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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:telmisartan
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Accession:CHEBI:9434 term browser browse the term
Definition:A member of the class of benzimidazoles used widely in the treatment of hypertension.
Synonyms:exact_synonym: 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
 related_synonym: 4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid;   4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid;   4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid;   BIBR 277;   Formula=C33H30N4O2;   InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39);   InChIKey=RMMXLENWKUUMAY-UHFFFAOYSA-N;   Micardis;   SMILES=CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
 xref: Beilstein:6624054;   CAS:144701-48-4;   DrugBank:DB00966;   Drug_Central:2583;   HMDB:HMDB0015101;   KEGG:C07710;   KEGG:D00627;   LINCS:LSM-3657
 xref_mesh: MESH:C084178
 xref: PMID:11558835;   PMID:15498586;   PMID:18008027;   PMID:18360028;   PMID:24048485;   Patent:EP502314;   Reaxys:6624054;   Wikipedia:Telmisartan


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telmisartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP telmisartan results in decreased activity of ABCB11 protein
telmisartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression		 EXP PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA] CTD PMID:22124178 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G ACE angiotensin I converting enzyme decreases expression
multiple interactions		 ISO Telmisartan results in decreased expression of ACE mRNA; Telmisartan results in decreased expression of ACE protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein]		 CTD PMID:19171132 PMID:25973029 PMID:29909460 PMID:31629013 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 multiple interactions
decreases expression
increases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
Telmisartan results in decreased expression of ACE2 mRNA; Telmisartan results in decreased expression of ACE2 protein
Telmisartan results in increased expression of ACE2 mRNA; Telmisartan results in increased expression of ACE2 protein		 CTD
RGD		 PMID:21381899 PMID:25973029 PMID:28656296 PMID:29909460 PMID:31629013 More... RGD:329956421 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:23060470 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant decreases activity ISO telmisartan decreases enzyme activity of Trap, Acp5 in serum of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO
EXP		 telmisartan results in increased expression of ADIPOQ mRNA
telmisartan results in increased expression of ADIPOQ protein		 CTD PMID:19730415 PMID:20555330 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AGT angiotensinogen multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]
telmisartan results in decreased expression of AGT mRNA; telmisartan results in decreased expression of AGT protein
Telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; Telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]		 CTD PMID:9533614 PMID:17620961 PMID:18487452 PMID:19171132 PMID:19289654 More... NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 affects binding
decreases expression
multiple interactions
increases expression		 ISO
EXP		 telmisartan binds to AGTR1 protein
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
telmisartan results in decreased expression of AGTR1A mRNA
telmisartan binds to and results in decreased activity of AGTR1 protein
Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
telmisartan results in increased expression of AGTR1 mRNA		 CTD
RGD		 PMID:8220885 PMID:9533614 PMID:9728324 PMID:17620961 PMID:19171132 More... RGD:329956421 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 increases expression ISO telmisartan increases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G AHR aryl hydrocarbon receptor increases activity ISO Telmisartan results in increased activity of AHR protein CTD PMID:28728110 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALB albumin affects expression
multiple interactions		 EXP
ISO		 telmisartan affects the expression of ALB protein modified form
Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]		 CTD PMID:16671338 PMID:34464088 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases activity
multiple interactions		 ISO telmisartan increases enzyme activity of Alpl in serum of rats with periodontal disease
Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein]		 CTD
RGD		 PMID:27269004 PMID:33364953 RGD:329956421 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA] CTD PMID:24831514 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA] CTD PMID:24831514 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein] CTD PMID:23747572 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
Telmisartan results in decreased expression of CASP3 protein
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 mRNA]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]		 CTD PMID:18565324 PMID:19452295 PMID:21620867 PMID:21819444 PMID:22750630 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO Telmisartan inhibits the reaction [arsenite results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:23750309 PMID:26929000 PMID:34339004 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
telmisartan results in decreased expression of CCL2 protein		 CTD PMID:17922026 PMID:22124178 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 decreases response to substance EXP telmisartan results in decreased susceptibility to CCL5 protein CTD PMID:18158351 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression ISO telmisartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) increases expression
multiple interactions		 EXP telmisartan results in increased expression of CD36 mRNA
PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; T 0070907 inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]		 CTD PMID:22124178 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]] CTD PMID:19289654 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein] CTD PMID:33872574 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CRP C-reactive protein decreases expression EXP telmisartan results in decreased expression of CRP protein CTD PMID:20555330 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CTSK cathepsin K decreases expression ISO telmisartan decreases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression ISO telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions
decreases response to substance		 EXP PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
telmisartan results in decreased susceptibility to CXCL12 protein		 CTD PMID:18158351 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP telmisartan metabolite results in decreased expression of CXCL8 mRNA CTD PMID:26528891 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYBA cytochrome b-245 alpha chain decreases expression
multiple interactions		 ISO telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]		 CTD PMID:16141465 PMID:19171132 PMID:21054405 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions
decreases expression		 ISO
EXP		 telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
Telmisartan inhibits the reaction [arsenite results in increased expression of CYBB mRNA]
Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB protein]
telmisartan results in decreased expression of CYBB mRNA		 CTD PMID:19171132 PMID:21381899 PMID:34339004 PMID:34464088 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CYCS mRNA] CTD PMID:24831514 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 decreases activity EXP Telmisartan results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 decreases expression ISO telmisartan results in decreased expression of DDIT3 protein CTD PMID:19102871 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein] CTD PMID:20888384 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein] CTD PMID:20888384 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G FASLG Fas ligand multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASL protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASLG protein]		 CTD PMID:21620867 PMID:21819444 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FN1 fibronectin 1 multiple interactions ISO telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein] CTD PMID:33872574 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein] CTD PMID:23747572 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
Telmisartan results in decreased expression of GFAP protein		 CTD PMID:23747572 PMID:29909460 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein] CTD PMID:23750309 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions EXP Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 protein] CTD PMID:37356649 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27269004 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] CTD PMID:26929000 PMID:27269004 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
decreases activity		 ISO Telmisartan inhibits the reaction [arsenite results in decreased activity of GSR protein]
Telmisartan results in decreased activity of GSR protein		 CTD PMID:34339004 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HGF hepatocyte growth factor increases expression ISO telmisartan results in increased expression of HGF mRNA CTD PMID:21479465 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression ISO telmisartan results in decreased expression of HSPA5 protein CTD PMID:19102871 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IBSP integrin binding sialoprotein increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]		 CTD PMID:17724226 PMID:20888384 PMID:22124178 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G ICAM3 intercellular adhesion molecule 3 multiple interactions EXP PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein] CTD PMID:18158351 NCBI chr19:10,333,776...10,339,624
Ensembl chr19:10,333,776...10,339,661 		JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
increases expression		 ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
telmisartan decreases expression of protein in mandible of WKY rats with periodontal disease
Telmisartan results in increased expression of IL10 protein		 CTD
RGD		 PMID:24831514 PMID:29909460 PMID:33364953 RGD:329956421 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression 		EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease
Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL1B protein]		 CTD
RGD		 PMID:22124178 PMID:33872574 PMID:34339004 PMID:33364953 RGD:329956421 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Telmisartan results in decreased expression of IL6 protein
telmisartan results in decreased expression of IL6 mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]		 CTD PMID:19289654 PMID:21479465 PMID:22124178 PMID:29909460 PMID:34339004 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS insulin decreases expression EXP telmisartan results in decreased expression of INS protein CTD PMID:15892894 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough increases expression ISO Telmisartan results in increased expression of INS1 protein CTD PMID:19171132 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions EXP [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 decreases expression EXP telmisartan decreases expression of KCNN4 mRNA and protein in CD4-positive alpha-beta T cell RGD PMID:26502942 RGD:329955577 NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976 		JBrowse link
G LEPR leptin receptor multiple interactions ISO Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]; Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA] CTD PMID:34464088 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559 		JBrowse link
G LIPE lipase E, hormone sensitive type multiple interactions
increases expression		 ISO PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein] CTD PMID:20176998 NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:22124178 PMID:33872574 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions
decreases phosphorylation		 EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
telmisartan results in decreased phosphorylation of MAPK14 protein		 CTD PMID:19292980 PMID:22124178 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:22124178 PMID:33872574 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form] CTD PMID:21381899 NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions
increases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Telmisartan results in increased expression of MAS1 protein		 CTD PMID:21381899 PMID:28656296 PMID:31629013 NCBI chr 6:159,888,787...159,917,447
Ensembl chr 6:159,890,988...159,917,447 		JBrowse link
G MIR146A microRNA 146a multiple interactions EXP
ISO		 [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A
telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney]		 CTD
RGD		 PMID:20524934 PMID:27760486 RGD:155882556 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR146B microRNA 146b multiple interactions EXP [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr10:102,436,512...102,436,584
Ensembl chr10:102,436,512...102,436,584 		JBrowse link
G MIR320A microRNA 320a multiple interactions ISO telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr 8:22,244,966...22,245,037
Ensembl chr 8:22,244,962...22,245,043 		JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
decreases expression 		ISO telmisartan results in decreased expression of MMP2 protein
telmisartan decreases expression of mRNA in mandible of WKY rats with periodontal disease		 CTD
RGD		 PMID:21054405 PMID:33364953 RGD:329956421 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]
telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; telmisartan inhibits the reaction [sodium arsenite results in increased activity of MPO protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]		 CTD PMID:23060470 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK protein] CTD PMID:34464088 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein]
telmisartan results in decreased expression of NCF1 mRNA; telmisartan results in decreased expression of NCF1 protein		 CTD PMID:16141465 PMID:19171132 PMID:21054405 PMID:21381899 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
telmisartan results in decreased expression of NCF2 mRNA; telmisartan results in decreased expression of NCF2 protein		 CTD PMID:16141465 PMID:21054405 PMID:21381899 NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein] CTD PMID:21620867 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA] CTD PMID:22124178 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]		 CTD PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased phosphorylation of NOS3 protein] CTD PMID:21156825 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein] CTD PMID:21054405 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Telmisartan inhibits the reaction [Daunorubicin results in decreased expression of NPHS1 protein] CTD PMID:20888384 NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287 		JBrowse link
G NPPB natriuretic peptide B affects expression
multiple interactions
decreases expression		 EXP
ISO		 telmisartan affects the expression of NPPB protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]
telmisartan results in decreased expression of NPPB protein		 CTD PMID:16671338 PMID:18712048 PMID:31629013 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G OCLN occludin multiple interactions EXP
ISO		 MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN protein]
Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA]		 CTD PMID:34464088 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 multiple interactions EXP telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 protein] CTD PMID:22124178 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions ISO telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases expression
multiple interactions		 ISO telmisartan results in increased expression of PPARD protein
PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein]		 CTD PMID:20176998 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression
increases activity		 EXP
ISO		 PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]
telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
telmisartan results in increased expression of PPARG protein
telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
Telmisartan results in increased activity of PPARG protein		 CTD PMID:18158351 PMID:20176998 PMID:20888384 PMID:21381899 PMID:22124178 More... NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein] CTD PMID:21381899 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of PRKAA2 protein] CTD PMID:37356649 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases activity		 EXP
ISO		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Telmisartan results in increased activity of PTGS2 protein
telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
[Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [arsenite results in increased activity of PTGS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]		 CTD PMID:20223228 PMID:20888384 PMID:22124178 PMID:22750630 PMID:24831514 More... NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTH1R parathyroid hormone 1 receptor multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTH1R protein] CTD PMID:23750309 NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799 		JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23750309 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
telmisartan inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]		 CTD PMID:20223228 PMID:22124178 PMID:24831514 PMID:26929000 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G REN renin increases expression ISO telmisartan results in increased expression of REN mRNA; telmisartan results in increased expression of REN protein CTD PMID:9533614 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO telmisartan increases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 increases activity EXP telmisartan results in increased activity of SCN5A protein CTD PMID:29306026 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743 		JBrowse link
G SEMA3B semaphorin 3B multiple interactions EXP telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein] CTD PMID:21933904 NCBI chr 3:50,267,652...50,277,546
Ensembl chr 3:50,267,558...50,277,546 		JBrowse link
G SEMA3F semaphorin 3F multiple interactions EXP telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3F protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3F protein] CTD PMID:21933904 NCBI chr 3:50,155,058...50,189,075
Ensembl chr 3:50,155,045...50,189,075 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]
telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]		 CTD PMID:17620961 PMID:19706694 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:23747572 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP telmisartan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:23747572 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SNCA synuclein alpha multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein] CTD PMID:23747572 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Telmisartan inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] CTD PMID:27269004 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SYP synaptophysin multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]		 CTD PMID:18487452 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,218 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
telmisartan results in decreased expression of TGFB1 mRNA
telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein]		 CTD PMID:19171132 PMID:19706694 PMID:20888384 PMID:21381899 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23747572 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions
decreases expression
affects localization		 EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]
Telmisartan results in decreased expression of TJP1 mRNA; Telmisartan results in decreased expression of TJP1 protein		 CTD PMID:19252288 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression 		EXP
ISO		 PPARG mutant form inhibits the reaction [Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [Telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease
Telmisartan results in decreased expression of TNF protein
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of TNF protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF]; Telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]		 CTD
RGD		 PMID:19289654 PMID:20223228 PMID:21620867 PMID:21819444 PMID:22124178 More... RGD:329956421 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFSF11 TNF superfamily member 11 decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G UCP1 uncoupling protein 1 multiple interactions
increases expression		 ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein] CTD PMID:20176998 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961 		JBrowse link
G UCP2 uncoupling protein 2 multiple interactions
increases expression		 ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein] CTD PMID:20176998 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G UCP3 uncoupling protein 3 multiple interactions
increases expression		 ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein] CTD PMID:20176998 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein] CTD PMID:20888384 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of VEGFA]
telmisartan results in decreased expression of VEGFA mRNA		 CTD PMID:17724226 PMID:19171132 PMID:26439596 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VTN vitronectin decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:28,367,284...28,370,307
Ensembl chr17:28,367,284...28,373,091 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26050
    role 25966
      biological role 25945
        xenobiotic 20379
          telmisartan 123
Path 2
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  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            heteroorganic entity 24781
                              organochalcogen compound 24394
                                organooxygen compound 24071
                                  carbon oxoacid 22773
                                    carboxylic acid 22753
                                      aromatic carboxylic acid 13402
                                        benzoic acids 13376
                                          carboxybiphenyl 125
                                            telmisartan 123
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