Csf3r (colony stimulating factor 3 receptor) - Rat Genome Database

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Pathways
Gene: Csf3r (colony stimulating factor 3 receptor) Mus musculus
Analyze
Symbol: Csf3r
Name: colony stimulating factor 3 receptor (Ensembl:colony stimulating factor 3 receptor (granulocyte))
RGD ID: 1319272
MGI Page MGI
Description: Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; bone marrow; early conceptus; gut; and male reproductive gland or organ. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd114; colony stimulating factor 3 receptor (granulocyte); Csf; Csfgr; G-CS; G-CSF receptor; G-CSF-R; G-CSFR; granulocyte colony-stimulating factor receptor; MGC141472; MGC141473
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Csf1r-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394125,917,241 - 125,938,768 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4125,918,343 - 125,938,233 (+)EnsemblGRCm39 Ensembl
GRCm384126,023,441 - 126,044,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,024,550 - 126,044,440 (+)EnsemblGRCm38mm10GRCm38
MGSCv374125,701,903 - 125,721,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,527,040 - 125,546,743 (+)NCBIMGSCv36mm8
Celera4124,355,298 - 124,375,078 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map459.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prevalence and impact of colony stimulating factor 3 receptor (CSF3R) mutations among Egyptian acute myeloid leukemia patients. Aref S, etal., Leuk Res. 2014 Jun;38(6):722-5. doi: 10.1016/j.leukres.2014.03.020. Epub 2014 Apr 1.
2. Granulocyte colony stimulating factor neuroprotective effects on spinal motoneurons after ventral root avulsion. De Freria CM, etal., Synapse. 2012 Feb;66(2):128-41. doi: 10.1002/syn.20993. Epub 2011 Nov 3.
3. Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Dong F, etal., Leukemia. 1997 Jan;11(1):120-5.
4. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Fleischman AG, etal., Blood. 2013 Nov 21;122(22):3628-31. doi: 10.1182/blood-2013-06-509976. Epub 2013 Sep 30.
5. Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey. Germeshausen M, etal., Blood. 2007 Jan 1;109(1):93-9. Epub 2006 Sep 19.
6. Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Gregory AD, etal., Blood. 2007 Apr 15;109(8):3235-43. Epub 2006 Dec 21.
7. GCSF-R expression in myelodysplastic and myeloproliferative disorders and blast dysmaturation in CML. Hanumanthu VS and Pirruccello SJ, Am J Clin Pathol. 2013 Aug;140(2):155-64. doi: 10.1309/AJCPCLHZR5KUHUBM.
8. Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Hermans MH, etal., Blood. 1998 Jul 1;92(1):32-9.
9. Mutation of the colony-stimulating factor-3 receptor gene is a rare event with poor prognosis in chronic myelomonocytic leukemia. Kosmider O, etal., Leukemia. 2013 Sep;27(9):1946-9. doi: 10.1038/leu.2013.182. Epub 2013 Jun 18.
10. A truncation mutant of Csf3r cooperates with PML-RARalpha to induce acute myeloid leukemia in mice. Kunter G, etal., Exp Hematol. 2011 Dec;39(12):1136-43. doi: 10.1016/j.exphem.2011.08.013. Epub 2011 Sep 10.
11. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Makam M, etal., Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5779-83. Epub 2009 Mar 17.
12. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, etal., Mamm Genome 1996 Jun;7(6):413-6.
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia. Nakamura K, etal., Blood. 2000 Dec 15;96(13):4366-9.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia. Pardanani A, etal., Leukemia. 2013 Sep;27(9):1870-3. doi: 10.1038/leu.2013.122. Epub 2013 Apr 22.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Expression and functional analysis of granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia. Sultana TA, etal., Br J Haematol. 2003 Apr;121(1):63-75.
24. A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome. Wolfler A, etal., Blood. 2005 May 1;105(9):3731-6. Epub 2005 Jan 11.
Additional References at PubMed
PMID:2158861   PMID:7601480   PMID:7790005   PMID:8143742   PMID:8499630   PMID:8663376   PMID:8704229   PMID:8777716   PMID:8934575   PMID:8943846   PMID:9012825   PMID:9070944  
PMID:9180904   PMID:9187659   PMID:9324354   PMID:9326216   PMID:9611252   PMID:9691084   PMID:9811459   PMID:9892696   PMID:9989983   PMID:10349636   PMID:10419886   PMID:10477673  
PMID:10485650   PMID:10718156   PMID:10940892   PMID:11042159   PMID:11058581   PMID:11076861   PMID:11197689   PMID:11217851   PMID:11239451   PMID:11756151   PMID:11986210   PMID:12384420  
PMID:12387736   PMID:12468431   PMID:12477932   PMID:12524421   PMID:12672695   PMID:12893769   PMID:14512302   PMID:14585378   PMID:14610273   PMID:15069015   PMID:15905556   PMID:15914564  
PMID:16033816   PMID:16037394   PMID:16141072   PMID:16141073   PMID:16299394   PMID:16595180   PMID:16735597   PMID:17001306   PMID:18292815   PMID:18363963   PMID:18371196   PMID:18799693  
PMID:18824600   PMID:19157683   PMID:19330008   PMID:19738066   PMID:20207226   PMID:20354107   PMID:20647008   PMID:20679530   PMID:20713966   PMID:21029969   PMID:21157041   PMID:21267068  
PMID:21282380   PMID:21385950   PMID:21422169   PMID:21873635   PMID:21940780   PMID:22042698   PMID:22371884   PMID:23136256   PMID:23337807   PMID:23559492   PMID:23820376   PMID:23863713  
PMID:24194600   PMID:24403076   PMID:24981628   PMID:25421439   PMID:25446897   PMID:25461255   PMID:25512469   PMID:25559893   PMID:25624500   PMID:25814527   PMID:25843711   PMID:25865621  
PMID:26538649   PMID:26678340   PMID:26718978   PMID:27595596   PMID:27596364   PMID:27626380   PMID:27807194   PMID:27941791   PMID:28320832   PMID:29202481   PMID:29868014   PMID:30312710  
PMID:30401566   PMID:30464050   PMID:30679689   PMID:30729183   PMID:30777853   PMID:31257026   PMID:31469473   PMID:31736098   PMID:31784538   PMID:31848046   PMID:32822472   PMID:33042110  
PMID:33123170   PMID:33511998   PMID:35856245   PMID:35941213   PMID:35979635   PMID:37001504  


Genomics

Comparative Map Data
Csf3r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394125,917,241 - 125,938,768 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4125,918,343 - 125,938,233 (+)EnsemblGRCm39 Ensembl
GRCm384126,023,441 - 126,044,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,024,550 - 126,044,440 (+)EnsemblGRCm38mm10GRCm38
MGSCv374125,701,903 - 125,721,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,527,040 - 125,546,743 (+)NCBIMGSCv36mm8
Celera4124,355,298 - 124,375,078 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map459.77NCBI
CSF3R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38136,466,043 - 36,483,314 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl136,466,043 - 36,483,278 (-)EnsemblGRCh38hg38GRCh38
GRCh37136,931,644 - 36,948,915 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,704,231 - 36,721,096 (-)NCBINCBI36Build 36hg18NCBI36
Celera135,207,427 - 35,224,699 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef135,048,209 - 35,065,480 (-)NCBIHuRef
CHM1_1137,047,772 - 37,065,042 (-)NCBICHM1_1
T2T-CHM13v2.0136,328,923 - 36,346,193 (-)NCBIT2T-CHM13v2.0
Csf3r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25138,298,605 - 138,318,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,301,506 - 138,317,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,001,001 - 141,020,163 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05142,771,006 - 142,790,174 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05142,779,986 - 142,799,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,031,353 - 144,051,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,031,402 - 144,051,600 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05147,793,488 - 147,820,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,374,596 - 145,394,045 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,387,406 - 145,403,597 (+)NCBI
Celera5136,809,042 - 136,828,201 (+)NCBICelera
Cytogenetic Map5q36NCBI
Csf3r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545214,411,708 - 14,422,187 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545214,409,484 - 14,425,818 (-)NCBIChiLan1.0ChiLan1.0
CSF3R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11189,485,632 - 189,502,489 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,730,678 - 35,747,939 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,897,148 - 36,914,398 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,897,153 - 36,910,612 (-)Ensemblpanpan1.1panPan2
CSF3R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1155,818,985 - 5,832,455 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl155,822,025 - 5,831,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,062,162 - 6,075,666 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0155,954,518 - 5,968,032 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl155,954,686 - 5,968,102 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1155,808,137 - 5,821,636 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0155,876,012 - 5,889,508 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,890,652 - 5,904,148 (+)NCBIUU_Cfam_GSD_1.0
Csf3r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505853,052,332 - 53,066,207 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,877,375 - 18,887,530 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647418,877,036 - 18,887,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF3R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl692,550,161 - 92,565,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1692,550,159 - 92,565,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSF3R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12096,380,798 - 96,397,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2096,384,222 - 96,398,618 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603320,341,273 - 20,358,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf3r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476419,356,361 - 19,367,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476419,356,848 - 19,396,209 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csf3r
840 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:843
Count of miRNA genes:398
Interacting mature miRNAs:448
Transcripts:ENSMUST00000030673, ENSMUST00000106162, ENSMUST00000140426, ENSMUST00000153968
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse

Markers in Region
M58288  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
Whitehead/MRC_RH41614.12UniSTS
PMC123164P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384126,026,384 - 126,026,743UniSTSGRCm38
MGSCv374125,703,628 - 125,703,987UniSTSGRCm37
Celera4124,357,024 - 124,357,383UniSTS
Cytogenetic Map4D2.2UniSTS
Csf3r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
cM Map457.5UniSTS
Csf3r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
Csf3r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
cM Map457.5UniSTS
Csf3r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK089305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC115865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC116635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000030673   ⟹   ENSMUSP00000030673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4125,921,085 - 125,938,232 (+)Ensembl
GRCm38.p6 Ensembl4126,027,292 - 126,044,439 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106162   ⟹   ENSMUSP00000101768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4125,918,343 - 125,938,233 (+)Ensembl
GRCm38.p6 Ensembl4126,024,550 - 126,044,440 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4125,931,877 - 125,937,668 (+)Ensembl
GRCm38.p6 Ensembl4126,038,084 - 126,043,875 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4125,918,519 - 125,925,689 (+)Ensembl
GRCm38.p6 Ensembl4126,024,726 - 126,031,896 (+)Ensembl
RefSeq Acc Id: NM_001252651   ⟹   NP_001239580
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,452 - 125,938,768 (+)NCBI
GRCm384126,024,659 - 126,044,975 (+)NCBI
Celera4124,355,298 - 124,375,614 (+)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007782   ⟹   NP_031808
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,452 - 125,938,768 (+)NCBI
GRCm384126,024,659 - 126,044,975 (+)NCBI
MGSCv374125,701,903 - 125,721,684 (+)RGD
Celera4124,355,298 - 124,375,614 (+)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_045561
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,452 - 125,938,768 (+)NCBI
GRCm384126,024,659 - 126,044,975 (+)NCBI
Celera4124,355,298 - 124,375,614 (+)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502709   ⟹   XP_006502772
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,917,241 - 125,938,230 (+)NCBI
GRCm384126,023,441 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502710   ⟹   XP_006502773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,447 - 125,938,230 (+)NCBI
GRCm384126,024,647 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502711   ⟹   XP_006502774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,919,864 - 125,938,230 (+)NCBI
GRCm384126,024,647 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502712   ⟹   XP_006502775
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,447 - 125,938,230 (+)NCBI
GRCm384126,024,648 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502713   ⟹   XP_006502776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,598 - 125,938,230 (+)NCBI
GRCm384126,024,647 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502714   ⟹   XP_006502777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,917,241 - 125,938,230 (+)NCBI
GRCm384126,023,441 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502716   ⟹   XP_006502779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,919,891 - 125,938,230 (+)NCBI
GRCm384126,024,649 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502717   ⟹   XP_006502780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,923,856 - 125,938,230 (+)NCBI
GRCm384126,030,069 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502718   ⟹   XP_006502781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,925,623 - 125,938,230 (+)NCBI
GRCm384126,030,009 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502719   ⟹   XP_006502782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,925,999 - 125,938,230 (+)NCBI
GRCm384126,032,206 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011240423   ⟹   XP_011238725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,919,891 - 125,938,230 (+)NCBI
GRCm384126,024,643 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319945   ⟹   XP_017175434
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,917,242 - 125,938,230 (+)NCBI
GRCm384126,023,442 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030253159   ⟹   XP_030109019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,917,241 - 125,938,230 (+)NCBI
GRCm384126,023,441 - 126,044,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163627   ⟹   XP_036019520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,919,891 - 125,938,230 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163628   ⟹   XP_036019521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394125,918,447 - 125,938,230 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001239580 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407820 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407821 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407822 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407823 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407824 (Get FASTA)   NCBI Sequence Viewer  
  NP_001407825 (Get FASTA)   NCBI Sequence Viewer  
  NP_031808 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502772 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502773 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502774 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502775 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502776 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502777 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502779 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502780 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502781 (Get FASTA)   NCBI Sequence Viewer  
  XP_006502782 (Get FASTA)   NCBI Sequence Viewer  
  XP_011238725 (Get FASTA)   NCBI Sequence Viewer  
  XP_017175434 (Get FASTA)   NCBI Sequence Viewer  
  XP_030109019 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019520 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019521 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37673 (Get FASTA)   NCBI Sequence Viewer  
  AAI15866 (Get FASTA)   NCBI Sequence Viewer  
  AAI16636 (Get FASTA)   NCBI Sequence Viewer  
  EDL30315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030673
  ENSMUSP00000101768
GenBank Protein P40223 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031808   ⟸   NM_007782
- Peptide Label: isoform 1 precursor
- UniProtKB: A2A8Y3 (UniProtKB/Swiss-Prot),   P40223 (UniProtKB/Swiss-Prot),   Q14AY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239580   ⟸   NM_001252651
- Peptide Label: isoform 2 precursor
- UniProtKB: Q14BI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502772   ⟸   XM_006502709
- Peptide Label: isoform X1
- UniProtKB: A2A8Y3 (UniProtKB/Swiss-Prot),   P40223 (UniProtKB/Swiss-Prot),   Q14AY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502777   ⟸   XM_006502714
- Peptide Label: isoform X1
- UniProtKB: P40223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502775   ⟸   XM_006502712
- Peptide Label: isoform X1
- UniProtKB: P40223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502779   ⟸   XM_006502716
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006502773   ⟸   XM_006502710
- Peptide Label: isoform X1
- UniProtKB: A2A8Y3 (UniProtKB/Swiss-Prot),   P40223 (UniProtKB/Swiss-Prot),   Q14AY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502776   ⟸   XM_006502713
- Peptide Label: isoform X1
- UniProtKB: P40223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502774   ⟸   XM_006502711
- Peptide Label: isoform X1
- UniProtKB: A2A8Y3 (UniProtKB/Swiss-Prot),   P40223 (UniProtKB/Swiss-Prot),   Q14AY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502780   ⟸   XM_006502717
- Peptide Label: isoform X3
- UniProtKB: Q14AY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502781   ⟸   XM_006502718
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006502782   ⟸   XM_006502719
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011238725   ⟸   XM_011240423
- Peptide Label: isoform X2
- UniProtKB: Q14BI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175434   ⟸   XM_017319945
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030109019   ⟸   XM_030253159
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000101768   ⟸   ENSMUST00000106162
RefSeq Acc Id: ENSMUSP00000030673   ⟸   ENSMUST00000030673
RefSeq Acc Id: XP_036019521   ⟸   XM_036163628
- Peptide Label: isoform X3
- UniProtKB: Q14AY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036019520   ⟸   XM_036163627
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40223-F1-model_v2 AlphaFold P40223 1-837 view protein structure

Promoters
RGD ID:6835095
Promoter ID:MM_KWN:39611
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000106162,   OTTMUST00000021098,   UC008USE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364125,701,774 - 125,702,274 (+)MPROMDB
RGD ID:6835090
Promoter ID:MM_KWN:39612
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000030673,   ENSMUST00000106163
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364125,703,886 - 125,704,587 (+)MPROMDB
RGD ID:6884624
Promoter ID:EPDNEW_M5763
Type:multiple initiation site
Name:Csf3r_1
Description:Mus musculus colony stimulating factor 3 receptor , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384126,024,726 - 126,024,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339755 AgrOrtholog
Ensembl Genes ENSMUSG00000028859 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030673 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106162 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12986 UniProtKB/Swiss-Prot
MGD MGI:1339755 ENTREZGENE
NCBI Gene 12986 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  CYTOKINE RECEPTOR UniProtKB/TrEMBL
  CYTOKINE RECEPTOR UniProtKB/TrEMBL
  GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR UniProtKB/Swiss-Prot
  GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR UniProtKB/TrEMBL
  GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csf3r PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A8Y3 ENTREZGENE
  CSF3R_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q14AY3 ENTREZGENE, UniProtKB/TrEMBL
  Q14BI3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A2A8Y3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Csf3r  colony stimulating factor 3 receptor  Csf3r  colony stimulating factor 3 receptor (granulocyte)  Symbol and/or name change 5135510 APPROVED