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Gene: GFRA3 (GDNF family receptor alpha 3) Sus scrofa

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Symbol:

GFRA3

Name:

GDNF family receptor alpha 3 (Ensembl:cell division cycle 25C)

RGD ID:

13870454

Description:

ENCODES a protein that exhibits axon guidance receptor activity (inferred); glial cell-derived neurotrophic factor receptor activity (inferred); histone H2AXY142 phosphatase activity (inferred); INVOLVED IN axon guidance (ortholog); neuron development (ortholog); neuron migration (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GDNF family receptor alpha-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	140,263,301 - 140,283,066 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	140,263,297 - 140,283,227 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	145,962,140 - 145,982,527 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

prostate cancer (ISO)

sciatic neuropathy (ISO)

STING-associated vasculopathy with onset in infancy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (IEA,ISO)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

chromatin remodeling (IEA)

glial cell-derived neurotrophic factor receptor signaling pathway (IEA)

nervous system development (IBA)

neuron development (IEA,ISO)

neuron migration (IEA,ISO)

sympathetic nervous system development (IEA,ISO)

Cellular Component

cytosol (IEA)

external side of plasma membrane (IBA,IEA)

plasma membrane (IEA,ISO)

receptor complex (IBA)

Molecular Function

axon guidance receptor activity (IEA)

glial cell-derived neurotrophic factor receptor activity (IEA)

histone H2AXY142 phosphatase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

protein binding (ISO)

protein tyrosine phosphatase activity, metal-dependent (IEA)

signaling receptor activity (IBA,IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GFRA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	140,263,301 - 140,283,066 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	140,263,297 - 140,283,227 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	145,962,140 - 145,982,527 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GFRA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	138,252,380 - 138,274,621 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	138,252,380 - 138,274,621 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	137,588,069 - 137,610,310 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	137,615,968 - 137,638,152 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	137,615,969 - 137,638,152	NCBI
Celera	5	133,709,300 - 133,731,054 (-)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	132,779,039 - 132,801,225 (-)	NCBI		HuRef
CHM1_1	5	137,020,644 - 137,042,862 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	138,778,613 - 138,800,853 (-)	NCBI		T2T-CHM13v2.0

Gfra3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	34,822,951 - 34,853,440 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	34,822,951 - 34,853,440 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	34,689,898 - 34,720,387 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	34,689,898 - 34,720,387 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	34,849,557 - 34,880,041 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	34,814,720 - 34,845,131 (-)	NCBI		MGSCv36	mm8
Celera	18	35,142,994 - 35,173,839 (-)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.69	NCBI

Gfra3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	26,571,952 - 26,600,225 (-)	NCBI		GRCr8
mRatBN7.2	18	26,297,828 - 26,326,105 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	26,297,829 - 26,326,105 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,425,209 - 26,453,481 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	27,189,072 - 27,217,348 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,523,972 - 26,552,248 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,491,860 - 27,520,133 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,491,845 - 27,520,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	27,205,217 - 27,233,490 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	27,167,576 - 27,195,848 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	27,195,323 - 27,208,736 (-)	NCBI
Celera	18	26,035,434 - 26,063,700 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

Gfra3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	2,143,169 - 2,163,286 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	2,152,887 - 2,162,883 (+)	NCBI	ChiLan1.0	ChiLan1.0

GFRA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	133,524,342 - 133,547,975 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	131,663,952 - 131,687,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	133,630,274 - 133,652,525 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	139,762,690 - 139,784,942 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	139,762,690 - 139,784,942 (-)	Ensembl	panpan1.1		panPan2

GFRA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	25,881,523 - 25,897,863 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	25,882,099 - 25,897,817 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	24,652,055 - 24,667,781 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	26,738,265 - 26,754,257 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	26,690,528 - 26,754,264 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	25,445,543 - 25,461,486 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	25,268,312 - 25,284,034 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	25,932,678 - 25,948,643 (-)	NCBI		UU_Cfam_GSD_1.0

Gfra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	154,146,854 - 154,167,704 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	7,444,147 - 7,464,523 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	7,443,842 - 7,457,518 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFRA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	40,927,283 - 40,948,591 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	40,927,289 - 40,946,023 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	36,940,183 - 36,964,179 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfra3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	31,074,302 - 31,096,301 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	31,079,591 - 31,095,595 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GFRA3
643 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003123953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU928408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01001643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000015654 ⟹ ENSSSCP00000015241

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	140,263,301 - 140,283,066 (-)	Ensembl

RefSeq Acc Id:

XM_003123953 ⟹ XP_003124001

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	140,263,297 - 140,283,227 (-)	NCBI

Sequence:

show sequence

GTCCAGTAGGAGAGGTGCTGTGGTCCGCTTCTGAGTTTGAGGGCGGCGCCCAGGACCCTGGTGG
GAGCGTGTCGGCGCCGTTCGCGCCAGGAGGGGCGGCCCAAGGCGGTGGGAGGTGCCGGCCGAGG
ATCCCGACTCTCAGAGCTCCAGCGCGCGGAAGCGAGGGGAACGCCGCGCCCTTCGCAGGCAGAG
CGCCCCAGACGCGGGCACCCGGCGTGTACACCGGGCCATGGCGCGCCCCCCGAGCCCGCGACAG
CTGCCGCCCGCGCTCCTGCTGCTGCTGCTGCCACTGCTGCTCAGAGCAGGGTACTACCTTCCCA
CAGAAGGCCGGCTCATGAACAGCTGTCTCNCGGCCAGGAGGAAGTGCCAGGCCNATCCCACTTG
CAATGCTACCTACCACTACCTGAGTTCCTGTGCCTCTAGTAGAAGCATCCCATCACCTGCAGAG
GAGCCTTCAGTCCCCAAGGACTGCATGGAAGCAGCACAGCAACTCAGGAATAGCTCTCTGATGA
GCTGCACATGCCACCGGCGCATGAAGAACCAAGCTACCTGCCTGGACATCTACTGGACTGTTCA
CCCTGCCCGCAGCCTTGGTGACTATGAGCTGGATGTCTCCCCCTATGAAGACACAGTGACCAGA
AAACCCTGGAAAATGAATCTCAGCAAACTCAGAATGCTCAAACCAGATTGGGATCGCTGCCTCA
AGTTCGCCATACTGTGCACATTTAATGAGAAGTGTGACCGGCCTGCGCCAAGGCCTATGGGGAG
GCTTGCTCGGGGGTCCCGCTGTCAGCGCCACAACTGCCAAGGGCAGCTTCGCGCCTTCTTTGAG
AAGNCGCCCGAGCCCCAGGCACAGGGCTTGCTGTTCTGCCCGTGTGCACCCACCGACCAGGGCT
GTGGGCAGCGCCGGCGCAACACATTGCACCCAGCTGCGTGCTACCTCNNTGAGGCCACCAACTG
CCTGGAGCTGCGTCAACAATGCCTGTCCNAGCCACTGTGCAGATCACGCCTGGCAGATTTTCAG
ACCCACTGCCATCCCATGGACGTCCTGGGGACCTGTGCAACAGAGCACTCCAGATGTCTGCAAG
CGTACATGGGGCTGATTGGGACTGCCATGACTCCCAACTTTGTCAGCAATGTCAGTGCCAGCAT
TGCCTTAAGCTGCACCTGCCGAGGCAGTGGCAACCTGCAGGAGGAGTGCGAACAGCTGGAAGAG
TCCTTCTCTCGCAACCCCTGCCTTGCGGAGGCCATTGCAGCTAAGATGCGTTTTCACAGCCAGC
TCTTCTCCCAGGACCAGGGCGGGGCAGACTCTGCCTTTTCGGTGATGGAGCACCAGAACAAAAA
CCCTGCTCTGAGACCACAGCCCTGGGTGCCCTCTCTTTTCTCCTGTACACTAATGTTGGTTCTG
CGTCCAAGCCTCTGGTAGCTGGACTTCCCTGGGGGCCCTCTTCCCTCACCACCCCCAGCCTGCC
CTGCAGTGAGCAGGAAAGGGTGAGGAAAGGGCAGCCTCAGGAAGGAGGCTCAGTAAACAACGTG
GCAACCTGGCCCCACACCGCACGTCCAGTGGACTCCGGATGAGGCCACAGTAGAAGCTGACTAG
CTTAGTTCCCCATTCCCTCCACTTCTGACTCAAGCTGCCCCTCCTTAGGACTTTGTGACCATGG
TTTAGCCATAGTTTAGCCATAGCTTCTGGTGATGTCCAGCTCTGCCAAGCTCTCTCCTTATTCC
TTTCTCCTGCTCGCCAAGATCACCTAGGCGCTAGCAAATCAGTCATGCTCTGGTGCATTCTCCG
GGTAGGCAGGGGTGGGTGTTCTGAGGCAGCCTGGAAGGACATTCCTCATGGTAAGGAGAGCTGA
AGAAAGACCTGGCCCCTTGTCTCCTCCTCTGAATGGGGGTTGGGAACCTACAGCCTGCCCTGCC
CAGGGATCCTGCAGAGCATTTGGGCATCAGGAGCTGGAGCATTTGGTCTTTGCTTTCTTCCTCC
CACTGTCCCAAAGTCCCCCTAGCCTCTTGGTTCATAATTAAACATTTTGACTTCAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003124001	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000015241
	ENSSSCP00000015241.5

RefSeq Acc Id:

XP_003124001 ⟸ XM_003123953

- UniProtKB:

A0A480JGE0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPPSPRQLPPALLLLLLPLLLRAGYYLPTEGRLMNSCLXARRKCQAXPTCNATYHYLSSCAS
SRSIPSPAEEPSVPKDCMEAAQQLRNSSLMSCTCHRRMKNQATCLDIYWTVHPARSLGDYELDV
SPYEDTVTRKPWKMNLSKLRMLKPDWDRCLKFAILCTFNEKCDRPAPRPMGRLARGSRCQRHNC
QGQLRAFFEKXPEPQAQGLLFCPCAPTDQGCGQRRRNTLHPAACYLXEATNCLELRQQCLSXPL
CRSRLADFQTHCHPMDVLGTCATEHSRCLQAYMGLIGTAMTPNFVSNVSASIALSCTCRGSGNL
QEECEQLEESFSRNPCLAEAIAAKMRFHSQLFSQDQGGADSAFSVMEHQNKNPALRPQPWVPSL
FSCTLMLVLRPSLW

hide sequence

Ensembl Acc Id:

ENSSSCP00000015241 ⟸ ENSSSCT00000015654

Protein Domains

GDNF/GAS1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000014329	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000015654	ENTREZGENE
	ENSSSCT00000015654.5	UniProtKB/TrEMBL
Gene3D-CATH	GDNF binding domain	UniProtKB/TrEMBL
InterPro	GDNF/GAS1	UniProtKB/TrEMBL
	GDNF_alpha	UniProtKB/TrEMBL
	GDNF_rcpt	UniProtKB/TrEMBL
	GDNF_rcpt_A3	UniProtKB/TrEMBL
KEGG Report	ssc:100515366	UniProtKB/TrEMBL
NCBI Gene	GFRA3	ENTREZGENE
PANTHER	GDNF FAMILY RECEPTOR ALPHA-3	UniProtKB/TrEMBL
	PTHR10269	UniProtKB/TrEMBL
Pfam	GDNF	UniProtKB/TrEMBL
PRINTS	GDNFRALPHA3	UniProtKB/TrEMBL
	GDNFRECEPTOR	UniProtKB/TrEMBL
SMART	GDNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF110035	UniProtKB/TrEMBL
UniProt	A0A480JGE0	ENTREZGENE, UniProtKB/TrEMBL
	A0A480PSU1_PIG	UniProtKB/TrEMBL
	F1RH78_PIG	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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