Gc (vitamin D binding protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gc (vitamin D binding protein) Mus musculus
Analyze
Symbol: Gc
Name: vitamin D binding protein
RGD ID: 10624
MGI Page MGI
Description: Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in axon; extracellular space; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; male reproductive gland or organ; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DB; DBP; gc-globulin; group specific component; group-specific component; VDB; vitamin D-binding protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,565,370 - 89,605,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,565,381 - 89,605,757 (-)EnsemblGRCm39 Ensembl
GRCm38589,417,511 - 89,457,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,417,522 - 89,457,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37589,846,547 - 89,886,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,492,721 - 90,532,964 (-)NCBIMGSCv36mm8
Celera587,554,559 - 87,593,435 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium silicate  (EXP)
calcium(0)  (ISO)
carbon atom  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
chromium trinitrate  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diquat  (EXP)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
fructose  (EXP)
furan  (ISO)
genistein  (ISO)
glucose  (EXP)
glyphosate  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methidathion  (EXP)
methylmercury(1+)  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
ouabain  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pyrethrins  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
valproic acid  (ISO)
verapamil  (ISO)
vitamin D  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gel-based proteomics of liver cancer progression in rat. Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
2. Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients. Albuquerque LM, etal., J Proteome Res. 2009 Dec;8(12):5431-41.
3. An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever. Bahr GM, etal., Immunology. 1989 May;67(1):126-8.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis. Borkowski J, etal., Postepy Hig Med Dosw (Online). 2008 Mar 3;62:103-9.
6. Bayesian approach to searching for susceptibility genes: Gc2 and EsD1 alleles and multiple sclerosis. Di Bacco M, etal., Coll Antropol. 2002 Jun;26(1):77-84.
7. Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis. Doherty NS, etal., Electrophoresis. 1998 Feb;19(2):355-63.
8. Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection. Eales LJ, etal., Lancet. 1987 May 2;1(8540):999-1002.
9. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. Eloranta JJ, etal., Pharmacogenet Genomics. 2011 Sep;21(9):559-64.
10. Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function. Gressner OA, etal., Clin Chim Acta. 2009 Feb;400(1-2):86-90. Epub 2008 Oct 30.
11. Proteomic identification of biomarkers of vascular injury. Huang NF, etal., Am J Transl Res. 2011 Feb;3(2):139-48. Epub 2010 Nov 21.
12. Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases. Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41.
13. Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Jimenez CR, etal., Mol Cell Proteomics. 2005 Feb;4(2):120-32. Epub 2004 Oct 25.
14. Associations of vitamin d binding protein gene polymorphisms with the development of peripheral arthritis and uveitis in ankylosing spondylitis. Jung KH, etal., J Rheumatol. 2011 Oct;38(10):2224-9. Epub 2011 Aug 15.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Kurylowicz A, etal., Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):329-35.
17. Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population. Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
18. Relationship between group-specific component protein and the development of asthma. Lee SH, etal., Am J Respir Crit Care Med. 2011 Sep 1;184(5):528-36.
19. Proteomic profiles of bronchoalveolar lavage fluid from patients with ventilator-associated pneumonia by gel-assisted digestion and 2-D-LC/MS/MS. Lu YT, etal., Proteomics Clin Appl. 2008 Sep;2(9):1208-22. doi: 10.1002/prca.200800069. Epub 2008 Aug 7.
20. Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study. Martin CB, etal., J Steroid Biochem Mol Biol. 2020 Oct;203:105729. doi: 10.1016/j.jsbmb.2020.105729. Epub 2020 Jul 15.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS. Niino M, etal., J Neuroimmunol. 2002 Jun;127(1-2):177-9.
24. 1,25-Dihydroxyvitamin D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats. Nyomba BL, etal., Endocrinology. 1985 Jun;116(6):2483-8.
25. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace. Ongagna JC, etal., Clin Biochem. 2001 Feb;34(1):59-63.
29. Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers. Ottervald J, etal., J Proteomics. 2010 Apr 18;73(6):1117-32. Epub 2010 Jan 20.
30. Proteomic analysis of vitreous from diabetic macular edema. Ouchi M, etal., Exp Eye Res. 2005 Aug;81(2):176-82.
31. A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. Pani MA, etal., J Clin Endocrinol Metab. 2002 Jun;87(6):2564-7.
32. Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population. Peng Q, etal., PLoS One. 2014 Dec 26;9(12):e116026. doi: 10.1371/journal.pone.0116026. eCollection 2014.
33. Alteration of DBP levels in CSF of patients with MS by proteomics analysis. Qin Z, etal., Cell Mol Neurobiol. 2009 Mar;29(2):203-10. Epub 2008 Sep 19.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Protein expression profiles in pediatric multiple sclerosis: potential biomarkers. Rithidech KN, etal., Mult Scler. 2009 Apr;15(4):455-64.
38. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. Rozek W, etal., J Proteome Res. 2007 Nov;6(11):4189-99. Epub 2007 Oct 12.
39. Vitamin D binding protein variants and the risk of COPD. Schellenberg D, etal., Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):957-61.
40. Increased turnover of Gc-globulin in patients with hepatic encephalopathy. Schiodt FV, etal., Scand J Gastroenterol. 2001 Sep;36(9):998-1003.
41. Rat gene mapping using PCR-analyzed microsatellites. Serikawa T, etal., Genetics 1992 Jul;131(3):701-21.
42. Acute-phase proteins before cerebral ischemia in stroke-prone rats: identification by proteomics. Sironi L, etal., Stroke. 2001 Mar;32(3):753-60.
43. Vitamin D and bone mineral homeostasis during pregnancy in the diabetic BB rat. Verhaeghe J, etal., Endocrinology. 1986 Mar;118(3):1019-25.
44. Differential proteomic characterization between normal peritoneal fluid and diabetic peritoneal dialysate. Wang HY, etal., Nephrol Dial Transplant. 2010 Jun;25(6):1955-63. Epub 2010 Jan 6.
45. Serum proteomic analysis of extracorporeal shock wave therapy-enhanced diabetic wound healing in a streptozotocin-induced diabetes model. Yang MY, etal., Plast Reconstr Surg. 2014 Jan;133(1):59-68. doi: 10.1097/01.prs.0000439050.08733.cf.
Additional References at PubMed
PMID:49052   PMID:1696927   PMID:3243374   PMID:8835525   PMID:9916136   PMID:10349636   PMID:10652269   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11777984   PMID:12477932  
PMID:15225763   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17330941   PMID:18372326   PMID:18554416   PMID:19423573   PMID:19968565   PMID:20376577   PMID:21267068   PMID:21873635  
PMID:23416408   PMID:23752613   PMID:24194600   PMID:27626380   PMID:30194503   PMID:31120862   PMID:31740596   PMID:31748273   PMID:32325033   PMID:32553153   PMID:34081922   PMID:34873873  
PMID:36445949   PMID:37395395  


Genomics

Comparative Map Data
Gc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,565,370 - 89,605,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,565,381 - 89,605,757 (-)EnsemblGRCm39 Ensembl
GRCm38589,417,511 - 89,457,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,417,522 - 89,457,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37589,846,547 - 89,886,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,492,721 - 90,532,964 (-)NCBIMGSCv36mm8
Celera587,554,559 - 87,593,435 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
GC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38471,741,693 - 71,805,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl471,741,696 - 71,804,041 (-)EnsemblGRCh38hg38GRCh38
GRCh37472,607,410 - 72,671,237 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,826,274 - 72,868,752 (-)NCBINCBI36Build 36hg18NCBI36
Build 34472,972,446 - 73,014,923NCBI
Celera469,964,129 - 70,006,624 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef468,412,706 - 68,476,557 (-)NCBIHuRef
CHM1_1472,643,398 - 72,707,216 (-)NCBICHM1_1
T2T-CHM13v2.0475,084,117 - 75,147,957 (-)NCBIT2T-CHM13v2.0
Gc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21418,632,146 - 18,667,563 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,632,135 - 18,667,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,622,611 - 18,658,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,941,501 - 19,976,920 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01418,653,131 - 18,688,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,267,023 - 20,302,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,266,891 - 20,302,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,173,467 - 20,209,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,166,243 - 20,197,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,166,180 - 20,201,613 (+)NCBI
Celera1417,992,337 - 18,027,605 (+)NCBICelera
Cytogenetic Map14p22NCBI
Gc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554471,361,566 - 1,402,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554471,361,698 - 1,400,633 (+)NCBIChiLan1.0ChiLan1.0
GC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1458,466,887 - 58,529,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0452,431,196 - 52,473,762 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1458,749,384 - 58,792,073 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl458,729,236 - 58,792,073 (+)Ensemblpanpan1.1panPan2
GC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11360,795,305 - 60,828,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1360,795,305 - 60,827,929 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1360,528,533 - 60,561,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,603,086 - 61,636,545 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,603,088 - 61,652,533 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11361,215,897 - 61,249,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01360,708,804 - 60,742,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01361,856,182 - 61,889,922 (-)NCBIUU_Cfam_GSD_1.0
Gc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528514,767,874 - 14,809,615 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365983,219,991 - 3,261,629 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365983,220,029 - 3,256,091 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl868,326,299 - 68,360,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1868,326,293 - 68,360,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2872,227,896 - 72,261,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1720,254,604 - 20,298,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl720,253,879 - 20,298,265 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660842,553,410 - 2,596,840 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248903,226,900 - 3,318,316 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248903,274,239 - 3,318,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gc
1443 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:71
Interacting mature miRNAs:81
Transcripts:ENSMUST00000049209
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
12738408Lfibq5_mliver fibrosis QTL 5 (mouse)58478385389966041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse

Markers in Region
17.MMHAP32FLF2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38589,425,963 - 89,426,152UniSTSGRCm38
MGSCv37589,854,988 - 89,855,177UniSTSGRCm37
Celera587,563,008 - 87,563,197UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS
Whitehead_YAC5 UniSTS
Gc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37589,868,654 - 89,870,266UniSTSGRCm37
Celera587,575,300 - 87,576,912UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS
cM Map544.0UniSTS
Gc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38589,439,629 - 89,441,241UniSTSGRCm38
MGSCv37589,868,654 - 89,870,266UniSTSGRCm37
Celera587,575,300 - 87,576,912UniSTS
Cytogenetic Map5E1UniSTS
cM Map544.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000049209   ⟹   ENSMUSP00000046636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl589,565,381 - 89,605,757 (-)Ensembl
GRCm38.p6 Ensembl589,417,522 - 89,457,898 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200534   ⟹   ENSMUSP00000143624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl589,569,744 - 89,583,487 (-)Ensembl
GRCm38.p6 Ensembl589,421,885 - 89,435,628 (-)Ensembl
RefSeq Acc Id: NM_008096   ⟹   NP_032122
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39589,565,370 - 89,605,757 (-)NCBI
GRCm38589,417,511 - 89,457,898 (-)ENTREZGENE
MGSCv37589,846,547 - 89,886,790 (-)RGD
Celera587,554,548 - 87,593,568 (-)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37669 (Get FASTA)   NCBI Sequence Viewer  
  AAH10762 (Get FASTA)   NCBI Sequence Viewer  
  AAH51395 (Get FASTA)   NCBI Sequence Viewer  
  BAB27297 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000046636
  ENSMUSP00000046636.9
  ENSMUSP00000143624.2
GenBank Protein P21614 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032122   ⟸   NM_008096
- Peptide Label: precursor
- UniProtKB: Q91XG1 (UniProtKB/Swiss-Prot),   Q7TS97 (UniProtKB/Swiss-Prot),   Q9CY31 (UniProtKB/Swiss-Prot),   P21614 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000046636   ⟸   ENSMUST00000049209
RefSeq Acc Id: ENSMUSP00000143624   ⟸   ENSMUST00000200534
Protein Domains
Albumin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21614-F1-model_v2 AlphaFold P21614 1-476 view protein structure

Promoters
RGD ID:6887098
Promoter ID:EPDNEW_M7000
Type:initiation region
Name:Gc_1
Description:Mus musculus group specific component , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38589,457,777 - 89,457,837EPDNEW
RGD ID:6847909
Promoter ID:MM_ACW:38366
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:GC.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36589,864,106 - 89,864,606 (-)MPROMDB
RGD ID:6837574
Promoter ID:MM_KWN:42814
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_008096
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36589,886,506 - 89,887,006 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95669 AgrOrtholog
Ensembl Genes ENSMUSG00000035540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049209 ENTREZGENE
  ENSMUST00000049209.13 UniProtKB/Swiss-Prot
  ENSMUST00000200534.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ALB/AFP/VDB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_albumin_CS UniProtKB/Swiss-Prot
  Serum_albumin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD-bind_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14473 UniProtKB/Swiss-Prot
MGD MGI:95669 ENTREZGENE
NCBI Gene 14473 ENTREZGENE
PANTHER PTHR11385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11385:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serum_albumin UniProtKB/Swiss-Prot
  VitD-bind_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gc PhenoGen
PRINTS SERUMALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VITAMNDBNDNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALBUMIN_1 UniProtKB/Swiss-Prot
  ALBUMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ALBUMIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGM6_MOUSE UniProtKB/TrEMBL
  P21614 ENTREZGENE
  Q7TS97 ENTREZGENE
  Q91XG1 ENTREZGENE
  Q9CY31 ENTREZGENE
  VTDB_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q7TS97 UniProtKB/Swiss-Prot
  Q91XG1 UniProtKB/Swiss-Prot
  Q9CY31 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Gc  vitamin D binding protein    group specific component  Symbol and/or name change 5135510 APPROVED