Gene: Qars (glutaminyl-tRNA synthetase) Mus musculus
Analyze
Symbol:
Qars
Name:
glutaminyl-tRNA synthetase
Description:
ENCODES a protein that exhibits glutamine-tRNA ligase activity (ortholog); protein kinase binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH Prostatic Neoplasms; attention deficit hyperactivity disorder (ortholog); genetic disease (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1110018N24Rik; 1200016L19Rik; C80286; GLNRS; glutamine--tRNA ligase; glutamine-tRNA ligase; MGC105238
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
QARS1 (glutaminyl-tRNA synthetase 1) HGNC
EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Qars1 (glutaminyl-tRNA synthetase 1) RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Qars1 (glutaminyl-tRNA synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
QARS1 (glutaminyl-tRNA synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
QARS1 (glutaminyl-tRNA synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Qars1 (glutaminyl-tRNA synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
QARS1 (glutaminyl-tRNA synthetase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
QARS1 (glutaminyl-tRNA synthetase 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Qars1 (glutaminyl-tRNA synthetase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
qars (glutaminyl-tRNA synthetase)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
GLN4
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
GlnRS
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
qars-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,508,005 - 108,515,941 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,410,336 - 108,418,272 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,366,177 - 108,374,016 (+) NCBI mm8 Celera 9 108,117,702 - 108,125,638 (+) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
attention deficit hyperactivity disorder ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Attention deficit hyperactivity disorder ClinVar PMID:28332277 genetic disease ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:24656866 more ... Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:25741868 Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:25432320 , PMID:28492532 Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:25741868 , PMID:28492532 Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:26467025 , PMID:28492532 Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:28492532 Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy ClinVar PMID:24656866 Sleep Initiation and Maintenance Disorders ISO RGD:1346181 8554872 ClinVar Annotator: match by term: Insomnia ClinVar PMID:25741868
Imported Annotations - CTD
Prostatic Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17013881 Imported Annotations - OMIM
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy ISO RGD:1346181 7240710 OMIM
17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of QARS mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of QARS mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1346181 6480464 Tetrachlorodibenzodioxin results in increased expression of QARS1 mRNA CTD PMID:11489354 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of QARS mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of QARS mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of QARS mRNA CTD PMID:17942748 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:19467301 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of QARS mRNA CTD PMID:28973697 aflatoxin B2 decreases methylation ISO RGD:1346181 6480464 aflatoxin B2 results in decreased methylation of QARS1 promoter CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:1346181 6480464 Tretinoin results in increased expression of QARS1 mRNA CTD PMID:17218384 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to QARS promoter] CTD PMID:19654925 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of QARS mRNA CTD PMID:20504355 benzo[e]pyrene decreases methylation ISO RGD:1346181 6480464 benzo(e)pyrene results in decreased methylation of QARS1 promoter CTD PMID:30157460 bisphenol A increases expression ISO RGD:1359448 6480464 bisphenol A results in increased expression of QARS1 mRNA CTD PMID:25181051 cadmium dichloride increases methylation ISO RGD:1359448 6480464 Cadmium Chloride results in increased methylation of QARS1 promoter CTD PMID:22457795 caffeine increases expression ISO RGD:1359448 6480464 Caffeine results in increased expression of QARS1 mRNA CTD PMID:20864626 chloropicrin increases expression ISO RGD:1346181 6480464 chloropicrin results in increased expression of QARS1 mRNA CTD PMID:26352163 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of QARS mRNA CTD PMID:21151649 cisplatin increases expression ISO RGD:1346181 6480464 Cisplatin results in increased expression of QARS1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1346181 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of QARS1 mRNA CTD PMID:27392435 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of QARS mRNA CTD PMID:22467019 enzyme inhibitor multiple interactions ISO RGD:1346181 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of QARS1 protein CTD PMID:23301498 lead diacetate decreases expression ISO RGD:1359448 6480464 lead acetate results in decreased expression of QARS1 mRNA CTD PMID:11578147 lead(0) affects expression ISO RGD:1346181 6480464 Lead affects the expression of QARS1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1346181 6480464 Lead affects the expression of QARS1 mRNA CTD PMID:28903495 lithium atom multiple interactions ISO RGD:1359448 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 lithium hydride multiple interactions ISO RGD:1359448 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 lithium(1+) multiple interactions ISO RGD:1359448 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 methamphetamine decreases expression ISO RGD:1359448 6480464 Methamphetamine results in decreased expression of QARS1 mRNA CTD PMID:19149911 methamphetamine multiple interactions ISO RGD:1359448 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA], Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 methapyrilene decreases methylation ISO RGD:1346181 6480464 Methapyrilene results in decreased methylation of QARS1 promoter CTD PMID:30157460 methoxyacetic acid increases expression ISO RGD:1359448 6480464 methoxyacetic acid results in increased expression of QARS1 mRNA CTD PMID:20864626 methylmercury chloride increases expression ISO RGD:1359448 6480464 methylmercuric chloride results in increased expression of QARS1 mRNA CTD PMID:20864626 Monobutylphthalate increases expression ISO RGD:1359448 6480464 monobutyl phthalate results in increased expression of QARS1 mRNA CTD PMID:20864626 okadaic acid affects expression ISO RGD:1346181 6480464 Okadaic Acid affects the expression of QARS1 mRNA CTD PMID:22788371 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of QARS mRNA CTD PMID:17562736 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of QARS protein CTD PMID:25505154 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of QARS mRNA CTD PMID:27339419 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of QARS protein CTD PMID:24648495 valproic acid decreases expression ISO RGD:1346181 6480464 Valproic Acid results in decreased expression of QARS1 mRNA CTD PMID:23179753 , PMID:29154799 valproic acid multiple interactions ISO RGD:1359448 6480464 Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of QARS1 mRNA] CTD PMID:19149911 valproic acid increases methylation ISO RGD:1346181 6480464 Valproic Acid results in increased methylation of QARS1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1346181 6480464 Valproic Acid affects the expression of QARS1 mRNA CTD PMID:25979313
Biological Process glutaminyl-tRNA aminoacylation IBA EcoGene:EG10390 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 negative regulation of apoptotic process ISO EMBL:X76013 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 translation IEA InterPro:IPR011035 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 translation IEA UniProtKB-KW:KW-0648 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 tRNA aminoacylation IEA InterPro:IPR000924 , InterPro:IPR020058 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 tRNA aminoacylation for protein translation IEA InterPro:IPR001412 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 Cellular Component aminoacyl-tRNA synthetase multienzyme complex ISO EMBL:X76013 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 aminoacyl-tRNA synthetase multienzyme complex IBA FB:FBgn0027090 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 aminoacyl-tRNA synthetase multienzyme complex IDA 2290270 (MGI:MGI:3055639, PMID:12060739) CAFA MGI:MGI:3055639 , PMID:12060739 cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoplasm IEA InterPro:IPR004514 more ... 2290270 UniProt GO_REF:0000002, MGI:MGI:2152098 cytosol IBA EcoGene:EG10390 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function aminoacyl-tRNA ligase activity IEA UniProtKB-KW:KW-0030 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 aminoacyl-tRNA ligase activity IEA InterPro:IPR000924 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ATP binding IEA InterPro:IPR000924 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 glutamine-tRNA ligase activity ISO EMBL:X76013 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 glutamine-tRNA ligase activity IBA EcoGene:EG10390 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ligase activity IEA UniProtKB-KW:KW-0436 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleotide binding IEA InterPro:IPR000924 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein kinase binding ISO EMBL:X76013 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 RNA binding ISO EMBL:X76013 2290270 MGI GO_REF:0000008, MGI:MGI:2154458
Gene-Chemical Interaction Annotations
