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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrathiomolybdate(2-)
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Accession:CHEBI:30703 term browser browse the term
Definition:A molybdenum coordination entity that has formula MoS4.
Synonyms:exact_synonym: tetrasulfidomolybdate(2-);   tetrasulfidomolybdate(VI)
 related_synonym: (T-4)-tetrathioxomolybdate(2-);   Formula=MoS4;   InChI=1S/Mo.4S/q;;;2*-1;   InChIKey=CXVCSRUYMINUSF-UHFFFAOYSA-N;   SMILES=[S-][Mo]([S-])(=S)=S;   [MoS4](2-);   tetrathiomolybdate;   tetrathioxomolybdate(2-);   thiomolybdate
 xref: CAS:16330-92-0;   Gmelin:2452
 xref_mesh: MESH:C020809
 xref: MolBase:788


show annotations for term's descendants           Sort by:
tetrathiomolybdate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 2200002D01Rik RIKEN cDNA 2200002D01 gene decreases expression ISO tetrathiomolybdate results in decreased expression of C19ORF33 mRNA CTD PMID:37290678 NCBI chr 7:28,946,946...28,947,892
Ensembl chr 7:28,945,986...28,947,891 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases phosphorylation EXP tetrathiomolybdate results in increased phosphorylation of ACACA protein CTD PMID:24218578 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of AKT1 protein CTD PMID:37290678 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Angpt2 angiopoietin 2 increases expression ISO tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA CTD PMID:19323979 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects binding		 ISO [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AQP1 mRNA CTD PMID:19323979 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions EXP tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide multiple interactions
decreases expression		 EXP
ISO		 tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper]
tetrathiomolybdate results in decreased expression of ATP7B protein		 CTD PMID:11803042 PMID:37290678 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO tetrathiomolybdate results in increased expression of BAX protein CTD PMID:37290678 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
decreases expression		 ISO tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein
tetrathiomolybdate results in decreased expression of BCL2 protein		 CTD PMID:19323979 PMID:37290678 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein CTD PMID:22276220 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Bcl2l2 BCL2-like 2 increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein CTD PMID:19323979 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein
tetrathiomolybdate results in increased cleavage of CASP3 protein		 CTD PMID:22276220 PMID:37290678 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO		 tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein]		 CTD PMID:15541506 PMID:21724870 PMID:24225134 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO tetrathiomolybdate results in decreased expression of CCNB1 protein CTD PMID:37290678 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression
decreases expression		 ISO tetrathiomolybdate results in increased expression of CCS protein
tetrathiomolybdate results in decreased expression of CCS protein		 CTD PMID:21784888 PMID:37290678 NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360 		JBrowse link
G Cd40 CD40 antigen increases expression ISO tetrathiomolybdate analog results in increased expression of CD40 mRNA CTD PMID:19323979 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO tetrathiomolybdate analog results in increased expression of CDKN1A protein CTD PMID:19323979 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Ckm creatine kinase, muscle multiple interactions EXP tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:16242529 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766 		JBrowse link
G Cldn18 claudin 18 decreases expression ISO tetrathiomolybdate results in decreased expression of CLDN18 mRNA CTD PMID:37290678 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO tetrathiomolybdate results in decreased expression of CLDN4 mRNA CTD PMID:37290678 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788 		JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO tetrathiomolybdate results in increased expression of COL1A1 mRNA CTD PMID:37290678 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col1a2 collagen, type I, alpha 2 increases expression ISO tetrathiomolybdate results in increased expression of COL1A2 mRNA CTD PMID:37290678 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544 		JBrowse link
G Col3a1 collagen, type III, alpha 1 increases expression ISO tetrathiomolybdate results in increased expression of COL3A1 mRNA CTD PMID:37290678 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone decreases expression ISO tetrathiomolybdate results in decreased expression of COX17 protein CTD PMID:37290678 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression ISO tetrathiomolybdate analog results in increased expression of COX5B mRNA CTD PMID:19323979 NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762 		JBrowse link
G Cp ceruloplasmin decreases activity
multiple interactions
decreases expression
decreases secretion		 EXP
ISO		 tetrathiomolybdate results in decreased activity of CP protein
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]
tetrathiomolybdate results in decreased expression of CP protein
tetrathiomolybdate results in decreased secretion of CP protein		 CTD PMID:10656425 PMID:12624602 PMID:21724870 PMID:21784888 PMID:24013775 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver decreases expression ISO tetrathiomolybdate results in decreased expression of CPT1A mRNA CTD PMID:21784888 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Crabp2 cellular retinoic acid binding protein II decreases expression ISO tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA CTD PMID:19323979 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683 		JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression ISO tetrathiomolybdate analog results in increased expression of CREBZF mRNA CTD PMID:19323979 NCBI chr 7:90,091,942...90,097,590
Ensembl chr 7:90,091,937...90,097,202 		JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression ISO tetrathiomolybdate results in increased expression of CSF3R mRNA CTD PMID:37290678 NCBI chr 4:125,917,241...125,938,233
Ensembl chr 4:125,918,343...125,938,233 		JBrowse link
G Cstb cystatin B decreases expression ISO tetrathiomolybdate results in decreased expression of CSTB mRNA CTD PMID:37290678 NCBI chr10:78,261,504...78,263,456
Ensembl chr10:78,261,503...78,263,456 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO tetrathiomolybdate analog results in increased expression of CXCR4 mRNA CTD PMID:19323979 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression		 ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
tetrathiomolybdate results in decreased expression of EGFR protein		 CTD PMID:18480265 PMID:37290678 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Eln elastin multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein CTD PMID:22276220 NCBI chr 5:134,731,449...134,776,300
Ensembl chr 5:134,731,447...134,776,177 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO tetrathiomolybdate results in decreased expression of ERO1A mRNA CTD PMID:37290678 NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228 		JBrowse link
G Fbln1 fibulin 1 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein CTD PMID:22276220 NCBI chr15:85,090,150...85,170,495
Ensembl chr15:85,090,150...85,170,736 		JBrowse link
G Fbln5 fibulin 5 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 NCBI chr12:101,712,820...101,785,541
Ensembl chr12:101,712,824...101,785,314 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein CTD PMID:22276220 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO tetrathiomolybdate results in decreased secretion of FGF1 protein CTD PMID:18400376 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18480265 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO tetrathiomolybdate results in increased expression of FOS mRNA CTD PMID:37290678 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fpr1 formyl peptide receptor 1 increases expression ISO tetrathiomolybdate results in increased expression of FPR1 mRNA CTD PMID:37290678 NCBI chr17:18,096,733...18,104,201
Ensembl chr17:18,096,733...18,104,202 		JBrowse link
G Gprc5a G protein-coupled receptor, family C, group 5, member A decreases expression ISO tetrathiomolybdate results in decreased expression of GPRC5A mRNA CTD PMID:37290678 NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO tetrathiomolybdate analog results in increased expression of GPX3 mRNA CTD PMID:19323979 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsr glutathione reductase increases expression ISO tetrathiomolybdate analog results in increased expression of GSR mRNA CTD PMID:19323979 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2-Pa histocompatibility 2, P region alpha locus increases expression ISO tetrathiomolybdate results in increased expression of HLA-DPA1 mRNA CTD PMID:37290678 NCBI chr17:34,303,587...34,304,826
Ensembl chr17:34,303,575...34,304,797 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain increases expression ISO tetrathiomolybdate results in increased expression of HBB mRNA CTD PMID:37290678
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein CTD PMID:22276220 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 decreases expression ISO tetrathiomolybdate results in decreased expression of HMGCS2 mRNA CTD PMID:21784888 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hmmr hyaluronan mediated motility receptor (RHAMM) decreases expression ISO tetrathiomolybdate analog results in decreased expression of RHAMM mRNA CTD PMID:19323979 NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
increases expression		 ISO tetrathiomolybdate results in decreased expression of HMOX1 protein
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]
tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein		 CTD PMID:19323979 PMID:21784888 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO		 tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifi211 interferon activated gene 211 increases expression ISO tetrathiomolybdate results in increased expression of MNDA mRNA CTD PMID:37290678 NCBI chr 1:173,723,907...173,740,650
Ensembl chr 1:173,723,911...173,740,612 		JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO tetrathiomolybdate results in increased expression of IFITM2 mRNA CTD PMID:37290678 NCBI chr 7:140,534,750...140,539,602
Ensembl chr 7:140,534,750...140,535,900 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 increases expression ISO tetrathiomolybdate results in increased expression of IGFBP7 mRNA CTD PMID:37290678 NCBI chr 5:77,497,092...77,555,892
Ensembl chr 5:77,497,087...77,555,888 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:16242529 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] CTD PMID:16242529 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases expression
multiple interactions		 ISO
EXP		 tetrathiomolybdate analog results in decreased expression of IL2RA mRNA
tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]		 CTD PMID:19323979 PMID:23134680 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21724870 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgb4 integrin beta 4 decreases expression ISO tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA CTD PMID:19323979 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238 		JBrowse link
G Itgb6 integrin beta 6 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA CTD PMID:22276220 NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987 		JBrowse link
G Jag1 jagged 1 increases expression ISO tetrathiomolybdate analog results in increased expression of JAG1 mRNA CTD PMID:19323979 NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564 		JBrowse link
G Jchain immunoglobulin joining chain increases expression ISO tetrathiomolybdate results in increased expression of JCHAIN mRNA CTD PMID:37290678 NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750 		JBrowse link
G Klf2 Kruppel-like transcription factor 2 (lung) decreases expression ISO tetrathiomolybdate analog results in decreased expression of KLF2 mRNA CTD PMID:19323979 NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500 		JBrowse link
G Krt19 keratin 19 decreases expression ISO tetrathiomolybdate results in decreased expression of KRT19 mRNA CTD PMID:37290678 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491 		JBrowse link
G Krt7 keratin 7 decreases expression ISO tetrathiomolybdate results in decreased expression of KRT7 mRNA CTD PMID:37290678 NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194 		JBrowse link
G Lamb3 laminin, beta 3 decreases expression ISO tetrathiomolybdate results in decreased expression of LAMB3 mRNA CTD PMID:37290678 NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186 		JBrowse link
G Lcn2 lipocalin 2 decreases expression ISO tetrathiomolybdate results in decreased expression of LCN2 mRNA CTD PMID:37290678 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939 		JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO tetrathiomolybdate results in increased expression of LST1 mRNA CTD PMID:37290678 NCBI chr17:35,404,071...35,407,416
Ensembl chr17:35,404,071...35,407,415 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein
tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] CTD PMID:25671100 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mgp matrix Gla protein increases expression ISO tetrathiomolybdate results in increased expression of MGP mRNA CTD PMID:37290678 NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of MTOR protein CTD PMID:37290678 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myo1f myosin IF increases expression ISO tetrathiomolybdate results in increased expression of MYO1F mRNA CTD PMID:37290678 NCBI chr17:33,774,681...33,826,738
Ensembl chr17:33,774,681...33,826,738 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO tetrathiomolybdate results in increased expression of NAMPT mRNA CTD PMID:37290678 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO tetrathiomolybdate results in increased expression of NCF1 mRNA CTD PMID:37290678 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 decreases expression ISO tetrathiomolybdate results in decreased expression of NDRG1 mRNA CTD PMID:37290678 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:19323979 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein CTD PMID:24225134 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO tetrathiomolybdate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide decreases expression ISO tetrathiomolybdate results in decreased expression of PDGFRB protein CTD PMID:18480265 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of PIK3R1 protein CTD PMID:37290678 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Plin2 perilipin 2 decreases expression ISO tetrathiomolybdate results in decreased expression of PLIN2 mRNA CTD PMID:37290678 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO tetrathiomolybdate results in decreased expression of PPARA mRNA CTD PMID:21784888 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of PTGS2 mRNA CTD PMID:19323979 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein CTD PMID:22276220 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] CTD PMID:18480265 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C increases expression ISO tetrathiomolybdate results in increased expression of PTPRC mRNA CTD PMID:37290678 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Reg1 regenerating islet-derived 1 increases expression ISO tetrathiomolybdate results in increased expression of REG1A mRNA CTD PMID:37290678 NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO tetrathiomolybdate results in increased expression of RGS2 mRNA CTD PMID:37290678 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 decreases expression ISO tetrathiomolybdate results in decreased expression of RICTOR protein CTD PMID:37290678 NCBI chr15:6,737,827...6,829,882
Ensembl chr15:6,737,860...6,829,882 		JBrowse link
G Ripor2 RHO family interacting cell polarization regulator 2 increases expression ISO tetrathiomolybdate results in increased expression of RIPOR2 mRNA CTD PMID:37290678 NCBI chr13:24,685,513...24,917,789
Ensembl chr13:24,685,508...24,917,799 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of RPS6KB1 protein CTD PMID:37290678 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression ISO tetrathiomolybdate results in decreased expression of RPTOR protein CTD PMID:37290678 NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO tetrathiomolybdate results in increased expression of S100A8 mRNA CTD PMID:37290678 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO tetrathiomolybdate results in increased expression of S100A9 mRNA CTD PMID:37290678 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Sfn stratifin decreases expression ISO tetrathiomolybdate results in decreased expression of SFN mRNA CTD PMID:37290678 NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases expression ISO tetrathiomolybdate results in decreased expression of SLC2A1 mRNA CTD PMID:37290678 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc31a1 solute carrier family 31, member 1 multiple interactions
increases expression
decreases expression		 ISO [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]
tetrathiomolybdate results in decreased expression of SLC31A1 protein		 CTD PMID:22172574 PMID:22914438 PMID:37290678 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006 		JBrowse link
G Slc31a2 solute carrier family 31, member 2 decreases response to substance ISO SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate CTD PMID:24522273 NCBI chr 4:62,198,630...62,216,649
Ensembl chr 4:62,180,799...62,216,648 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA CTD PMID:19323979 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression
multiple interactions
decreases activity
affects localization		 ISO tetrathiomolybdate results in decreased expression of SOD1 protein
tetrathiomolybdate analog results in decreased expression of SOD1 mRNA
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog affects the localization of SOD1 protein		 CTD PMID:18480265 PMID:19323979 PMID:21784888 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein CTD PMID:19323979 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions
increases activity
increases expression		 ISO [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]
tetrathiomolybdate results in increased activity of SP1 protein
tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA		 CTD PMID:22172574 PMID:22914438 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Sp3 trans-acting transcription factor 3 decreases expression ISO tetrathiomolybdate results in decreased expression of SP3 CTD PMID:22172574 NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO tetrathiomolybdate results in decreased expression of SPP1 mRNA CTD PMID:37290678 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srgn serglycin increases expression ISO tetrathiomolybdate results in increased expression of SRGN mRNA CTD PMID:37290678 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230 		JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO tetrathiomolybdate results in decreased expression of TACSTD2 mRNA CTD PMID:37290678 NCBI chr 6:67,511,043...67,512,806
Ensembl chr 6:67,511,046...67,512,780 		JBrowse link
G Tagln transgelin increases expression ISO tetrathiomolybdate results in increased expression of TAGLN mRNA CTD PMID:37290678 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression ISO tetrathiomolybdate results in decreased expression of TFB1M mRNA CTD PMID:21784888 NCBI chr17:3,569,119...3,608,064
Ensembl chr17:3,569,531...3,608,056 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO tetrathiomolybdate results in decreased expression of TFF1 mRNA CTD PMID:37290678 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tff3 trefoil factor 3, intestinal decreases expression ISO tetrathiomolybdate results in decreased expression of TFF3 mRNA CTD PMID:37290678 NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] CTD PMID:15541506 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tm4sf1 transmembrane 4 superfamily member 1 decreases expression ISO tetrathiomolybdate results in decreased expression of TM4SF1 mRNA CTD PMID:37290678 NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:15541506 PMID:16242529 PMID:21724870 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions EXP tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:16242529 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases phosphorylation		 ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein
tetrathiomolybdate results in increased phosphorylation of TP53 protein		 CTD PMID:22276220 PMID:37290678 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Try10 trypsin 10 increases expression ISO tetrathiomolybdate results in increased expression of PRSS1 mRNA CTD PMID:37290678 NCBI chr 6:41,331,039...41,334,878
Ensembl chr 6:41,331,039...41,334,848 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression ISO tetrathiomolybdate results in increased expression of TSC22D3 mRNA CTD PMID:37290678 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA CTD PMID:19323979 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO		 tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein
tetrathiomolybdate results in decreased expression of VEGFA protein		 CTD PMID:16277669 PMID:22276220 PMID:37290678 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO tetrathiomolybdate results in decreased expression of VEGFB protein CTD PMID:37290678 NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    chemical entity 22181
      molecular entity 22173
        transition element molecular entity 17679
          transition element coordination entity 11996
            molybdenum coordination entity 149
              tetrathiomolybdate(2-) 133
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  metal atom 18886
                    transition element atom 17962
                      d-block element atom 17952
                        chromium group element atom 7978
                          molybdenum atom 154
                            molybdenum molecular entity 149
                              molybdenum coordination entity 149
                                tetrathiomolybdate(2-) 133
paths to the root