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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nerve Degeneration
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Accession:DOID:9002955 term browser browse the term
Definition:Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Synonyms:exact_synonym: Nerve Degenerations;   Neuron Degeneration;   Neuron Degenerations
 related_synonym: striatal degeneration
 primary_id: MESH:D009410


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Nerve Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Adra1b adrenergic receptor, alpha 1b ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037 		JBrowse link
G Agtpbp1 ATP/GTP binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16952463 NCBI chr13:59,597,348...59,705,184
Ensembl chr13:59,593,556...59,733,041 		JBrowse link
G Angpt1 angiopoietin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G Ank2 ankyrin 2, brain ISO RGD PMID:12949909 RGD:1599116 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999 		JBrowse link
G Aplp2 amyloid beta precursor-like protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11784781 NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111 		JBrowse link
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:11784781 PMID:11800653 PMID:12396081 PMID:12963085 PMID:16951259 More... NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Arg2 arginase type II ISO CTD Direct Evidence: marker/mechanism CTD PMID:30618589 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075 		JBrowse link
G Atp13a2 ATPase type 13A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22847264 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641 		JBrowse link
G Atrn attractin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16860906 NCBI chr 2:130,734,363...130,872,249
Ensembl chr 2:130,748,415...130,872,253 		JBrowse link
G Atxn3 ataxin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9635424 NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19740541 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein ISO CTD Direct Evidence: therapeutic CTD PMID:20385067 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11146106 PMID:17967740 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:8921280 PMID:8978711 PMID:15372491 PMID:19457078 PMID:19686240 More... RGD:10059347 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related ISO protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G C9orf72 C9orf72, member of C9orf72-SMCR8 complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:33661518 NCBI chr 4:35,191,285...35,226,153
Ensembl chr 4:35,191,285...35,226,175 		JBrowse link
G Casp3 caspase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14999069 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cd4 CD4 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9546790 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184 		JBrowse link
G Cd44 CD44 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:15191797 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd9 CD9 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 6:125,437,229...125,471,723
Ensembl chr 6:125,437,229...125,471,754 		JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh2 cadherin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17581637 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 ISO CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:11517236 PMID:24211273 PMID:18313855 RGD:10059347 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cntf ciliary neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:15372491 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: therapeutic CTD PMID:18804145 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dag1 dystroglycan 1 ISO RGD PMID:16228655 RGD:11537480 NCBI chr 9:108,082,060...108,141,176
Ensembl chr 9:108,081,833...108,141,157 		JBrowse link
G Ddc dopa decarboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17005863 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 ISO protein:increased expression:CA1&CA3 fields of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chr 2:180,783,551...180,798,808
Ensembl chr 2:180,789,446...180,798,807 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:17010629 PMID:17166730 PMID:19497871 PMID:30837834 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Epor erythropoietin receptor ISO CTD Direct Evidence: therapeutic CTD PMID:19497871 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802 		JBrowse link
G Ets2 E26 avian leukemia oncogene 2, 3' domain ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:19969022 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:10203697 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Ghrl ghrelin ISO CTD Direct Evidence: therapeutic CTD PMID:19429016 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 7:45,481,307...45,520,708
Ensembl chr 7:45,481,307...45,527,802 		JBrowse link
G Grm4 glutamate receptor, metabotropic 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17446080 NCBI chr17:27,641,361...27,732,800
Ensembl chr17:27,641,361...27,740,377 		JBrowse link
G Grn granulin ISO CTD Direct Evidence: therapeutic CTD PMID:21820214 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Hotair HOX transcript antisense RNA (non-protein coding) ISO CTD Direct Evidence: therapeutic CTD PMID:32968928 NCBI chr15:102,852,497...102,856,381
Ensembl chr15:102,852,494...102,862,817 		JBrowse link
G Hspa5 heat shock protein 5 ISO protein:decreased expression:spinal cord RGD PMID:21436843 RGD:5685686 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:15153526 PMID:16307444 PMID:19457078 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 PMID:10203697 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24667322 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Itgam integrin alpha M ISO CTD Direct Evidence: therapeutic CTD PMID:32375810 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18619942 NCBI chr15:79,364,427...79,396,712
Ensembl chr15:79,367,915...79,389,442 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15256069 NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560 		JBrowse link
G Lamc1 laminin, gamma 1 ISO CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:17993459 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19741132 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha ISO protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mir204 microRNA 204 ISO CTD Direct Evidence: therapeutic CTD PMID:36177783 NCBI chr19:22,727,969...22,728,036
Ensembl chr19:22,727,969...22,728,036 		JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr 1:170,978,282...170,988,699
Ensembl chr 1:170,978,280...170,988,699 		JBrowse link
G Mt1 metallothionein 1 EXP CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 EXP CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:22666365 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO CTD Direct Evidence: marker/mechanism CTD PMID:10436046 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO CTD Direct Evidence: marker/mechanism CTD PMID:9436549 PMID:10791088 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nrg1 neuregulin 1 ISO mRNA:decreased expression:median nerve RGD PMID:28059646 RGD:405255649 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:8921280 PMID:8978711 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntf5 neurotrophin 5 ISO
EXP		 CTD Direct Evidence: therapeutic CTD PMID:8921280 NCBI chr 7:45,063,119...45,066,603
Ensembl chr 7:45,063,119...45,066,603 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26629949 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263 		JBrowse link
G Otx2 orthodenticle homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20573704 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Pank1 pantothenate kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:35589691 NCBI chr19:34,784,335...34,862,420
Ensembl chr19:34,784,340...34,856,855 		JBrowse link
G Pank2 pantothenate kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20493851 NCBI chr 2:131,103,928...131,141,108
Ensembl chr 2:131,104,415...131,141,108 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 ISO CTD Direct Evidence: therapeutic CTD PMID:29649621 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Pde8b phosphodiesterase 8B ISO ClinVar Annotator: match by term: Striatal Degeneration ClinVar PMID:25741868 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
G Pink1 PTEN induced putative kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: therapeutic CTD PMID:18289512 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17687034 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psen1 presenilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 PMID:33971107 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17360923 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Selenop selenoprotein P ISO CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17581637 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18643795 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28703795 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:22645130 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 PMID:18206288 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Snca synuclein, alpha ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21039522 PMID:23106139 PMID:27585560 PMID:34562559 PMID:38311184 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sncg synuclein, gamma IMP RGD PMID:19246516 RGD:6478696 NCBI chr14:34,092,231...34,096,626
Ensembl chr14:34,092,231...34,096,746 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO CTD Direct Evidence: marker/mechanism CTD PMID:17581637 PMID:19243126 PMID:24885036 PMID:24918341 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: therapeutic CTD PMID:11146106 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tfeb transcription factor EB ISO CTD Direct Evidence: therapeutic CTD PMID:34562559 NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344 		JBrowse link
G Tgfa transforming growth factor alpha ISO CTD Direct Evidence: therapeutic CTD PMID:9263032 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701 		JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tigar Trp53 induced glycolysis regulatory phosphatase ISO CTD Direct Evidence: therapeutic CTD PMID:33359019 NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9710261 PMID:15153526 PMID:22921461 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trf transferrin resistance ISO RGD PMID:17010319 RGD:1601536 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21419848 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) IMP RGD PMID:11555633 RGD:1302546 NCBI chr14:101,891,387...101,933,561
Ensembl chr14:101,891,403...101,933,561 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:26201024 RGD:11079183 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vps54 VPS54 GARP complex subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19693665 NCBI chr11:21,189,032...21,271,133
Ensembl chr11:21,189,281...21,271,136 		JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:9147382 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Zfp110 zinc finger protein 110 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18815271 NCBI chr 7:12,565,225...12,584,513
Ensembl chr 7:12,568,688...12,584,504 		JBrowse link
G Zmat3 zinc finger matrin type 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234339 NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163 		JBrowse link
Retrograde Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qb complement component 1, q subcomponent, beta polypeptide ISO mRNA:increased expression RGD PMID:16934480 RGD:1599508 NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:29609077 RGD:402463965 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO ClinVar Annotator: match by term: Skeletal dysplasia and progressive central nervous system degeneration, lethal ClinVar PMID:20425821 PMID:20577006 PMID:21573172 PMID:22791502 PMID:25741868 More... NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482 		JBrowse link
striatal degeneration 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 2 OMIM
ClinVar		 PMID:25741868 PMID:27058447 PMID:28492532 PMID:29159890 PMID:29165877 NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480 		JBrowse link
Striatal Degeneration, Autosomal Dominant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde8b phosphodiesterase 8B ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
Striatal Degeneration, Autosomal Dominant 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde8b phosphodiesterase 8B ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 1 OMIM
ClinVar		 PMID:24033266 PMID:25741868 PMID:26475694 PMID:26769607 PMID:28492532 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
Subacute Combined Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 antigen treatment ISO RGD PMID:16716410 PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand treatment ISO protein:increased expression:cerebrospinal fluid RGD PMID:16716410 PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration and Progressive Polyneuropathy Type) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 ISO ClinVar Annotator: match by term: BILATERAL STRIATAL DEGENERATION AND PROGRESSIVE POLYNEUROPATHY | ClinVar Annotator: match by term: Striatal necrosis, bilateral, and progressive polyneuropathy OMIM
ClinVar		 PMID:18414213 PMID:19798730 PMID:25741868 PMID:26467025 PMID:28492532 More... NCBI chr11:115,504,991...115,519,122
Ensembl chr11:115,505,004...115,519,121 		JBrowse link
Wallerian Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle activator and apoptosis regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr14:70,375,617...70,391,272
Ensembl chr14:70,375,613...70,391,260 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9030624 RGD:68774 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:9030624 RGD:68774 NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO mRNA:increased expression:sciatic nerve, macrophage RGD PMID:1533683 RGD:2316290 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G Il18 interleukin 18 ISO mmRNA, protein:increased expression:macrophage, microglia: RGD PMID:11494369 RGD:4889526 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Mag myelin-associated glycoprotein ISO RGD PMID:12730963 RGD:9685301 NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298 		JBrowse link
G Nefh neurofilament, heavy polypeptide ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Nefl neurofilament, light polypeptide ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nefm neurofilament, medium polypeptide ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295 		JBrowse link
G Nf1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 4:149,552,026...149,569,667
Ensembl chr 4:149,552,029...149,569,659 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:10320723 RGD:1642322 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Pgf placental growth factor IMP RGD PMID:21264946 RGD:6483582 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO
IMP		 RGD PMID:14664823 PMID:18718965 RGD:1642469, RGD:6482738 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pla2g6 phospholipase A2, group VI IMP RGD PMID:18718965 RGD:6482738 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590 		JBrowse link
G Rxra retinoid X receptor alpha ISO mRNA:increased expression:sciatic nerve RGD PMID:16782282 RGD:1643108 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Srsf3 serine and arginine-rich splicing factor 3 ISO associated with Sciatic Neuropathy RGD PMID:8568916 RGD:10059662 NCBI chr17:29,251,634...29,262,346
Ensembl chr17:29,251,602...29,262,347 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA:increased expression:optic (II) nerve, sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO protein:decreased expression:sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370 		JBrowse link
G Tlr2 toll-like receptor 2 IAGP RGD PMID:18003835 RGD:2312723 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 IAGP RGD PMID:18003835 RGD:2312723 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Ube4b ubiquitination factor E4B ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 4:149,412,873...149,512,618
Ensembl chr 4:149,412,873...149,511,206 		JBrowse link
Term paths to the root