CCR2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: CCR2 (C-C motif chemokine receptor 2) Homo sapiens
Symbol: CCR2
Name: C-C motif chemokine receptor 2
RGD ID: 1603716
Description: Enables CCR2 chemokine receptor binding activity. Involved in positive regulation of astrocyte chemotaxis and positive regulation of monocyte chemotaxis. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm and plasma membrane. Implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Biomarker of several diseases, including lung disease (multiple); macular degeneration (multiple); myeloid sarcoma; myositis (multiple); and periapical granuloma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (ISS)
aggressive periodontitis  (IAGP)
Alcoholic Fatty Liver  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (EXP,ISO)
allergic disease  (EXP)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (IEP)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (IAGP,ISO)
atopic dermatitis  (IEP)
bacterial pneumonia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (IEP)
congestive heart failure  (IAGP)
corneal neovascularization  (ISO)
coronary artery disease  (IAGP)
Coronavirus infectious disease  (ISS)
cutaneous leishmaniasis  (ISO)
demyelinating disease  (ISO)
dermatomyositis  (IEP)
Diabetic Nephropathies  (IAGP,ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (IEP)
Geographic Atrophy  (IEP)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (IAGP)
Hyperalgesia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
ileitis  (ISO)
inclusion body myositis  (IEP)
intermediate uveitis  (IAGP)
interstitial lung disease  (IEP)
Intervertebral Disc Disease  (ISO)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (IAGP)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (IEP)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (EXP)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,ISO)
macular degeneration  (IEP)
Mouth Neoplasms  (IAGP)
myeloid sarcoma  (IEP)
myocardial infarction  (IAGP)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (IEP)
non-alcoholic fatty liver disease  (IAGP)
oral squamous cell carcinoma  (IAGP)
Pain  (ISO)
Perennial Allergic Rhinitis  (IEP)
Peri-Implantitis  (IEP)
Periapical Diseases  (ISO)
periapical granuloma  (IEP)
periapical periodontitis  (ISO)
Periodontal Cyst  (IEP)
pleural tuberculosis  (IDA)
pneumonia  (EXP,ISO)
polymyositis  (IEP)
posterior uveitis  (IAGP)
prediabetes syndrome  (IAGP)
psoriasis  (IEP)
psoriatic arthritis  (IAGP)
pulmonary fibrosis  (EXP,ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (IAGP)
sarcoidosis  (IAGP)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (EXP)
systemic scleroderma  (ISO)
Thoracic Injuries  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IAGP)
type 2 diabetes mellitus  (IEP)
urticaria  (IAGP)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(R)-mevalonic acid  (EXP)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
3-chlorophenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
amphetamine  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
asbestos  (EXP)
asperentin  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
chenodeoxycholic acid  (EXP)
chloroprene  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diethylstilbestrol  (ISO)
disulfiram  (EXP)
doxorubicin  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
flumequine  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
isoniazide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
linuron  (ISO)
losartan  (ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
MeIQx  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
nefazodone  (EXP)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
olaparib  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (EXP)
perindopril  (ISO)
picrotoxin  (ISO)
piperidines  (EXP)
proanthocyanidin  (EXP)
protein kinase inhibitor  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (EXP)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tetrachloromethane  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc sulfate  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA,ISO,ISS)
calcium-mediated signaling  (IBA)
cell chemotaxis  (IBA)
cellular calcium ion homeostasis  (ISO,ISS)
cellular defense response  (IEA,ISO)
cellular homeostasis  (ISS)
chemokine-mediated signaling pathway  (IEA,ISO,ISS)
chemotaxis  (IEA,TAS)
cytokine-mediated signaling pathway  (IDA,ISO)
dendritic cell chemotaxis  (TAS)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
humoral immune response  (IEA,ISO)
immune response  (IBA,IEA,ISO)
inflammatory response  (IBA,IEA,ISO)
inflammatory response to antigenic stimulus  (ISO)
inflammatory response to wounding  (ISS)
leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
macrophage migration  (ISS)
monocyte chemotaxis  (IEA,ISO)
monocyte extravasation  (ISS)
negative regulation of adenylate cyclase activity  (TAS)
negative regulation of angiogenesis  (ISS)
negative regulation of eosinophil degranulation  (ISS)
negative regulation of type 2 immune response  (ISS)
neutrophil clearance  (IEA,ISO)
positive regulation of alpha-beta T cell proliferation  (ISS)
positive regulation of astrocyte chemotaxis  (IDA)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (ISS)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of hematopoietic stem cell migration  (ISS)
positive regulation of immune complex clearance by monocytes and macrophages  (ISS)
positive regulation of inflammatory response  (ISS)
positive regulation of interferon-gamma production  (ISS)
positive regulation of interleukin-2 production  (ISS)
positive regulation of leukocyte tethering or rolling  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IDA,IEA,ISS)
positive regulation of monocyte extravasation  (ISS)
positive regulation of NMDA glutamate receptor activity  (ISS)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISS)
positive regulation of T cell activation  (ISS)
positive regulation of T cell chemotaxis  (ISS)
positive regulation of T-helper 1 type immune response  (ISS)
positive regulation of thymocyte migration  (ISS)
positive regulation of tumor necrosis factor production  (ISO,ISS)
receptor signaling pathway via JAK-STAT  (TAS)
regulation of cell migration  (ISO)
regulation of inflammatory response  (ISS)
regulation of T cell cytokine production  (ISS)
regulation of T cell differentiation  (ISS)
regulation of vascular endothelial growth factor production  (ISS)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to wounding  (TAS)
sensory perception of pain  (ISO,ISS)
T-helper 17 cell chemotaxis  (ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

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Additional References at PubMed
PMID:2834384   PMID:8048929   PMID:8146186   PMID:8530354   PMID:8884276   PMID:8995400   PMID:9058802   PMID:9115216   PMID:9143512   PMID:9195948   PMID:9225989   PMID:9252328  
PMID:9287323   PMID:9501202   PMID:9548499   PMID:9653051   PMID:9662369   PMID:9670957   PMID:9710230   PMID:9736741   PMID:9789057   PMID:9886417   PMID:10201901   PMID:10479649  
PMID:10486323   PMID:10529171   PMID:10623817   PMID:10741397   PMID:10751368   PMID:10877489   PMID:10888629   PMID:10985245   PMID:11023492   PMID:11046064   PMID:11115360   PMID:11120855  
PMID:11175286   PMID:11181995   PMID:11264152   PMID:11350939   PMID:11377705   PMID:11385319   PMID:11468722   PMID:11470772   PMID:11477473   PMID:11485615   PMID:11500196   PMID:11590385  
PMID:11596075   PMID:11694103   PMID:11696224   PMID:11709782   PMID:11729511   PMID:11752157   PMID:11779135   PMID:11782014   PMID:11804551   PMID:11856781   PMID:11860793   PMID:11860823  
PMID:11873083   PMID:11898620   PMID:11958683   PMID:11964548   PMID:11988632   PMID:12001056   PMID:12010355   PMID:12032878   PMID:12070001   PMID:12078856   PMID:12079277   PMID:12082592  
PMID:12149192   PMID:12192431   PMID:12201365   PMID:12215924   PMID:12239249   PMID:12271471   PMID:12374865   PMID:12399623   PMID:12403355   PMID:12436194   PMID:12445801   PMID:12447757  
PMID:12469616   PMID:12477932   PMID:12556692   PMID:12557141   PMID:12571520   PMID:12584049   PMID:12651900   PMID:12654703   PMID:12680626   PMID:12837756   PMID:12853745   PMID:12882757  
PMID:12884524   PMID:12889997   PMID:12913933   PMID:13678532   PMID:14533004   PMID:14533983   PMID:14624371   PMID:14644039   PMID:14647058   PMID:14742283   PMID:14981141   PMID:15053339  
PMID:15076247   PMID:15086346   PMID:15086398   PMID:15135805   PMID:15140377   PMID:15192276   PMID:15230854   PMID:15236615   PMID:15257681   PMID:15319853   PMID:15362666   PMID:15458467  
PMID:15465089   PMID:15466648   PMID:15472820   PMID:15488313   PMID:15489334   PMID:15575507   PMID:15579296   PMID:15585333   PMID:15602133   PMID:15611878   PMID:15639953   PMID:15721423  
PMID:15750046   PMID:15754978   PMID:15769362   PMID:15793370   PMID:15863470   PMID:15929697   PMID:15976001   PMID:15980693   PMID:15992849   PMID:15995708   PMID:16033640   PMID:16055130  
PMID:16123688   PMID:16140745   PMID:16196460   PMID:16206074   PMID:16207551   PMID:16261210   PMID:16286054   PMID:16286055   PMID:16305685   PMID:16314800   PMID:16320328   PMID:16323127  
PMID:16344560   PMID:16356504   PMID:16415174   PMID:16426243   PMID:16461193   PMID:16478397   PMID:16480760   PMID:16485782   PMID:16524739   PMID:16529059   PMID:16598837   PMID:16621978  
PMID:16641997   PMID:16733654   PMID:16781696   PMID:16831471   PMID:16858645   PMID:16865553   PMID:16903979   PMID:16908772   PMID:16950632   PMID:17060059   PMID:17091019   PMID:17094383  
PMID:17216598   PMID:17240189   PMID:17295203   PMID:17355643   PMID:17361671   PMID:17364026   PMID:17395051   PMID:17413295   PMID:17426779   PMID:17428349   PMID:17464174   PMID:17465499  
PMID:17482150   PMID:17499741   PMID:17504503   PMID:17558413   PMID:17560067   PMID:17596666   PMID:17604544   PMID:17615573   PMID:17653321   PMID:17664883   PMID:17688234   PMID:17703277  
PMID:17703412   PMID:17704101   PMID:17715128   PMID:17786209   PMID:17845302   PMID:17917677   PMID:17934338   PMID:17989610   PMID:18055544   PMID:18060801   PMID:18093816   PMID:18164016  
PMID:18186797   PMID:18197127   PMID:18240029   PMID:18306985   PMID:18332000   PMID:18391751   PMID:18577758   PMID:18587271   PMID:18615095   PMID:18633131   PMID:18676680   PMID:18763111  
PMID:18829011   PMID:18845960   PMID:18846510   PMID:18855658   PMID:18928397   PMID:18936436   PMID:18974840   PMID:18977759   PMID:18996288   PMID:19002595   PMID:19017998   PMID:19028820  
PMID:19032065   PMID:19037908   PMID:19055601   PMID:19064579   PMID:19082218   PMID:19098363   PMID:19124913   PMID:19131662   PMID:19170196   PMID:19196047   PMID:19225544   PMID:19258923  
PMID:19263529   PMID:19411748   PMID:19420105   PMID:19433914   PMID:19465829   PMID:19479237   PMID:19506371   PMID:19520154   PMID:19526283   PMID:19527467   PMID:19535619   PMID:19559392  
PMID:19578796   PMID:19625176   PMID:19643177   PMID:19669591   PMID:19692168   PMID:19693089   PMID:19720836   PMID:19841162   PMID:19904283   PMID:19917610   PMID:19942750   PMID:19950235  
PMID:19958843   PMID:19965779   PMID:20017911   PMID:20038229   PMID:20066125   PMID:20181074   PMID:20182805   PMID:20190752   PMID:20220260   PMID:20231199   PMID:20339010   PMID:20364004  
PMID:20380698   PMID:20411675   PMID:20442634   PMID:20449800   PMID:20452482   PMID:20483750   PMID:20485444   PMID:20503287   PMID:20531015   PMID:20536507   PMID:20537184   PMID:20603037  
PMID:20605053   PMID:20628649   PMID:20637631   PMID:20673868   PMID:20681057   PMID:20726788   PMID:20740585   PMID:20808917   PMID:20842059   PMID:20947712   PMID:21054877   PMID:21091093  
PMID:21097527   PMID:21097672   PMID:21146687   PMID:21148810   PMID:21220372   PMID:21322034   PMID:21348591   PMID:21396623   PMID:21429204   PMID:21440726   PMID:21450101   PMID:21461583  
PMID:21527853   PMID:21602126   PMID:21667221   PMID:21682549   PMID:21868018   PMID:21873635   PMID:21890375   PMID:22026334   PMID:22041342   PMID:22081934   PMID:22086059   PMID:22159219  
PMID:22183310   PMID:22197827   PMID:22218121   PMID:22226505   PMID:22276574   PMID:22285384   PMID:22479344   PMID:22554651   PMID:22607625   PMID:22612293   PMID:22615942   PMID:22685564  
PMID:22752804   PMID:22815949   PMID:22842622   PMID:22909007   PMID:22927430   PMID:23007133   PMID:23041556   PMID:23057571   PMID:23090289   PMID:23185481   PMID:23185512   PMID:23251661  
PMID:23298254   PMID:23325742   PMID:23374597   PMID:23376609   PMID:23408426   PMID:23427179   PMID:23612252   PMID:23632061   PMID:23657965   PMID:23686489   PMID:23771498   PMID:23846739  
PMID:23876399   PMID:23880174   PMID:23922698   PMID:23938203   PMID:24011637   PMID:24078580   PMID:24083412   PMID:24098976   PMID:24128342   PMID:24185682   PMID:24327013   PMID:24332572  
PMID:24344240   PMID:24406043   PMID:24453913   PMID:24489825   PMID:24639350   PMID:24778447   PMID:24906148   PMID:24970887   PMID:24984897   PMID:24999842   PMID:25139016   PMID:25149422  
PMID:25250834   PMID:25261725   PMID:25266801   PMID:25283965   PMID:25312802   PMID:25312961   PMID:25313609   PMID:25340798   PMID:25370917   PMID:25411969   PMID:25503251   PMID:25604634  
PMID:25614627   PMID:25716470   PMID:25760842   PMID:25779331   PMID:25797207   PMID:25808810   PMID:25893607   PMID:25924204   PMID:25966143   PMID:26123579   PMID:26211665   PMID:26300579  
PMID:26556868   PMID:26648448   PMID:26733169   PMID:26823487   PMID:26839895   PMID:26885690   PMID:26982176   PMID:26992207   PMID:27013693   PMID:27055731   PMID:27084102   PMID:27239844  
PMID:27384580   PMID:27458015   PMID:27534043   PMID:27665382   PMID:27788494   PMID:27820834   PMID:27895119   PMID:27909248   PMID:27926736   PMID:27956622   PMID:28045930   PMID:28059456  
PMID:28073847   PMID:28212753   PMID:28232185   PMID:28298427   PMID:28383062   PMID:28420351   PMID:28458180   PMID:28514442   PMID:28536301   PMID:28650671   PMID:28761107   PMID:28818997  
PMID:28892735   PMID:28951461   PMID:28954264   PMID:28971904   PMID:29057937   PMID:29115520   PMID:29133591   PMID:29145242   PMID:29154245   PMID:29186373   PMID:29352259   PMID:29420066  
PMID:29751565   PMID:30132565   PMID:30138893   PMID:30175654   PMID:30321592   PMID:30374624   PMID:30403025   PMID:30446625   PMID:30650073   PMID:30730243   PMID:30764543   PMID:30816510  
PMID:30975755   PMID:30984198   PMID:31034839   PMID:31320454   PMID:31377844   PMID:31471711   PMID:31705064   PMID:31957197   PMID:32103760   PMID:32241914   PMID:32550891   PMID:32943658  
PMID:33508012   PMID:34112803  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBImm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBI
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBI
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBI
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBI
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1227,795,192 - 7,801,242 (+)NCBI
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)Ensembl
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,915 - 46,400,263UniSTSGRCh37
Build 36346,374,919 - 46,375,267RGDNCBI36
Celera346,337,236 - 46,337,584RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,443,553 - 46,443,901UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,261 - 46,399,340UniSTSGRCh37
Build 36346,374,265 - 46,374,344RGDNCBI36
Celera346,336,582 - 46,336,661RGD
HuRef346,442,899 - 46,442,978UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,398,988 - 46,399,658UniSTSGRCh37
Build 36346,373,992 - 46,374,662RGDNCBI36
Celera346,336,309 - 46,336,979RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,442,626 - 46,443,296UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,399,838 - 46,400,033UniSTSGRCh37
Build 36346,374,842 - 46,375,037RGDNCBI36
Celera346,337,159 - 46,337,354RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,443,476 - 46,443,671UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
GeneMap99-GB4 RH Map3151.95UniSTS
NCBI RH Map3458.7UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,402,143 - 46,402,261UniSTSGRCh37
Build 36346,377,147 - 46,377,265RGDNCBI36
Celera346,339,464 - 46,339,582RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,445,781 - 46,445,899UniSTS
TNG Radiation Hybrid Map329204.0UniSTS
GeneMap99-GB4 RH Map3155.98UniSTS
NCBI RH Map3473.3UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37346,401,378 - 46,401,491UniSTSGRCh37
Build 36346,376,382 - 46,376,495RGDNCBI36
Celera346,338,699 - 46,338,812RGD
Cytogenetic Map3p21.31UniSTS
HuRef346,445,016 - 46,445,129UniSTS
Whitehead-YAC Contig Map3 UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:638
Interacting mature miRNAs:700
Transcripts:ENST00000292301, ENST00000400888, ENST00000421659, ENST00000445132, ENST00000465202
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
Medium 41 419 16 7 697 5 8 1 1 25 22 111 3 6 3
Low 1721 1464 962 380 800 234 2146 662 636 220 682 1123 145 942 1341 1
Below cutoff 556 1080 707 211 254 197 1892 1431 2517 120 619 176 15 256 1396 1


Nucleotide Sequences
RefSeq Transcripts NG_021428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001123041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001123396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF068265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF545480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV715904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX705062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ027284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX101672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D29984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA927445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC401093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC418358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU037782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU037783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC248079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000292301   ⟹   ENSP00000292301
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl346,353,744 - 46,360,921 (+)Ensembl
RefSeq Acc Id: ENST00000400888   ⟹   ENSP00000383681
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl346,357,489 - 46,360,928 (+)Ensembl
RefSeq Acc Id: ENST00000421659   ⟹   ENSP00000396736
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl346,354,126 - 46,357,892 (+)Ensembl
RefSeq Acc Id: ENST00000445132   ⟹   ENSP00000399285
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl346,353,734 - 46,359,418 (+)Ensembl
RefSeq Acc Id: ENST00000465202
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl346,353,864 - 46,358,688 (+)Ensembl
RefSeq Acc Id: NM_001123041   ⟹   NP_001116513
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38346,354,111 - 46,360,940 (+)NCBI
GRCh37346,395,235 - 46,402,413 (+)ENTREZGENE
HuRef346,438,874 - 46,446,051 (+)ENTREZGENE
CHM1_1346,345,233 - 46,352,410 (+)NCBI
RefSeq Acc Id: NM_001123396   ⟹   NP_001116868
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38346,354,111 - 46,360,940 (+)NCBI
GRCh37346,395,235 - 46,402,413 (+)ENTREZGENE
HuRef346,438,874 - 46,446,051 (+)ENTREZGENE
CHM1_1346,345,233 - 46,350,865 (+)NCBI
RefSeq Acc Id: XM_011534069   ⟹   XP_011532371
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38346,354,126 - 46,360,940 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001116513 (Get FASTA)   NCBI Sequence Viewer  
  NP_001116868 (Get FASTA)   NCBI Sequence Viewer  
  XP_011532371 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19119 (Get FASTA)   NCBI Sequence Viewer  
  AAA19120 (Get FASTA)   NCBI Sequence Viewer  
  AAB57791 (Get FASTA)   NCBI Sequence Viewer  
  AAB57792 (Get FASTA)   NCBI Sequence Viewer  
  AAC51636 (Get FASTA)   NCBI Sequence Viewer  
  AAC51637 (Get FASTA)   NCBI Sequence Viewer  
  AAH74751 (Get FASTA)   NCBI Sequence Viewer  
  AAH95540 (Get FASTA)   NCBI Sequence Viewer  
  AAI26453 (Get FASTA)   NCBI Sequence Viewer  
  AAI36397 (Get FASTA)   NCBI Sequence Viewer  
  AAN16400 (Get FASTA)   NCBI Sequence Viewer  
  ABW17216 (Get FASTA)   NCBI Sequence Viewer  
  ABW17217 (Get FASTA)   NCBI Sequence Viewer  
  AGC02842 (Get FASTA)   NCBI Sequence Viewer  
  AGC02843 (Get FASTA)   NCBI Sequence Viewer  
  AGC02844 (Get FASTA)   NCBI Sequence Viewer  
  AGC02845 (Get FASTA)   NCBI Sequence Viewer  
  AGC02846 (Get FASTA)   NCBI Sequence Viewer  
  AGC02847 (Get FASTA)   NCBI Sequence Viewer  
  AGC02848 (Get FASTA)   NCBI Sequence Viewer  
  AGC02849 (Get FASTA)   NCBI Sequence Viewer  
  AGC02850 (Get FASTA)   NCBI Sequence Viewer  
  AGC02851 (Get FASTA)   NCBI Sequence Viewer  
  BAA06253 (Get FASTA)   NCBI Sequence Viewer  
  BAF85374 (Get FASTA)   NCBI Sequence Viewer  
  BAF85609 (Get FASTA)   NCBI Sequence Viewer  
  CAA64835 (Get FASTA)   NCBI Sequence Viewer  
  CAD88094 (Get FASTA)   NCBI Sequence Viewer  
  EAW64760 (Get FASTA)   NCBI Sequence Viewer  
  EAW64761 (Get FASTA)   NCBI Sequence Viewer  
  EAW64762 (Get FASTA)   NCBI Sequence Viewer  
  P41597 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001116513   ⟸   NM_001123041
- Peptide Label: isoform A
- UniProtKB: P41597 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116868   ⟸   NM_001123396
- Peptide Label: isoform B
- UniProtKB: P41597 (UniProtKB/Swiss-Prot),   A0A024R2Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532371   ⟸   XM_011534069
- Peptide Label: isoform X1
- UniProtKB: P41597 (UniProtKB/Swiss-Prot),   A0A024R2Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000292301   ⟸   ENST00000292301
RefSeq Acc Id: ENSP00000383681   ⟸   ENST00000400888
RefSeq Acc Id: ENSP00000399285   ⟸   ENST00000445132
RefSeq Acc Id: ENSP00000396736   ⟸   ENST00000421659
Protein Domains

RGD ID:6864188
Promoter ID:EPDNEW_H5259
Type:initiation region
Description:C-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38346,353,860 - 46,353,920EPDNEW
RGD ID:6800738
Promoter ID:HG_KWN:44761
SO ACC ID:SO:0000170
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000344294,   OTTHUMT00000344295,   UC003CPM.2,   UC003CPN.2
Human AssemblyChrPosition (strand)Source
Build 36346,370,224 - 46,370,724 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001123041.2(CCR2):c.190G>A (p.Val64Ile) single nucleotide variant Human immunodeficiency virus type 1, susceptibility to [RCV000008756] Chr3:46357717 [GRCh38]
Chr3:46399208 [GRCh37]
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
NM_001123041.2(CCR2):c.941+102C>T single nucleotide variant not provided [RCV000767918] Chr3:46358570 [GRCh38]
Chr3:46400061 [GRCh37]
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
NM_001123396.3(CCR2):c.*1179G>A single nucleotide variant not provided [RCV000767917] Chr3:46359789 [GRCh38]
Chr3:46401280 [GRCh37]
uncertain significance
NM_001123041.2(CCR2):c.189C>T (p.Val63=) single nucleotide variant not provided [RCV000937622] Chr3:46357716 [GRCh38]
Chr3:46399207 [GRCh37]
likely benign
NM_001123041.2(CCR2):c.378C>T (p.Gly126=) single nucleotide variant not provided [RCV000909239] Chr3:46357905 [GRCh38]
Chr3:46399396 [GRCh37]
likely benign
NM_001123041.2(CCR2):c.156G>T (p.Val52=) single nucleotide variant not provided [RCV000886510] Chr3:46357683 [GRCh38]
Chr3:46399174 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1603 AgrOrtholog
Ensembl Genes ENSG00000121807 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000292301 UniProtKB/Swiss-Prot
  ENSP00000383681 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000396736 UniProtKB/TrEMBL
  ENSP00000399285 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000292301 UniProtKB/Swiss-Prot
  ENST00000400888 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000421659 UniProtKB/TrEMBL
  ENST00000445132 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000121807 GTEx
Human Proteome Map CCR2 Human Proteome Map
InterPro Chemokine_CCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:729230 UniProtKB/Swiss-Prot
OMIM 601267 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26167 PharmGKB
  CHEMOKINER2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CCR2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A0AVQ3 UniProtKB/Swiss-Prot
  B2RMT0 UniProtKB/Swiss-Prot
  O95950 UniProtKB/Swiss-Prot
  Q4VBL2 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CCR2  C-C motif chemokine receptor 2    chemokine (C-C motif) receptor 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 CCR2  chemokine (C-C motif) receptor 2  CCR2  chemokine (C-C motif) receptor 2  Symbol and/or name change 5135510 APPROVED