Reg1 (regenerating islet-derived 1) - Rat Genome Database
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Gene: Reg1 (regenerating islet-derived 1) Mus musculus
Analyze
Symbol: Reg1
Name: regenerating islet-derived 1
RGD ID: 737019
MGI Page MGI
Description: Is expressed in several structures, including esophagus; lung; and pancreas. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: islet of Langerhans regenerating protein 1; lithostathine-1; pancreatic stone protein 1; pancreatic thread protein 1; PSP; PTP; REG 1; regenerating islet-derived, mouse homolog 1; regenerating protein 1
RGD Orthologs
Human
Rat
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,402,966 - 78,405,651 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,399,694 - 78,405,650 (+)Ensembl
GRCm38678,425,983 - 78,428,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,422,711 - 78,428,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,375,977 - 78,378,660 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,355,492 - 78,358,175 (+)NCBImm8
Celera680,448,960 - 80,451,643 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Chen JJ, etal., Exp Biol Med (Maywood). 2011 Jul;236(7):823-31. doi: 10.1258/ebm.2011.010399. Epub 2011 Jun 17.
2. De Caro A, etal., Biochimie. 1988 Sep;70(9):1209-14.
3. de la Monte SM, etal., J Clin Invest. 1990 Sep;86(3):1004-13.
4. Gross DJ, etal., Endocrinology. 1998 May;139(5):2369-74.
5. Harada K, etal., Hepatology. 2001 May;33(5):1036-42.
6. Higham AD, etal., Gastroenterology. 1999 Jun;116(6):1310-8.
7. Kiji T, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H277-84. Epub 2005 Mar 18.
8. Kimura T, etal., Clin Exp Immunol. 2009 Jan;155(1):16-20. doi: 10.1111/j.1365-2249.2008.03806.x. Epub 2008 Nov 6.
9. Meili S, etal., Cell Tissue Res. 2003 Jun;312(3):291-9. Epub 2003 May 23.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
12. MGD IEA
13. Ohno T, etal., Endocr J. 1995 Oct;42(5):649-53.
14. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Pin CL, etal., J Cell Biol 2001 Nov 12;155(4):519-30. Epub 2001 Nov 5.
16. RGD automated import pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. Rouquier S, etal., J Biol Chem 1991 Jan 15;266(2):786-91.
20. Terazono K, etal., J Biol Chem 1988 Feb 15;263(5):2111-4.
21. Viterbo D, etal., JOP. 2009 Jan 8;10(1):15-23.
22. Watanabe T, etal., J Biol Chem. 1990 May 5;265(13):7432-9.
23. Watanabe T, etal., Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3589-92.
Additional References at PubMed
PMID:8340418   PMID:8522062   PMID:8751373   PMID:8808978   PMID:8863190   PMID:8903735   PMID:9055810   PMID:10349636   PMID:10526060   PMID:10767532   PMID:11042159   PMID:11076861  
PMID:11097844   PMID:11217851   PMID:12475793   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16405968   PMID:16909126   PMID:17463184   PMID:18554416   PMID:18712671  
PMID:19969026   PMID:20050810   PMID:20157293   PMID:20508157   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22037600   PMID:22158612   PMID:23269672   PMID:23986224   PMID:24587207  
PMID:25747353   PMID:27055226   PMID:28071719   PMID:28415799   PMID:29339122   PMID:29935186   PMID:30914711   PMID:31166710  


Genomics

Comparative Map Data
Reg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,402,966 - 78,405,651 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,399,694 - 78,405,650 (+)Ensembl
GRCm38678,425,983 - 78,428,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,422,711 - 78,428,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,375,977 - 78,378,660 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,355,492 - 78,358,175 (+)NCBImm8
Celera680,448,960 - 80,451,643 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.77NCBI
REG1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl279,120,362 - 79,123,409 (+)EnsemblGRCh38hg38GRCh38
GRCh38279,120,488 - 79,123,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37279,347,614 - 79,350,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,201,092 - 79,204,053 (+)NCBINCBI36hg18NCBI36
Build 34279,259,238 - 79,262,200NCBI
Celera279,176,313 - 79,179,273 (+)NCBI
Cytogenetic Map2p12NCBI
HuRef279,082,895 - 79,085,855 (+)NCBIHuRef
CHM1_1279,277,113 - 79,280,074 (+)NCBICHM1_1
Reg1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24110,892,451 - 110,895,115 (+)NCBI
Rnor_6.0 Ensembl4109,497,962 - 109,501,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04109,497,962 - 109,500,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04174,199,389 - 174,202,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,386,071 - 112,389,205 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14112,630,551 - 112,633,685 (+)NCBI
Celera499,924,400 - 99,927,064 (+)NCBICelera
Cytogenetic Map4q33NCBI
Reg1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365564,873,331 - 4,875,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Reg1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474923,993,755 - 23,995,923 (+)NCBI

Position Markers
D14010  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38678,428,458 - 78,428,590UniSTSGRCm38
MGSCv37678,378,452 - 78,378,584UniSTSGRCm37
Celera680,451,435 - 80,451,567UniSTS
Cytogenetic Map6C-DUniSTS
Reg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Cytogenetic Map6C-DUniSTS
cM Map633.5UniSTS
cM Map6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:97
Interacting mature miRNAs:103
Transcripts:ENSMUST00000079926
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079926   ⟹   ENSMUSP00000078847
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,425,983 - 78,428,666 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204601   ⟹   ENSMUSP00000144840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,422,771 - 78,428,667 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204687   ⟹   ENSMUSP00000145161
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,422,711 - 78,428,667 (+)Ensembl
RefSeq Acc Id: NM_009042   ⟹   NP_033068
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39678,402,966 - 78,405,651 (+)NCBI
GRCm38678,425,983 - 78,428,668 (+)NCBI
MGSCv37678,375,977 - 78,378,660 (+)RGD
Celera680,448,960 - 80,451,643 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033068   ⟸   NM_009042
- Peptide Label: precursor
- UniProtKB: P43137 (UniProtKB/Swiss-Prot),   Q3TV26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078847   ⟸   ENSMUST00000079926
RefSeq Acc Id: ENSMUSP00000144840   ⟸   ENSMUST00000204601
RefSeq Acc Id: ENSMUSP00000145161   ⟸   ENSMUST00000204687
Protein Domains
C-type lectin

Promoters
RGD ID:6890072
Promoter ID:EPDNEW_M8486
Type:multiple initiation site
Name:Reg1_1
Description:Mus musculus regenerating islet-derived 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,425,983 - 78,426,043EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97895 AgrOrtholog
Ensembl Genes ENSMUSG00000059654 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078847 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144840 UniProtKB/Swiss-Prot
  ENSMUSP00000145161 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079926 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000204601 UniProtKB/Swiss-Prot
  ENSMUST00000204687 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19692 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97895 ENTREZGENE
NCBI Gene 19692 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LIT1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TV26 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6F9_MOUSE UniProtKB/TrEMBL