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Gene: AGTR1 (angiotensin II receptor type 1) Homo sapiens
Symbol: AGTR1
Name: angiotensin II receptor type 1
Description: Exhibits angiotensin receptor activity; bradykinin receptor binding activity; and protein heterodimerization activity. Involved in several processes, including intracellular signal transduction; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cellular metabolic process. Localizes to the plasma membrane. Implicated in several diseases, including Alzheimer's disease; artery disease (multiple); cerebrovascular disease (multiple); chronic kidney disease; and sarcoidosis. Biomarker of several diseases, including IgA glomerulonephritis; atrial fibrillation; intermediate coronary syndrome; neurodegenerative disease (multiple); and vesicoureteral reflux.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AG2S; AGTR1A; AGTR1B; angiotensin II receptor, type 1; angiotensin II type-1 receptor; angiotensin receptor 1; angiotensin receptor 1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; type-1 angiotensin II receptor; type-1B angiotensin II receptor
Mus musculus (house mouse) : Agtr1a (angiotensin II receptor, type 1a)  MGI  Alliance
Rattus norvegicus (Norway rat) : Agtr1a (angiotensin II receptor, type 1a)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agtr1 (angiotensin II receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AGTR1 (angiotensin II receptor type 1)
Canis lupus familiaris (dog) : AGTR1 (angiotensin II receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agtr1 (angiotensin II receptor type 1)
Sus scrofa (pig) : AGTR1 (angiotensin II receptor type 1)
Chlorocebus sabaeus (green monkey) : AGTR1 (angiotensin II receptor type 1)
Heterocephalus glaber (naked mole-rat) : Agtr1 (angiotensin II receptor type 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BP24_H   BP36_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3148,697,784 - 148,743,008 (+)Ensembl
GRCh383148,697,871 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373148,415,658 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGTR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68977
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.