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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1increases expressionEXP 6480464CTDSilybin results in increased expression of EGR1 proteinPMID:24440808
EGR1multiple interactionsEXP 6480464CTDEGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]PMID:24440808
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