Gfra3 (glial cell line derived neurotrophic factor family receptor alpha 3) - Rat Genome Database

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Gene: Gfra3 (glial cell line derived neurotrophic factor family receptor alpha 3) Mus musculus
Analyze
Symbol: Gfra3
Name: glial cell line derived neurotrophic factor family receptor alpha 3
RGD ID: 1552970
MGI Page MGI
Description: Enables axon guidance receptor activity. Acts upstream of or within axon guidance; neuron migration; and sympathetic nervous system development. Located in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; alimentary system; cranial nerve; ganglia; and genitourinary system. Orthologous to human GFRA3 (GDNF family receptor alpha 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR alpha-3; GFR-alpha-3; GFRa; GFRalpha3; Y15110
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,822,951 - 34,853,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,822,951 - 34,853,440 (-)EnsemblGRCm39 Ensembl
GRCm381834,689,898 - 34,720,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,689,898 - 34,720,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv371834,849,557 - 34,880,041 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,814,720 - 34,845,131 (-)NCBIMGSCv36mm8
Celera1835,142,994 - 35,173,839 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. Hoke A, etal., Neuroreport. 2000 Jun 5;11(8):1651-4.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9448325   PMID:9452475   PMID:9535755   PMID:9576965   PMID:9608533   PMID:9749804   PMID:9786421   PMID:10331972   PMID:10349636   PMID:10482239   PMID:10712625   PMID:10860579  
PMID:11003834   PMID:11042159   PMID:11069590   PMID:11076861   PMID:11217851   PMID:11585795   PMID:12160745   PMID:12477932   PMID:14610273   PMID:15204970   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16497798   PMID:16602821   PMID:17322904   PMID:17553423   PMID:18287559   PMID:19580811   PMID:20064391   PMID:21123573   PMID:21193524   PMID:21677750   PMID:21873635  
PMID:22855506   PMID:23884957   PMID:24516396   PMID:24952961   PMID:25079320   PMID:25918373   PMID:26576643   PMID:26904955   PMID:27051069   PMID:27571008   PMID:28270618   PMID:30093553  
PMID:31302761   PMID:31812516   PMID:32098917   PMID:32857879   PMID:33305192   PMID:36898840  


Genomics

Comparative Map Data
Gfra3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,822,951 - 34,853,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,822,951 - 34,853,440 (-)EnsemblGRCm39 Ensembl
GRCm381834,689,898 - 34,720,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,689,898 - 34,720,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv371834,849,557 - 34,880,041 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,814,720 - 34,845,131 (-)NCBIMGSCv36mm8
Celera1835,142,994 - 35,173,839 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
GFRA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,252,380 - 138,274,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,252,380 - 138,274,621 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,588,069 - 137,610,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,615,968 - 137,638,152 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,615,969 - 137,638,152NCBI
Celera5133,709,300 - 133,731,054 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,779,039 - 132,801,225 (-)NCBIHuRef
CHM1_15137,020,644 - 137,042,862 (-)NCBICHM1_1
T2T-CHM13v2.05138,778,613 - 138,800,853 (-)NCBIT2T-CHM13v2.0
Gfra3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,571,952 - 26,600,225 (-)NCBIGRCr8
mRatBN7.21826,297,828 - 26,326,105 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,297,829 - 26,326,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,425,209 - 26,453,481 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,189,072 - 27,217,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,523,972 - 26,552,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,491,860 - 27,520,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,491,845 - 27,520,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,205,217 - 27,233,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,167,576 - 27,195,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,195,323 - 27,208,736 (-)NCBI
Celera1826,035,434 - 26,063,700 (-)NCBICelera
Cytogenetic Map18p12NCBI
Gfra3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,143,169 - 2,163,286 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,152,887 - 2,162,883 (+)NCBIChiLan1.0ChiLan1.0
GFRA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,524,342 - 133,547,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,663,952 - 131,687,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,630,274 - 133,652,525 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,762,690 - 139,784,942 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,762,690 - 139,784,942 (-)Ensemblpanpan1.1panPan2
GFRA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,881,523 - 25,897,863 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,882,099 - 25,897,817 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,652,055 - 24,667,781 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,738,265 - 26,754,257 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,690,528 - 26,754,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,445,543 - 25,461,486 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,268,312 - 25,284,034 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,932,678 - 25,948,643 (-)NCBIUU_Cfam_GSD_1.0
Gfra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,146,854 - 154,167,704 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,444,147 - 7,464,523 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,443,842 - 7,457,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFRA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,263,301 - 140,283,040 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,263,297 - 140,283,227 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,962,140 - 145,982,527 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GFRA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,927,283 - 40,948,591 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,927,289 - 40,946,023 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,940,183 - 36,964,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfra3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,074,302 - 31,096,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,079,591 - 31,095,595 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gfra3
792 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:196
Interacting mature miRNAs:207
Transcripts:ENSMUST00000025224
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse

Markers in Region
Y15110  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381834,690,051 - 34,690,188UniSTSGRCm38
MGSCv371834,849,705 - 34,849,842UniSTSGRCm37
Celera1835,143,142 - 35,143,279UniSTS
Cytogenetic Map18B1UniSTS
Gfra3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B1UniSTS
cM Map18 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025224   ⟹   ENSMUSP00000025224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1834,822,951 - 34,853,440 (-)Ensembl
GRCm38.p6 Ensembl1834,689,898 - 34,720,387 (-)Ensembl
RefSeq Acc Id: NM_010280   ⟹   NP_034410
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391834,822,951 - 34,853,440 (-)NCBI
GRCm381834,689,898 - 34,720,387 (-)NCBI
MGSCv371834,849,557 - 34,880,041 (-)RGD
Celera1835,142,994 - 35,173,839 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034410   ⟸   NM_010280
- Peptide Label: preproprotein
- UniProtKB: Q6NZC2 (UniProtKB/Swiss-Prot),   O55243 (UniProtKB/Swiss-Prot),   O35325 (UniProtKB/Swiss-Prot),   Q8C8L9 (UniProtKB/Swiss-Prot),   O35118 (UniProtKB/Swiss-Prot),   Q9R2D0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025224   ⟸   ENSMUST00000025224
Protein Domains
GDNF/GAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35118-F1-model_v2 AlphaFold O35118 1-397 view protein structure

Promoters
RGD ID:13677382
Promoter ID:EPDNEW_M22840
Type:initiation region
Name:Gfra3_1
Description:Mus musculus glial cell line derived neurotrophic factor familyreceptor alpha 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381834,720,291 - 34,720,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201403 AgrOrtholog
Ensembl Genes ENSMUSG00000024366 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025224 ENTREZGENE
  ENSMUST00000025224.9 UniProtKB/Swiss-Prot
Gene3D-CATH GDNF binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GDNF/GAS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF_rcpt_A3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14587 UniProtKB/Swiss-Prot
MGD MGI:1201403 ENTREZGENE
NCBI Gene 14587 ENTREZGENE
PANTHER GDNF FAMILY RECEPTOR ALPHA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10269 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gfra3 PhenoGen
PRINTS GDNFRALPHA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GFRA3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O35325 ENTREZGENE
  O55243 ENTREZGENE
  Q6NZC2 ENTREZGENE
  Q8C8L9 ENTREZGENE
  Q9R2D0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35325 UniProtKB/Swiss-Prot
  O55243 UniProtKB/Swiss-Prot
  Q6NZC2 UniProtKB/Swiss-Prot
  Q8C8L9 UniProtKB/Swiss-Prot