CACNA1H (calcium voltage-gated channel subunit alpha1 H) - Rat Genome Database

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Gene: CACNA1H (calcium voltage-gated channel subunit alpha1 H) Homo sapiens
Analyze
Symbol: CACNA1H
Name: calcium voltage-gated channel subunit alpha1 H
RGD ID: 68993
HGNC Page HGNC
Description: Exhibits low voltage-gated calcium channel activity and scaffold protein binding activity. Involved in several processes, including cation transport; positive regulation of acrosome reaction; and primary alcohol biosynthetic process. Localizes to integral component of plasma membrane. Implicated in childhood absence epilepsy and primary hyperaldosteronism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACNA1HB; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.2; ECA6; EIG6; FLJ90484; HALD4; low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated calcium channel subunit alpha Cav3.2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,153,106 - 1,221,771 (+)EnsemblGRCh38hg38GRCh38
GRCh38161,153,106 - 1,221,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBINCBI36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3-cyanoalanine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamiprid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
amiloride  (EXP,ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
barium(0)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cefaloridine  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
desferrioxamine B  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP)
enzacamene  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
herbimycin  (EXP)
hexamethylene diisocyanate  (EXP)
imidacloprid  (ISO)
leflunomide  (EXP)
linsidomine  (ISO)
methapyrilene  (EXP)
Mibefradil  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP,ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
p-menthan-3-ol  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (EXP)
potassium dichromate  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sunitinib  (EXP)
telmisartan  (ISO)
tributylstannane  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP,ISO)
verapamil  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (EXP)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (EXP)
amiodarone pharmacodynamics pathway  (EXP)
amlodipine pharmacodynamics pathway  (EXP)
atenolol pharmacodynamics pathway  (EXP)
betaxolol pharmacodynamics pathway  (EXP)
bisoprolol pharmacodynamics pathway  (EXP)
bupranolol drug pathway  (EXP)
bupranolol pharmacodynamics pathway  (EXP)
calcium transport pathway  (TAS)
calcium/calcium-mediated signaling pathway  (TAS)
carvedilol pharmacodynamics pathway  (EXP)
diltiazem pharmacodynamics pathway  (EXP)
disopyramide pharmacodynamics pathway  (EXP)
dobutamine pharmacodynamics pathway  (EXP)
esmolol pharmacodynamics pathway  (EXP)
flecainde pharmacodynamics pathway  (EXP)
fosphenytoin pharmacodynamics pathway  (EXP)
ibutilide pharmacodynamics pathway  (EXP)
isoprenaline pharmacodynamics pathway  (EXP)
isradipine pharmacodynamics pathway  (EXP)
levobunolol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
metoprolol pharmacodynamics pathway  (EXP)
mexiletine pharmacodynamics pathway  (EXP)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (EXP)
nebivolol pharmacodynamics pathway  (EXP)
nifedipine pharmacodynamics pathway  (EXP)
nimodipine pharmacodynamics pathway  (EXP)
nisoldipine pharmacodynamics pathway  (EXP)
nitrendipine pharmacodynamics pathway  (EXP)
penbutolol pharmacodynamics pathway  (EXP)
phenytoin pharmacodynamics pathway  (EXP)
pindolol pharmacodynamics pathway  (EXP)
procainamide pharmacodynamics pathway  (EXP)
propranolol pharmacodynamics pathway  (EXP)
quinidine pharmacodynamics pathway  (EXP)
sotalol pharmacodynamics pathway  (EXP)
timolol pharmacodynamics pathway  (EXP)
verapamil pharmacodynamics pathway  (EXP)

References

Additional References at PubMed
PMID:8619474   PMID:9110174   PMID:9670923   PMID:9930755   PMID:10414291   PMID:10861024   PMID:11157797   PMID:11751928   PMID:11799114   PMID:11927664   PMID:12808460   PMID:12853961  
PMID:14529577   PMID:14602827   PMID:14631046   PMID:14729682   PMID:15498803   PMID:15616553   PMID:15833171   PMID:15852375   PMID:16133267   PMID:16301824   PMID:16303743   PMID:16377633  
PMID:16382099   PMID:16443692   PMID:16475676   PMID:16504478   PMID:16565161   PMID:16754686   PMID:16905256   PMID:16973746   PMID:17081983   PMID:17156077   PMID:17215393   PMID:17696120  
PMID:18218623   PMID:18230611   PMID:18309285   PMID:18591418   PMID:18708747   PMID:19131331   PMID:19144837   PMID:19336002   PMID:19342457   PMID:19609347   PMID:19641113   PMID:19903827  
PMID:19948975   PMID:20147652   PMID:20201926   PMID:20394732   PMID:20699644   PMID:21059758   PMID:21084288   PMID:21099341   PMID:21438841   PMID:21788606   PMID:21873635   PMID:22130660  
PMID:22469755   PMID:22564432   PMID:22572848   PMID:22574369   PMID:23111027   PMID:23488970   PMID:23503728   PMID:23602568   PMID:23626738   PMID:23669360   PMID:23671274   PMID:23849427  
PMID:23903007   PMID:23970551   PMID:24277868   PMID:24508802   PMID:25798074   PMID:25889575   PMID:25907736   PMID:25931121   PMID:26216687   PMID:26220996   PMID:26460568   PMID:26483470  
PMID:26488564   PMID:26706850   PMID:26745591   PMID:27130589   PMID:27149520   PMID:27196538   PMID:27258646   PMID:27729216   PMID:28165634   PMID:28298427   PMID:28330839   PMID:28611215  
PMID:28655554   PMID:28846697   PMID:28972185   PMID:29507755   PMID:29581247   PMID:29720258   PMID:29948376   PMID:30686625   PMID:31455361   PMID:31527367   PMID:31744861   PMID:31983310  
PMID:32143681   PMID:32785697  


Genomics

Comparative Map Data
CACNA1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,153,106 - 1,221,771 (+)EnsemblGRCh38hg38GRCh38
GRCh38161,153,106 - 1,221,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBINCBI36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
Cacna1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,593,259 - 25,655,308 (-)NCBIGRCm39mm39
GRCm39 Ensembl1725,593,259 - 25,652,757 (-)Ensembl
GRCm381725,374,285 - 25,436,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,374,285 - 25,433,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,511,232 - 25,570,728 (-)NCBIGRCm37mm9NCBIm37
MGSCv361725,101,887 - 25,161,368 (-)NCBImm8
Celera1725,902,087 - 25,961,468 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Cacna1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,390,104 - 14,448,204 (-)NCBI
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Celera1014,061,778 - 14,119,454 (-)NCBICelera
Cytogenetic Map10q12NCBI
Cacna1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
CACNA1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1161,195,991 - 1,222,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,195,364 - 1,222,917 (+)Ensemblpanpan1.1panPan2
CACNA1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,510,129 - 39,533,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,510,121 - 39,533,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,776,915 - 40,826,321 (-)NCBI
ROS_Cfam_1.0639,855,337 - 39,904,743 (-)NCBI
UMICH_Zoey_3.1639,531,855 - 39,581,243 (-)NCBI
UNSW_CanFamBas_1.0639,504,487 - 39,553,874 (-)NCBI
UU_Cfam_GSD_1.0639,983,132 - 40,032,548 (-)NCBI
Cacna1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,984,951 - 104,007,239 (+)NCBI
SpeTri2.0NW_0049366942,702,224 - 2,724,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,637,436 - 40,694,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,637,420 - 40,694,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CACNA1H
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,039,709 - 1,106,212 (+)NCBI
ChlSab1.1 Ensembl51,078,973 - 1,106,507 (+)Ensembl
Vero_WHO_p1.0NW_02366606829,985,587 - 30,052,739 (-)NCBI
Cacna1h
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249131,926,405 - 1,952,426 (+)NCBI

Position Markers
CACNA1H_1248  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37161,270,804 - 1,271,697UniSTSGRCh37
Build 36161,210,805 - 1,211,698RGDNCBI36
Celera161,486,698 - 1,487,591RGD
HuRef161,203,863 - 1,204,756UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3520
Count of miRNA genes:690
Interacting mature miRNAs:802
Transcripts:ENST00000348261, ENST00000358590, ENST00000562079, ENST00000564231, ENST00000564927, ENST00000564954, ENST00000565831, ENST00000569107, ENST00000569953
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1979 1229 1298 144 129 144 2918 970 1514 135 1180 1251 2 981 1773
Low 386 1200 396 456 610 296 1384 1205 2087 255 208 270 166 1 223 1015 3
Below cutoff 31 558 23 20 727 20 27 14 98 17 42 47 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001005407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005255652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AE006466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF073931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM554380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA335096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD243650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ363526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ363527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ363528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ363529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences