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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736015
Species: Homo sapiens
RGD Object: Gene
Symbol: ACACA
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACACAincreases phosphorylationEXP 6480464CTDSilybin results in increased phosphorylation of ACACA proteinPMID:25294820
ACACAmultiple interactionsISOAcaca (Mus musculus)6480464CTDSilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased phosphorylation of ACACA protein]PMID:25559859
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