RGD Reference Report - The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. - Rat Genome Database

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The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.

Authors: Avari, P  Huang, W  Averill, S  Colom, B  Imhof, BA  Nourshargh, S  Priestley, JV 
Citation: Avari P, etal., Brain Behav. 2012 Jul;2(4):402-14. doi: 10.1002/brb3.63.
RGD ID: 7488944
Pubmed: PMID:22950044   (View Abstract at PubMed)
PMCID: PMC3432963   (View Article at PubMed Central)
DOI: DOI:10.1002/brb3.63   (Journal Full-text)

JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
JAM3Humansciatic neuropathy  ISOJam3 (Rattus norvegicus) RGD 
Jam3Ratsciatic neuropathy  IEP  RGD 
Jam3Mousesciatic neuropathy  ISOJam3 (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Jam3Rataxon regeneration  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jam3  (junctional adhesion molecule 3)

Genes (Mus musculus)
Jam3  (junction adhesion molecule 3)

Genes (Homo sapiens)
JAM3  (junctional adhesion molecule 3)


Additional Information