AGTR1 (angiotensin II receptor type 1) - Rat Genome Database
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Gene: AGTR1 (angiotensin II receptor type 1) Homo sapiens
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Symbol: AGTR1
Name: angiotensin II receptor type 1
RGD ID: 68977
HGNC Page HGNC
Description: Exhibits angiotensin receptor activity; bradykinin receptor binding activity; and protein heterodimerization activity. Involved in several processes, including intracellular signal transduction; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cellular metabolic process. Localizes to plasma membrane. Implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Biomarker of several diseases, including IgA glomerulonephritis; atrial fibrillation; intermediate coronary syndrome; neurodegenerative disease (multiple); and vesicoureteral reflux.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AG2S; AGTR1A; AGTR1B; angiotensin II receptor, type 1; angiotensin II type-1 receptor; angiotensin receptor 1; angiotensin receptor 1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; type-1 angiotensin II receptor; type-1B angiotensin II receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BP24_H   BP36_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP,ISO)
AIDS-Associated Nephropathy  (ISO)
Allanson Pantzar McLeod Syndrome  (EXP)
Alzheimer's disease  (IEP,IMP)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atrial fibrillation  (IEP)
breast cancer  (IAGP)
breast lobular carcinoma  (ISO)
Cardiac Arrhythmias  (IAGP)
Cardiomegaly  (IMP,ISO)
carotid artery disease  (IAGP)
Carotid Artery Injuries  (ISO)
cerebrovascular disease  (IAGP)
chronic kidney disease  (IAGP,ISO)
congestive heart failure  (EXP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (IAGP,IEA)
Coronary Disease  (IAGP)
COVID-19  (IMP)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (EXP)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Ductal Carcinoma  (ISO)
Endotoxemia  (ISO)
essential hypertension  (IAGP,IMP)
Experimental Liver Cirrhosis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
glomerulosclerosis  (ISO)
glucose intolerance  (ISO)
Huntington's disease  (IEP)
hyperinsulinism  (ISO)
hypertension  (EXP,IAGP,IEA,ISO)
Hypertensive Nephropathy  (ISO)
IgA glomerulonephritis  (IEP)
Inflammation  (ISO)
intermediate coronary syndrome  (IEP)
kidney disease  (EXP,IAGP,ISO)
Left Ventricular Hypertrophy  (IAGP)
Limb Ischemia  (ISO)
lung disease  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Metabolic Syndrome  (IAGP)
myocardial infarction  (IAGP,IEA,ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (EXP)
nephritis  (ISO)
pancreatic ductal carcinoma  (EXP)
Parkinson's disease  (IEP)
patent ductus arteriosus  (EXP)
Pituitary Neoplasms  (EXP)
placental insufficiency  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
proteinuria  (EXP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IAGP)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (IAGP)
renovascular hypertension  (ISO)
sarcoidosis  (IAGP)
Spontaneous Abortions  (EXP)
Vascular System Injuries  (ISO)
Ventricular Remodeling  (ISO)
vesicoureteral reflux  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
amlodipine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
aspartame  (EXP)
ATP  (ISO)
benazepril  (EXP,ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (EXP)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (ISO)
capsaicin  (ISO)
captopril  (ISO)
cholesterol  (ISO)
chromium(6+)  (EXP)
cilazapril monohydrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
corticosterone  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
diisononyl phthalate  (ISO)
diminazene diaceturate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (EXP)
endosulfan  (ISO)
esculetin  (ISO)
estriol  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (EXP,ISO)
glucose  (EXP)
glycochenodeoxycholic acid  (ISO)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
irbesartan  (EXP,ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-ethionine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mevinphos  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Nandrolone decanoate  (ISO)
nickel atom  (EXP)
nicotinamide  (ISO)
nicotine  (ISO)
nitrendipine  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
olmesartan  (EXP)
omeprazole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
phenylarsine oxide  (ISO)
picrotoxin  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregabalin  (ISO)
propanal  (EXP)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
spironolactone  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sucrose  (ISO)
superoxide  (ISO)
telmisartan  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
aging  (ISO)
angiotensin-activated signaling pathway  (IDA,IEA,ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (IC)
brain renin-angiotensin system  (ISO)
calcium-mediated signaling  (IDA)
cell chemotaxis  (IDA)
cellular response to dexamethasone stimulus  (ISO)
dopamine biosynthetic process  (ISO)
drinking behavior  (ISO)
G protein-coupled receptor signaling pathway  (IBA,IDA,ISO,TAS)
heart development  (ISO)
inflammatory response  (IBA,ISO)
kidney development  (IMP,ISO)
low-density lipoprotein particle remodeling  (NAS)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IC)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
phospholipase C-activating angiotensin-activated signaling pathway  (IDA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO,NAS)
positive regulation of blood pressure  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IGI)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein metabolic process  (IMP)
positive regulation of cholesterol esterification  (IMP)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,IDA)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IDA)
positive regulation of inflammatory response  (TAS)
positive regulation of macrophage derived foam cell differentiation  (IC)
positive regulation of NAD(P)H oxidase activity  (TAS)
positive regulation of phospholipase A2 activity  (IMP)
positive regulation of reactive oxygen species metabolic process  (TAS)
positive regulation of receptor recycling  (ISO)
positive regulation of superoxide anion generation  (ISO)
regulation of cell growth  (NAS)
regulation of cell population proliferation  (NAS)
regulation of inflammatory response  (IC)
regulation of pH  (ISO)
regulation of renal output by angiotensin  (ISO)
regulation of renal sodium excretion  (NAS)
regulation of smooth muscle cell apoptotic process  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IC)
regulation of vasoconstriction  (IC,IDA,IEA,NAS)
renin secretion into blood stream  (ISO)
renin-angiotensin regulation of aldosterone production  (ISO,NAS)
response to activity  (ISO)
response to angiotensin  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to salt stress  (ISO)
Rho protein signal transduction  (IDA)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (EXP)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (EXP)
amiodarone pharmacodynamics pathway  (EXP)
amlodipine pharmacodynamics pathway  (EXP)
angiotensin II signaling pathway  (ISO)
angiotensin II signaling pathway via AT1 receptor  (ISO,TAS)
angiotensin III signaling pathway  (ISO)
angiotensin III signaling pathway via AT1 receptor  (ISO)
atenolol pharmacodynamics pathway  (EXP)
benazepril pharmacodynamics pathway  (EXP)
betaxolol pharmacodynamics pathway  (EXP)
bisoprolol pharmacodynamics pathway  (EXP)
bupranolol drug pathway  (EXP)
bupranolol pharmacodynamics pathway  (EXP)
candesartan pharmacodynamics pathway  (EXP)
captopril pharmacodynamics pathway  (EXP)
carvedilol pharmacodynamics pathway  (EXP)
cilazapril pharmacodynamics pathway  (EXP)
diltiazem pharmacodynamics pathway  (EXP)
disopyramide pharmacodynamics pathway  (EXP)
dobutamine pharmacodynamics pathway  (EXP)
enalapril pharmacodynamics pathway  (EXP)
eprosartan pharmacodynamics pathway  (EXP)
esmolol pharmacodynamics pathway  (EXP)
flecainde pharmacodynamics pathway  (EXP)
forasartsn pharmacodynamics pathway  (EXP)
fosinopril pharmacodynamics pathway  (EXP)
fosphenytoin pharmacodynamics pathway  (EXP)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
ibutilide pharmacodynamics pathway  (EXP)
irbesartan pharmacodynamics pathway  (EXP)
isoprenaline pharmacodynamics pathway  (EXP)
isradipine pharmacodynamics pathway  (EXP)
levobunolol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
lisinopril pharmacodynamics pathway  (EXP)
losartan pharmacodynamics pathway  (EXP,TAS)
metoprolol pharmacodynamics pathway  (EXP)
mexiletine pharmacodynamics pathway  (EXP)
moexipril pharmacodynamics pathway  (EXP)
nadolol pharmacodynamics pathway  (EXP)
nebivolol pharmacodynamics pathway  (EXP)
nifedipine pharmacodynamics pathway  (EXP)
nimodipine pharmacodynamics pathway  (EXP)
nisoldipine pharmacodynamics pathway  (EXP)
nitrendipine pharmacodynamics pathway  (EXP)
olmesartan pharmacodynamics pathway  (EXP)
penbutolol pharmacodynamics pathway  (EXP)
perindopril pharmacodynamics pathway  (EXP)
phenytoin pharmacodynamics pathway  (EXP)
pindolol pharmacodynamics pathway  (EXP)
procainamide pharmacodynamics pathway  (EXP)
propranolol pharmacodynamics pathway  (EXP)
quinapril pharmacodynamics pathway  (EXP)
quinidine pharmacodynamics pathway  (EXP)
ramipril pharmacodynamics pathway  (EXP)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (EXP)
spirapril pharmacodynamics pathway  (EXP)
telmisartan pharmacodynamics pathway  (EXP)
timolol pharmacodynamics pathway  (EXP)
trandolapril pharmacodynamics pathway  (EXP)
valsartan pharmacodynamics pathway  (EXP)
verapamil pharmacodynamics pathway  (EXP)

References

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Additional References at PubMed
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PMID:10993080   PMID:11079515   PMID:11081769   PMID:11082147   PMID:11085286   PMID:11106322   PMID:11110972   PMID:11122322   PMID:11136175   PMID:11137090   PMID:11152457   PMID:11158334  
PMID:11208365   PMID:11213892   PMID:11226259   PMID:11246471   PMID:11250978   PMID:11279203   PMID:11288810   PMID:11289708   PMID:11317203   PMID:11324803   PMID:11330506   PMID:11336183  
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PMID:11687736   PMID:11688760   PMID:11689223   PMID:11692158   PMID:11696658   PMID:11696688   PMID:11707217   PMID:11707686   PMID:11709400   PMID:11709801   PMID:11711524   PMID:11733189  
PMID:11752456   PMID:11774217   PMID:11775887   PMID:11776100   PMID:11793101   PMID:11793845   PMID:11798574   PMID:11799082   PMID:11852019   PMID:11865575   PMID:11881039   PMID:11882570  
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Genomics

Comparative Map Data
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
Agtr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBImm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
Agtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,733,942 - 8,781,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,733,942 - 8,781,305 (-)NCBIChiLan1.0ChiLan1.0
AGTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13153,301,331 - 153,346,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,341,947 - 153,345,380 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03145,722,475 - 145,767,550 (+)NCBIMhudiblu_PPA_v0panPan3
AGTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2343,614,035 - 43,616,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12343,569,658 - 43,617,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Agtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBI
Agtr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBI

Position Markers
GDB:251663  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,306 - 148,459,600UniSTSGRCh37
Build 363149,941,996 - 149,942,290RGDNCBI36
Celera3146,869,647 - 146,869,941RGD
Cytogenetic Map3q24UniSTS
HuRef3145,831,679 - 145,831,973UniSTS
GDB:438967  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,879 - 148,460,418UniSTSGRCh37
Build 363149,942,569 - 149,943,108RGDNCBI36
Celera3146,870,220 - 146,870,759RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,252 - 145,832,791UniSTS
GDB:455679  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,973 - 148,460,172UniSTSGRCh37
Build 363149,942,663 - 149,942,862RGDNCBI36
Celera3146,870,314 - 146,870,513RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,346 - 145,832,545UniSTS
SHGC-145843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,436,375 - 148,436,711UniSTSGRCh37
Build 363149,919,065 - 149,919,401RGDNCBI36
Celera3146,846,716 - 146,847,052RGD
Cytogenetic Map3q24UniSTS
HuRef3145,808,748 - 145,809,084UniSTS
TNG Radiation Hybrid Map384063.0UniSTS
RH17842  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,460,564 - 148,460,755UniSTSGRCh37
Build 363149,943,254 - 149,943,445RGDNCBI36
Celera3146,870,905 - 146,871,096RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,937 - 145,833,128UniSTS
GeneMap99-GB4 RH Map3542.39UniSTS
PMC310924P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,841 - 148,460,017UniSTSGRCh37
Build 363149,942,531 - 149,942,707RGDNCBI36
Celera3146,870,182 - 146,870,358RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,214 - 145,832,390UniSTS
PMC55900P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,792 - 148,460,211UniSTSGRCh37
Build 363149,942,482 - 149,942,901RGDNCBI36
Celera3146,870,133 - 146,870,552RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,165 - 145,832,584UniSTS
SHGC-12732  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,459,959 - 148,460,284UniSTSGRCh37
Build 363149,942,649 - 149,942,974RGDNCBI36
Celera3146,870,300 - 146,870,625RGD
Cytogenetic Map3q24UniSTS
HuRef3145,832,332 - 145,832,657UniSTS
Stanford-G3 RH Map36745.0UniSTS
GeneMap99-G3 RH Map37215.0UniSTS
RH11116  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,415,702 - 148,415,979UniSTSGRCh37
GRCh373148,414,669 - 148,415,979UniSTSGRCh37
Build 363149,898,392 - 149,898,669RGDNCBI36
Celera3146,825,011 - 146,826,321UniSTS
Celera3146,826,044 - 146,826,321RGD
Cytogenetic Map3q21-q25UniSTS
Cytogenetic Map3q24UniSTS
HuRef3145,788,075 - 145,788,352UniSTS
HuRef3145,787,042 - 145,788,352UniSTS
GeneMap99-GB4 RH Map13312.01UniSTS
NCBI RH Map131041.4UniSTS
RH48548  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,455,199 - 148,455,378UniSTSGRCh37
Build 363149,937,889 - 149,938,068RGDNCBI36
Celera3146,865,540 - 146,865,719RGD
Cytogenetic Map3q24UniSTS
HuRef3145,827,572 - 145,827,751UniSTS
GeneMap99-GB4 RH Map3534.53UniSTS
MARC_14779-14780:1010671130:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373148,458,955 - 148,459,456UniSTSGRCh37
Build 363149,941,645 - 149,942,146RGDNCBI36
Celera3146,869,296 - 146,869,797RGD
HuRef3145,831,328 - 145,831,829UniSTS
SGC38226  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q24UniSTS
HuRef3145,805,547 - 145,805,797UniSTS
GeneMap99-GB4 RH Map3536.18UniSTS
Whitehead-RH Map3669.3UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR155hsa-miR-155-5pOncomiRDBexternal_infoNANA19177201
MIR155hsa-miR-155-3pMirecordsexternal_info{unchanged}NA16675453
MIR155hsa-miR-155-3pMirecordsexternal_info{unchanged}{unchanged}NA17588946
MIR155hsa-miR-155-3pMirecordsexternal_infoNANA17668390
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI17668390
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//Real time PCR//ReporterFunctional MTI17588946
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Quantitative pFunctional MTI20735984
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI16675453
MIR155hsa-miR-155-5pMirtarbaseexternal_infoWestern blotFunctional MTI21310411

Predicted Target Of
Summary Value
Count of predictions:2638
Count of miRNA genes:361
Interacting mature miRNAs:376
Transcripts:ENST00000349243, ENST00000402260, ENST00000404754, ENST00000418473, ENST00000461609, ENST00000474935, ENST00000475166, ENST00000475347, ENST00000497524, ENST00000542281
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 946 601 1206 407 52 398 2128 416 399 109 160 892 10 1187 1277 1
Low 1266 1604 458 198 443 50 1953 1708 921 220 1077 475 149 17 1510 1
Below cutoff 83 584 43 12 647 10 179 35 2347 52 101 95 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC024897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF245699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI016286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI240900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV651073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY221090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY436325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA649921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M87290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000349243   ⟹   ENSP00000273430
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,697,871 - 148,743,003 (+)Ensembl
RefSeq Acc Id: ENST00000402260   ⟹   ENSP00000385641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,739,798 - 148,743,001 (+)Ensembl
RefSeq Acc Id: ENST00000404754   ⟹   ENSP00000385612
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,697,918 - 148,743,008 (+)Ensembl
RefSeq Acc Id: ENST00000418473   ⟹   ENSP00000398832
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,730,180 - 148,743,001 (+)Ensembl
RefSeq Acc Id: ENST00000461609   ⟹   ENSP00000418851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,730,124 - 148,742,247 (+)Ensembl
RefSeq Acc Id: ENST00000474935   ⟹   ENSP00000418084
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,730,100 - 148,742,247 (+)Ensembl
RefSeq Acc Id: ENST00000475166
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,698,175 - 148,731,497 (+)Ensembl
RefSeq Acc Id: ENST00000475347   ⟹   ENSP00000419783
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,730,100 - 148,742,247 (+)Ensembl
RefSeq Acc Id: ENST00000497524   ⟹   ENSP00000419422
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3148,697,784 - 148,743,003 (+)Ensembl
RefSeq Acc Id: NM_000685   ⟹   NP_000676
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
GRCh373148,415,658 - 148,460,790 (+)ENTREZGENE
Build 363149,898,348 - 149,943,480 (+)NCBI Archive
HuRef3145,788,031 - 145,833,163 (+)ENTREZGENE
CHM1_13148,378,782 - 148,423,918 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382736   ⟹   NP_001369665
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
RefSeq Acc Id: NM_001382737   ⟹   NP_001369666
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
RefSeq Acc Id: NM_004835   ⟹   NP_004826
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
GRCh373148,415,658 - 148,460,790 (+)ENTREZGENE
Build 363149,898,348 - 149,943,480 (+)NCBI Archive
HuRef3145,788,031 - 145,833,163 (+)ENTREZGENE
CHM1_13148,378,782 - 148,423,918 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009585   ⟹   NP_033611
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
GRCh373148,415,658 - 148,460,790 (+)ENTREZGENE
Build 363149,898,348 - 149,943,480 (+)NCBI Archive
HuRef3145,788,031 - 145,833,163 (+)ENTREZGENE
CHM1_13148,378,782 - 148,423,918 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031850   ⟹   NP_114038
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
GRCh373148,415,658 - 148,460,790 (+)ENTREZGENE
Build 363149,898,348 - 149,943,480 (+)NCBI Archive
HuRef3145,788,031 - 145,833,163 (+)ENTREZGENE
CHM1_13148,378,782 - 148,423,918 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032049   ⟹   NP_114438
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,743,003 (+)NCBI
GRCh373148,415,658 - 148,460,790 (+)ENTREZGENE
Build 363149,930,657 - 149,943,480 (+)NCBI Archive
HuRef3145,788,031 - 145,833,163 (+)ENTREZGENE
CHM1_13148,411,095 - 148,423,918 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000676 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369665 (Get FASTA)   NCBI Sequence Viewer  
  NP_001369666 (Get FASTA)   NCBI Sequence Viewer  
  NP_004826 (Get FASTA)   NCBI Sequence Viewer  
  NP_033611 (Get FASTA)   NCBI Sequence Viewer  
  NP_114038 (Get FASTA)   NCBI Sequence Viewer  
  NP_114438 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35535 (Get FASTA)   NCBI Sequence Viewer  
  AAA35569 (Get FASTA)   NCBI Sequence Viewer  
  AAA58370 (Get FASTA)   NCBI Sequence Viewer  
  AAB34644 (Get FASTA)   NCBI Sequence Viewer  
  AAB35647 (Get FASTA)   NCBI Sequence Viewer  
  AAF70464 (Get FASTA)   NCBI Sequence Viewer  
  AAH22447 (Get FASTA)   NCBI Sequence Viewer  
  AAH68494 (Get FASTA)   NCBI Sequence Viewer  
  AAO65968 (Get FASTA)   NCBI Sequence Viewer  
  AAR03503 (Get FASTA)   NCBI Sequence Viewer  
  ABY87526 (Get FASTA)   NCBI Sequence Viewer  
  BAA02968 (Get FASTA)   NCBI Sequence Viewer  
  BAF84230 (Get FASTA)   NCBI Sequence Viewer  
  CAA46621 (Get FASTA)   NCBI Sequence Viewer  
  CAA77513 (Get FASTA)   NCBI Sequence Viewer  
  EAW78905 (Get FASTA)   NCBI Sequence Viewer  
  EAW78906 (Get FASTA)   NCBI Sequence Viewer  
  EAW78907 (Get FASTA)   NCBI Sequence Viewer  
  EAW78908 (Get FASTA)   NCBI Sequence Viewer  
  EAW78909 (Get FASTA)   NCBI Sequence Viewer  
  P30556 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_114038   ⟸   NM_031850
- Sequence:
RefSeq Acc Id: NP_000676   ⟸   NM_000685
- UniProtKB: P30556 (UniProtKB/Swiss-Prot),   Q53YY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004826   ⟸   NM_004835
- Sequence:
RefSeq Acc Id: NP_033611   ⟸   NM_009585
- UniProtKB: P30556 (UniProtKB/Swiss-Prot),   Q53YY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_114438   ⟸   NM_032049
- Sequence:
RefSeq Acc Id: NP_001369666   ⟸   NM_001382737
RefSeq Acc Id: NP_001369665   ⟸   NM_001382736
RefSeq Acc Id: ENSP00000273430   ⟸   ENST00000349243
RefSeq Acc Id: ENSP00000385641   ⟸   ENST00000402260
RefSeq Acc Id: ENSP00000398832   ⟸   ENST00000418473
RefSeq Acc Id: ENSP00000385612   ⟸   ENST00000404754
RefSeq Acc Id: ENSP00000419422   ⟸   ENST00000497524
RefSeq Acc Id: ENSP00000418084   ⟸   ENST00000474935
RefSeq Acc Id: ENSP00000419783   ⟸   ENST00000475347
RefSeq Acc Id: ENSP00000418851   ⟸   ENST00000461609
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AT1a I-TASSER model P30556 1-359 view protein structure  

Promoters
RGD ID:6865938
Promoter ID:EPDNEW_H6133
Type:multiple initiation site
Name:AGTR1_2
Description:angiotensin II receptor type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6134  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,653 - 148,697,713EPDNEW
RGD ID:6865940
Promoter ID:EPDNEW_H6134
Type:initiation region
Name:AGTR1_1
Description:angiotensin II receptor type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H6133  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383148,697,903 - 148,697,963EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_031850.3(AGTR1):c.*86A>C single nucleotide variant Hypertension, essential, susceptibility to [RCV000019688]|Renal dysplasia [RCV000374969] Chr3:148742201 [GRCh38]
Chr3:148459988 [GRCh37]
Chr3:3q24
risk factor|benign
NM_000685.4(AGTR1):c.110dup (p.Ile38fs) duplication Renal dysplasia [RCV000019689] Chr3:148741144..148741145 [GRCh38]
Chr3:148458931..148458932 [GRCh37]
Chr3:3q24
pathogenic
NM_000685.4(AGTR1):c.845C>T (p.Thr282Met) single nucleotide variant Renal dysplasia [RCV000019690] Chr3:148741880 [GRCh38]
Chr3:148459667 [GRCh37]
Chr3:3q24
pathogenic
NM_000685.4(AGTR1):c.376C>T (p.Arg126Ter) single nucleotide variant Renal dysplasia [RCV000043469] Chr3:148741411 [GRCh38]
Chr3:148459198 [GRCh37]
Chr3:3q24
pathogenic
NM_031850.3(AGTR1):c.356G>A (p.Trp119Ter) single nucleotide variant Renal dysplasia [RCV000043468] Chr3:148741286 [GRCh38]
Chr3:148459073 [GRCh37]
Chr3:3q24
pathogenic|likely pathogenic|conflicting interpretations of pathogenicity|uncertain significance
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q22.2-25.1(chr3:134257180-149729538)x1 copy number loss See cases [RCV000138135] Chr3:134257180..149729538 [GRCh38]
Chr3:133976022..149447325 [GRCh37]
Chr3:135458712..150930015 [NCBI36]
Chr3:3q22.2-25.1
pathogenic|likely benign
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29
pathogenic
NM_031850.3(AGTR1):c.*135C>T single nucleotide variant Renal dysplasia [RCV000261670] Chr3:148742250 [GRCh38]
Chr3:148460037 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.-339T>G single nucleotide variant Renal dysplasia [RCV000267765] Chr3:148697873 [GRCh38]
Chr3:148415660 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-192G>T single nucleotide variant Renal dysplasia [RCV000278792] Chr3:148698020 [GRCh38]
Chr3:148415807 [GRCh37]
Chr3:3q24
likely benign|uncertain significance
NM_031850.3(AGTR1):c.998A>G (p.Asn333Ser) single nucleotide variant Renal dysplasia [RCV000266272] Chr3:148741928 [GRCh38]
Chr3:148459715 [GRCh37]
Chr3:3q24
uncertain significance
NM_000685.4(AGTR1):c.1062A>G (p.Pro354=) single nucleotide variant Renal dysplasia [RCV000260416]|not specified [RCV000243429] Chr3:148742097 [GRCh38]
Chr3:148459884 [GRCh37]
Chr3:3q24
benign
NM_000685.4(AGTR1):c.573C>T (p.Leu191=) single nucleotide variant Renal dysplasia [RCV000392743]|not specified [RCV000248373] Chr3:148741608 [GRCh38]
Chr3:148459395 [GRCh37]
Chr3:3q24
benign
NM_031850.3(AGTR1):c.445G>A (p.Ala149Thr) single nucleotide variant Renal dysplasia [RCV000314268] Chr3:148741375 [GRCh38]
Chr3:148459162 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*362G>A single nucleotide variant Renal dysplasia [RCV000333971] Chr3:148742477 [GRCh38]
Chr3:148460264 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*70T>G single nucleotide variant Renal dysplasia [RCV000315608] Chr3:148742185 [GRCh38]
Chr3:148459972 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.413T>C (p.Ile138Thr) single nucleotide variant Renal dysplasia [RCV000399815] Chr3:148741343 [GRCh38]
Chr3:148459130 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*798G>A single nucleotide variant Renal dysplasia [RCV000401559] Chr3:148742913 [GRCh38]
Chr3:148460700 [GRCh37]
Chr3:3q24
benign
NM_031850.3(AGTR1):c.1047C>T (p.Leu349=) single nucleotide variant Renal dysplasia [RCV000302585] Chr3:148741977 [GRCh38]
Chr3:148459764 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*461C>A single nucleotide variant Renal dysplasia [RCV000289445] Chr3:148742576 [GRCh38]
Chr3:148460363 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.-137C>A single nucleotide variant Renal dysplasia [RCV000338548] Chr3:148698075 [GRCh38]
Chr3:148415862 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.*437G>T single nucleotide variant Renal dysplasia [RCV000381534] Chr3:148742552 [GRCh38]
Chr3:148460339 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.1113G>A (p.Thr371=) single nucleotide variant Renal dysplasia [RCV000361974] Chr3:148742043 [GRCh38]
Chr3:148459830 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-329G>T single nucleotide variant Renal dysplasia [RCV000323444] Chr3:148697883 [GRCh38]
Chr3:148415670 [GRCh37]
Chr3:3q24
benign|uncertain significance
NM_031850.3(AGTR1):c.*317G>A single nucleotide variant Renal dysplasia [RCV000385487] Chr3:148742432 [GRCh38]
Chr3:148460219 [GRCh37]
Chr3:3q24
benign|likely benign
NM_031850.3(AGTR1):c.275T>C (p.Met92Thr) single nucleotide variant Renal dysplasia [RCV000293905] Chr3:148741205 [GRCh38]
Chr3:148458992 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.532C>A (p.Leu178Ile) single nucleotide variant Renal dysplasia [RCV000345798] Chr3:148741462 [GRCh38]
Chr3:148459249 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*335A>T single nucleotide variant Renal dysplasia [RCV000295423] Chr3:148742450 [GRCh38]
Chr3:148460237 [GRCh37]
Chr3:3q24
uncertain significance
NM_000685.4(AGTR1):c.284_291del (p.Pro95fs) deletion not provided [RCV000722621] Chr3:148741315..148741322 [GRCh38]
Chr3:148459102..148459109 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*251G>A single nucleotide variant Renal dysplasia [RCV000330933] Chr3:148742366 [GRCh38]
Chr3:148460153 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*463A>G single nucleotide variant Renal dysplasia [RCV000346632] Chr3:148742578 [GRCh38]
Chr3:148460365 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.869C>T (p.Pro290Leu) single nucleotide variant Renal dysplasia [RCV000365536] Chr3:148741799 [GRCh38]
Chr3:148459586 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-284C>G single nucleotide variant Renal dysplasia [RCV000373386] Chr3:148697928 [GRCh38]
Chr3:148415715 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.714T>C (p.Gly238=) single nucleotide variant Renal dysplasia [RCV000310631] Chr3:148741644 [GRCh38]
Chr3:148459431 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.257T>C (p.Ile86Thr) single nucleotide variant Renal dysplasia [RCV000374387] Chr3:148741187 [GRCh38]
Chr3:148458974 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*899T>G single nucleotide variant Renal dysplasia [RCV000277321] Chr3:148743014 [GRCh38]
Chr3:148460801 [GRCh37]
Chr3:3q24
likely benign
NM_000685.4(AGTR1):c.941T>G (p.Leu314Arg) single nucleotide variant not provided [RCV000734441] Chr3:148741976 [GRCh38]
Chr3:148459763 [GRCh37]
Chr3:3q24
uncertain significance
GRCh37/hg19 3q24-25.2(chr3:148425748-153220169)x1 copy number loss See cases [RCV000447056] Chr3:148425748..153220169 [GRCh37]
Chr3:3q24-25.2
pathogenic
GRCh37/hg19 3q24-26.2(chr3:147180945-168415875)x1 copy number loss See cases [RCV000448130] Chr3:147180945..168415875 [GRCh37]
Chr3:3q24-26.2
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_031850.3(AGTR1):c.1164A>C (p.Ala388=) single nucleotide variant not provided [RCV000925644] Chr3:148742094 [GRCh38]
Chr3:148459881 [GRCh37]
Chr3:3q24
likely benign
NM_031850.3(AGTR1):c.298G>A (p.Val100Ile) single nucleotide variant Renal dysplasia [RCV001149672]|not provided [RCV000901265] Chr3:148741228 [GRCh38]
Chr3:148459015 [GRCh37]
Chr3:3q24
likely benign
NM_031850.3(AGTR1):c.681G>A (p.Pro227=) single nucleotide variant not provided [RCV000943142] Chr3:148741611 [GRCh38]
Chr3:148459398 [GRCh37]
Chr3:3q24
likely benign
GRCh37/hg19 3q24-25.1(chr3:144053029-150272658)x1 copy number loss not provided [RCV001005476] Chr3:144053029..150272658 [GRCh37]
Chr3:3q24-25.1
likely pathogenic
NM_031850.3(AGTR1):c.*40A>T single nucleotide variant Renal dysplasia [RCV001147301] Chr3:148742155 [GRCh38]
Chr3:148459942 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*229C>T single nucleotide variant Renal dysplasia [RCV001148223] Chr3:148742344 [GRCh38]
Chr3:148460131 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*556T>C single nucleotide variant Renal dysplasia [RCV001149773] Chr3:148742671 [GRCh38]
Chr3:148460458 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-306C>G single nucleotide variant Renal dysplasia [RCV001148115] Chr3:148697906 [GRCh38]
Chr3:148415693 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-180T>C single nucleotide variant Renal dysplasia [RCV001148116] Chr3:148698032 [GRCh38]
Chr3:148415819 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.-68A>G single nucleotide variant Renal dysplasia [RCV001148117] Chr3:148707960 [GRCh38]
Chr3:148425747 [GRCh37]
Chr3:3q24
uncertain significance
GRCh37/hg19 3q24(chr3:146996270-148622676)x1 copy number loss not provided [RCV000845962] Chr3:146996270..148622676 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*93A>G single nucleotide variant Renal dysplasia [RCV001147303] Chr3:148742208 [GRCh38]
Chr3:148459995 [GRCh37]
Chr3:3q24
benign
NM_031850.3(AGTR1):c.592G>A (p.Ala198Thr) single nucleotide variant Renal dysplasia [RCV001145355]|not provided [RCV000889099] Chr3:148741522 [GRCh38]
Chr3:148459309 [GRCh37]
Chr3:3q24
likely benign
NM_031850.3(AGTR1):c.835G>T (p.Ala279Ser) single nucleotide variant Renal dysplasia [RCV001145358]|not provided [RCV000953205] Chr3:148741765 [GRCh38]
Chr3:148459552 [GRCh37]
Chr3:3q24
benign
NM_031850.3(AGTR1):c.90G>A (p.Ser30=) single nucleotide variant Renal dysplasia [RCV001149670]|not provided [RCV000907538] Chr3:148741020 [GRCh38]
Chr3:148458807 [GRCh37]
Chr3:3q24
likely benign|uncertain significance
NM_031850.3(AGTR1):c.403C>T (p.Leu135=) single nucleotide variant not provided [RCV000943438] Chr3:148741333 [GRCh38]
Chr3:148459120 [GRCh37]
Chr3:3q24
likely benign
NM_031850.3(AGTR1):c.-1+7G>A single nucleotide variant Renal dysplasia [RCV001148118] Chr3:148708034 [GRCh38]
Chr3:148425821 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*432G>A single nucleotide variant Renal dysplasia [RCV001148224] Chr3:148742547 [GRCh38]
Chr3:148460334 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.513C>A (p.Ser171=) single nucleotide variant not provided [RCV000911609] Chr3:148741443 [GRCh38]
Chr3:148459230 [GRCh37]
Chr3:3q24
likely benign
NM_031850.3(AGTR1):c.605G>A (p.Arg202Gln) single nucleotide variant Renal dysplasia [RCV001145356] Chr3:148741535 [GRCh38]
Chr3:148459322 [GRCh37]
Chr3:3q24
uncertain significance
GRCh37/hg19 3q22.3-26.1(chr3:138145289-162275610)x3 copy number gain See cases [RCV001194586] Chr3:138145289..162275610 [GRCh37]
Chr3:3q22.3-26.1
pathogenic
NM_031850.3(AGTR1):c.*593G>A single nucleotide variant Renal dysplasia [RCV001149775] Chr3:148742708 [GRCh38]
Chr3:148460495 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*672G>C single nucleotide variant Renal dysplasia [RCV001149776] Chr3:148742787 [GRCh38]
Chr3:148460574 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.218T>C (p.Ile73Thr) single nucleotide variant Renal dysplasia [RCV001149671] Chr3:148741148 [GRCh38]
Chr3:148458935 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*584C>T single nucleotide variant Renal dysplasia [RCV001149774] Chr3:148742699 [GRCh38]
Chr3:148460486 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.920G>C (p.Arg307Pro) single nucleotide variant Renal dysplasia [RCV001145359] Chr3:148741850 [GRCh38]
Chr3:148459637 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*816C>A single nucleotide variant Renal dysplasia [RCV001143878] Chr3:148742931 [GRCh38]
Chr3:148460718 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*883T>C single nucleotide variant Renal dysplasia [RCV001143879] Chr3:148742998 [GRCh38]
Chr3:148460785 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*902A>G single nucleotide variant Renal dysplasia [RCV001143880] Chr3:148743017 [GRCh38]
Chr3:148460804 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.802C>A (p.Pro268Thr) single nucleotide variant Renal dysplasia [RCV001145357] Chr3:148741732 [GRCh38]
Chr3:148459519 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*48G>A single nucleotide variant Renal dysplasia [RCV001147302] Chr3:148742163 [GRCh38]
Chr3:148459950 [GRCh37]
Chr3:3q24
uncertain significance
NM_031850.3(AGTR1):c.*178G>A single nucleotide variant Renal dysplasia [RCV001148222] Chr3:148742293 [GRCh38]
Chr3:148460080 [GRCh37]
Chr3:3q24
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:336 AgrOrtholog
COSMIC AGTR1 COSMIC
Ensembl Genes ENSG00000144891 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000273430 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385612 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385641 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000398832 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000418084 UniProtKB/Swiss-Prot
  ENSP00000418851 UniProtKB/Swiss-Prot
  ENSP00000419422 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000419783 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000349243 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000402260 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000404754 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000418473 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000461609 UniProtKB/Swiss-Prot
  ENST00000474935 UniProtKB/Swiss-Prot
  ENST00000475347 UniProtKB/Swiss-Prot
  ENST00000497524 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000144891 GTEx
HGNC ID HGNC:336 ENTREZGENE
Human Proteome Map AGTR1 Human Proteome Map
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:185 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 185 ENTREZGENE
OMIM 106165 OMIM
  145500 OMIM
  267430 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGTR1 RGD, PharmGKB
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGIOTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MSE3_HUMAN UniProtKB/TrEMBL
  AGTR1_HUMAN UniProtKB/Swiss-Prot
  D3DNG8_HUMAN UniProtKB/TrEMBL
  P30556 ENTREZGENE
  Q53YY0 ENTREZGENE, UniProtKB/TrEMBL
  Q6NUP5_HUMAN UniProtKB/TrEMBL
UniProt Secondary A0A0A0MSP9 UniProtKB/TrEMBL
  D3DNG9 UniProtKB/TrEMBL
  Q13725 UniProtKB/Swiss-Prot
  Q8TBK4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 AGTR1  angiotensin II receptor type 1    angiotensin II receptor, type 1  Symbol and/or name change 5135510 APPROVED