decreased activity of GSR protein] CTD PMID:22229868 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G H2AX H2A.X variant histone increases phosphorylation
multiple interactions		 EXP Silybin results in increased phosphorylation of H2AX protein
Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]		 CTD PMID:16777994 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP Silybin results in decreased expression of HMGCR protein CTD PMID:25294820 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Silybin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1] CTD PMID:24062023 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Silybin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein] CTD PMID:28914761 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:33839235 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Silybin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; Silybin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]; Silybin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]; Silybin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:28914761 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP Silybin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein] CTD PMID:28914761 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33839235 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of DLK1 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNA2 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCND1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of AKT1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RB1 protein]; Silybin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Silybin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 PMID:25559859 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G JAK2 Janus kinase 2 multiple interactions EXP silibinin decreases expression and phosphorylation of JAK2 protein in breast epithelium RGD PMID:28440514 RGD:149735360 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G KLF2 KLF transcription factor 2 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA] CTD PMID:25559859 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685 		JBrowse link
G KLF4 KLF transcription factor 4 multiple interactions ISO
EXP		 Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]
silibinin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells] 		CTD
RGD		 PMID:25559859 PMID:29127880 RGD:155230825 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482 		JBrowse link
G KLF5 KLF transcription factor 5 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA] CTD PMID:25559859 NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541 		JBrowse link
G LPIN1 lipin 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein] CTD PMID:25559859 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:25559859 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:25559859 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP Silybin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:16777994 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein] CTD PMID:16777994 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MFN1 mitofusin 1 multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in decreased expression of MFN1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of MFN1 protein] CTD PMID:35158046 NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase multiple interactions EXP Silybin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983 		JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions EXP [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP14 mRNA; Arsenic Trioxide inhibits the reaction [Silybin results in increased expression of MMP14 mRNA] CTD PMID:21969006 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
increases expression		 EXP
ISO		 [Arsenic Trioxide co-treated with Silybin] results in decreased activity of MMP2 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP2 mRNA; [Silybin co-treated with Arsenic] results in decreased expression of MMP2; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]
Silybin results in increased expression of MMP2 mRNA
[Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]		 CTD PMID:16169303 PMID:21969006 PMID:25868784 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression		 EXP [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP9 mRNA; [Silybin co-treated with Arsenic Trioxide] results in decreased activity of MMP9 protein
Silybin results in decreased activity of MMP9 protein
Silybin results in decreased expression of MMP9 mRNA		 CTD PMID:21969006 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Silybin results in decreased expression of MYC protein CTD PMID:27746612 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NAT2 N-acetyltransferase 2 multiple interactions ISO Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA] CTD PMID:28619387 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in increased expression of NCOA4 mRNA]; Silybin inhibits the reaction [Ethanol results in increased expression of NCOA4 mRNA] CTD PMID:35595033 NCBI chr10:46,005,088...46,030,623
Ensembl chr10:46,005,088...46,030,623 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Silybin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2] CTD PMID:24062023 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression ISO Silybin results in decreased expression of NOS2 protein CTD PMID:16788158 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO Silybin inhibits the reaction [sodium arsenite results in increased expression of NOX4] CTD PMID:24062023 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 ISO
EXP		 Silymarin decreases Nqo1 mRNA in liver
Silybin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]		 CTD
RGD		 PMID:31330490 PMID:31432116 RGD:25823187 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 increases expression ISO silymarin increases Nr1h4 mRNA expression in rat kidney and liver RGD PMID:30308196 RGD:15042865 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases expression EXP Silybin results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in decreased expression of OPA1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of OPA1 protein] CTD PMID:35158046 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage		 EXP benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Silybin results in increased cleavage of and results in increased activity of PARP1 protein
Silybin results in increased expression of PARP1 protein		 CTD PMID:16777994 PMID:24440808 PMID:27402681 PMID:35158046 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression ISO Silybin results in decreased expression of PCNA protein CTD PMID:16788158 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Silybin results in decreased expression of PECAM1 protein CTD PMID:16788158 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PF4 platelet factor 4 multiple interactions EXP Silybin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein] CTD PMID:29439388 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PINK1 mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PINK1 protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of PINK1 mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of PINK1 protein] CTD PMID:35595033 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions
decreases expression		 EXP [Silybin co-treated with Arsenic Trioxide] results in decreased expression of PLAU mRNA; Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of PLAU mRNA]; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of PLAU mRNA] CTD PMID:21969006 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions ISO Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA] CTD PMID:28619387 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO
EXP		 Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]
Silybin results in increased expression of PPARG protein		 CTD PMID:25559859 PMID:27746612 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PRKN mRNA]; Silybin inhibits the reaction [Acetaldehyde results in decreased expression of PRKN protein]; Silybin inhibits the reaction [Ethanol results in decreased expression of PRKN mRNA]; Silybin inhibits the reaction [Ethanol results in decreased expression of PRKN protein] CTD PMID:35595033 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Silybin results in decreased expression of PTGS2 protein CTD PMID:16788158 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 multiple interactions EXP Silybin binds to and results in decreased activity of PTPN1 protein CTD PMID:30160205 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions ISO Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of RB1 protein] CTD PMID:25559859 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of RUNX2 protein] CTD PMID:36087815 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein] CTD PMID:36087815 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SKP2 S-phase kinase associated protein 2 decreases expression EXP Silybin results in decreased expression of SKP2 protein CTD PMID:18435416 NCBI chr 5:36,152,111...36,193,530
Ensembl chr 5:36,151,989...36,196,849 		JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP Silybin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] CTD PMID:17976262 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Silybin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SOD2 protein] CTD PMID:36087815 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases response to substance
multiple interactions		 EXP SREBF1 protein results in decreased susceptibility to Silybin
fatostatin promotes the reaction [Silybin results in decreased cleavage of SREBF1 protein]; Silybin results in decreased cleavage of and results in increased phosphorylation of SREBF1 protein		 CTD PMID:25294820 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TFRC transferrin receptor multiple interactions EXP Silybin inhibits the reaction [Acetaldehyde results in increased expression of TFRC protein]; Silybin inhibits the reaction [Ethanol results in increased expression of TFRC protein] CTD PMID:35595033 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]
Silybin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; Silybin inhibits the reaction [IL1B protein results in increased secretion of TNF protein]		 CTD PMID:28619387 PMID:28914761 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b increases expression
multiple interactions		 EXP Silybin results in increased expression of TNFRSF10B
DDIT3 affects the reaction [Silybin results in increased expression of TNFRSF10B]		 CTD PMID:19939880 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TP53 tumor protein p53 increases expression
affects localization
multiple interactions
increases phosphorylation		 EXP Silybin results in increased expression of TP53 protein
Silybin affects the localization of TP53 protein
Caffeine inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; Silybin inhibits the reaction [Mitomycin results in increased expression of TP53]		 CTD PMID:16777994 PMID:19834285 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 decreases activity
multiple interactions		 ISO
EXP		 Silybin metabolite results in decreased activity of UGT1A1 protein
Silybin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]		 CTD PMID:15155549 PMID:15921999 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
decreases activity		 EXP
ISO		 Silybin inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin]
Silybin metabolite results in decreased activity of UGT1A6 protein		 CTD PMID:15155549 PMID:15921999 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 multiple interactions EXP Silybin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 multiple interactions EXP Silybin inhibits the reaction [UGT2B15 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP Silybin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin] CTD PMID:15155549 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G VASP vasodilator stimulated phosphoprotein increases phosphorylation EXP Silybin results in increased phosphorylation of VASP protein CTD PMID:29439388 NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,989 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression		 EXP
ISO		 Silybin promotes the reaction [Lipids deficiency inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]; Silybin promotes the reaction [Lipids deficiency results in decreased expression of VEGFA protein]
Silybin inhibits the reaction [Urethane results in increased secretion of VEGFA protein]
Silybin results in decreased expression of VEGFA protein		 CTD PMID:16788158 PMID:26087400 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIM vimentin multiple interactions EXP [Silybin co-treated with Arsenic] results in decreased expression of VIM CTD PMID:25868784 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      chemical role 24245
        antioxidant 17490
          silibinin 132
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbonyl compound 23571
                                    ketone 19350
                                      oxyketone 9421
                                        alpha-oxyketone 9421
                                          alpha-hydroxy ketone 9421
                                            secondary alpha-hydroxy ketone 1059
                                              silibinin 132
paths to the root