Atxn3 (ataxin 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Atxn3 (ataxin 3) Mus musculus
Analyze
Symbol: Atxn3
Name: ataxin 3
RGD ID: 1332234
MGI Page MGI
Description: Enables cysteine-type deubiquitinase activity and ubiquitin protein ligase binding activity. Involved in cellular response to misfolded protein; monoubiquitinated protein deubiquitination; and proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including cellular response to heat; exploration behavior; and ubiquitin-dependent protein catabolic process. Located in mitochondrial matrix; mitochondrial membrane; and nuclear inclusion body. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; musculature; and testis. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Orthologous to human ATXN3 (ataxin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2210008M02Rik; AI463012; AI647473; atax; ataxin-3; Atx; ATX3; expressed sequence AI463012; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; machado-Joseph disease protein 1 homolog; Mjd; MJD1; Sc; Sca3; spinocerebellar ataxia 3 homolog; spinocerebellar ataxia 3 homolog (human)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,885,160 - 101,928,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,885,160 - 101,924,505 (-)EnsemblGRCm39 Ensembl
GRCm3812101,918,901 - 101,959,121 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,918,901 - 101,958,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,157,111 - 103,196,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,320,604 - 102,359,232 (-)NCBIMGSCv36mm8
Celera12103,135,861 - 103,175,388 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
chlorpyrifos  (EXP)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
hypochlorous acid  (EXP)
L-serine  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
succimer  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
2. Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Alves S, etal., Hum Mol Genet. 2010 Jun 15;19(12):2380-94. doi: 10.1093/hmg/ddq111. Epub 2010 Mar 22.
3. Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease. Alves S, etal., PLoS One. 2008 Oct 8;3(10):e3341. doi: 10.1371/journal.pone.0003341.
4. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. Beuckmann CT, etal., J Neurosci 2004 May 5;24(18):4469-77.
5. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
6. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Kawaguchi Y, etal., Nat Genet. 1994 Nov;8(3):221-8.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients. Schmidt T, etal., Brain Pathol. 1998 Oct;8(4):669-79.
Additional References at PubMed
PMID:8640226   PMID:8889548   PMID:10349636   PMID:10595501   PMID:10860780   PMID:11042159   PMID:11076861   PMID:11978767   PMID:12477932   PMID:12486728   PMID:12520002   PMID:12904583  
PMID:12914917   PMID:14610273   PMID:14661975   PMID:15233999   PMID:15345747   PMID:15639784   PMID:15664989   PMID:16099943   PMID:16141072   PMID:16141073   PMID:16432517   PMID:16525503  
PMID:16939621   PMID:17488727   PMID:17626202   PMID:17632007   PMID:17712857   PMID:17764659   PMID:18353661   PMID:18502140   PMID:18668148   PMID:18799693   PMID:19661182   PMID:19666135  
PMID:19843543   PMID:20059953   PMID:20064935   PMID:20079840   PMID:20347968   PMID:20637808   PMID:20668528   PMID:20940148   PMID:20943656   PMID:20945165   PMID:21060878   PMID:21267068  
PMID:21653538   PMID:21677750   PMID:21855799   PMID:21873635   PMID:22081612   PMID:22337953   PMID:22761419   PMID:22777893   PMID:22843411   PMID:23100324   PMID:23242710   PMID:23349684  
PMID:23626768   PMID:23955261   PMID:24683430   PMID:25143392   PMID:25301414   PMID:25320121   PMID:26490332   PMID:26505994   PMID:27851749   PMID:28190767   PMID:28445460   PMID:28676741  
PMID:28854700   PMID:29111377   PMID:29802126   PMID:30231063   PMID:30364204   PMID:30576445   PMID:30973865   PMID:32681165   PMID:33176149   PMID:33741019   PMID:34220448   PMID:34716557  
PMID:34815492   PMID:35042771   PMID:35794401   PMID:36010688   PMID:36875652   PMID:37122622   PMID:38355793  


Genomics

Comparative Map Data
Atxn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,885,160 - 101,928,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,885,160 - 101,924,505 (-)EnsemblGRCm39 Ensembl
GRCm3812101,918,901 - 101,959,121 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,918,901 - 101,958,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,157,111 - 103,196,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,320,604 - 102,359,232 (-)NCBIMGSCv36mm8
Celera12103,135,861 - 103,175,388 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.32NCBI
ATXN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,044,775 - 92,106,582 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,044,496 - 92,106,621 (-)EnsemblGRCh38hg38GRCh38
GRCh371492,511,119 - 92,572,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,598,883 - 91,642,707 (-)NCBINCBI36Build 36hg18NCBI36
Celera1472,577,489 - 72,625,559 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,705,822 - 72,754,183 (-)NCBIHuRef
CHM1_11492,463,194 - 92,511,266 (-)NCBICHM1_1
T2T-CHM13v2.01486,274,279 - 86,336,122 (-)NCBIT2T-CHM13v2.0
Atxn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,837,107 - 126,872,919 (-)NCBIGRCr8
mRatBN7.26121,072,228 - 121,107,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,223,964 - 121,257,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,519,222 - 121,552,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,855,537 - 120,889,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
Atxn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,405,643 - 14,440,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,405,415 - 14,443,457 (-)NCBIChiLan1.0ChiLan1.0
ATXN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,222,124 - 93,265,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,433,581 - 92,481,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,693,446 - 72,741,772 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,041,114 - 92,083,840 (-)NCBIpanpan1.1PanPan1.1panPan2
ATXN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,318,440 - 1,354,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,247,155 - 1,354,720 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,337,255 - 1,373,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,367,340 - 1,403,659 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,367,738 - 1,403,671 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,305,295 - 1,341,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,261,283 - 1,297,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,382,578 - 1,418,851 (-)NCBIUU_Cfam_GSD_1.0
Atxn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,119,860 - 13,160,641 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733310,836 - 347,112 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733306,400 - 347,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATXN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,608,783 - 113,645,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17113,611,566 - 113,645,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,219,165 - 120,253,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATXN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12469,810,433 - 69,855,308 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605357,057,799 - 57,105,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atxn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247348,685,994 - 8,726,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atxn3
1385 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1649
Count of miRNA genes:716
Interacting mature miRNAs:937
Transcripts:ENSMUST00000021606, ENSMUST00000159883, ENSMUST00000160186, ENSMUST00000160251, ENSMUST00000161011
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
4141586Ssrq6_mstress response QTL 6 (mouse)Not determined100532075102461265Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
AI647473  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812101,922,343 - 101,922,428UniSTSGRCm38
MGSCv3712103,160,553 - 103,160,638UniSTSGRCm37
Celera12103,139,302 - 103,139,387UniSTS
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12940.32UniSTS
AI463012  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812101,918,961 - 101,919,107UniSTSGRCm38
MGSCv3712103,157,171 - 103,157,317UniSTSGRCm37
Celera12103,135,921 - 103,136,067UniSTS
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12940.71UniSTS
AV074322  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12EUniSTS
Whitehead/MRC_RH12940.28UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001167914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF537188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ174976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX526801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000021606   ⟹   ENSMUSP00000021606
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12101,885,160 - 101,924,505 (-)Ensembl
GRCm38.p6 Ensembl12101,918,901 - 101,958,246 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159883   ⟹   ENSMUSP00000124419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12101,899,208 - 101,924,407 (-)Ensembl
GRCm38.p6 Ensembl12101,932,949 - 101,958,148 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160186   ⟹   ENSMUSP00000124178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12101,889,340 - 101,900,614 (-)Ensembl
GRCm38.p6 Ensembl12101,923,081 - 101,934,355 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160251   ⟹   ENSMUSP00000125082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12101,899,183 - 101,924,502 (-)Ensembl
GRCm38.p6 Ensembl12101,932,924 - 101,958,243 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161011   ⟹   ENSMUSP00000125378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12101,899,185 - 101,924,502 (-)Ensembl
GRCm38.p6 Ensembl12101,932,926 - 101,958,243 (-)Ensembl
RefSeq Acc Id: NM_001167914   ⟹   NP_001161386
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,899,183 - 101,924,502 (-)NCBI
GRCm3812101,932,924 - 101,958,243 (-)NCBI
MGSCv3712103,157,111 - 103,196,453 (-)RGD
Celera12103,135,861 - 103,175,388 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029705   ⟹   NP_083981
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,924,502 (-)NCBI
GRCm3812101,918,901 - 101,958,243 (-)NCBI
MGSCv3712103,157,111 - 103,196,453 (-)RGD
Celera12103,135,861 - 103,175,388 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030246522   ⟹   XP_030102382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,928,139 (-)NCBI
GRCm3812101,918,901 - 101,959,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246523   ⟹   XP_030102383
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,924,454 (-)NCBI
GRCm3812101,918,901 - 101,958,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246526   ⟹   XP_030102386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,897,214 - 101,928,139 (-)NCBI
GRCm3812101,932,945 - 101,959,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157162   ⟹   XP_036013055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,889,689 - 101,928,139 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157163   ⟹   XP_036013056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,924,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157164   ⟹   XP_036013057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,924,382 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004937404
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912101,885,160 - 101,928,139 (-)NCBI
Sequence:
RefSeq Acc Id: NP_083981   ⟸   NM_029705
- Peptide Label: isoform 1
- UniProtKB: Q9CVD2 (UniProtKB/Swiss-Prot),   Q546X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001161386   ⟸   NM_001167914
- Peptide Label: isoform 2
- UniProtKB: E9Q717 (UniProtKB/TrEMBL),   F6T5L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030102382   ⟸   XM_030246522
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030102383   ⟸   XM_030246523
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030102386   ⟸   XM_030246526
- Peptide Label: isoform X5
- UniProtKB: F6T5L3 (UniProtKB/TrEMBL),   Q5M8S1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000124419   ⟸   ENSMUST00000159883
Ensembl Acc Id: ENSMUSP00000124178   ⟸   ENSMUST00000160186
Ensembl Acc Id: ENSMUSP00000125082   ⟸   ENSMUST00000160251
Ensembl Acc Id: ENSMUSP00000021606   ⟸   ENSMUST00000021606
Ensembl Acc Id: ENSMUSP00000125378   ⟸   ENSMUST00000161011
RefSeq Acc Id: XP_036013056   ⟸   XM_036157163
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036013057   ⟸   XM_036157164
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036013055   ⟸   XM_036157162
- Peptide Label: isoform X2
- UniProtKB: F6T5L3 (UniProtKB/TrEMBL)
Protein Domains
Josephin   UIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CVD2-F1-model_v2 AlphaFold Q9CVD2 1-355 view protein structure

Promoters
RGD ID:8679034
Promoter ID:EPDNEW_M17548
Type:initiation region
Name:Atxn3_1
Description:Mus musculus ataxin 3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812101,958,169 - 101,958,229EPDNEW
RGD ID:6822747
Promoter ID:MM_KWN:12520
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:NM_001167914,   OTTMUST00000075997,   OTTMUST00000076082,   OTTMUST00000079284
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612103,196,229 - 103,196,729 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1099442 AgrOrtholog
Ensembl Genes ENSMUSG00000021189 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021606 ENTREZGENE
  ENSMUST00000021606.12 UniProtKB/Swiss-Prot
  ENSMUST00000159883.2 UniProtKB/TrEMBL
  ENSMUST00000160186.2 UniProtKB/TrEMBL
  ENSMUST00000160251 ENTREZGENE
  ENSMUST00000160251.8 UniProtKB/TrEMBL
  ENSMUST00000161011 ENTREZGENE
  ENSMUST00000161011.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.70.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ataxin-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1099442 ENTREZGENE
NCBI Gene Atxn3 ENTREZGENE
PANTHER ATAXIN-3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUIM_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atxn3 PhenoGen
PRINTS JOSEPHIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE JOSEPHIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATX3_MOUSE UniProtKB/Swiss-Prot
  E9Q717 ENTREZGENE, UniProtKB/TrEMBL
  F6T5L3 ENTREZGENE, UniProtKB/TrEMBL
  F6TRN1_MOUSE UniProtKB/TrEMBL
  Q546X9 ENTREZGENE, UniProtKB/TrEMBL
  Q5M8S1 ENTREZGENE, UniProtKB/TrEMBL
  Q810M8_MOUSE UniProtKB/TrEMBL
  Q9CVD2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Atxn3  ataxin 3  Sca3  spinocerebellar ataxia 3 homolog (human)  Symbol and/or name change 5135510 APPROVED
2024-08-21 Sca3  spinocerebellar ataxia 3 homolog (human)  Atxn3  ataxin 3  Symbol and/or name change 5135510 APPROVED
2016-04-04 Atxn3  ataxin 3  AI463012  expressed sequence AI463012  Data merged from RGD:1609526 737654 PROVISIONAL