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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sciatic neuropathy
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Accession:DOID:11446 term browser browse the term
Definition:Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Synonyms:exact_synonym: Sciatic Nerve Disease;   Sciatic Nerve Injuries;   Sciatic Nerve Injury;   Sciatic Nerve Neuralgia-Neuritides;   Sciatic Nerve Neuralgia-Neuritis;   Sciatic Nerve Palsies;   Sciatic Nerve Palsy;   Sciatic Neuritides;   Sciatic Neuritis;   sciatic nerve diseases;   sciatic neuropathies
 related_synonym: Sciatic Inflammatory Neuropathy
 primary_id: MESH:D020426
 xref: EFO:1001166
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
sciatic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Abcc9 ATP-binding cassette, sub-family C member 9 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 treatment IDA RGD PMID:19912227 RGD:8548489 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:20886512 RGD:5129198 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Akap12 A kinase anchor protein 12 ISO mRNA,protein:increased expression:spinal cord: RGD PMID:19937403 RGD:14348968 NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470 		JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 ISO protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 9:107,930,358...107,932,900
Ensembl chr 9:107,930,358...107,932,900 		JBrowse link
G Apoa1 apolipoprotein A-I ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoe apolipoprotein E ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 ISO RGD PMID:18182225 RGD:5129227 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 ISO RGD PMID:18182225 RGD:5129227 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO protein:increased expression:dorsal root ganglion: RGD PMID:22309829 PMID:24388817 RGD:8657100, RGD:10059363 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G C3 complement component 3 ISO protein:increased expression:sciatic nerve RGD PMID:18052971 RGD:5129535 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit ISO mRNA:decreased expression:spinal cord dorsal horn RGD PMID:16026470 RGD:6906922 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412 		JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO CTD Direct Evidence: therapeutic CTD PMID:19852068 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Capn1 calpain 1 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Capn2 calpain 2 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Casp12 caspase 12 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase ISO protein:decreased activity:sciatic nerve, spinal cord, dorsal root ganglion: RGD PMID:19675389 RGD:9479064 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cav1 caveolin 1, caveolae protein ISO protein:decreased expression:spinal cord, blood vessel RGD PMID:21795534 RGD:6784526 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO
IEP		 protein:increased expression:spinal cord dorsal horn, axon terminal (rat)
protein:increased expression:lumbar dorsal root ganglion (mouse)		 RGD PMID:19059387 PMID:22564672 RGD:2307005, RGD:8549487 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:19152028 RGD:4890004 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IEP RGD PMID:24907405 RGD:8661781 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cers2 ceramide synthase 2 ISO mRNA,protein:decreased expression:sciatic nerve: RGD PMID:22393241 RGD:11041067 NCBI chr 3:95,222,077...95,230,910
Ensembl chr 3:95,222,102...95,230,910 		JBrowse link
G Cnr2 cannabinoid receptor 2 treatment ISO RGD PMID:19345493 RGD:2316195 NCBI chr 4:135,622,500...135,647,530
Ensembl chr 4:135,622,705...135,647,518 		JBrowse link
G Crcp calcitonin gene-related peptide-receptor component protein ISO RGD PMID:12895509 RGD:727768 NCBI chr 5:130,058,147...130,089,628
Ensembl chr 5:130,058,131...130,089,630 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO protein:increased phosphorylation:nucleus RGD PMID:19918364 PMID:33596416 RGD:10059430, RGD:401960870 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crh corticotropin releasing hormone ISO mRNA:increased expression:central nucleus of amygdala, bed nucleus of stria terminalis (rat) RGD PMID:21684787 RGD:5490542 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment IMP
ISO		 RGD PMID:20524966 PMID:15341587 PMID:20921832 RGD:9354422, RGD:1358720, RGD:9491396 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 ISO protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:16632873 RGD:4889134 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO mRNA:decreased expression:spinal cord (rat) RGD PMID:17720801 RGD:4889112 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Dbn1 drebrin 1 ISO protein:increased expression:neuron: RGD PMID:11578820 RGD:10398813 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924 		JBrowse link
G Dnmt3a DNA methyltransferase 3A IEP protein:increased expression:brain: RGD PMID:22031875 RGD:9589072 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 ISO RGD PMID:12957493 RGD:1579851 NCBI chr 4:110,060,934...110,209,127
Ensembl chr 4:110,060,919...110,209,106 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:29970988 RGD:13792563 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:increased expression:neuron: RGD PMID:8971765 RGD:10402092 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO RGD PMID:36545239 PMID:33829413 RGD:329951012, RGD:329951014 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Fubp1 far upstream element (FUSE) binding protein 1 ISO RGD PMID:23939805 RGD:13673880 NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463 		JBrowse link
G Gc vitamin D binding protein ISO protein:increased expression:nerve RGD PMID:15509515 RGD:2316214 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO protein:increased expression:dorsal horn of spinal cord RGD PMID:23515624 RGD:401700393 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 ISO protein:increased expression:spinal cord dorsal horn RGD PMID:20533358 RGD:6218963 NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341 		JBrowse link
G Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr18:34,822,951...34,853,440
Ensembl chr18:34,822,951...34,853,440 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:28508406 RGD:401827908 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:26656067 RGD:13792690 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ISO RGD PMID:26656067 RGD:13792690 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:27125978 RGD:13792740 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:18941443 RGD:8548631 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:23991202 RGD:10402062 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:23224421 RGD:10755722 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:17350523 RGD:1626418 NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO mRNA:increased expression:fourth lumbar dorsal root ganglion (rat) RGD PMID:12648755 RGD:632873 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:20546684 RGD:8547739 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 treatment ISO associated with Constriction, Pathologic RGD PMID:22889616 PMID:22173123 RGD:7364826, RGD:7364836 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:12574433 RGD:7175064 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Jak1 Janus kinase 1 ISO mRNA:increased expression:spinal cord RGD PMID:32012267 RGD:150527842 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jam3 junction adhesion molecule 3 ISO RGD PMID:22950044 RGD:7488944 NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717 		JBrowse link
G Kars1 lysyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr 8:112,720,071...112,737,986
Ensembl chr 8:112,720,075...112,737,955 		JBrowse link
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 ISO RGD PMID:17855600 RGD:10411908 NCBI chr 3:107,345,614...107,367,617
Ensembl chr 3:107,345,619...107,366,868 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:17108688 RGD:7297043 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 treatment ISO RGD PMID:30015858 RGD:13703060 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 treatment ISO RGD PMID:26656067 PMID:18060043 RGD:13792690, RGD:13800561 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Mag myelin-associated glycoprotein treatment ISO RGD PMID:17705198 RGD:9685295 NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298 		JBrowse link
G Map2 microtubule-associated protein 2 ISO protein:decrease expression:dorsal root ganglion RGD PMID:21933624 RGD:6483083 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mc4r melanocortin 4 receptor ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:21985621 RGD:6484557 NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577 		JBrowse link
G Mir21a microRNA 21a ISO RNA:increased expression:dorsal root ganglion neuron RGD PMID:25484256 RGD:151893491 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir221 microRNA 221 ISO RNA:increased expression:sciatic nerve: RGD PMID:22393241 RGD:11041067 NCBI chr  X:19,012,533...19,012,627
Ensembl chr  X:19,012,533...19,012,627 		JBrowse link
G Mir222 microRNA 222 ISO RNA:increased expression:dorsal root ganglion neuron
RNA:increased expression:sciatic nerve:		 RGD PMID:25484256 PMID:22393241 RGD:151893491, RGD:11041067 NCBI chr  X:19,013,132...19,013,210
Ensembl chr  X:19,013,132...19,013,210 		JBrowse link
G Mir381 microRNA 381 ISO RNA:decreased expression:spinal cord RGD PMID:30142543 RGD:13838658 NCBI chr12:109,693,256...109,693,330
Ensembl chr12:109,693,256...109,693,330 		JBrowse link
G Mir96 microRNA 96 ISO RNA:decreased expression:dorsal root ganglion: RGD PMID:24234845 RGD:11553932 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO RGD PMID:25172308 RGD:13207330 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpz myelin protein zero treatment ISO RGD PMID:23545781 RGD:9685778 NCBI chr 1:170,978,282...170,988,699
Ensembl chr 1:170,978,280...170,988,699 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:20452291 RGD:10041037 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myh4 myosin, heavy polypeptide 4, skeletal muscle treatment ISO RGD PMID:14973145 RGD:9686059 NCBI chr11:67,128,638...67,151,273
Ensembl chr11:67,128,855...67,151,272 		JBrowse link
G Nefh neurofilament, heavy polypeptide treatment ISO RGD PMID:3135913 PMID:12445968 RGD:9693730, RGD:9743941 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Nefl neurofilament, light polypeptide ISO associated with Diabetes Mellitus, Type 1 RGD PMID:12445968 PMID:3135913 PMID:12638730 RGD:9743941, RGD:9693730, RGD:9743948 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nefm neurofilament, medium polypeptide treatment ISO associated with Diabetes Mellitus, Type 1 RGD PMID:12445968 PMID:12638730 PMID:3135913 RGD:9743941, RGD:9743948, RGD:9693730 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295 		JBrowse link
G Nf1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha treatment ISO RGD PMID:18938092 RGD:10413869 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngf nerve growth factor treatment IDA
IEP		 protein:increased expression:sciatic nerve RGD PMID:22776032 PMID:32652504 RGD:7242913, RGD:401976543 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) IMP
ISO		 RGD PMID:17576803 PMID:23138653 RGD:5144067, RGD:10414078 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nlgn2 neuroligin 2 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr11:69,713,949...69,728,610
Ensembl chr11:69,713,948...69,728,610 		JBrowse link
G Nlgn3 neuroligin 3 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr  X:100,342,785...100,364,956
Ensembl chr  X:100,342,774...100,369,569 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO mRNA:increased expression:dorsal root ganglion: RGD PMID:16914673 RGD:13781948 NCBI chr 4:149,552,026...149,569,667
Ensembl chr 4:149,552,029...149,569,659 		JBrowse link
G Nos1ap nitric oxide synthase 1 (neuronal) adaptor protein ISO mRNA:increased expression:sciatic nerve RGD PMID:17768032 RGD:7327169 NCBI chr 1:170,143,039...170,417,371
Ensembl chr 1:170,130,237...170,417,430 		JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:20957456 RGD:10449012 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nts neurotensin ISO RGD PMID:8518953 RGD:9743903 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO mRNA:increased expression:brain: RGD PMID:15862535 RGD:9835022 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO mRNA, protein:decreased expression:dorsal root ganglion RGD PMID:26917724 PMID:31836522 RGD:11531866, RGD:401842373 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pcna proliferating cell nuclear antigen ISO RGD PMID:23014974 RGD:10448976 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO mRNA,protein:increased expression:nerve: RGD PMID:9729404 RGD:11556234 NCBI chr19:17,409,678...17,815,076
Ensembl chr19:17,409,683...17,814,996 		JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide ISO RGD PMID:19909480 RGD:11080976 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide ISO RGD PMID:19909480 RGD:11080976 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Plat plasminogen activator, tissue ISO RGD PMID:18716863 RGD:6483827 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase treatment ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:18716863 PMID:21151668 RGD:6483827, RGD:7241585 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pmp22 peripheral myelin protein 22 ISO RGD PMID:1556154 RGD:1358785 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO associated with Diabetes Mellitus, Experimental RGD PMID:22996345 RGD:7242051 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ptafr platelet-activating factor receptor ISO mRNA:increased expression:spinal cord, microglia (rat) RGD PMID:22296727 RGD:9999207 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptn pleiotrophin ISO mRNA:altered expression:dorsal root ganglia (rat) RGD PMID:18365878 RGD:9831453 NCBI chr 6:36,691,863...36,787,114
Ensembl chr 6:36,691,864...36,787,155 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr 9:108,385,204...108,393,140
Ensembl chr 9:108,384,905...108,393,140 		JBrowse link
G Ran RAN, member RAS oncogene family ISO RGD PMID:18667152 RGD:9835000 NCBI chr 5:129,097,264...129,101,388
Ensembl chr 5:129,097,133...129,101,387 		JBrowse link
G Ranbp1 RAN binding protein 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:18667152 RGD:9835000 NCBI chr16:18,057,843...18,066,558
Ensembl chr16:18,057,648...18,066,596 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 ISO protein:increased expression:sciatic nerve, axon, cytoplasm (rat) RGD PMID:18667152 RGD:9835000 NCBI chr15:81,588,449...81,614,120
Ensembl chr15:81,588,449...81,629,731 		JBrowse link
G Rara retinoic acid receptor, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rarb retinoic acid receptor, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 ISO protein:increased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr 5:92,096,701...92,110,988
Ensembl chr 5:92,096,763...92,110,927 		JBrowse link
G Reg3b regenerating islet-derived 3 beta ISO mRNA:increased expression:lumbar spinal cord, dorsal root ganglia (rat) RGD PMID:21561713 RGD:9831430 NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449 		JBrowse link
G Rgma repulsive guidance molecule family member A ISO RGD PMID:16863689 RGD:9850145 NCBI chr 7:73,025,268...73,069,647
Ensembl chr 7:73,025,257...73,069,647 		JBrowse link
G Rpsa ribosomal protein SA ISO RGD PMID:19196078 RGD:11041651 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435 		JBrowse link
G Runx1 runt related transcription factor 1 IEP mRNA:decreased expression:dorsal root ganglion RGD PMID:22216140 RGD:6482827 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Rxra retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha ISO RGD PMID:21965668 RGD:6484251 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO RGD PMID:25967608 RGD:11075075 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment ISO human protein in a mouse model RGD PMID:10441236 RGD:8554886 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566 		JBrowse link
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115 		JBrowse link
G Snw1 SNW domain containing 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:23389663 RGD:11035242 NCBI chr12:87,496,680...87,519,069
Ensembl chr12:87,495,845...87,519,044 		JBrowse link
G Sod1 superoxide dismutase 1, soluble severity
treatment		 ISO human gene in a rat model;DNA:missense mutation:cds:p.G93A (human) RGD PMID:21489258 PMID:15707675 RGD:8655638, RGD:8655979 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO RNA:decreased expression:dorsal root ganglion neuron RGD PMID:25484256 RGD:151893491 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370 		JBrowse link
G Tlr2 toll-like receptor 2 IEP
IMP		 mRNA:increased expression:sciatic nerve: RGD PMID:21125644 PMID:21125644 RGD:8553062, RGD:8553062 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEP		 mRNA,protein:increased expression:spinal cord:
mRNA:increased expression:spinal cord:		 RGD PMID:22173123 PMID:18615568 RGD:7364836, RGD:7815041 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IMP
ISO		 protein:increased expression:dorsal root ganglia (rat) RGD PMID:9582261 PMID:11240015 RGD:5130898, RGD:5130963 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:11240015 RGD:5130963 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chr19:44,127,685...44,134,909
Ensembl chr19:44,127,685...44,134,885 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16106
    disease of anatomical entity 15662
      nervous system disease 13530
        peripheral nervous system disease 4129
          mononeuropathy 149
            mononeuritis 148
              mononeuritis of lower limb 137
                lesion of sciatic nerve 137
                  sciatic neuropathy 134
                    Piriformis Muscle Syndrome + 0
                    Sciatica + 2
Path 2
Term Annotations click to browse term
  disease 16106
    disease of anatomical entity 15662
      nervous system disease 13530
        peripheral nervous system disease 4129
          neuropathy 3927
            mononeuropathy 149
              mononeuritis 148
                mononeuritis of lower limb 137
                  lesion of sciatic nerve 137
                    sciatic neuropathy 134
                      Piriformis Muscle Syndrome + 0
                      Sciatica + 2
paths to the root