CCNA1 (cyclin A1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CCNA1 (cyclin A1) Homo sapiens
Analyze
Symbol: CCNA1
Name: cyclin A1
RGD ID: 1321661
HGNC Page HGNC
Description: Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Localizes to cyclin A2-CDK2 complex and microtubule cytoskeleton. Implicated in prostate cancer. Biomarker of acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CT146; cyclin-A1; testicular tissue protein Li 34
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1336,431,520 - 36,442,870 (+)EnsemblGRCh38hg38GRCh38
GRCh381336,430,488 - 36,442,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371337,006,092 - 37,017,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361335,904,633 - 35,915,008 (+)NCBINCBI36hg18NCBI36
Build 341335,904,632 - 35,915,008NCBI
Celera1318,073,175 - 18,084,229 (+)NCBI
Cytogenetic Map13q13.3NCBI
HuRef1317,817,953 - 17,828,979 (+)NCBIHuRef
CHM1_11336,973,445 - 36,984,499 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-taxifolin  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
8-Br-cAMP  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
atropine  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cadmium sulfate  (EXP)
calcitriol  (EXP)
carbon nanotube  (EXP,ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
diethyl maleate  (EXP)
dimethylarsinous acid  (EXP)
dinophysistoxin 2  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
flavanones  (EXP)
folic acid  (EXP)
fulvestrant  (EXP)
furan  (ISO)
harmine  (EXP)
heptanal  (EXP)
hexanal  (EXP)
homocysteine  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
L-ascorbic acid  (ISO)
lead(II) chloride  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (EXP)
nonanal  (EXP)
octanal  (EXP)
okadaic acid  (EXP)
ouabain  (EXP)
paracetamol  (ISO)
parathion  (EXP)
PCB138  (ISO)
pentanal  (EXP)
pioglitazone  (ISO)
poly(propylene imine) macromolecule  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP)
propanal  (EXP)
propylparaben  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
sodium arsenite  (EXP)
sunitinib  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
Triptolide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1628647   PMID:7478582   PMID:7799941   PMID:7969176   PMID:8125298   PMID:8397206   PMID:8463339   PMID:8565853   PMID:8756624   PMID:9041194   PMID:9139732   PMID:9244350  
PMID:9636170   PMID:9663463   PMID:9843212   PMID:9860976   PMID:10022926   PMID:10068472   PMID:10196209   PMID:10373534   PMID:10559988   PMID:10593981   PMID:10652300   PMID:10679238  
PMID:10790373   PMID:10926775   PMID:10995387   PMID:11076863   PMID:11172814   PMID:11256614   PMID:11259605   PMID:11264176   PMID:11340163   PMID:11381140   PMID:11584018   PMID:11598016  
PMID:11733001   PMID:11884610   PMID:12121569   PMID:12190313   PMID:12191604   PMID:12383116   PMID:12477932   PMID:12579332   PMID:12628165   PMID:12800980   PMID:12970441   PMID:14681231  
PMID:14701826   PMID:14985333   PMID:15004027   PMID:15050687   PMID:15138268   PMID:15159402   PMID:15232106   PMID:15342377   PMID:15456866   PMID:15489336   PMID:15583032   PMID:15601848  
PMID:15649124   PMID:15829981   PMID:16007189   PMID:16009130   PMID:16159883   PMID:16191191   PMID:16381901   PMID:16449996   PMID:16519687   PMID:16774918   PMID:16777603   PMID:16799873  
PMID:16982699   PMID:17047026   PMID:17098733   PMID:17274640   PMID:17308064   PMID:17353931   PMID:17455244   PMID:17530187   PMID:18305109   PMID:18372919   PMID:18692475   PMID:18692784  
PMID:18787932   PMID:19056339   PMID:19270695   PMID:19379570   PMID:19423708   PMID:19477924   PMID:19668232   PMID:19738611   PMID:19786724   PMID:19843677   PMID:19886767   PMID:20013084  
PMID:20219923   PMID:20457893   PMID:21145461   PMID:21412159   PMID:21540187   PMID:21563216   PMID:21646351   PMID:21764057   PMID:21873635   PMID:22370483   PMID:22500553   PMID:22529286  
PMID:22712549   PMID:22718346   PMID:22763964   PMID:23042265   PMID:23333304   PMID:23972993   PMID:23991063   PMID:24002705   PMID:24019929   PMID:24163370   PMID:24359512   PMID:24705021  
PMID:25039670   PMID:25173755   PMID:25198553   PMID:25241761   PMID:25265349   PMID:25292097   PMID:25294903   PMID:26186194   PMID:26250467   PMID:26264872   PMID:26387543   PMID:26921336  
PMID:27432908   PMID:27669502   PMID:28514442   PMID:29154753   PMID:29997244   PMID:30935108   PMID:31012142   PMID:31160578   PMID:31420536   PMID:31436300   PMID:31760882   PMID:32102526  
PMID:32157447   PMID:32538752   PMID:32814053  


Genomics

Comparative Map Data
CCNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1336,431,520 - 36,442,870 (+)EnsemblGRCh38hg38GRCh38
GRCh381336,430,488 - 36,442,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371337,006,092 - 37,017,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361335,904,633 - 35,915,008 (+)NCBINCBI36hg18NCBI36
Build 341335,904,632 - 35,915,008NCBI
Celera1318,073,175 - 18,084,229 (+)NCBI
Cytogenetic Map13q13.3NCBI
HuRef1317,817,953 - 17,828,979 (+)NCBIHuRef
CHM1_11336,973,445 - 36,984,499 (+)NCBICHM1_1
Ccna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,952,890 - 54,965,055 (-)NCBIGRCm39mm39
GRCm39 Ensembl354,952,890 - 54,962,922 (-)Ensembl
GRCm38355,045,469 - 55,057,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl355,045,469 - 55,055,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv37354,849,391 - 54,858,977 (-)NCBIGRCm37mm9NCBIm37
MGSCv36355,133,404 - 55,142,984 (-)NCBImm8
Celera354,763,020 - 54,772,599 (-)NCBICelera
Cytogenetic Map3CNCBI
Ccna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22139,231,738 - 139,278,066 (-)NCBI
Rnor_6.0 Ensembl2144,458,153 - 144,467,912 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02144,456,689 - 144,503,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02163,874,794 - 163,886,211 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42144,275,211 - 144,285,196 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12144,225,173 - 144,235,159 (-)NCBI
Celera2133,716,972 - 133,726,933 (-)NCBICelera
Cytogenetic Map2q26NCBI
Ccna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554319,658,015 - 9,668,087 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554319,658,301 - 9,668,659 (-)NCBIChiLan1.0ChiLan1.0
CCNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11336,080,331 - 36,092,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1336,080,331 - 36,092,078 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01317,649,064 - 17,660,550 (+)NCBIMhudiblu_PPA_v0panPan3
CCNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,189,457 - 4,198,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,189,457 - 4,198,373 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,219,718 - 4,228,956 (-)NCBI
ROS_Cfam_1.0254,288,085 - 4,297,327 (-)NCBI
UMICH_Zoey_3.1254,195,452 - 4,204,690 (-)NCBI
UNSW_CanFamBas_1.0254,191,619 - 4,200,848 (-)NCBI
UU_Cfam_GSD_1.0254,255,371 - 4,264,612 (-)NCBI
Ccna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945165,363,959 - 165,379,007 (-)NCBI
SpeTri2.0NW_00493647230,574,957 - 30,586,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,396,301 - 12,405,353 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11112,396,149 - 12,405,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,355,480 - 12,364,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1314,979,775 - 14,992,609 (+)NCBI
ChlSab1.1 Ensembl314,982,392 - 14,993,562 (+)Ensembl
Vero_WHO_p1.0NW_02366605729,300,504 - 29,312,984 (-)NCBI
Ccna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624776941,107 - 951,256 (-)NCBI

Position Markers
RH44746  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371337,011,774 - 37,011,898UniSTSGRCh37
Build 361335,909,774 - 35,909,898RGDNCBI36
Celera1318,078,984 - 18,079,108RGD
Cytogenetic Map13q12.3-q13UniSTS
HuRef1317,823,734 - 17,823,858UniSTS
GeneMap99-GB4 RH Map13121.46UniSTS
RH25577  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371337,016,791 - 37,016,960UniSTSGRCh37
Build 361335,914,791 - 35,914,960RGDNCBI36
Celera1318,084,001 - 18,084,170RGD
Cytogenetic Map13q12.3-q13UniSTS
HuRef1317,828,751 - 17,828,920UniSTS
PMC193706P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371337,007,248 - 37,007,331UniSTSGRCh37
Build 361335,905,248 - 35,905,331RGDNCBI36
Celera1318,074,456 - 18,074,539RGD
Cytogenetic Map13q12.3-q13UniSTS
HuRef1317,819,234 - 17,819,317UniSTS
RH71252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371337,016,746 - 37,016,880UniSTSGRCh37
Build 361335,914,746 - 35,914,880RGDNCBI36
Celera1318,083,956 - 18,084,090RGD
Cytogenetic Map13q12.3-q13UniSTS
HuRef1317,828,706 - 17,828,840UniSTS
GeneMap99-GB4 RH Map13126.96UniSTS
NCBI RH Map13305.6UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIRLET7Bhsa-let-7b-5pMirtarbaseexternal_infoReporter assayNon-Functional MTI18379589
MIRLET7Bhsa-let-7b-5pTarbaseexternal_infoReporter GeneNEGATIVE

Predicted Target Of
Summary Value
Count of predictions:613
Count of miRNA genes:299
Interacting mature miRNAs:317
Transcripts:ENST00000255465, ENST00000418263, ENST00000440264, ENST00000449823, ENST00000463403
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 1 110 165 2 152 2 20 12 624 7 519 100 4 9
Low 825 1189 747 108 1044 14 1664 438 2684 121 660 1077 99 447 1088
Below cutoff 1457 1630 628 336 589 271 2528 1609 390 233 240 385 66 753 1582 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA553454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF124143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG723613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD171793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC395631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC396283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC411883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH771162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH771214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ662956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U97680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000255465   ⟹   ENSP00000255465
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1336,432,495 - 36,442,870 (+)Ensembl
RefSeq Acc Id: ENST00000440264   ⟹   ENSP00000400666
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1336,431,903 - 36,442,869 (+)Ensembl
RefSeq Acc Id: ENST00000625767   ⟹   ENSP00000486017
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1336,432,523 - 36,442,870 (+)Ensembl
RefSeq Acc Id: ENST00000630422   ⟹   ENSP00000486482
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1336,431,520 - 36,442,869 (+)Ensembl
RefSeq Acc Id: NM_001111045   ⟹   NP_001104515
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,432,495 - 36,442,870 (+)NCBI
GRCh371337,005,257 - 37,017,019 (+)NCBI
HuRef1317,817,953 - 17,828,979 (+)ENTREZGENE
CHM1_11336,973,887 - 36,984,499 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001111046   ⟹   NP_001104516
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,431,955 - 36,442,870 (+)NCBI
GRCh371337,005,257 - 37,017,019 (+)NCBI
HuRef1317,817,953 - 17,828,979 (+)ENTREZGENE
CHM1_11336,973,445 - 36,984,499 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001111047   ⟹   NP_001104517
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,431,955 - 36,442,870 (+)NCBI
GRCh371337,005,257 - 37,017,019 (+)NCBI
HuRef1317,817,953 - 17,828,979 (+)ENTREZGENE
CHM1_11336,973,445 - 36,984,499 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003914   ⟹   NP_003905
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,432,495 - 36,442,870 (+)NCBI
GRCh371337,005,257 - 37,017,019 (+)NCBI
Build 361335,904,633 - 35,915,008 (+)NCBI Archive
HuRef1317,817,953 - 17,828,979 (+)ENTREZGENE
CHM1_11336,973,887 - 36,984,499 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535294   ⟹   XP_011533596
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,430,488 - 36,442,870 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535295   ⟹   XP_011533597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,430,488 - 36,442,870 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535296   ⟹   XP_011533598
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,432,439 - 36,442,870 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001104516   ⟸   NM_001111046
- Peptide Label: isoform c
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104517   ⟸   NM_001111047
- Peptide Label: isoform c
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003905   ⟸   NM_003914
- Peptide Label: isoform a
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104515   ⟸   NM_001111045
- Peptide Label: isoform b
- UniProtKB: P78396 (UniProtKB/Swiss-Prot),   A0A140VJG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011533596   ⟸   XM_011535294
- Peptide Label: isoform X1
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533597   ⟸   XM_011535295
- Peptide Label: isoform X1
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533598   ⟸   XM_011535296
- Peptide Label: isoform X1
- UniProtKB: P78396 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000255465   ⟸   ENST00000255465
RefSeq Acc Id: ENSP00000486017   ⟸   ENST00000625767
RefSeq Acc Id: ENSP00000400666   ⟸   ENST00000440264
RefSeq Acc Id: ENSP00000486482   ⟸   ENST00000630422
Protein Domains
Cyclin N-terminal

Promoters
RGD ID:7226221
Promoter ID:EPDNEW_H18857
Type:initiation region
Name:CCNA1_2
Description:cyclin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18858  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,432,267 - 36,432,327EPDNEW
RGD ID:7226225
Promoter ID:EPDNEW_H18858
Type:multiple initiation site
Name:CCNA1_1
Description:cyclin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18857  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381336,432,495 - 36,432,555EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000050293] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q12.3-21.33(chr13:30697728-69471973)x1 copy number loss See cases [RCV000051373] Chr13:30697728..69471973 [GRCh38]
Chr13:31271865..70046105 [GRCh37]
Chr13:30169865..68944106 [NCBI36]
Chr13:13q12.3-21.33
pathogenic
GRCh38/hg38 13q13.3-14.11(chr13:35232476-41375955)x1 copy number loss See cases [RCV000051375] Chr13:35232476..41375955 [GRCh38]
Chr13:35806613..41950091 [GRCh37]
Chr13:34704613..40848091 [NCBI36]
Chr13:13q13.3-14.11
pathogenic
GRCh38/hg38 13q13.2-13.3(chr13:33754469-36942137)x3 copy number gain See cases [RCV000052004] Chr13:33754469..36942137 [GRCh38]
Chr13:34328606..37516274 [GRCh37]
Chr13:33226606..36414274 [NCBI36]
Chr13:13q13.2-13.3
uncertain significance
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-31.1(chr13:30318913-83610426)x3 copy number gain See cases [RCV000053737] Chr13:30318913..83610426 [GRCh38]
Chr13:30893050..84184561 [GRCh37]
Chr13:29791050..83082562 [NCBI36]
Chr13:13q12.3-31.1
pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q11-13.3(chr13:18676442-37656039)x3 copy number gain See cases [RCV000053721] Chr13:18676442..37656039 [GRCh38]
Chr13:19250582..38230176 [GRCh37]
Chr13:18148582..37128176 [NCBI36]
Chr13:13q11-13.3
pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34
pathogenic
NM_001111045.1(CCNA1):c.778C>T (p.Arg260Ter) single nucleotide variant Malignant melanoma [RCV000070348] Chr13:36438755 [GRCh38]
Chr13:37012892 [GRCh37]
Chr13:35910892 [NCBI36]
Chr13:13q13.3
not provided
NM_001111045.1(CCNA1):c.1058G>A (p.Arg353Gln) single nucleotide variant Malignant melanoma [RCV000070349] Chr13:36440146 [GRCh38]
Chr13:37014283 [GRCh37]
Chr13:35912283 [NCBI36]
Chr13:13q13.3
not provided
NM_001111045.1(CCNA1):c.146C>T (p.Pro49Leu) single nucleotide variant Malignant melanoma [RCV000062666] Chr13:36433073 [GRCh38]
Chr13:37007210 [GRCh37]
Chr13:35905210 [NCBI36]
Chr13:13q13.3
not provided
NM_001111045.1(CCNA1):c.147C>T (p.Pro49=) single nucleotide variant Malignant melanoma [RCV000062667] Chr13:36433074 [GRCh38]
Chr13:37007211 [GRCh37]
Chr13:35905211 [NCBI36]
Chr13:13q13.3
not provided
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-21.32(chr13:31553608-65470367)x3 copy number gain See cases [RCV000135808] Chr13:31553608..65470367 [GRCh38]
Chr13:32127745..66044499 [GRCh37]
Chr13:31025745..64942500 [NCBI36]
Chr13:13q12.3-21.32
pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-14.11(chr13:19671934-40914767)x3 copy number gain See cases [RCV000137892] Chr13:19671934..40914767 [GRCh38]
Chr13:20246074..41488903 [GRCh37]
Chr13:19144074..40386903 [NCBI36]
Chr13:13q12.11-14.11
pathogenic
GRCh38/hg38 13q12.3-13.3(chr13:29073320-36556014)x1 copy number loss See cases [RCV000137923] Chr13:29073320..36556014 [GRCh38]
Chr13:29647457..37130151 [GRCh37]
Chr13:28545457..36028151 [NCBI36]
Chr13:13q12.3-13.3
pathogenic
GRCh38/hg38 13q12.3-14.2(chr13:31018160-48491204)x1 copy number loss See cases [RCV000138723] Chr13:31018160..48491204 [GRCh38]
Chr13:31592297..49065340 [GRCh37]
Chr13:30490297..47963341 [NCBI36]
Chr13:13q12.3-14.2
pathogenic
GRCh38/hg38 13q13.1-31.1(chr13:32531486-86757044)x3 copy number gain See cases [RCV000138339] Chr13:32531486..86757044 [GRCh38]
Chr13:33105623..87409299 [GRCh37]
Chr13:32003623..86207300 [NCBI36]
Chr13:13q13.1-31.1
pathogenic
GRCh38/hg38 13q12.3-13.3(chr13:30313809-39267681)x1 copy number loss See cases [RCV000139225] Chr13:30313809..39267681 [GRCh38]
Chr13:30887946..39841818 [GRCh37]
Chr13:29785946..38739818 [NCBI36]
Chr13:13q12.3-13.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.3-13.3(chr13:29321454-36995348)x3 copy number gain See cases [RCV000142869] Chr13:29321454..36995348 [GRCh38]
Chr13:29895591..37569485 [GRCh37]
Chr13:28793591..36467485 [NCBI36]
Chr13:13q12.3-13.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000148244] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q13.3(chr13:36064105-39230796)x1 copy number loss See cases [RCV000449219] Chr13:36064105..39230796 [GRCh37]
Chr13:13q13.3
likely pathogenic
GRCh37/hg19 13q13.3(chr13:35531798-39607778)x1 copy number loss See cases [RCV000449245] Chr13:35531798..39607778 [GRCh37]
Chr13:13q13.3
likely pathogenic
GRCh37/hg19 13q13.1-21.31(chr13:32946120-62698217)x1 copy number loss See cases [RCV000446067] Chr13:32946120..62698217 [GRCh37]
Chr13:13q13.1-21.31
pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-22.1(chr13:19436286-74045459)x3 copy number gain not provided [RCV000683572] Chr13:19436286..74045459 [GRCh37]
Chr13:13q11-22.1
pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q13.3(chr13:36965469-37148422)x1 copy number loss not provided [RCV000738171] Chr13:36965469..37148422 [GRCh37]
Chr13:13q13.3
benign
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34
pathogenic
NM_003914.4(CCNA1):c.720G>A (p.Thr240=) single nucleotide variant not provided [RCV000963309] Chr13:36438694 [GRCh38]
Chr13:37012831 [GRCh37]
Chr13:13q13.3
benign
NM_003914.4(CCNA1):c.321T>C (p.Tyr107=) single nucleotide variant not provided [RCV000963981] Chr13:36437652 [GRCh38]
Chr13:37011789 [GRCh37]
Chr13:13q13.3
benign
NM_003914.4(CCNA1):c.567A>G (p.Ser189=) single nucleotide variant not provided [RCV000929151] Chr13:36438089 [GRCh38]
Chr13:37012226 [GRCh37]
Chr13:13q13.3
likely benign
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
NM_003914.4(CCNA1):c.1158G>A (p.Leu386=) single nucleotide variant not provided [RCV000907199] Chr13:36441177 [GRCh38]
Chr13:37015314 [GRCh37]
Chr13:13q13.3
benign
NM_003914.4(CCNA1):c.544+5C>A single nucleotide variant not provided [RCV000963308] Chr13:36437880 [GRCh38]
Chr13:37012017 [GRCh37]
Chr13:13q13.3
benign
NM_003914.4(CCNA1):c.804T>C (p.Ala268=) single nucleotide variant not provided [RCV000932242] Chr13:36438778 [GRCh38]
Chr13:37012915 [GRCh37]
Chr13:13q13.3
likely benign
GRCh37/hg19 13q11-34(chr13:19053605-115108528)x3 copy number gain See cases [RCV001353184] Chr13:19053605..115108528 [GRCh37]
Chr13:13q11-34
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1577 AgrOrtholog
COSMIC CCNA1 COSMIC
Ensembl Genes ENSG00000133101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000255465 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000400666 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000486017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000486482 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000255465 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000440264 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000625767 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000630422 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000133101 GTEx
HGNC ID HGNC:1577 ENTREZGENE
Human Proteome Map CCNA1 Human Proteome Map
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8900 UniProtKB/Swiss-Prot
NCBI Gene 8900 ENTREZGENE
OMIM 604036 OMIM
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CCNA1 RGD, PharmGKB
PROSITE CYCLINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJG0 ENTREZGENE, UniProtKB/TrEMBL
  CCNA1_HUMAN UniProtKB/Swiss-Prot
  F6KX25_HUMAN UniProtKB/TrEMBL
  P78396 ENTREZGENE
UniProt Secondary B7Z7E3 UniProtKB/Swiss-Prot
  Q5T3V0 UniProtKB/Swiss-Prot
  Q5U0G2 UniProtKB/Swiss-Prot
  Q8IY91 UniProtKB/Swiss-Prot