Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane and presynapse. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit).
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] more ...
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]] more ...
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] and Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] and tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]
N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]
acetamiprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] and acetamiprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ...
Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] and Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
[ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein
Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]] and Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
[CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine] and [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]
[ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein
[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium more ...
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ...
[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium more ...
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ...
Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein] and Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Choline affects the activity of [CHRNA4 protein binds to CHRNB2 protein] and Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA]
clothianidin results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] and clothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ...
dihydro-beta-erythroidine affects binding to Chrnb2 protein and dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine more ...
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] and Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
dinotefuran results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] and dinotefuran results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]
[pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine and Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]
EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein] and EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein] and fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] and Hexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] and imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
[ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]
mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]] more ...
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid] more ...
[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHRNB2 mRNA]
Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]] and Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]
rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein
[ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein
Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
thiacloprid results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] and thiacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]
Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] and Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]] and Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]] and Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein] and Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor alpha 4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes.
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.
