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Gene: Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1) Mus musculus
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Symbol: Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Description: Predicted to have several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Localizes to the axon; cell surface; and endosome. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; familial medullary thyroid carcinoma; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and thyroid gland. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1); PARTICIPATES IN apoptotic cell death pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C80751; high affinity nerve growth factor receptor; neurotrophic tyrosine kinase receptor type 1; Tkr; trk; TrkA
Orthologs:
Homo sapiens (human) : NTRK1 (neurotrophic receptor tyrosine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Sus scrofa (pig) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl387,778,244 - 87,795,162 (-)Ensembl
GRCm38387,778,244 - 87,795,242 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37387,582,166 - 87,599,084 (-)NCBIGRCm37mm9NCBIm37
MGSCv36387,864,171 - 87,881,089 (-)NCBImm8
Celera387,816,061 - 87,832,981 (-)NCBICelera
Cytogenetic Map3 F1NCBI
cM Map338.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Ntrk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1624082
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.