Chrnb2 (cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)) - Rat Genome Database

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Gene: Chrnb2 (cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)) Mus musculus
Symbol: Chrnb2
Name: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
RGD ID: 735795
Description: Enables acetylcholine-gated cation-selective channel activity. Involved in membrane depolarization and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [b]2-nA; [b]2-nAchR; acetylcholine receptor beta 2 neural; Acr; Acrb; Acrb-2; Acrb2; C030030P04Rik; neuronal acetylcholine receptor subunit beta-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39389,660,755 - 89,671,939 (-)NCBIGRCm39mm39
GRCm39 Ensembl389,653,502 - 89,671,939 (-)Ensembl
GRCm38389,753,448 - 89,764,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,746,195 - 89,764,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,557,370 - 89,568,554 (-)NCBIGRCm37mm9NCBIm37
MGSCv36389,839,375 - 89,850,512 (-)NCBImm8
Celera389,790,490 - 89,801,674 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-lobeline  (ISO)
(E)-thiamethoxam  (ISO)
(S)-anabasine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
13-desmethylspirolide C  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetamiprid  (EXP,ISO)
acetylcholine  (ISO)
alcuronium  (ISO)
all-trans-retinoic acid  (EXP)
aluminium hydroxide  (ISO)
Amaranth  (ISO)
amitriptyline  (EXP,ISO)
ammonium chloride  (ISO)
Antimony trioxide  (ISO)
antimycin A  (ISO)
atracurium  (ISO)
atropine  (ISO)
barium(0)  (ISO)
bentonite  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Brilliant Blue  (ISO)
butan-1-ol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbachol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisatracurium  (ISO)
Citreoviridin  (EXP)
clofibrate  (EXP)
clothianidin  (ISO)
cocaine  (EXP,ISO)
cyclosporin A  (ISO)
cytisine  (EXP,ISO)
decabromodiphenyl ether  (ISO)
decamethonium  (ISO)
deguelin  (ISO)
Desformylflustrabromine  (ISO)
diazinon  (ISO)
dichloroacetic acid  (EXP)
dichlorvos  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (EXP,ISO)
dinotefuran  (ISO)
dopamine  (EXP)
endosulfan  (ISO)
epibatidine  (ISO)
ethanol  (EXP,ISO)
fenoxycarb  (ISO)
folic acid  (EXP)
furan  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
graphite  (ISO)
hexachlorophene  (EXP,ISO)
Hexamethonium  (EXP,ISO)
imidacloprid  (ISO)
indigo carmine  (ISO)
lead diacetate  (ISO)
LY294002  (ISO)
magnesium dihydroxide  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (ISO)
methyllycaconitine  (ISO)
Mivacurium  (ISO)
nicotine  (EXP,ISO)
nitenpyram  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
paraoxon  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
physostigmine  (ISO)
progesterone  (ISO)
pyrazines  (ISO)
pyridines  (ISO)
rivastigmine  (ISO)
rocuronium  (ISO)
scopolamine  (ISO)
sterigmatocystin  (ISO)
succinylcholine  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (EXP)
tacrine  (EXP,ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiacloprid  (ISO)
thiamethoxam  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tubocurarine  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
varenicline  (EXP,ISO)
vecuronium bromide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (IDA,ISO)
action potential  (IMP)
associative learning  (IGI)
B cell activation  (IMP)
B cell proliferation  (IC,IGI)
behavioral response to nicotine  (IMP,ISO)
calcium ion transport  (IGI)
central nervous system neuron axonogenesis  (IMP)
central nervous system projection neuron axonogenesis  (IMP)
chemical synaptic transmission  (IBA)
cognition  (ISO)
conditioned taste aversion  (IMP)
dopamine secretion  (IMP)
establishment of localization in cell  (IMP)
ion transmembrane transport  (IBA)
ion transport  (IEA)
lateral geniculate nucleus development  (IMP)
learning  (IMP,ISO)
locomotory behavior  (IMP)
membrane depolarization  (IDA,IMP,ISO)
memory  (IMP,ISO)
negative regulation of neuronal action potential  (IMP)
nervous system process  (IBA,ISO)
neuronal action potential  (IGI,IMP)
optic nerve morphogenesis  (IMP)
positive regulation of B cell proliferation  (IC,IGI)
positive regulation of dopamine secretion  (IMP)
positive regulation of synaptic transmission, dopaminergic  (IMP)
regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
regulation of circadian sleep/wake cycle, REM sleep  (IMP)
regulation of dendrite morphogenesis  (IMP)
regulation of dopamine metabolic process  (IMP)
regulation of dopamine secretion  (IMP)
regulation of membrane potential  (IBA,IGI,IMP)
regulation of synapse assembly  (IMP)
regulation of synaptic transmission, dopaminergic  (IMP)
regulation of synaptic vesicle exocytosis  (IDA,IMP)
response to acetylcholine  (ISO)
response to cocaine  (IMP)
response to ethanol  (IMP)
response to hypoxia  (IMP,ISO)
response to nicotine  (IGI,IMP,ISO)
sensory perception of pain  (IMP)
sensory perception of sound  (IMP)
signal transduction  (IBA,ISO)
smooth muscle contraction  (IGI)
social behavior  (IMP)
synaptic transmission involved in micturition  (IGI)
synaptic transmission, cholinergic  (ISO)
vestibulocochlear nerve development  (IMP)
visual learning  (IMP,ISO)
visual perception  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylcholine signaling pathway via nicotinic acetylcholine receptor  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nicotine pharmacokinetics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal associative learning  (IAGP)
abnormal autonomic nervous system physiology  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to nicotine  (IAGP)
abnormal brain morphology  (IAGP)
abnormal epididymis morphology  (IEA)
abnormal eye electrophysiology  (IAGP)
abnormal habituation to a new environment  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal lateral geniculate nucleus morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nicotine-mediated receptor currents  (IAGP)
abnormal pulmonary ventilation  (IAGP)
abnormal response to new environment  (IAGP)
abnormal response to novelty  (IAGP)
abnormal single cell response  (IAGP)
abnormal social investigation  (IAGP)
abnormal superior colliculus morphology  (IAGP)
abnormal tidal volume  (IAGP)
abnormal urinary bladder physiology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
apnea  (IAGP)
cystolithiasis  (IAGP)
decreased anxiety-related response  (IAGP)
decreased B cell number  (IAGP)
decreased chemically-elicited antinociception  (IAGP)
decreased erythroblast number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased visual acuity  (IAGP)
delayed ear emergence  (IAGP)
delayed hair appearance  (IAGP)
distended urinary bladder  (IAGP)
enhanced coordination  (IAGP)
enhanced spatial learning  (IAGP)
enlarged heart  (IEA)
eyelids fail to open  (IAGP)
fragmentation of sleep/wake states  (IAGP)
hyperactivity  (IAGP)
impaired passive avoidance behavior  (IAGP)
impaired pupillary reflex  (IAGP)
increased B cell proliferation  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased IgG level  (IAGP)
increased locomotor activity  (IAGP)
increased pulmonary ventilation  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induction of seizure by inducing agent  (IAGP)
increased tidal volume  (IAGP)
increased total body fat amount  (IEA)
intestinal hypoperistalsis  (IAGP)
mydriasis  (IAGP)
myeloid hyperplasia  (IAGP)
narrow eye opening  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
urinary bladder inflammation  (IAGP)
urinary incontinence  (IAGP)

Additional References at PubMed
PMID:1505988   PMID:2338144   PMID:7870173   PMID:8563774   PMID:8596650   PMID:8838678   PMID:8889548   PMID:9428762   PMID:9614223   PMID:10095079   PMID:10235262   PMID:10349636  
PMID:10441742   PMID:10531434   PMID:10767319   PMID:10771006   PMID:11027228   PMID:11042159   PMID:11044747   PMID:11076861   PMID:11145999   PMID:11217851   PMID:11222635   PMID:11226321  
PMID:11282258   PMID:11344259   PMID:11434511   PMID:11790724   PMID:11906696   PMID:11955523   PMID:12059039   PMID:12079404   PMID:12097474   PMID:12225896   PMID:12228730   PMID:12477932  
PMID:12736354   PMID:12871652   PMID:12876201   PMID:12944511   PMID:14596621   PMID:14681479   PMID:14687549   PMID:14687550   PMID:15210938   PMID:15215293   PMID:15450117   PMID:15456819  
PMID:15464132   PMID:15472930   PMID:15489024   PMID:15536004   PMID:15537871   PMID:15541879   PMID:15569257   PMID:15608630   PMID:15681842   PMID:15694199   PMID:15727510   PMID:15738419  
PMID:15741168   PMID:15788760   PMID:15922075   PMID:15926916   PMID:15963492   PMID:16001069   PMID:16033902   PMID:16033903   PMID:16141072   PMID:16141073   PMID:16253349   PMID:16337917  
PMID:16602821   PMID:16752141   PMID:16772172   PMID:16901939   PMID:16965547   PMID:17016705   PMID:17136517   PMID:17167078   PMID:17192649   PMID:17301182   PMID:17401441   PMID:17443806  
PMID:17470777   PMID:17584502   PMID:17622669   PMID:18077321   PMID:18083057   PMID:18095155   PMID:18162309   PMID:18171946   PMID:18184829   PMID:18287559   PMID:18304481   PMID:18321647  
PMID:18498732   PMID:18524488   PMID:18607712   PMID:18701068   PMID:18757739   PMID:18831991   PMID:18832468   PMID:18848921   PMID:18945909   PMID:19020025   PMID:19023420   PMID:19077117  
PMID:19139153   PMID:19153075   PMID:19176801   PMID:19200240   PMID:19228980   PMID:19278836   PMID:19474315   PMID:19481067   PMID:19481555   PMID:19521566   PMID:19567877   PMID:19573576  
PMID:19804762   PMID:19828805   PMID:19874788   PMID:20203212   PMID:20377613   PMID:20534523   PMID:20603624   PMID:20974182   PMID:20976039   PMID:21135238   PMID:21272629   PMID:21368050  
PMID:21402717   PMID:21406211   PMID:21485013   PMID:21547082   PMID:21689598   PMID:21706059   PMID:21768117   PMID:21784105   PMID:21794985   PMID:21795541   PMID:21810785   PMID:21836018  
PMID:21873635   PMID:21939740   PMID:22039094   PMID:22065784   PMID:22072695   PMID:22102330   PMID:22179110   PMID:22241831   PMID:22291029   PMID:22359587   PMID:22380605   PMID:22433585  
PMID:22462479   PMID:22699919   PMID:22897520   PMID:22926197   PMID:23056257   PMID:23213462   PMID:23280428   PMID:23313759   PMID:23352115   PMID:23399696   PMID:23469004   PMID:23613527  
PMID:23681253   PMID:23811311   PMID:23882123   PMID:23986674   PMID:24144909   PMID:24184117   PMID:24194600   PMID:24223920   PMID:24422997   PMID:24554727   PMID:24607228   PMID:24607281  
PMID:24631336   PMID:24647947   PMID:24685552   PMID:24952961   PMID:24953818   PMID:25031416   PMID:25107281   PMID:25193667   PMID:25339742   PMID:25451094   PMID:25466916   PMID:25610381  
PMID:25787992   PMID:25948261   PMID:26139609   PMID:26222090   PMID:26269589   PMID:26269630   PMID:26276394   PMID:26402608   PMID:26688111   PMID:26727264   PMID:26780509   PMID:26904947  
PMID:27012889   PMID:27030771   PMID:27199738   PMID:27336596   PMID:27522251   PMID:27559543   PMID:27626380   PMID:27793780   PMID:28049845   PMID:28112735   PMID:28457669   PMID:28606623  
PMID:28722015   PMID:29061702   PMID:29074617   PMID:29791835   PMID:29969495   PMID:30176987   PMID:30414940   PMID:30891952   PMID:30936179   PMID:31078264   PMID:31776253   PMID:31881170  
PMID:32737187   PMID:32959891   PMID:34913435   PMID:35021080  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39389,660,755 - 89,671,939 (-)NCBIGRCm39mm39
GRCm39 Ensembl389,653,502 - 89,671,939 (-)Ensembl
GRCm38389,753,448 - 89,764,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,746,195 - 89,764,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,557,370 - 89,568,554 (-)NCBIGRCm37mm9NCBIm37
MGSCv36389,839,375 - 89,850,512 (-)NCBImm8
Celera389,790,490 - 89,801,674 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381154,567,778 - 154,580,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1154,567,778 - 154,580,013 (+)EnsemblGRCh38hg38GRCh38
GRCh371154,540,254 - 154,552,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,806,881 - 152,818,978 (+)NCBINCBI36hg18NCBI36
Build 341151,353,329 - 151,362,156NCBI
Celera1127,611,891 - 127,623,988 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1125,903,718 - 125,915,813 (+)NCBIHuRef
CHM1_11155,936,657 - 155,948,754 (+)NCBICHM1_1
T2T-CHM13v2.01153,704,898 - 153,717,133 (+)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22175,181,402 - 175,189,619 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2175,181,402 - 175,189,619 (-)Ensembl
Rnor_6.02189,088,570 - 189,096,785 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,088,570 - 189,096,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,511,421 - 208,519,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,961,373 - 181,969,581 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,911,478 - 181,919,687 (-)NCBI
Celera2169,123,949 - 169,132,124 (-)NCBICelera
Cytogenetic Map2q34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555451,065,457 - 1,077,526 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,065,457 - 1,077,056 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11133,535,023 - 133,547,361 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,535,023 - 133,547,361 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01129,922,740 - 129,931,582 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1742,786,505 - 42,797,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,789,600 - 42,795,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,277,266 - 42,288,752 (-)NCBI
ROS_Cfam_1.0742,656,510 - 42,668,001 (-)NCBI
ROS_Cfam_1.0 Ensembl742,656,517 - 42,667,042 (-)Ensembl
UMICH_Zoey_3.1742,435,765 - 42,447,248 (-)NCBI
UNSW_CanFamBas_1.0742,489,629 - 42,501,090 (-)NCBI
UU_Cfam_GSD_1.0742,773,221 - 42,784,709 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505825,136,236 - 25,149,726 (+)NCBI
SpeTri2.0NW_0049365804,165,255 - 4,179,285 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl495,198,717 - 95,211,037 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,196,992 - 95,211,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,024,711 - 104,036,882 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1209,245,803 - 9,255,430 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl209,247,231 - 9,253,795 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660388,581,863 - 8,595,204 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248852,843,899 - 2,848,522 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248852,839,607 - 2,851,934 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,753,031 - 89,753,304UniSTSGRCm38
MGSCv37389,556,953 - 89,557,226UniSTSGRCm37
Celera389,790,073 - 89,790,346UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map3F1UniSTS
cM Map341.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,764,809 - 89,765,069UniSTSGRCm38
MGSCv37389,568,731 - 89,568,991UniSTSGRCm37
Celera389,801,851 - 89,802,111UniSTS
Cytogenetic Map3F1UniSTS
cM Map341.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1838
Count of miRNA genes:700
Interacting mature miRNAs:921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_009602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF089739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF145286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF299083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF325349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY574267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY123599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029562   ⟹   ENSMUSP00000029562
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,659,740 - 89,671,939 (-)Ensembl
GRCm38.p6 Ensembl389,752,433 - 89,764,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199372
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,659,740 - 89,670,708 (-)Ensembl
GRCm38.p6 Ensembl389,752,433 - 89,763,401 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200558   ⟹   ENSMUSP00000143441
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,653,502 - 89,671,915 (-)Ensembl
GRCm38.p6 Ensembl389,746,195 - 89,764,608 (-)Ensembl
RefSeq Acc Id: NM_009602   ⟹   NP_033732
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39389,660,755 - 89,671,939 (-)NCBI
GRCm38389,753,448 - 89,764,632 (-)ENTREZGENE
MGSCv37389,557,370 - 89,568,554 (-)RGD
Celera389,790,490 - 89,801,674 (-)RGD
RefSeq Acc Id: XM_030252389   ⟹   XP_030108249
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,660,755 - 89,671,588 (-)NCBI
GRCm38389,753,448 - 89,764,277 (-)NCBI
RefSeq Acc Id: XM_036162861   ⟹   XP_036018754
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,660,755 - 89,671,588 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033732   ⟸   NM_009602
- Peptide Label: precursor
- UniProtKB: Q9ERK7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030108249   ⟸   XM_030252389
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000029562   ⟸   ENSMUST00000029562
RefSeq Acc Id: ENSMUSP00000143441   ⟸   ENSMUST00000200558
RefSeq Acc Id: XP_036018754   ⟸   XM_036162861
- Peptide Label: isoform X1
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERK7-F1-model_v2 AlphaFold Q9ERK7 1-501 view protein structure

RGD ID:6833578
Promoter ID:MM_KWN:34982
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain
Mouse AssemblyChrPosition (strand)Source
MGSCv36389,568,256 - 89,568,756 (-)MPROMDB
RGD ID:6881282
Promoter ID:EPDNEW_M4092
Type:initiation region
Description:Mus musculus cholinergic receptor, nicotinic, beta polypeptide2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38389,764,614 - 89,764,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87891 AgrOrtholog
Ensembl Genes ENSMUSG00000027950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029562 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000143441 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029562 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000200558 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CHRNB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11444 UniProtKB/Swiss-Prot
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945:SF80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chrnb2 PhenoGen
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACHB2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BGP7 UniProtKB/Swiss-Prot