|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
molybdate inhibits the reaction [Potassium Chloride inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]] |
CTD |
PMID:3015922 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
molybdate results in decreased activity of CA2 protein |
CTD |
PMID:15664814 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Car4 |
carbonic anhydrase 4 |
decreases activity |
ISO |
molybdate results in decreased activity of CA4 protein |
CTD |
PMID:15664814 |
|
NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
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G |
Car5a |
carbonic anhydrase 5A |
decreases activity |
ISO |
molybdate results in decreased activity of CA5A protein |
CTD |
PMID:15664814 |
|
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
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G |
Car9 |
carbonic anhydrase 9 |
decreases activity |
ISO |
molybdate results in decreased activity of CA9 protein |
CTD |
PMID:15664814 |
|
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
[molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] |
CTD |
PMID:1321133 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Insr |
insulin receptor |
multiple interactions |
EXP |
[molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein |
CTD |
PMID:1321133 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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|
G |
Irs4 |
insulin receptor substrate 4 |
multiple interactions |
EXP |
[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] |
CTD |
PMID:1321133 |
|
NCBI chr X:105,344,020...105,360,004
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|
G |
Ivl |
involucrin |
decreases expression |
ISO |
molybdate results in decreased expression of IVL protein |
CTD |
PMID:7848924 |
|
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression |
EXP |
molybdate results in increased expression of NR3C1 protein |
CTD |
PMID:3015922 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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|
G |
Papss1 |
3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
multiple interactions |
ISO |
PAPSS1 protein binds to and affects the metabolism of molybdate |
CTD |
PMID:15065880 |
|
NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
[sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein |
CTD |
PMID:34320920 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
[sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein |
CTD |
PMID:34320920 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Cd80 |
Cd80 molecule |
increases secretion |
ISO |
molybdenum chloride results in increased secretion of CD80 protein |
CTD |
PMID:19844976 |
|
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Il1b |
interleukin 1 beta |
increases secretion |
ISO |
molybdenum chloride results in increased secretion of IL1B protein |
CTD |
PMID:19844976 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
molybdenum chloride results in increased secretion of IL6 protein |
CTD |
PMID:19844976 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Tnf |
tumor necrosis factor |
increases secretion |
ISO |
molybdenum chloride results in increased secretion of TNF protein |
CTD |
PMID:19844976 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Cat |
catalase |
decreases activity multiple interactions |
ISO |
molybdenum trioxide results in decreased activity of CAT protein chromous chloride affects the reaction [molybdenum trioxide results in decreased activity of CAT protein]; molybdenum trioxide affects the reaction [chromous chloride results in decreased activity of CAT protein] |
CTD |
PMID:30389395 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
[molybdenum trioxide results in increased abundance of Molybdenum] inhibits the reaction [Glucose results in increased secretion of INS1 protein] |
CTD |
PMID:33038468 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression |
ISO |
molybdenum trioxide results in increased activity of NQO1 protein molybdenum trioxide results in increased expression of NQO1 mRNA |
CTD |
PMID:9029048 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Uqcrc1 |
ubiquinol-cytochrome c reductase core protein 1 |
multiple interactions |
ISO |
[molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 mRNA |
CTD |
PMID:33038468 |
|
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
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|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity |
ISO EXP |
sodium molybdate(VI) promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein] sodium molybdate(VI) inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] sodium molybdate(VI) results in increased activity of AHR protein |
CTD |
PMID:3040233 PMID:8079350 PMID:8395819 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
[sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein |
CTD |
PMID:34320920 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
[sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein |
CTD |
PMID:34320920 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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|
G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation |
ISO |
tetrathiomolybdate results in increased phosphorylation of ACACA protein |
CTD |
PMID:24218578 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Agtr2 |
angiotensin II receptor, type 2 |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Angpt2 |
angiopoietin 2 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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G |
App |
amyloid beta precursor protein |
multiple interactions affects binding |
ISO |
[tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form |
CTD |
PMID:15681799 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp1 |
aquaporin 1 |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of AQP1 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] |
CTD |
PMID:19351718 |
|
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper] |
CTD |
PMID:11803042 |
|
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein |
CTD |
PMID:19323979 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Bcl2l11 |
Bcl2-like 11 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein |
CTD |
PMID:22276220 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bcl2l2 |
Bcl2-like 2 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein |
CTD |
PMID:19323979 |
|
NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein |
CTD |
PMID:22276220 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein |
CTD |
PMID:22276220 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein] tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein] |
CTD |
PMID:15541506 PMID:21724870 PMID:24225134 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccs |
copper chaperone for superoxide dismutase |
increases expression |
EXP |
tetrathiomolybdate results in increased expression of CCS protein |
CTD |
PMID:21784888 |
|
NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
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G |
Cd40 |
CD40 molecule |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of CD40 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of CDKN1A protein |
CTD |
PMID:19323979 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] |
CTD |
PMID:16242529 |
|
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Cox5b |
cytochrome c oxidase subunit 5B |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of COX5B mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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G |
Cp |
ceruloplasmin |
decreases activity decreases expression decreases secretion multiple interactions |
ISO EXP |
tetrathiomolybdate results in decreased activity of CP protein tetrathiomolybdate results in decreased expression of CP protein tetrathiomolybdate results in decreased secretion of CP protein tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein] |
CTD |
PMID:10656425 PMID:12624602 PMID:21724870 PMID:21784888 PMID:24013775 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression |
EXP |
tetrathiomolybdate results in decreased expression of CPT1A mRNA |
CTD |
PMID:21784888 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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|
G |
Crebzf |
CREB/ATF bZIP transcription factor |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of CREBZF mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of CXCR4 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:18480265 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:18480265 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Eln |
elastin |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein |
CTD |
PMID:22276220 |
|
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein |
CTD |
PMID:22276220 |
|
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Fbln1 |
fibulin 1 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein |
CTD |
PMID:22276220 |
|
NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
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G |
Fbln5 |
fibulin 5 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein |
CTD |
PMID:22276220 |
|
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
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G |
Fbn1 |
fibrillin 1 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein |
CTD |
PMID:22276220 |
|
NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases secretion |
ISO |
tetrathiomolybdate results in decreased secretion of FGF1 protein |
CTD |
PMID:18400376 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:18480265 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of GPX3 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of GSR mRNA |
CTD |
PMID:19323979 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein |
CTD |
PMID:22276220 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
EXP |
tetrathiomolybdate results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:21784888 |
|
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hmmr |
hyaluronan-mediated motility receptor |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of RHAMM mRNA |
CTD |
PMID:19323979 |
|
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression increases expression multiple interactions |
EXP ISO |
tetrathiomolybdate results in decreased expression of HMOX1 protein tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein [tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein] |
CTD |
PMID:19323979 PMID:21784888 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein] tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein] |
CTD |
PMID:21724870 PMID:24225134 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] |
CTD |
PMID:18480265 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] |
CTD |
PMID:18480265 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] |
CTD |
PMID:21724870 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] |
CTD |
PMID:16242529 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] |
CTD |
PMID:16242529 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
decreases expression multiple interactions |
ISO |
tetrathiomolybdate analog results in decreased expression of IL2RA mRNA tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]] |
CTD |
PMID:19323979 PMID:23134680 |
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NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] |
CTD |
PMID:21724870 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb4 |
integrin subunit beta 4 |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA |
CTD |
PMID:19323979 |
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NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Itgb6 |
integrin subunit beta 6 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA |
CTD |
PMID:22276220 |
|
NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
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G |
Jag1 |
jagged canonical Notch ligand 1 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of JAG1 mRNA |
CTD |
PMID:19323979 |
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NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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G |
Klf2 |
KLF transcription factor 2 |
decreases expression |
ISO |
tetrathiomolybdate analog results in decreased expression of KLF2 mRNA |
CTD |
PMID:19323979 |
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NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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G |
Lox |
lysyl oxidase |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein |
CTD |
PMID:22276220 |
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NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]] tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:18480265 PMID:19323979 PMID:22276220 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:18480265 PMID:19323979 PMID:22276220 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] |
CTD |
PMID:25671100 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein |
CTD |
PMID:19323979 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein |
CTD |
PMID:24225134 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
tetrathiomolybdate results in decreased expression of PCNA protein |
CTD |
PMID:24614111 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
decreases expression |
ISO |
tetrathiomolybdate results in decreased expression of PDGFRB protein |
CTD |
PMID:18480265 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression |
EXP |
tetrathiomolybdate results in decreased expression of PPARA mRNA |
CTD |
PMID:21784888 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of PTGS2 mRNA |
CTD |
PMID:19323979 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein |
CTD |
PMID:22276220 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] |
CTD |
PMID:18480265 |
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NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions increases expression |
ISO |
[tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter] |
CTD |
PMID:22172574 PMID:22914438 |
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NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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G |
Slc31a2 |
solute carrier family 31 member 2 |
decreases response to substance |
ISO |
SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate |
CTD |
PMID:24522273 |
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NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA |
CTD |
PMID:19323979 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression affects localization decreases activity multiple interactions |
EXP ISO |
tetrathiomolybdate results in decreased expression of SOD1 protein tetrathiomolybdate analog affects the localization of SOD1 protein tetrathiomolybdate results in decreased activity of SOD1 protein [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] tetrathiomolybdate analog results in decreased expression of SOD1 mRNA |
CTD |
PMID:18480265 PMID:19323979 PMID:21784888 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein |
CTD |
PMID:19323979 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions increases expression increases activity |
ISO |
[tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter] tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA tetrathiomolybdate results in increased activity of SP1 protein |
CTD |
PMID:22172574 PMID:22914438 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sp3 |
Sp3 transcription factor |
decreases expression |
ISO |
tetrathiomolybdate results in decreased expression of SP3 |
CTD |
PMID:22172574 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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G |
Tfb1m |
transcription factor B1, mitochondrial |
decreases expression |
EXP |
tetrathiomolybdate results in decreased expression of TFB1M mRNA |
CTD |
PMID:21784888 |
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NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] |
CTD |
PMID:15541506 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] |
CTD |
PMID:15541506 PMID:16242529 PMID:21724870 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] |
CTD |
PMID:16242529 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein |
CTD |
PMID:22276220 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA |
CTD |
PMID:19323979 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein] tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein] |
CTD |
PMID:21724870 PMID:24225134 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
EXP |
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein tetrathiomolybdate results in decreased expression of VEGFA protein |
CTD |
PMID:16277669 PMID:22276220 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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