RGD Reference Report - Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. - Rat Genome Database

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Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats.

Authors: Hoke, A  Cheng, C  Zochodne, DW 
Citation: Hoke A, etal., Neuroreport. 2000 Jun 5;11(8):1651-4.
RGD ID: 6218977
Pubmed: PMID:10852218   (View Abstract at PubMed)

The glial cell line-derived neurotrophic factor (GDNF) family of growth factors may be involved in the regenerative support of neurons in the peripheral nervous system. In order to study the role of these growth factors and their receptors following rat peripheral nerve injury we examined the changes in their mRNA levels in the spinal cord, the dorsal root ganglia and the peripheral nerve trunk. Following transaction of the sciatic nerve GDNF mRNA was up-regulated rapidly in the denervated nerve distal to the cut along with the mRNA for one of its receptors, GFRalpha-1. GFRalpha-1 mRNA was also increased in the DRG ipsilateral to the nerve injury suggesting that GDNF may be involved in the trophic support of DRG sensory neurons. In contrast there were no analogous changes in the mRNA levels of neurturin, persephin and artemin following injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sciatic neuropathy  ISOGdnf (Rattus norvegicus)6218977; 6218977mRNA:increased expression:sciatic nerveRGD 
sciatic neuropathy  ISOGfra3 (Rattus norvegicus)6218977; 6218977mRNA:increased expression:sciatic nerveRGD 
sciatic neuropathy  IEP 6218977; 6218977mRNA:increased expression:sciatic nerveRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gdnf  (glial cell derived neurotrophic factor)
Gfra3  (GDNF family receptor alpha 3)

Genes (Mus musculus)
Gdnf  (glial cell line derived neurotrophic factor)
Gfra3  (glial cell line derived neurotrophic factor family receptor alpha 3)

Genes (Homo sapiens)
GDNF  (glial cell derived neurotrophic factor)
GFRA3  (GDNF family receptor alpha 3)


Additional Information