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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:molybdenum atom
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Accession:CHEBI:28685 term browser browse the term
Definition:A chromium group element atom that has formula Mo.
Synonyms:related_synonym: 42Mo;   Formula=Mo;   InChI=1S/Mo;   InChIKey=ZOKXTWBITQBERF-UHFFFAOYSA-N;   Mo;   Molybdaen;   Molybdenum;   SMILES=[Mo];   molibdeno;   molybdene
 alt_id: CHEBI:25369;   CHEBI:49750;   CHEBI:6968
 xref: CAS:7439-98-7;   Gmelin:16205;   KEGG:C00150
 xref_mesh: MESH:D008982
 xref: WebElements:Mo


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molybdenum atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO Molybdenum analog results in increased activity of CASP3 protein CTD PMID:26391003 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Molybdenum analog results in increased activity of CASP7 protein CTD PMID:26391003 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Molybdenum analog results in increased activity of CASP8 protein CTD PMID:26391003 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Molybdenum analog results in increased activity of CASP9 protein CTD PMID:26391003 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:33038468 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mir196b microRNA 196b multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Molybdenum] which results in increased expression of MIR196B mRNA CTD PMID:27506416 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571 		JBrowse link
G Prl prolactin decreases expression ISO Molybdenum results in decreased expression of PRL protein CTD PMID:19595304 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Slc13a4 solute carrier family 13 member 4 multiple interactions EXP Molybdenum inhibits the reaction [SLC13A4 protein affects the transport of Sulfates] CTD PMID:16129486 NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Molybdenum analog results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:26391003 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 mRNA CTD PMID:33038468 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
molybdate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP molybdate inhibits the reaction [Potassium Chloride inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]] CTD PMID:3015922 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO molybdate results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car4 carbonic anhydrase 4 decreases activity ISO molybdate results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501 		JBrowse link
G Car5a carbonic anhydrase 5A decreases activity ISO molybdate results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906 		JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO molybdate results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein CTD PMID:1321133 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs4 insulin receptor substrate 4 multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr  X:105,344,020...105,360,004 JBrowse link
G Ivl involucrin decreases expression ISO molybdate results in decreased expression of IVL protein CTD PMID:7848924 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP molybdate results in increased expression of NR3C1 protein CTD PMID:3015922 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of molybdate CTD PMID:15065880 NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein CTD PMID:34320920 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein CTD PMID:34320920 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
molybdenum trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd80 Cd80 molecule increases secretion ISO molybdenum chloride results in increased secretion of CD80 protein CTD PMID:19844976 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO molybdenum chloride results in increased secretion of IL1B protein CTD PMID:19844976 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion ISO molybdenum chloride results in increased secretion of IL6 protein CTD PMID:19844976 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO molybdenum chloride results in increased secretion of TNF protein CTD PMID:19844976 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
molybdenum trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions		 ISO molybdenum trioxide results in decreased activity of CAT protein
chromous chloride affects the reaction [molybdenum trioxide results in decreased activity of CAT protein]; molybdenum trioxide affects the reaction [chromous chloride results in decreased activity of CAT protein]		 CTD PMID:30389395 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:33038468 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO molybdenum trioxide results in increased activity of NQO1 protein
molybdenum trioxide results in increased expression of NQO1 mRNA		 CTD PMID:9029048 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 mRNA CTD PMID:33038468 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
sodium molybdate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO
EXP		 sodium molybdate(VI) promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) results in increased activity of AHR protein		 CTD PMID:3040233 PMID:8079350 PMID:8395819 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein CTD PMID:34320920 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein CTD PMID:34320920 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
tetrathiomolybdate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO tetrathiomolybdate results in increased phosphorylation of ACACA protein CTD PMID:24218578 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Angpt2 angiopoietin 2 increases expression ISO tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA CTD PMID:19323979 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects binding		 ISO [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AQP1 mRNA CTD PMID:19323979 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper] CTD PMID:11803042 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein CTD PMID:19323979 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein CTD PMID:22276220 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein CTD PMID:19323979 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein CTD PMID:22276220 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein]		 CTD PMID:15541506 PMID:21724870 PMID:24225134 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression EXP tetrathiomolybdate results in increased expression of CCS protein CTD PMID:21784888 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915 		JBrowse link
G Cd40 CD40 molecule increases expression ISO tetrathiomolybdate analog results in increased expression of CD40 mRNA CTD PMID:19323979 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tetrathiomolybdate analog results in increased expression of CDKN1A protein CTD PMID:19323979 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:16242529 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression ISO tetrathiomolybdate analog results in increased expression of COX5B mRNA CTD PMID:19323979 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Cp ceruloplasmin decreases activity
decreases expression
decreases secretion
multiple interactions		 ISO
EXP		 tetrathiomolybdate results in decreased activity of CP protein
tetrathiomolybdate results in decreased expression of CP protein
tetrathiomolybdate results in decreased secretion of CP protein
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]		 CTD PMID:10656425 PMID:12624602 PMID:21724870 PMID:21784888 PMID:24013775 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP tetrathiomolybdate results in decreased expression of CPT1A mRNA CTD PMID:21784888 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA CTD PMID:19323979 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression ISO tetrathiomolybdate analog results in increased expression of CREBZF mRNA CTD PMID:19323979 NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO tetrathiomolybdate analog results in increased expression of CXCR4 mRNA CTD PMID:19323979 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eln elastin multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein CTD PMID:22276220 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fbln1 fibulin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein CTD PMID:22276220 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fbln5 fibulin 5 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein CTD PMID:22276220 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO tetrathiomolybdate results in decreased secretion of FGF1 protein CTD PMID:18400376 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18480265 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO tetrathiomolybdate analog results in increased expression of GPX3 mRNA CTD PMID:19323979 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO tetrathiomolybdate analog results in increased expression of GSR mRNA CTD PMID:19323979 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein CTD PMID:22276220 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP tetrathiomolybdate results in decreased expression of HMGCS2 mRNA CTD PMID:21784888 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO tetrathiomolybdate analog results in decreased expression of RHAMM mRNA CTD PMID:19323979 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 tetrathiomolybdate results in decreased expression of HMOX1 protein
tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]		 CTD PMID:19323979 PMID:21784888 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:16242529 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] CTD PMID:16242529 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression
multiple interactions		 ISO tetrathiomolybdate analog results in decreased expression of IL2RA mRNA
tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]		 CTD PMID:19323979 PMID:23134680 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21724870 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA CTD PMID:19323979 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA CTD PMID:22276220 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO tetrathiomolybdate analog results in increased expression of JAG1 mRNA CTD PMID:19323979 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Klf2 KLF transcription factor 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of KLF2 mRNA CTD PMID:19323979 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Lox lysyl oxidase multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]
tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] CTD PMID:25671100 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:19323979 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein CTD PMID:24225134 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO tetrathiomolybdate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO tetrathiomolybdate results in decreased expression of PDGFRB protein CTD PMID:18480265 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP tetrathiomolybdate results in decreased expression of PPARA mRNA CTD PMID:21784888 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of PTGS2 mRNA CTD PMID:19323979 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein CTD PMID:22276220 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] CTD PMID:18480265 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression		 ISO [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter] CTD PMID:22172574 PMID:22914438 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases response to substance ISO SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate CTD PMID:24522273 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA CTD PMID:19323979 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
affects localization
decreases activity
multiple interactions		 EXP
ISO		 tetrathiomolybdate results in decreased expression of SOD1 protein
tetrathiomolybdate analog affects the localization of SOD1 protein
tetrathiomolybdate results in decreased activity of SOD1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog results in decreased expression of SOD1 mRNA		 CTD PMID:18480265 PMID:19323979 PMID:21784888 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein CTD PMID:19323979 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression
increases activity		 ISO [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]
tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA
tetrathiomolybdate results in increased activity of SP1 protein		 CTD PMID:22172574 PMID:22914438 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor decreases expression ISO tetrathiomolybdate results in decreased expression of SP3 CTD PMID:22172574 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression EXP tetrathiomolybdate results in decreased expression of TFB1M mRNA CTD PMID:21784888 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] CTD PMID:15541506 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:15541506 PMID:16242529 PMID:21724870 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:16242529 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein CTD PMID:22276220 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA CTD PMID:19323979 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein
tetrathiomolybdate results in decreased expression of VEGFA protein		 CTD PMID:16277669 PMID:22276220 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    chemical entity 19905
      atom 19905
        metal atom 17630
          transition element atom 17066
            chromium group element atom 7616
              molybdenum atom 98
                molybdenum molecular entity + 93
                molybdenum-95 0
                molybdenum-98 atom 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  metal atom 17630
                    transition element atom 17066
                      d-block element atom 17059
                        chromium group element atom 7616
                          molybdenum atom 98
                            molybdenum molecular entity + 93
                            molybdenum-95 0
                            molybdenum-98 atom 0
paths to the root