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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3increases expressionISONos3 (Mus musculus)6480464CTDtelmisartan results in increased expression of NOS3 proteinPMID:21156825
NOS3increases phosphorylationISONos3 (Mus musculus)6480464CTDtelmisartan results in increased phosphorylation of NOS3 proteinPMID:21156825
NOS3multiple interactionsISONos3 (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased phosphorylation of NOS3 protein]PMID:21156825
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