RGD Reference Report - Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy. - Rat Genome Database

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Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.

Authors: Veber, D  Mutti, E  Galmozzi, E  Cedrola, S  Galbiati, S  Morabito, A  Tredici, G  La Porta, CA  Scalabrino, G 
Citation: Veber D, etal., J Neuroimmunol. 2006 Jul;176(1-2):24-33. Epub 2006 May 22.
RGD ID: 2313422
Pubmed: (View Article at PubMed) PMID:16716410
DOI: Full-text: DOI:10.1016/j.jneuroim.2006.04.002

The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after treatment with Cbl, transforming growth factor-beta1 or S-adenosyl-L-methionine, and the normal myelin ultrastructure of the spinal cord was concomitantly restored. The concomitance of the two beneficial effects of these treatments strongly suggests that the increases in CSF sCD40:sCD40L levels may participate in the pathogenesis of purely myelinolytic Cbl-D central neuropathy in the rat. In keeping with this, an anti-CD40 treatment prevented myelin lesions.



Disease Annotations    

Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40  (CD40 antigen)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40  (CD40 molecule)
CD40LG  (CD40 ligand)


Additional Information