CRH (corticotropin releasing hormone) - Rat Genome Database

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Gene: CRH (corticotropin releasing hormone) Homo sapiens
Analyze
Symbol: CRH
Name: corticotropin releasing hormone
RGD ID: 730946
HGNC Page HGNC:2355
Description: Predicted to enable corticotropin-releasing hormone activity. Involved in several processes, including dopaminergic synaptic transmission; positive regulation of hormone secretion; and regulation of NMDA receptor activity. Located in extracellular space. Implicated in obesity and panic disorder. Biomarker of Alzheimer's disease; Parkinson's disease; and brain edema.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: corticoliberin; corticotropin-releasing factor; corticotropin-releasing hormone; CRF; CRH1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BP49_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dichlorophenol  (EXP)
2-arachidonoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenoxybenzoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
8-Br-cAMP  (ISO)
8-OH-DPAT  (ISO)
acephate  (ISO)
acetylcholine  (ISO)
adinazolam  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenous acid  (EXP)
astemizole  (ISO)
astressin  (ISO)
atropine  (EXP,ISO)
benzo[a]pyrene  (EXP)
beta-endorphin  (ISO)
beta-naphthoflavone  (EXP)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cannabidiol  (ISO)
carbon dioxide  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cis-caffeic acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
corticotropin  (ISO)
cortisol  (EXP)
Cuprizon  (ISO)
cyanamide  (ISO)
cyclohexane  (ISO)
cyclophosphamide  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diprotium oxide  (ISO)
dorsomorphin  (EXP)
doxapram  (ISO)
dynorphin A  (ISO)
E-4031  (ISO)
enzacamene  (ISO)
ethanol  (ISO)
fentanyl  (ISO)
finasteride  (EXP)
flavonoids  (ISO)
fluoxetine  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
glycidol  (ISO)
Goe 6976  (EXP)
GTP  (ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (ISO)
haloperidol  (EXP)
hemin  (EXP)
hydrogen peroxide  (EXP)
idazoxan  (ISO)
imipramine  (ISO)
indometacin  (ISO)
ketamine  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mesoporphyrin IX  (EXP)
metamizole sodium  (ISO)
methamidophos  (ISO)
methamphetamine  (ISO)
methoxamine  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
naloxone  (ISO)
naltrexone  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
Phenelzine  (ISO)
phenytoin  (ISO)
pioglitazone  (EXP)
prednisolone  (ISO)
progesterone  (EXP,ISO)
promazine  (EXP)
propranolol  (ISO)
quercetin  (ISO)
reserpine  (ISO)
rimonabant  (ISO)
risperidone  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
serotonin  (ISO)
sertraline  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
Soman  (ISO)
sphingosine  (ISO)
staurosporine  (ISO)
Sulpyrine  (ISO)
telmisartan  (ISO)
terbutaline  (EXP)
testosterone  (ISO)
tetraethylammonium  (ISO)
tetrodotoxin  (EXP)
thioridazine  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
valproic acid  (EXP)
vanadyl sulfate  (EXP)
water  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
associative learning  (IEA,ISO)
cellular response to cocaine  (IEA)
cellular response to dexamethasone stimulus  (IEA,ISO)
chemical synaptic transmission  (TAS)
diterpenoid metabolic process  (IEA,ISO)
female pregnancy  (IDA,TAS)
glucocorticoid biosynthetic process  (IEA,ISO)
hormone-mediated apoptotic signaling pathway  (IEA,ISO)
hypothalamus development  (IEA,ISO)
inflammatory response  (IDA,IEA,ISO)
learning or memory  (IEA,ISO,TAS)
locomotory exploration behavior  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung development  (IEA,ISO)
monoatomic ion homeostasis  (IEA,ISO)
negative regulation of circadian sleep/wake cycle, REM sleep  (NAS)
negative regulation of epinephrine secretion  (IBA,IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucagon secretion  (IBA,IEA,ISO)
negative regulation of luteinizing hormone secretion  (IEA,ISO)
negative regulation of norepinephrine secretion  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
parturition  (TAS)
positive regulation of behavioral fear response  (IEA,ISO)
positive regulation of calcium ion import  (IEA,ISO)
positive regulation of cAMP-mediated signaling  (IEA)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular process  (ISO)
positive regulation of circadian sleep/wake cycle, wakefulness  (NAS)
positive regulation of corticosterone secretion  (IEA,ISO)
positive regulation of corticotropin secretion  (IDA,IEA,ISO)
positive regulation of cortisol secretion  (IBA,IDA)
positive regulation of digestive system process  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of NMDA receptor activity  (IDA,IEA)
regulation of serotonin secretion  (IEA,ISO)
response to alcohol  (IEA,ISO)
response to aldosterone  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to corticosterone  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to ether  (IEA,ISO)
response to immobilization stress  (IEA,ISO)
response to pain  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
signal transduction  (TAS)
steroid metabolic process  (IEA,ISO)
synaptic transmission, dopaminergic  (IDA,IEA)

Cellular Component
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA,ISO)
neuronal cell body  (IEA,ISO)
neuronal dense core vesicle lumen  (IEA,ISO)
perikaryon  (IEA,ISO)
synapse  (IEA)
varicosity  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Behan DP, etal., Nature. 1995 Nov 16;378(6554):284-7.
2. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
3. Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer's disease and other human disorders. De Souza EB, etal., Ann N Y Acad Sci. 1987;512:237-47.
4. Potential signalling pathways underlying corticotrophin-releasing hormone-mediated neuroprotection from excitotoxicity in rat hippocampus. Elliott-Hunt CR, etal., J Neurochem 2002 Feb;80(3):416-25.
5. Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. Esposito P, etal., Brain Res 2003 Apr 11;968(2):192-8.
6. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
7. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
8. Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Flanagan DE, etal., Diabetes 2003 Mar;52(3):605-13.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. Gonzalez-Gay MA, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):133-8.
11. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Heinrichs SC, etal., Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.
12. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
13. Diurnal changes in corticotropin-releasing hormone messenger RNA in the rat thalamus. Hsu DT, etal., Neurosci Lett 2003 Feb 20;338(1):33-6.
14. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. Liu L, etal., PLoS One. 2011 May 12;6(5):e19498.
15. Role of corticotropin-releasing hormone in ovarian steroidogenesis. Murase M, etal., Endocrine 2002 Aug;18(3):255-60.
16. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Corticotropin-releasing hormone and proopiomelanocortin gene expression is altered selectively in the male rat fetal thymus by maternal alcohol consumption. Revskoy S, etal., Endocrinology. 1997 Jan;138(1):389-96. doi: 10.1210/endo.138.1.4838.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
22. Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats. Richardson RD, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1321-6.
23. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Roberto M, etal., Biol Psychiatry. 2010 May 1;67(9):831-9. Epub 2010 Jan 8.
24. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Roozendaal B, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13908-13.
25. Experimental neuropathy increases limbic forebrain CRF. Rouwette T, etal., Eur J Pain. 2011 Jun 17.
26. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Samarghandian S, etal., Neuroscience 2003;116(2):519-24.
27. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. Schwartz MW, etal., Regul Pept. 1997 Oct 31;72(2-3):105-12.
28. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
29. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Smoller JW, etal., Biol Psychiatry 2003 Dec 15;54(12):1376-81.
30. Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. Swain MG, etal., J Clin Invest. 1993 May;91(5):1903-8.
31. Central alpha-adrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress. Tan Y, etal., Brain Res 2003 Apr 4;968(1):122-9.
32. The function of the adrenocortical axis in permanent middle cerebral artery occlusion: effect of glucocorticoids on the neurological outcome. Weidenfeld J, etal., Brain Res. 2011 Aug 17;1407:90-6. Epub 2011 Jun 23.
33. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
34. Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Wong ML, etal., Neuroreport. 1995 Sep 11;6(13):1785-8.
35. Corticotrophin-releasing hormone (CRH) facilitates axon outgrowth. Yuan H, etal., Spinal Cord. 2010 Dec;48(12):850-6. Epub 2010 May 11.
36. [The relationship of ultrastructure and function of hypothalamus-pituitary-adrenal axis in early stage of sepsis in rats]. Zhang YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 May;23(5):286-9.
37. Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Zhou Y, etal., Brain Res Mol Brain Res. 2003 May 26;114(1):73-9.
Additional References at PubMed
PMID:2365075   PMID:2783917   PMID:3259914   PMID:3262120   PMID:6605851   PMID:7489943   PMID:7585095   PMID:7589495   PMID:7867564   PMID:8161822   PMID:8243338   PMID:8386360  
PMID:9178757   PMID:9423932   PMID:9620773   PMID:9783915   PMID:10598591   PMID:10822340   PMID:11140838   PMID:11168450   PMID:11182747   PMID:11329063   PMID:11341487   PMID:11406119  
PMID:11511529   PMID:11555839   PMID:11854458   PMID:11932939   PMID:11936276   PMID:12011471   PMID:12036966   PMID:12062896   PMID:12114295   PMID:12154211   PMID:12477932   PMID:12583606  
PMID:12679466   PMID:12734882   PMID:12784189   PMID:12853091   PMID:12895416   PMID:14573312   PMID:14576187   PMID:14667971   PMID:14675201   PMID:14698679   PMID:14706771   PMID:15072543  
PMID:15077295   PMID:15126558   PMID:15468147   PMID:15489334   PMID:15591024   PMID:15816833   PMID:15883387   PMID:16222669   PMID:16245303   PMID:16303743   PMID:16309788   PMID:16446741  
PMID:16523405   PMID:16639867   PMID:16675846   PMID:16734917   PMID:16740657   PMID:16984517   PMID:17068474   PMID:17294739   PMID:17554801   PMID:17568667   PMID:17667919   PMID:17676473  
PMID:17693031   PMID:17766644   PMID:17959886   PMID:18182033   PMID:18212352   PMID:18234674   PMID:18240029   PMID:18295412   PMID:18329818   PMID:18384079   PMID:18404132   PMID:18456686  
PMID:18559919   PMID:18597742   PMID:18662259   PMID:18801728   PMID:18803662   PMID:18818748   PMID:18838498   PMID:18844820   PMID:18996102   PMID:19019335   PMID:19031275   PMID:19086053  
PMID:19124613   PMID:19127063   PMID:19131402   PMID:19177170   PMID:19190112   PMID:19246974   PMID:19258402   PMID:19379831   PMID:19404232   PMID:19409922   PMID:19450691   PMID:19453261  
PMID:19460861   PMID:19527514   PMID:19628576   PMID:19723618   PMID:19874574   PMID:19889985   PMID:20043013   PMID:20047160   PMID:20140262   PMID:20301348   PMID:20368512   PMID:20403506  
PMID:20468064   PMID:20472145   PMID:20602615   PMID:20626567   PMID:20727865   PMID:20943787   PMID:20966082   PMID:21106714   PMID:21261589   PMID:21289256   PMID:21360527   PMID:21525005  
PMID:21765902   PMID:21873635   PMID:22045495   PMID:22073145   PMID:22201770   PMID:22234467   PMID:22360979   PMID:22533365   PMID:22535604   PMID:22608025   PMID:22666496   PMID:22703673  
PMID:22734038   PMID:22763913   PMID:22768175   PMID:22869609   PMID:23076876   PMID:23371389   PMID:23380766   PMID:23416839   PMID:23466050   PMID:23477585   PMID:23478074   PMID:23593457  
PMID:23644483   PMID:23666959   PMID:23849813   PMID:23928667   PMID:23933692   PMID:23987517   PMID:24597258   PMID:24835211   PMID:24841552   PMID:24985398   PMID:25339828   PMID:25416956  
PMID:25521515   PMID:25573209   PMID:25591114   PMID:25630718   PMID:25673853   PMID:25771405   PMID:26055202   PMID:26074267   PMID:26212818   PMID:26307012   PMID:26331704   PMID:26350463  
PMID:26818776   PMID:26871637   PMID:26882083   PMID:27377597   PMID:27448273   PMID:27534449   PMID:27567427   PMID:27663146   PMID:27754786   PMID:27908212   PMID:28071586   PMID:28103784  
PMID:28151936   PMID:28240194   PMID:28260504   PMID:28514442   PMID:28618089   PMID:28780891   PMID:28795329   PMID:29277323   PMID:29857328   PMID:29992644   PMID:30157679   PMID:30231016  
PMID:30464231   PMID:30481088   PMID:31477210   PMID:31805553   PMID:32296183   PMID:32814053   PMID:33845478   PMID:33961781   PMID:35905107   PMID:35938903   PMID:35983792   PMID:36126617  
PMID:36529126   PMID:36949045   PMID:37401376   PMID:38184094   PMID:38616821  


Genomics

Comparative Map Data
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,910,573 - 15,913,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBIUU_Cfam_GSD_1.0
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,760,532 - 7,761,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,194,495 - 25,196,488 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRH
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000756.2(CRH):c.-669C>A single nucleotide variant Autosomal dominant nocturnal frontal lobe epilepsy [RCV000033935]|CRH-related disorder [RCV003894839] Chr8:66178947 [GRCh38]
Chr8:67091182 [GRCh37]
Chr8:8q13.1		 pathogenic|likely benign|not provided
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q12.1-21.13(chr8:57361243-79170078)x3 copy number gain See cases [RCV000053653] Chr8:57361243..79170078 [GRCh38]
Chr8:58273802..80082313 [GRCh37]
Chr8:58436356..80244868 [NCBI36]
Chr8:8q12.1-21.13		 pathogenic
GRCh38/hg38 8q12.3-21.13(chr8:61691800-82537696)x3 copy number gain See cases [RCV000053654] Chr8:61691800..82537696 [GRCh38]
Chr8:62604359..83449931 [GRCh37]
Chr8:62766913..83612486 [NCBI36]
Chr8:8q12.3-21.13		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q12.3-21.11(chr8:62230636-73227786)x1 copy number loss See cases [RCV000054242] Chr8:62230636..73227786 [GRCh38]
Chr8:63143195..74140021 [GRCh37]
Chr8:63305749..74302575 [NCBI36]
Chr8:8q12.3-21.11		 pathogenic
NM_184085.1(TRIM55):c.1616C>T (p.Ser539Phe) single nucleotide variant Malignant melanoma [RCV000061820] Chr8:66174562 [GRCh38]
Chr8:67086797 [GRCh37]
Chr8:67249351 [NCBI36]
Chr8:8q13.1		 not provided
NM_000756.3(CRH):c.-365G>C single nucleotide variant Autosomal dominant nocturnal frontal lobe epilepsy [RCV000033934] Chr8:66178643 [GRCh38]
Chr8:67090878 [GRCh37]
Chr8:8q13.1		 pathogenic|likely pathogenic|not provided
NM_000756.4(CRH):c.89C>G (p.Pro30Arg) single nucleotide variant Autosomal dominant nocturnal frontal lobe epilepsy [RCV000192059]|not provided [RCV000172993]|not specified [RCV004019949] Chr8:66177389 [GRCh38]
Chr8:67089624 [GRCh37]
Chr8:8q13.1		 pathogenic|likely benign|uncertain significance|not provided
GRCh38/hg38 8q11.1-13.2(chr8:46031334-69303787)x3 copy number gain See cases [RCV000133720] Chr8:46031334..69303787 [GRCh38]
Chr8:46942956..70216022 [GRCh37]
Chr8:47062121..70378576 [NCBI36]
Chr8:8q11.1-13.2		 pathogenic
GRCh38/hg38 8q12.1-13.1(chr8:60519222-66659025)x3 copy number gain See cases [RCV000134830] Chr8:60519222..66659025 [GRCh38]
Chr8:61431781..67571260 [GRCh37]
Chr8:61594335..67733814 [NCBI36]
Chr8:8q12.1-13.1		 pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
NM_000756.4(CRH):c.72G>A (p.Ala24=) single nucleotide variant not specified [RCV004026852] Chr8:66177406 [GRCh38]
Chr8:67089641 [GRCh37]
Chr8:8q13.1		 likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q12.3-13.2(chr8:65194424-68570319)x1 copy number loss See cases [RCV000445999] Chr8:65194424..68570319 [GRCh37]
Chr8:8q12.3-13.2		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
NM_000756.4(CRH):c.110C>T (p.Ala37Val) single nucleotide variant not specified [RCV004026839] Chr8:66177368 [GRCh38]
Chr8:67089603 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.438G>A (p.Glu146=) single nucleotide variant not specified [RCV004026855] Chr8:66177040 [GRCh38]
Chr8:67089275 [GRCh37]
Chr8:8q13.1		 likely benign
NM_000756.4(CRH):c.239A>G (p.Asn80Ser) single nucleotide variant not specified [RCV004026844] Chr8:66177239 [GRCh38]
Chr8:67089474 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.288A>C (p.Gly96=) single nucleotide variant not provided [RCV000711323]|not specified [RCV004026801] Chr8:66177190 [GRCh38]
Chr8:67089425 [GRCh37]
Chr8:8q13.1		 benign
NM_000756.4(CRH):c.456G>A (p.Arg152=) single nucleotide variant CRH-related disorder [RCV003907967]|not provided [RCV000711324]|not specified [RCV004026802] Chr8:66177022 [GRCh38]
Chr8:67089257 [GRCh37]
Chr8:8q13.1		 benign|likely benign
NM_000756.4(CRH):c.51G>C (p.Leu17=) single nucleotide variant not provided [RCV000711325]|not specified [RCV004026803] Chr8:66177427 [GRCh38]
Chr8:67089662 [GRCh37]
Chr8:8q13.1		 benign
NM_000756.4(CRH):c.146CGC[4] (p.Pro51dup) microsatellite not provided [RCV000953582]|not specified [RCV004026842] Chr8:66177323..66177324 [GRCh38]
Chr8:67089558..67089559 [GRCh37]
Chr8:8q13.1		 benign
NM_000756.4(CRH):c.579T>C (p.Ile193=) single nucleotide variant not specified [RCV004026916] Chr8:66176899 [GRCh38]
Chr8:67089134 [GRCh37]
Chr8:8q13.1		 likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q12.3-13.1(chr8:65280508-67782846)x1 copy number loss not provided [RCV000846825] Chr8:65280508..67782846 [GRCh37]
Chr8:8q12.3-13.1		 pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_000756.4(CRH):c.378C>G (p.Leu126=) single nucleotide variant not provided [RCV000894512] Chr8:66177100 [GRCh38]
Chr8:67089335 [GRCh37]
Chr8:8q13.1		 likely benign
GRCh37/hg19 8q13.1(chr8:67066779-67162066)x1 copy number loss not provided [RCV001258412] Chr8:67066779..67162066 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.123T>G (p.Pro41=) single nucleotide variant not specified [RCV001665515] Chr8:66177355 [GRCh38]
Chr8:67089590 [GRCh37]
Chr8:8q13.1		 likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8q13.1-13.2(chr8:66045954-69807260)x1 copy number loss not provided [RCV001836560] Chr8:66045954..69807260 [GRCh37]
Chr8:8q13.1-13.2		 pathogenic
GRCh37/hg19 8q12.3-13.2(chr8:65194424-68570319) copy number loss not specified [RCV002053768] Chr8:65194424..68570319 [GRCh37]
Chr8:8q12.3-13.2		 pathogenic
NM_000756.4(CRH):c.202A>T (p.Met68Leu) single nucleotide variant not specified [RCV004059562] Chr8:66177276 [GRCh38]
Chr8:67089511 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.70G>A (p.Ala24Thr) single nucleotide variant not specified [RCV004055257] Chr8:66177408 [GRCh38]
Chr8:67089643 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.424G>A (p.Gly142Ser) single nucleotide variant not specified [RCV004316866] Chr8:66177054 [GRCh38]
Chr8:67089289 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.85G>A (p.Gly29Arg) single nucleotide variant not specified [RCV004056546] Chr8:66177393 [GRCh38]
Chr8:67089628 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.157_180dup (p.Gln60_Ala61insSerGluGlnProGlnGlnProGln) duplication not specified [RCV004059191] Chr8:66177297..66177298 [GRCh38]
Chr8:67089532..67089533 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.329A>G (p.Asn110Ser) single nucleotide variant not specified [RCV004049488] Chr8:66177149 [GRCh38]
Chr8:67089384 [GRCh37]
Chr8:8q13.1		 likely benign|uncertain significance
NM_000756.4(CRH):c.468G>A (p.Glu156=) single nucleotide variant not specified [RCV004051986] Chr8:66177010 [GRCh38]
Chr8:67089245 [GRCh37]
Chr8:8q13.1		 likely benign
NM_000756.4(CRH):c.367C>G (p.Arg123Gly) single nucleotide variant not specified [RCV004138967] Chr8:66177111 [GRCh38]
Chr8:67089346 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.529G>A (p.Ala177Thr) single nucleotide variant not specified [RCV004093090] Chr8:66176949 [GRCh38]
Chr8:67089184 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.421C>G (p.Leu141Val) single nucleotide variant not specified [RCV004162523] Chr8:66177057 [GRCh38]
Chr8:67089292 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.394C>G (p.Leu132Val) single nucleotide variant not specified [RCV004099973] Chr8:66177084 [GRCh38]
Chr8:67089319 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.52C>T (p.Pro18Ser) single nucleotide variant not specified [RCV004172019] Chr8:66177426 [GRCh38]
Chr8:67089661 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.340G>C (p.Val114Leu) single nucleotide variant not specified [RCV004265042] Chr8:66177138 [GRCh38]
Chr8:67089373 [GRCh37]
Chr8:8q13.1		 uncertain significance
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_000756.4(CRH):c.522G>C (p.Met174Ile) single nucleotide variant not specified [RCV004367286] Chr8:66176956 [GRCh38]
Chr8:67089191 [GRCh37]
Chr8:8q13.1		 uncertain significance
NM_000756.4(CRH):c.419C>G (p.Ala140Gly) single nucleotide variant not specified [RCV004613298] Chr8:66177059 [GRCh38]
Chr8:67089294 [GRCh37]
Chr8:8q13.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:179
Interacting mature miRNAs:190
Transcripts:ENST00000276571
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407269316GWAS918292_Hbody height QTL GWAS918292 (human)9e-16body height (VT:0001253)body height (CMO:0000106)86617763566177636Human
1300005BP49_HBlood pressure QTL 49 (human)2.240.00066Blood pressuresystolic85317742079177420Human

Markers in Region
STS-V00571  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37867,088,443 - 67,088,699UniSTSGRCh37
Build 36867,250,997 - 67,251,253RGDNCBI36
Celera863,080,156 - 63,080,412RGD
Cytogenetic Map8q13UniSTS
HuRef862,578,598 - 62,578,854UniSTS
GeneMap99-GB4 RH Map8358.28UniSTS
NCBI RH Map8833.0UniSTS
RH69917  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37867,088,672 - 67,088,763UniSTSGRCh37
Build 36867,251,226 - 67,251,317RGDNCBI36
Celera863,080,385 - 63,080,476RGD
Cytogenetic Map8q13UniSTS
HuRef862,578,827 - 62,578,918UniSTS
GeneMap99-GB4 RH Map8355.23UniSTS
NCBI RH Map8833.0UniSTS
STS-T54293  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37867,089,111 - 67,089,240UniSTSGRCh37
Build 36867,251,665 - 67,251,794RGDNCBI36
Celera863,080,824 - 63,080,953RGD
Cytogenetic Map8q13UniSTS
HuRef862,579,266 - 62,579,395UniSTS
GeneMap99-GB4 RH Map8358.28UniSTS
NCBI RH Map8833.0UniSTS
UniSTS:16032  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37867,088,954 - 67,089,062UniSTSGRCh37
Build 36867,251,508 - 67,251,616RGDNCBI36
Celera863,080,667 - 63,080,775RGD
HuRef862,579,109 - 62,579,217UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054359801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054359802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054359803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC090195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB992265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU177994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU177995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000276571   ⟹   ENSP00000276571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)Ensembl
RefSeq Acc Id: NM_000756   ⟹   NP_000747
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38866,176,376 - 66,178,464 (-)NCBI
GRCh37867,088,612 - 67,090,846 (-)ENTREZGENE
Build 36867,251,173 - 67,253,252 (-)NCBI Archive
HuRef862,578,767 - 62,581,001 (-)ENTREZGENE
CHM1_1867,143,265 - 67,145,533 (-)NCBI
T2T-CHM13v2.0866,602,063 - 66,604,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054359801   ⟹   XP_054215776
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0866,602,063 - 66,612,331 (-)NCBI
RefSeq Acc Id: XM_054359802   ⟹   XP_054215777
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBI
RefSeq Acc Id: XM_054359803   ⟹   XP_054215778
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0866,602,063 - 66,609,624 (-)NCBI
RefSeq Acc Id: NP_000747   ⟸   NM_000756
- Peptide Label: preproprotein
- UniProtKB: B3KQS4 (UniProtKB/Swiss-Prot),   P06850 (UniProtKB/Swiss-Prot),   A0A0S2Z478 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000276571   ⟸   ENST00000276571
RefSeq Acc Id: XP_054215777   ⟸   XM_054359802
- Peptide Label: isoform X1
- UniProtKB: B3KQS4 (UniProtKB/Swiss-Prot),   P06850 (UniProtKB/Swiss-Prot),   A0A0S2Z478 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054215776   ⟸   XM_054359801
- Peptide Label: isoform X1
- UniProtKB: B3KQS4 (UniProtKB/Swiss-Prot),   P06850 (UniProtKB/Swiss-Prot),   A0A0S2Z478 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054215778   ⟸   XM_054359803
- Peptide Label: isoform X1
- UniProtKB: B3KQS4 (UniProtKB/Swiss-Prot),   P06850 (UniProtKB/Swiss-Prot),   A0A0S2Z478 (UniProtKB/TrEMBL)
Protein Domains
Corticotropin-releasing factor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06850-F1-model_v2 AlphaFold P06850 1-196 view protein structure

Promoters
RGD ID:7213423
Promoter ID:EPDNEW_H12457
Type:initiation region
Name:CRH_1
Description:corticotropin releasing hormone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38866,178,463 - 66,178,523EPDNEW
RGD ID:6849966
Promoter ID:EP30039
Type:single initiation site
Name:HS_CRH
Description:Corticotropin-releasing factor, CRH gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 170; Mammalian corticotropin-releasing factor
Tissues & Cell Lines:hypothalamus
Experiment Methods:Primer extension; experiments performed with closely related; gene
Position:
Human AssemblyChrPosition (strand)Source
Build 36867,253,252 - 67,253,312EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2355 AgrOrtholog
COSMIC CRH COSMIC
Ensembl Genes ENSG00000147571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000276571 ENTREZGENE
  ENST00000276571.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000147571 GTEx
HGNC ID HGNC:2355 ENTREZGENE
Human Proteome Map CRH Human Proteome Map
InterPro Corticotropin-releasing_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urocortin_CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1392 ENTREZGENE
OMIM 122560 OMIM
PANTHER CORTICOLIBERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRH RGD, PharmGKB
PRINTS CRFFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z3P5_HUMAN UniProtKB/TrEMBL
  A0A0S2Z478 ENTREZGENE, UniProtKB/TrEMBL
  B3KQS4 ENTREZGENE
  CRF_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B3KQS4 UniProtKB/Swiss-Prot