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Gene: JAM3 (junctional adhesion molecule 3) Homo sapiens
Symbol: JAM3
Name: junctional adhesion molecule 3
Description: Exhibits cell-cell adhesion mediator activity and integrin binding activity. Involved in several processes, including apical protein localization; hematopoietic stem cell migration to bone marrow; and negative regulation of integrin activation. Localizes to several cellular components, including cell-cell contact zone; desmosome; and filamentous actin. Colocalizes with bicellular tight junction. Biomarker of systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ14529; JAM-2; JAM-3; JAM-C; JAMC; junctional adhesion molecule C
Mus musculus (house mouse) : Jam3 (junction adhesion molecule 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jam3 (junctional adhesion molecule 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jam3 (junctional adhesion molecule 3)
Pan paniscus (bonobo/pygmy chimpanzee) : JAM3 (junctional adhesion molecule 3)
Canis lupus familiaris (dog) : JAM3 (junctional adhesion molecule 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jam3 (junctional adhesion molecule 3)
Sus scrofa (pig) : JAM3 (junctional adhesion molecule 3)
Chlorocebus sabaeus (African green monkey) : JAM3 (junctional adhesion molecule 3)
Heterocephalus glaber (naked mole-rat) : Jam3 (junctional adhesion molecule 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11134,069,071 - 134,152,001 (+)EnsemblGRCh38hg38GRCh38
GRCh3811134,068,925 - 134,152,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711133,938,820 - 134,021,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611133,444,030 - 133,526,861 (+)NCBINCBI36hg18NCBI36
Build 3411133,444,029 - 133,526,858NCBI
Celera11131,112,218 - 131,194,832 (+)NCBI
Cytogenetic Map11q25NCBI
HuRef11129,893,248 - 129,976,188 (+)NCBIHuRef
CHM1_111133,826,755 - 133,908,474 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on JAM3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346212
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.