Ifitm2 (interferon induced transmembrane protein 2) - Rat Genome Database

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Gene: Ifitm2 (interferon induced transmembrane protein 2) Mus musculus
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Symbol: Ifitm2
Name: interferon induced transmembrane protein 2
RGD ID: 736841
MGI Page MGI
Description: Involved in defense response to virus and negative regulation of viral entry into host cell. Predicted to localize to plasma membrane and protein-containing complex. Is expressed in several structures, including 4-cell stage embryo; brain; genitourinary system; hemolymphoid system; and liver. Orthologous to human IFITM2 (interferon induced transmembrane protein 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dispanin subfamily A member 2c; DSPA2c; fra; fragilis protein 3; fragilis R; fragilis3; Ifit; Ifitm3l; interferon induced transmembrane protein 3-like; interferon induced transmembrane protein, like; interferon-induced transmembrane protein 2; MGC102396; mil; mil-3
RGD Orthologs
Human
Rat
Bonobo
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm2518   Gm5331  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,534,750 - 140,539,602 (-)NCBIGRCm39mm39
GRCm39 Ensembl7140,534,750 - 140,535,900 (-)Ensembl
GRCm387140,954,837 - 140,959,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,954,837 - 140,955,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,140,738 - 148,141,860 (-)NCBIGRCm37mm9NCBIm37
MGSCv367140,806,159 - 140,807,281 (-)NCBImm8
Celera7140,747,247 - 140,748,369 (-)NCBICelera
Cytogenetic Map7F5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diclofenac  (EXP)
diuron  (ISO)
elemental selenium  (ISO)
fenamidone  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12659663   PMID:12904583   PMID:14516695   PMID:14610273   PMID:16141072  
PMID:16141073   PMID:16395393   PMID:16602821   PMID:18505827   PMID:18799693   PMID:20064371   PMID:20376577   PMID:21253575   PMID:21267068   PMID:21677750   PMID:21731673   PMID:21873635  
PMID:21947380   PMID:25738301   PMID:28246125   PMID:28880886   PMID:30365177   PMID:30550785  


Genomics

Comparative Map Data
Ifitm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,534,750 - 140,539,602 (-)NCBIGRCm39mm39
GRCm39 Ensembl7140,534,750 - 140,535,900 (-)Ensembl
GRCm387140,954,837 - 140,959,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,954,837 - 140,955,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,140,738 - 148,141,860 (-)NCBIGRCm37mm9NCBIm37
MGSCv367140,806,159 - 140,807,281 (-)NCBImm8
Celera7140,747,247 - 140,748,369 (-)NCBICelera
Cytogenetic Map7F5NCBI
IFITM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11303,655 - 309,397 (+)EnsemblGRCh38hg38GRCh38
GRCh3811307,816 - 309,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711308,107 - 309,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611298,107 - 299,410 (+)NCBINCBI36hg18NCBI36
Build 3411297,914 - 299,392NCBI
Celera11250,035 - 251,338 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11127,655 - 128,958 (+)NCBIHuRef
CHM1_111307,071 - 308,374 (+)NCBICHM1_1
Ifitm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21196,051,539 - 196,052,719 (-)NCBI
Rnor_6.0 Ensembl1213,750,192 - 213,751,405 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,750,219 - 213,751,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,671,382 - 220,672,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,134,357 - 201,135,537 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,284,348 - 201,285,529 (-)NCBI
Celera1193,685,703 - 193,686,883 (-)NCBICelera
Cytogenetic Map1q41NCBI
LOC100969436
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111348,341 - 349,557 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11348,341 - 349,551 (+)Ensemblpanpan1.1panPan2

Position Markers
Ifitm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B4UniSTS
Cytogenetic Map7F5UniSTS
cM Map786.18UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:155
Interacting mature miRNAs:166
Transcripts:ENSMUST00000081649
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000081649   ⟹   ENSMUSP00000071470
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7140,954,837 - 140,955,987 (-)Ensembl
RefSeq Acc Id: NM_030694   ⟹   NP_109619
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,534,752 - 140,535,874 (-)NCBI
GRCm387140,954,839 - 140,955,961 (-)ENTREZGENE
MGSCv377148,140,738 - 148,141,860 (-)RGD
Celera7140,747,247 - 140,748,369 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030243121   ⟹   XP_030098981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,534,750 - 140,539,598 (-)NCBI
GRCm387140,954,837 - 140,959,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153595   ⟹   XP_036009488
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,534,750 - 140,539,602 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_109619   ⟸   NM_030694
- UniProtKB: Q99J93 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030098981   ⟸   XM_030243121
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000071470   ⟸   ENSMUST00000081649
RefSeq Acc Id: XP_036009488   ⟸   XM_036153595
- Peptide Label: isoform X1

Promoters
RGD ID:8666047
Promoter ID:EPDNEW_M11055
Type:initiation region
Name:Ifitm2_1
Description:Mus musculus interferon induced transmembrane protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,955,938 - 140,955,998EPDNEW
RGD ID:6841315
Promoter ID:MM_KWN:53205
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000081649
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,141,376 - 148,142,487 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933382 AgrOrtholog
Ensembl Genes ENSMUSG00000060591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000071470 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081649 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CD225/Dispanin_fam UniProtKB/Swiss-Prot
KEGG Report mmu:80876 UniProtKB/Swiss-Prot
MGD MGI:1933382 ENTREZGENE
NCBI Gene 80876 ENTREZGENE
Pfam CD225 UniProtKB/Swiss-Prot
PhenoGen Ifitm2 PhenoGen
UniProt IFM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TIG4 UniProtKB/Swiss-Prot