CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: purine-6-thiol
Accession: CHEBI:2208
browse the term
Definition: A thiol that is the tautomer of mercaptopurine.
Synonyms: exact_synonym: 7H-purine-6-thiol
related_synonym: 1,7-Dihydro-6H-purine-6-thione; 3H-Purine-6-thiol; 6-MP; 6-Thiohypoxanthine; Formula=C5H4N4S; InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10); InChIKey=GLVAUDGFNGKCSF-UHFFFAOYSA-N; SMILES=Sc1ncnc2nc[nH]c12
xref: CAS:50-44-2; DrugBank:DB01033; KEGG:C01756; KEGG:C02380
xref_mesh: MESH:D015122
xref: PDBeChem:PM6; PMID:24211998; PMID:24651962; PMID:24670805; PMID:24774509; Reaxys:608595
cyclic_relationship: is_tautomer_of CHEBI:50667
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ABCC8
ATP binding cassette subfamily C member 8
decreases expression
ISO
Mercaptopurine results in decreased expression of ABCC8 mRNA
CTD
PMID:23358152
NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
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ACER2
alkaline ceramidase 2
increases expression
ISO
Mercaptopurine results in increased expression of ACER2 mRNA
CTD
PMID:23358152
NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505
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ACOD1
aconitate decarboxylase 1
increases expression
ISO
Mercaptopurine results in increased expression of ACOD1 mRNA
CTD
PMID:23358152
NCBI chr13:76,948,511...76,958,638
Ensembl chr13:76,948,511...76,958,638
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ACTG2
actin gamma 2, smooth muscle
decreases expression
ISO
Mercaptopurine results in decreased expression of ACTG2 mRNA
CTD
PMID:23358152
NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865
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ACTRT3
actin related protein T3
increases expression
ISO
Mercaptopurine results in increased expression of ACTRT3 mRNA
CTD
PMID:23358152
NCBI chr 3:169,766,921...169,769,561
Ensembl chr 3:169,766,921...169,769,561
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ADM
adrenomedullin
increases expression
ISO
Mercaptopurine results in increased expression of ADM mRNA
CTD
PMID:23358152
NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
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AGT
angiotensinogen
decreases expression
ISO
Mercaptopurine results in decreased expression of AGT mRNA
CTD
PMID:23358152
NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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AGXT
alanine--glyoxylate aminotransferase
increases expression
ISO
Mercaptopurine results in increased expression of AGXT mRNA
CTD
PMID:23358152
NCBI chr 2:240,868,824...240,880,500
Ensembl chr 2:240,868,824...240,880,502
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AKAP12
A-kinase anchoring protein 12
decreases expression
ISO
Mercaptopurine results in decreased expression of AKAP12 mRNA
CTD
PMID:23358152
NCBI chr 6:151,239,967...151,358,559
Ensembl chr 6:151,239,967...151,358,559
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AKAP3
A-kinase anchoring protein 3
increases expression
ISO
Mercaptopurine results in increased expression of AKAP3 mRNA
CTD
PMID:23358152
NCBI chr12:4,615,518...4,649,051
Ensembl chr12:4,615,508...4,649,051
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ALDH1B1
aldehyde dehydrogenase 1 family member B1
decreases expression
ISO
Mercaptopurine results in decreased expression of ALDH1B1 mRNA
CTD
PMID:23358152
NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661
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ALOX15
arachidonate 15-lipoxygenase
decreases expression
ISO
Mercaptopurine results in decreased expression of ALOX15 mRNA
CTD
PMID:23358152
NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
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ALPI
alkaline phosphatase, intestinal
decreases expression
ISO
Mercaptopurine results in decreased expression of ALPI mRNA
CTD
PMID:23358152
NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753
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AMPD3
adenosine monophosphate deaminase 3
increases expression
ISO
Mercaptopurine results in increased expression of AMPD3 mRNA
CTD
PMID:23358152
NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579
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ANGPT2
angiopoietin 2
increases expression
ISO
Mercaptopurine results in increased expression of ANGPT2 mRNA
CTD
PMID:23358152
NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409
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ANXA9
annexin A9
decreases expression
ISO
Mercaptopurine results in decreased expression of ANXA9 mRNA
CTD
PMID:23358152
NCBI chr 1:150,977,306...150,995,634
Ensembl chr 1:150,982,249...150,995,634
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APOC3
apolipoprotein C3
decreases expression
ISO
Mercaptopurine results in decreased expression of APOC3 mRNA
CTD
PMID:23358152
NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
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ART3
ADP-ribosyltransferase 3 (inactive)
increases expression
ISO
Mercaptopurine results in increased expression of ART3 mRNA
CTD
PMID:23358152
NCBI chr 4:76,011,190...76,112,786
Ensembl chr 4:76,011,184...76,114,048
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ASB14
ankyrin repeat and SOCS box containing 14
increases expression
ISO
Mercaptopurine results in increased expression of ASB14 mRNA
CTD
PMID:23358152
NCBI chr 3:57,268,342...57,292,685
Ensembl chr 3:57,268,342...57,292,685
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ASPRV1
aspartic peptidase retroviral like 1
increases expression
ISO
Mercaptopurine results in increased expression of ASPRV1 mRNA
CTD
PMID:23358152
NCBI chr 2:69,932,717...70,087,375
Ensembl chr 2:69,960,089...69,961,631
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ATP2A3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
decreases expression
ISO
Mercaptopurine results in decreased expression of ATP2A3 mRNA
CTD
PMID:23358152
NCBI chr17:3,923,873...3,964,437
Ensembl chr17:3,923,870...3,964,464
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BARD1
BRCA1 associated RING domain 1
decreases expression
ISO
Mercaptopurine results in decreased expression of BARD1 mRNA
CTD
PMID:23358152
NCBI chr 2:214,725,646...214,809,683
Ensembl chr 2:214,725,646...214,809,683
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BATF3
basic leucine zipper ATF-like transcription factor 3
decreases expression
ISO
Mercaptopurine results in decreased expression of BATF3 mRNA
CTD
PMID:23358152
NCBI chr 1:212,686,417...212,699,840
Ensembl chr 1:212,686,417...212,699,840
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BAX
BCL2 associated X, apoptosis regulator
increases expression
ISO
Mercaptopurine results in increased expression of BAX protein
CTD
PMID:9058596
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BCL2
BCL2 apoptosis regulator
decreases expression multiple interactions
ISO EXP
Mercaptopurine results in decreased expression of BCL2 protein [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein
CTD
PMID:9058596 PMID:21182165
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BCL2L1
BCL2 like 1
decreases expression
EXP
Mercaptopurine results in decreased expression of BCL2L1 protein
CTD
PMID:12697733
NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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BCORL1
BCL6 corepressor like 1
decreases expression
ISO
Mercaptopurine results in decreased expression of BCORL1 mRNA
CTD
PMID:23358152
NCBI chr X:129,980,313...130,058,071
Ensembl chr X:129,981,107...130,058,071
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BSPRY
B-box and SPRY domain containing
decreases expression
ISO
Mercaptopurine results in decreased expression of BSPRY mRNA
CTD
PMID:23358152
NCBI chr 9:113,349,541...113,371,222
Ensembl chr 9:113,349,541...113,371,233
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BTBD16
BTB domain containing 16
increases expression
ISO
Mercaptopurine results in increased expression of BTBD16 mRNA
CTD
PMID:23358152
NCBI chr10:122,271,296...122,338,159
Ensembl chr10:122,271,296...122,338,159
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C1QA
complement C1q A chain
increases expression
ISO
Mercaptopurine results in increased expression of C1QA mRNA
CTD
PMID:23358152
NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
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CA4
carbonic anhydrase 4
decreases expression
ISO
Mercaptopurine results in decreased expression of CAR4 mRNA
CTD
PMID:23358152
NCBI chr17:60,149,973...60,179,021
Ensembl chr17:60,149,942...60,170,899
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CA7
carbonic anhydrase 7
decreases expression
ISO
Mercaptopurine results in decreased expression of CAR7 mRNA
CTD
PMID:23358152
NCBI chr16:66,844,414...66,854,147
Ensembl chr16:66,844,414...66,854,153
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CAP2
cyclase associated actin cytoskeleton regulatory protein 2
increases expression
ISO
Mercaptopurine results in increased expression of CAP2 mRNA
CTD
PMID:23358152
NCBI chr 6:17,393,595...17,557,780
Ensembl chr 6:17,393,595...17,557,780
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CASP3
caspase 3
increases expression
ISO
Mercaptopurine results in increased expression of CASP3 protein
CTD
PMID:22688000
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CCL5
C-C motif chemokine ligand 5
decreases expression
ISO
Mercaptopurine results in decreased expression of CCL5 mRNA
CTD
PMID:23358152
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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CCNE1
cyclin E1
decreases expression
ISO
Mercaptopurine results in decreased expression of CCNE1 mRNA
CTD
PMID:23358152
NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
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CCR6
C-C motif chemokine receptor 6
decreases expression
ISO
Mercaptopurine results in decreased expression of CCR6 mRNA
CTD
PMID:23358152
NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141
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CD19
CD19 molecule
decreases expression
ISO
Mercaptopurine results in decreased expression of CD19 mRNA
CTD
PMID:23358152
NCBI chr16:28,931,971...28,939,342
Ensembl chr16:28,931,965...28,939,342
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CD28
CD28 molecule
multiple interactions
EXP
Mercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:12697733
NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,475...203,738,912
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CD68
CD68 molecule
increases expression
ISO
Mercaptopurine results in increased expression of CD68 mRNA
CTD
PMID:23358152
NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
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CD79B
CD79b molecule
decreases expression
ISO
Mercaptopurine results in decreased expression of CD79B mRNA
CTD
PMID:23358152
NCBI chr17:63,928,740...63,932,331
Ensembl chr17:63,928,738...63,932,336
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CDC25B
cell division cycle 25B
decreases expression
ISO
Mercaptopurine results in decreased expression of CDC25B mRNA
CTD
PMID:23358152
NCBI chr20:3,786,951...3,806,115
Ensembl chr20:3,786,772...3,806,121
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CDCA3
cell division cycle associated 3
decreases expression
ISO
Mercaptopurine results in decreased expression of CDCA3 mRNA
CTD
PMID:23358152
NCBI chr12:6,844,798...6,851,286
Ensembl chr12:6,844,793...6,851,292
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CDCA7L
cell division cycle associated 7 like
decreases expression
ISO
Mercaptopurine results in decreased expression of CDCA7L mRNA
CTD
PMID:23358152
NCBI chr 7:21,900,899...21,945,899
Ensembl chr 7:21,900,899...21,945,903
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CELA1
chymotrypsin like elastase 1
increases expression
ISO
Mercaptopurine results in increased expression of CELA1 mRNA
CTD
PMID:23358152
NCBI chr12:51,328,442...51,346,679
Ensembl chr12:51,328,442...51,346,679
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CENPW
centromere protein W
decreases expression
ISO
Mercaptopurine results in decreased expression of CENPW mRNA
CTD
PMID:23358152
NCBI chr 6:126,340,115...126,483,320
Ensembl chr 6:126,340,115...126,348,875
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CES3
carboxylesterase 3
increases expression
ISO
Mercaptopurine results in increased expression of CES3 mRNA
CTD
PMID:23358152
NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
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CES4A
carboxylesterase 4A
increases expression
ISO
Mercaptopurine results in increased expression of CES4A mRNA
CTD
PMID:23358152
NCBI chr16:66,988,589...67,010,417
Ensembl chr16:66,988,589...67,010,417
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CHRD
chordin
increases expression
ISO
Mercaptopurine results in increased expression of CHRD mRNA
CTD
PMID:23358152
NCBI chr 3:184,380,054...184,390,739
Ensembl chr 3:184,380,054...184,390,736
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CHRDL1
chordin like 1
decreases expression
ISO
Mercaptopurine results in decreased expression of CHRDL1 mRNA
CTD
PMID:23358152
NCBI chr X:110,673,856...110,795,817
Ensembl chr X:110,673,856...110,795,819
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CHRNA2
cholinergic receptor nicotinic alpha 2 subunit
decreases expression
ISO
Mercaptopurine results in decreased expression of CHRNA2 mRNA
CTD
PMID:23358152
NCBI chr 8:27,459,756...27,479,261
Ensembl chr 8:27,459,756...27,479,883
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CLEC14A
C-type lectin domain containing 14A
decreases expression
ISO
Mercaptopurine results in decreased expression of CLEC14A mRNA
CTD
PMID:23358152
NCBI chr14:38,254,000...38,256,093
Ensembl chr14:38,254,000...38,256,093
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CLEC4D
C-type lectin domain family 4 member D
increases expression
ISO
Mercaptopurine results in increased expression of CLEC4D mRNA
CTD
PMID:23358152
NCBI chr12:8,513,503...8,531,696
Ensembl chr12:8,509,475...8,522,366
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CLGN
calmegin
decreases expression
ISO
Mercaptopurine results in decreased expression of CLGN mRNA
CTD
PMID:23358152
NCBI chr 4:140,388,453...140,427,648
Ensembl chr 4:140,388,453...140,427,661
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CLIC2
chloride intracellular channel 2
increases expression
ISO
Mercaptopurine results in increased expression of CLIC2 mRNA
CTD
PMID:23358152
NCBI chr X:155,276,211...155,334,614
Ensembl chr X:155,276,211...155,334,657
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CNMD
chondromodulin
decreases expression
ISO
Mercaptopurine results in decreased expression of CNMD mRNA
CTD
PMID:23358152
NCBI chr13:52,703,264...52,739,820
Ensembl chr13:52,703,264...52,739,820
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COL11A1
collagen type XI alpha 1 chain
decreases expression
ISO
Mercaptopurine results in decreased expression of COL11A1 mRNA
CTD
PMID:23358152
NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872
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COL1A1
collagen type I alpha 1 chain
decreases expression
ISO
Mercaptopurine results in decreased expression of COL1A1 mRNA
CTD
PMID:23358152
NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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COL2A1
collagen type II alpha 1 chain
decreases expression
ISO
Mercaptopurine results in decreased expression of COL2A1 mRNA
CTD
PMID:23358152
NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
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CORIN
corin, serine peptidase
increases expression
ISO
Mercaptopurine results in increased expression of CORIN mRNA
CTD
PMID:23358152
NCBI chr 4:47,594,001...47,838,067
Ensembl chr 4:47,593,999...47,838,106
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CORO6
coronin 6
increases expression
ISO
Mercaptopurine results in increased expression of CORO6 mRNA
CTD
PMID:23358152
NCBI chr17:29,614,762...29,622,912
Ensembl chr17:29,614,756...29,622,912
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CPE
carboxypeptidase E
increases expression
ISO
Mercaptopurine results in increased expression of CPE mRNA
CTD
PMID:23358152
NCBI chr 4:165,379,008...165,498,547
Ensembl chr 4:165,361,194...165,498,547
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CTSK
cathepsin K
increases expression
ISO
Mercaptopurine results in increased expression of CTSK mRNA
CTD
PMID:23358152
NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577
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CTXN3
cortexin 3
increases expression
ISO
Mercaptopurine results in increased expression of CTXN3 mRNA
CTD
PMID:23358152
NCBI chr 5:127,649,082...127,658,630
Ensembl chr 5:127,649,082...127,658,630
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CUBN
cubilin
decreases expression
ISO
Mercaptopurine results in decreased expression of CUBN mRNA
CTD
PMID:23358152
NCBI chr10:16,823,966...17,129,811
Ensembl chr10:16,823,966...17,129,811
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CXCL2
C-X-C motif chemokine ligand 2
increases expression
ISO
Mercaptopurine results in increased expression of CXCL2 mRNA
CTD
PMID:23358152
NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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CYP26A1
cytochrome P450 family 26 subfamily A member 1
increases expression
ISO
Mercaptopurine results in increased expression of CYP26A1 mRNA
CTD
PMID:23358152
NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
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CYP2J2
cytochrome P450 family 2 subfamily J member 2
increases expression
ISO
Mercaptopurine results in increased expression of CYP2J4 mRNA
CTD
PMID:23358152
NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773
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DCAF12L1
DDB1 and CUL4 associated factor 12 like 1
decreases expression
ISO
Mercaptopurine results in decreased expression of DCAF12L1 mRNA
CTD
PMID:23358152
NCBI chr X:126,549,383...126,552,814
Ensembl chr X:126,549,383...126,552,814
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DEF6
DEF6 guanine nucleotide exchange factor
increases expression
ISO
Mercaptopurine results in increased expression of DEF6 mRNA
CTD
PMID:23358152
NCBI chr 6:35,297,818...35,321,771
Ensembl chr 6:35,297,818...35,321,771
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DHRS9
dehydrogenase/reductase 9
increases expression
ISO
Mercaptopurine results in increased expression of DHRS9 mRNA
CTD
PMID:23358152
NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167
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DIO2
iodothyronine deiodinase 2
increases expression
ISO
Mercaptopurine results in increased expression of DIO2 mRNA
CTD
PMID:23358152
NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757
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DKKL1
dickkopf like acrosomal protein 1
decreases expression
ISO
Mercaptopurine results in decreased expression of DKKL1 mRNA
CTD
PMID:23358152
NCBI chr19:49,360,515...49,375,116
Ensembl chr19:49,361,783...49,375,116
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DLK2
delta like non-canonical Notch ligand 2
increases expression
ISO
Mercaptopurine results in increased expression of DLK2 mRNA
CTD
PMID:23358152
NCBI chr 6:43,450,352...43,456,632
Ensembl chr 6:43,450,352...43,456,632
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DLL3
delta like canonical Notch ligand 3
decreases expression
ISO
Mercaptopurine results in decreased expression of DLL3 mRNA
CTD
PMID:23358152
NCBI chr19:39,498,947...39,508,469
Ensembl chr19:39,498,895...39,508,481
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DRD4
dopamine receptor D4
increases expression
ISO
Mercaptopurine results in increased expression of DRD4 mRNA
CTD
PMID:23358152
NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706
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DUOX2
dual oxidase 2
increases expression
ISO
Mercaptopurine results in increased expression of DUOX2 mRNA
CTD
PMID:23358152
NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172
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EFEMP1
EGF containing fibulin extracellular matrix protein 1
increases expression
ISO
Mercaptopurine results in increased expression of EFEMP1 mRNA
CTD
PMID:23358152
NCBI chr 2:55,865,967...55,923,782
Ensembl chr 2:55,865,967...55,924,139
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EFNA1
ephrin A1
multiple interactions
ISO
Mercaptopurine promotes the reaction [GW 1929 results in increased expression of EFNA1 mRNA]
CTD
PMID:27435855
NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899
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EHD3
EH domain containing 3
increases expression
ISO
Mercaptopurine results in increased expression of EHD3 mRNA
CTD
PMID:23358152
NCBI chr 2:31,234,152...31,269,451
Ensembl chr 2:31,234,152...31,269,451
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ELF5
E74 like ETS transcription factor 5
decreases expression
ISO
Mercaptopurine results in decreased expression of ELF5 mRNA
CTD
PMID:23358152
NCBI chr11:34,478,791...34,513,794
Ensembl chr11:34,478,791...34,525,193
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EMCN
endomucin
decreases expression
ISO
Mercaptopurine results in decreased expression of EMCN mRNA
CTD
PMID:23358152
NCBI chr 4:100,395,341...100,518,022
Ensembl chr 4:100,395,341...100,880,126
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ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
decreases expression
ISO
Mercaptopurine results in decreased expression of ENPP2 mRNA
CTD
PMID:23358152
NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453
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EPB41L3
erythrocyte membrane protein band 4.1 like 3
decreases expression
ISO
Mercaptopurine results in decreased expression of EPB41L3 mRNA
CTD
PMID:23358152
NCBI chr18:5,392,386...5,630,663
Ensembl chr18:5,392,381...5,630,700
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ERBB2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
Mercaptopurine results in decreased expression of ERBB2 mRNA
CTD
PMID:23358152
NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
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ERVFRD-1
endogenous retrovirus group FRD member 1, envelope
decreases expression
ISO
Mercaptopurine results in decreased expression of ERVFRD-1 mRNA
CTD
PMID:23358152
NCBI chr 6:11,102,489...11,111,725
Ensembl chr 6:11,102,324...11,111,845
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ESR1
estrogen receptor 1
increases expression
ISO
Mercaptopurine results in increased expression of ESR1 mRNA
CTD
PMID:23358152
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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F13A1
coagulation factor XIII A chain
increases expression
ISO
Mercaptopurine results in increased expression of F13A1 mRNA
CTD
PMID:23358152
NCBI chr 6:6,144,084...6,320,662
Ensembl chr 6:6,144,084...6,321,013
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FAM25A
family with sequence similarity 25 member A
increases expression
ISO
Mercaptopurine results in increased expression of FAM25A mRNA
CTD
PMID:23358152
NCBI chr10:87,020,294...87,024,730
Ensembl chr10:87,020,294...87,024,730
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FCGR3A
Fc gamma receptor IIIa
increases expression
ISO
Mercaptopurine results in increased expression of FCGR3A mRNA
CTD
PMID:23358152
NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968
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FCN1
ficolin 1
increases expression
ISO
Mercaptopurine results in increased expression of FCN1 mRNA
CTD
PMID:23358152
NCBI chr 9:134,903,232...134,917,912
Ensembl chr 9:134,903,232...134,917,912
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FTL
ferritin light chain
increases expression
ISO
Mercaptopurine results in increased expression of FTL mRNA
CTD
PMID:27435855
NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
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G0S2
G0/G1 switch 2
increases expression
ISO
Mercaptopurine results in increased expression of G0S2 mRNA
CTD
PMID:23358152
NCBI chr 1:209,675,412...209,676,390
Ensembl chr 1:209,675,412...209,676,390
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GAPDH
glyceraldehyde-3-phosphate dehydrogenase
affects localization
EXP
Mercaptopurine affects the localization of GAPDH protein
CTD
PMID:19628630
NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
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GATM
glycine amidinotransferase
increases expression
ISO
Mercaptopurine results in increased expression of GATM mRNA
CTD
PMID:23358152
NCBI chr15:45,361,124...45,402,227
Ensembl chr15:45,361,124...45,402,327
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GCLM
glutamate-cysteine ligase modifier subunit
increases expression
EXP
Mercaptopurine results in increased expression of GCLM mRNA
CTD
PMID:18222062
NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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GCM1
glial cells missing transcription factor 1
decreases expression
ISO
Mercaptopurine results in decreased expression of GCM1 mRNA
CTD
PMID:23358152
NCBI chr 6:53,126,961...53,148,841
Ensembl chr 6:53,126,961...53,148,841
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GDF9
growth differentiation factor 9
increases expression
ISO
Mercaptopurine results in increased expression of GDF9 mRNA
CTD
PMID:23358152
NCBI chr 5:132,861,185...132,866,651
Ensembl chr 5:132,861,181...132,866,884
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GHRL
ghrelin and obestatin prepropeptide
decreases expression
ISO
Mercaptopurine results in decreased expression of GHRL mRNA
CTD
PMID:23358152
NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
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GJB4
gap junction protein beta 4
increases expression
ISO
Mercaptopurine results in increased expression of GJB4 mRNA
CTD
PMID:23358152
NCBI chr 1:34,759,740...34,762,327
Ensembl chr 1:34,759,740...34,762,327
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GNG8
G protein subunit gamma 8
increases expression
ISO
Mercaptopurine results in increased expression of GNG8 mRNA
CTD
PMID:23358152
NCBI chr19:46,633,953...46,639,326
Ensembl chr19:46,633,953...46,636,541
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GPX2
glutathione peroxidase 2
increases expression
EXP
Mercaptopurine results in increased expression of GPX2 mRNA
CTD
PMID:18222062
NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
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GPX3
glutathione peroxidase 3
increases expression
EXP
Mercaptopurine results in increased expression of GPX3 mRNA
CTD
PMID:18222062
NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
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GREM1
gremlin 1, DAN family BMP antagonist
increases expression
ISO
Mercaptopurine results in increased expression of GREM1 mRNA
CTD
PMID:23358152
NCBI chr15:32,718,004...32,745,106
Ensembl chr15:32,718,004...32,745,106
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GRP
gastrin releasing peptide
increases expression
ISO
Mercaptopurine results in increased expression of GRP mRNA
CTD
PMID:23358152
NCBI chr18:59,219,189...59,230,771
Ensembl chr18:59,220,158...59,230,774
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GRXCR2
glutaredoxin and cysteine rich domain containing 2
increases expression
ISO
Mercaptopurine results in increased expression of GRXCR2 mRNA
CTD
PMID:23358152
NCBI chr 5:145,857,670...145,931,673
Ensembl chr 5:145,858,521...145,937,126
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GSS
glutathione synthetase
increases expression
EXP
Mercaptopurine results in increased expression of GSS mRNA
CTD
PMID:18222062
NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
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GSTM1
glutathione S-transferase mu 1
affects response to substance
EXP
GSTM1 gene polymorphism affects the susceptibility to Mercaptopurine
CTD
PMID:15713801
NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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GUCA2A
guanylate cyclase activator 2A
increases expression
ISO
Mercaptopurine results in increased expression of GUCA2A mRNA
CTD
PMID:23358152
NCBI chr 1:42,162,690...42,164,745
Ensembl chr 1:42,162,690...42,164,745
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GZMB
granzyme B
increases expression
ISO
Mercaptopurine results in increased expression of GZMB mRNA
CTD
PMID:23358152
NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267
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HAMP
hepcidin antimicrobial peptide
increases expression
ISO
Mercaptopurine results in increased expression of HAMP mRNA
CTD
PMID:23358152
NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
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HAND2
heart and neural crest derivatives expressed 2
increases expression
ISO
Mercaptopurine results in increased expression of HAND2 mRNA
CTD
PMID:23358152
NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229
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HBB
hemoglobin subunit beta
decreases expression
ISO
Mercaptopurine results in decreased expression of HBB mRNA; Mercaptopurine results in decreased expression of HBB-B1 mRNA
CTD
PMID:23358152
NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
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HBEGF
heparin binding EGF like growth factor
decreases expression
ISO
Mercaptopurine results in decreased expression of HBEGF mRNA
CTD
PMID:23358152
NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
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HEPH
hephaestin
decreases expression
ISO
Mercaptopurine results in decreased expression of HEPH mRNA
CTD
PMID:23358152
NCBI chr X:66,162,671...66,268,863
Ensembl chr X:66,162,671...66,268,867
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HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
affects response to substance
EXP
HLA-DQA1 gene polymorphism affects the susceptibility to Mercaptopurine
CTD
PMID:25217962
NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062
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HLA-DRB1
major histocompatibility complex, class II, DR beta 1
decreases expression affects response to substance
ISO EXP
Mercaptopurine results in decreased expression of RT1-DB1 mRNA HLA-DRB1 gene polymorphism affects the susceptibility to Mercaptopurine
CTD
PMID:23358152 PMID:25217962
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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HOXA13
homeobox A13
decreases expression
ISO
Mercaptopurine results in decreased expression of HOXA13 mRNA
CTD
PMID:23358152
NCBI chr 7:27,194,364...27,200,091
Ensembl chr 7:27,193,503...27,200,091
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HPGDS
hematopoietic prostaglandin D synthase
increases expression
ISO
Mercaptopurine results in increased expression of HPGDS mRNA
CTD
PMID:23358152
NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876
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HPX
hemopexin
increases expression
ISO
Mercaptopurine results in increased expression of HPX mRNA
CTD
PMID:23358152
NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617
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HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
increases expression
ISO
Mercaptopurine results in increased expression of HSD11B1 mRNA
CTD
PMID:23358152
NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
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HTR2B
5-hydroxytryptamine receptor 2B
increases expression
ISO
Mercaptopurine results in increased expression of HTR2B mRNA
CTD
PMID:23358152
NCBI chr 2:231,108,230...231,125,042
Ensembl chr 2:231,108,230...231,125,042
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HTRA3
HtrA serine peptidase 3
increases expression
ISO
Mercaptopurine results in increased expression of HTRA3 mRNA
CTD
PMID:23358152
NCBI chr 4:8,269,754...8,307,098
Ensembl chr 4:8,269,754...8,307,098
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HTRA4
HtrA serine peptidase 4
increases expression
ISO
Mercaptopurine results in increased expression of HTRA4 mRNA
CTD
PMID:23358152
NCBI chr 8:38,974,228...38,988,663
Ensembl chr 8:38,974,228...38,988,663
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IGSF11
immunoglobulin superfamily member 11
increases expression
ISO
Mercaptopurine results in increased expression of IGSF11 mRNA
CTD
PMID:23358152
NCBI chr 3:118,900,557...119,146,020
Ensembl chr 3:118,900,557...119,146,068
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IL1RN
interleukin 1 receptor antagonist
increases expression
ISO
Mercaptopurine results in increased expression of IL1RN mRNA
CTD
PMID:23358152
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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IL23R
interleukin 23 receptor
increases expression
ISO
Mercaptopurine results in increased expression of IL23R mRNA
CTD
PMID:23358152
NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979
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IMPDH2
inosine monophosphate dehydrogenase 2
increases expression
EXP
Mercaptopurine results in increased expression of IMPDH2 mRNA
CTD
PMID:18222062
NCBI chr 3:49,024,325...49,029,398
Ensembl chr 3:49,024,325...49,029,447
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INS
insulin
decreases expression
ISO
Mercaptopurine results in decreased expression of INS2 mRNA
CTD
PMID:23358152
NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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IRX4
iroquois homeobox 4
decreases expression
ISO
Mercaptopurine results in decreased expression of IRX4 mRNA
CTD
PMID:23358152
NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236
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JAM2
junctional adhesion molecule 2
increases expression
ISO
Mercaptopurine results in increased expression of JAM2 mRNA
CTD
PMID:23358152
NCBI chr21:25,639,258...25,717,562
Ensembl chr21:25,639,258...25,717,562
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KCNMB4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
increases expression
ISO
Mercaptopurine results in increased expression of KCNMB4 mRNA
CTD
PMID:23358152
NCBI chr12:70,366,290...70,434,292
Ensembl chr12:70,366,290...70,434,292
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KCNQ2
potassium voltage-gated channel subfamily Q member 2
decreases expression
ISO
Mercaptopurine results in decreased expression of KCNQ2 mRNA
CTD
PMID:23358152
NCBI chr20:63,400,208...63,472,655
Ensembl chr20:63,400,208...63,472,677
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KCNT1
potassium sodium-activated channel subfamily T member 1
increases expression
ISO
Mercaptopurine results in increased expression of KCNT1 mRNA
CTD
PMID:23358152
NCBI chr 9:135,702,185...135,795,502
Ensembl chr 9:135,702,185...135,795,508
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KIF20A
kinesin family member 20A
decreases expression
ISO
Mercaptopurine results in decreased expression of KIF20A mRNA
CTD
PMID:23358152
NCBI chr 5:138,179,112...138,187,723
Ensembl chr 5:138,178,719...138,187,723
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KIF23
kinesin family member 23
decreases expression
ISO
Mercaptopurine results in decreased expression of KIF23 mRNA
CTD
PMID:23358152
NCBI chr15:69,414,349...69,448,427
Ensembl chr15:69,414,246...69,448,427
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KLHL40
kelch like family member 40
increases expression
ISO
Mercaptopurine results in increased expression of KLHL40 mRNA
CTD
PMID:23358152
NCBI chr 3:42,685,537...42,692,544
Ensembl chr 3:42,685,537...42,692,544
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KNL1
kinetochore scaffold 1
decreases expression
ISO
Mercaptopurine results in decreased expression of KNL1 mRNA
CTD
PMID:23358152
NCBI chr15:40,594,249...40,664,342
Ensembl chr15:40,594,020...40,664,342
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KRT23
keratin 23
increases expression
ISO
Mercaptopurine results in increased expression of KRT23 mRNA
CTD
PMID:23358152
NCBI chr17:40,922,700...40,937,646
Ensembl chr17:40,922,700...40,937,646
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L1TD1
LINE1 type transposase domain containing 1
decreases expression
ISO
Mercaptopurine results in decreased expression of L1TD1 mRNA
CTD
PMID:23358152
NCBI chr 1:62,194,849...62,212,328
Ensembl chr 1:62,194,849...62,212,328
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LARP6
La ribonucleoprotein 6, translational regulator
increases expression
ISO
Mercaptopurine results in increased expression of LARP6 mRNA
CTD
PMID:23358152
NCBI chr15:70,829,130...70,854,157
Ensembl chr15:70,829,130...70,854,157
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LIPM
lipase family member M
increases expression
ISO
Mercaptopurine results in increased expression of LIPM mRNA
CTD
PMID:23358152
NCBI chr10:88,802,730...88,820,546
Ensembl chr10:88,802,730...88,820,546
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LUM
lumican
decreases expression
ISO
Mercaptopurine results in decreased expression of LUM mRNA
CTD
PMID:23358152
NCBI chr12:91,102,629...91,111,494
Ensembl chr12:91,102,629...91,111,494
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MAP2K1
mitogen-activated protein kinase kinase 1
decreases phosphorylation
EXP
Mercaptopurine results in decreased phosphorylation of MAP2K1 protein
CTD
PMID:12697733
NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
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MEOX2
mesenchyme homeobox 2
decreases expression
ISO
Mercaptopurine results in decreased expression of MEOX2 mRNA
CTD
PMID:23358152
NCBI chr 7:15,611,212...15,686,683
Ensembl chr 7:15,611,212...15,686,683
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MEST
mesoderm specific transcript
decreases expression
ISO
Mercaptopurine results in decreased expression of MEST mRNA
CTD
PMID:23358152
NCBI chr 7:130,486,175...130,506,465
Ensembl chr 7:130,486,171...130,506,465
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MFAP3L
microfibril associated protein 3 like
increases expression
ISO
Mercaptopurine results in increased expression of MFAP3L mRNA
CTD
PMID:23358152
NCBI chr 4:169,986,602...170,027,277
Ensembl chr 4:169,986,597...170,033,031
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MIR10B
microRNA 10b
increases expression
ISO
Mercaptopurine results in increased expression of MIR10B mRNA
CTD
PMID:23358152
NCBI chr 2:176,150,303...176,150,412
Ensembl chr 2:176,150,303...176,150,412
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MIR142
microRNA 142
decreases expression
ISO
Mercaptopurine results in decreased expression of MIR142 mRNA
CTD
PMID:23358152
NCBI chr17:58,331,232...58,331,318
Ensembl chr17:58,331,232...58,331,318
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MIR144
microRNA 144
decreases expression
ISO
Mercaptopurine results in decreased expression of MIR144 mRNA
CTD
PMID:23358152
NCBI chr17:28,861,533...28,861,618
Ensembl chr17:28,861,533...28,861,618
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MIR146B
microRNA 146b
increases expression
ISO
Mercaptopurine results in increased expression of MIR146B mRNA
CTD
PMID:23358152
NCBI chr10:102,436,512...102,436,584
Ensembl chr10:102,436,512...102,436,584
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MIR195
microRNA 195
increases expression
ISO
Mercaptopurine results in increased expression of MIR195 mRNA
CTD
PMID:23358152
NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701
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MIR196B
microRNA 196b
increases expression
ISO
Mercaptopurine results in increased expression of MIR196B mRNA
CTD
PMID:23358152
NCBI chr 7:27,169,480...27,169,563
Ensembl chr 7:27,169,480...27,169,563
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MIR21
microRNA 21
increases expression
ISO
Mercaptopurine results in increased expression of MIR21 mRNA
CTD
PMID:23358152
NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
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MIR23A
microRNA 23a
increases expression
ISO
Mercaptopurine results in increased expression of MIR23A mRNA
CTD
PMID:23358152
NCBI chr19:13,836,587...13,836,659
Ensembl chr19:13,836,587...13,836,659
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MIR29A
microRNA 29a
increases expression
ISO
Mercaptopurine results in increased expression of MIR29A mRNA
CTD
PMID:23358152
NCBI chr 7:130,876,747...130,876,810
Ensembl chr 7:130,876,747...130,876,810
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MIR31
microRNA 31
increases expression
ISO
Mercaptopurine results in increased expression of MIR31 mRNA
CTD
PMID:23358152
NCBI chr 9:21,512,115...21,512,185
Ensembl chr 9:21,512,115...21,512,185
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MIR345
microRNA 345
increases expression
ISO
Mercaptopurine results in increased expression of MIR345 mRNA
CTD
PMID:23358152
NCBI chr14:100,307,859...100,307,956
Ensembl chr14:100,307,859...100,307,956
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MIR34A
microRNA 34a
increases expression
ISO
Mercaptopurine results in increased expression of MIR34A mRNA
CTD
PMID:23358152
NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777
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MIR451A
microRNA 451a
decreases expression
ISO
Mercaptopurine results in decreased expression of MIR451A mRNA
CTD
PMID:23358152
NCBI chr17:28,861,369...28,861,440
Ensembl chr17:28,861,369...28,861,440
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MIR497
microRNA 497
increases expression
ISO
Mercaptopurine results in increased expression of MIR497 mRNA
CTD
PMID:23358152
NCBI chr17:7,017,911...7,018,022
Ensembl chr17:7,017,911...7,018,022
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MIRLET7B
microRNA let-7b
increases expression
ISO
Mercaptopurine results in increased expression of MIRLET7B mRNA
CTD
PMID:23358152
NCBI chr22:46,113,686...46,113,768
Ensembl chr22:46,113,686...46,113,768
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MMP10
matrix metallopeptidase 10
increases expression
ISO
Mercaptopurine results in increased expression of MMP10 mRNA
CTD
PMID:23358152
NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
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MMP7
matrix metallopeptidase 7
increases expression
ISO
Mercaptopurine results in increased expression of MMP7 mRNA
CTD
PMID:23358152
NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
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MOCOS
molybdenum cofactor sulfurase
multiple interactions decreases oxidation
EXP
[MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in decreased chemical synthesis of 6-thiouric acid; [MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in decreased chemical synthesis of 6-thioxanthine; [MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in increased chemical synthesis of Thioguanine
CTD
PMID:29935280
NCBI chr18:36,187,497...36,272,157
Ensembl chr18:36,187,497...36,272,157
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MSX2
msh homeobox 2
decreases expression
ISO
Mercaptopurine results in decreased expression of MSX2 mRNA
CTD
PMID:23358152
NCBI chr 5:174,724,582...174,730,896
Ensembl chr 5:174,724,582...174,730,896
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MT2A
metallothionein 2A
increases expression
ISO
Mercaptopurine results in increased expression of MT2A mRNA
CTD
PMID:23358152
NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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MT3
metallothionein 3
increases expression
ISO
Mercaptopurine results in increased expression of MT3 mRNA
CTD
PMID:23358152
NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
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MVP
major vault protein
decreases response to substance
EXP
MVP results in decreased susceptibility to Mercaptopurine
CTD
PMID:19232821
NCBI chr16:29,820,394...29,848,039
Ensembl chr16:29,820,394...29,848,039
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MYH6
myosin heavy chain 6
decreases expression
ISO
Mercaptopurine results in decreased expression of MYH6 mRNA
CTD
PMID:23358152
NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
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MYL7
myosin light chain 7
increases expression
ISO
Mercaptopurine results in increased expression of MYL7 mRNA
CTD
PMID:23358152
NCBI chr 7:44,138,864...44,141,332
Ensembl chr 7:44,138,864...44,141,332
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MYO16
myosin XVI
increases expression
ISO
Mercaptopurine results in increased expression of MYO16 mRNA
CTD
PMID:23358152
NCBI chr13:108,495,716...109,208,005
Ensembl chr13:108,596,152...109,208,005
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NASP
nuclear autoantigenic sperm protein
decreases expression
ISO
Mercaptopurine results in decreased expression of NASP mRNA
CTD
PMID:23358152
NCBI chr 1:45,584,041...45,618,893
Ensembl chr 1:45,583,846...45,618,904
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NFKB1
nuclear factor kappa B subunit 1
multiple interactions
EXP
Mercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:12697733
NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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NPHS1
NPHS1 adhesion molecule, nephrin
increases expression
ISO
Mercaptopurine results in increased expression of NPHS1 mRNA
CTD
PMID:23358152
NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287
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NR4A2
nuclear receptor subfamily 4 group A member 2
multiple interactions increases expression
ISO
[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 mRNA; [GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 protein; Mercaptopurine results in increased expression of and affects the localization of NR4A2 protein Mercaptopurine results in increased expression of NR4A2 mRNA
CTD
PMID:27435855
NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348
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NTAQ1
N-terminal glutamine amidase 1
increases expression
ISO
Mercaptopurine results in increased expression of IFIT1 mRNA
CTD
PMID:23358152
NCBI chr 8:123,416,725...123,475,696
Ensembl chr 8:123,416,726...123,470,028
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NTF3
neurotrophin 3
increases expression
ISO
Mercaptopurine results in increased expression of NTF3 mRNA
CTD
PMID:23358152
NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536
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NUDT15
nudix hydrolase 15
increases response to substance
EXP
NUDT15 gene SNP results in increased susceptibility to Mercaptopurine
CTD
PMID:25108385
NCBI chr13:48,037,726...48,052,755
Ensembl chr13:48,037,726...48,047,221
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OGN
osteoglycin
decreases expression
ISO
Mercaptopurine results in decreased expression of OGN mRNA
CTD
PMID:23358152
NCBI chr 9:92,383,268...92,404,699
Ensembl chr 9:92,383,268...92,404,696
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OLAH
oleoyl-ACP hydrolase
increases expression
ISO
Mercaptopurine results in increased expression of OLAH mRNA
CTD
PMID:23358152
NCBI chr10:15,032,195...15,073,853
Ensembl chr10:15,032,227...15,073,853
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ORM1
orosomucoid 1
increases expression
ISO
Mercaptopurine results in increased expression of ORM1 mRNA
CTD
PMID:23358152
NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479
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PACSIN1
protein kinase C and casein kinase substrate in neurons 1
decreases expression
ISO
Mercaptopurine results in decreased expression of PACSIN1 mRNA
CTD
PMID:23358152
NCBI chr 6:34,466,076...34,535,223
Ensembl chr 6:34,466,061...34,535,229
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PCDH19
protocadherin 19
decreases expression
ISO
Mercaptopurine results in decreased expression of PCDH19 mRNA
CTD
PMID:23358152
NCBI chr X:100,291,644...100,410,273
Ensembl chr X:100,291,644...100,410,273
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PELI2
pellino E3 ubiquitin protein ligase family member 2
increases expression
ISO
Mercaptopurine results in increased expression of PELI2 mRNA
CTD
PMID:23358152
NCBI chr14:56,118,411...56,301,524
Ensembl chr14:56,117,814...56,301,524
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PENK
proenkephalin
decreases expression
ISO
Mercaptopurine results in decreased expression of PENK mRNA
CTD
PMID:23358152
NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671
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PGR
progesterone receptor
increases expression
ISO
Mercaptopurine results in increased expression of PGR mRNA
CTD
PMID:23358152
NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
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PHACTR3
phosphatase and actin regulator 3
increases expression
ISO
Mercaptopurine results in increased expression of PHACTR3 mRNA
CTD
PMID:23358152
NCBI chr20:59,577,509...59,847,711
Ensembl chr20:59,577,509...59,847,711
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PHLDA2
pleckstrin homology like domain family A member 2
decreases expression
ISO
Mercaptopurine results in decreased expression of PHLDA2 mRNA
CTD
PMID:23358152
NCBI chr11:2,928,273...2,929,420
Ensembl chr11:2,928,273...2,929,420
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PI16
peptidase inhibitor 16
increases expression
ISO
Mercaptopurine results in increased expression of PI16 mRNA
CTD
PMID:23358152
NCBI chr 6:36,948,296...36,964,837
Ensembl chr 6:36,948,263...36,964,837
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PIMREG
PICALM interacting mitotic regulator
decreases expression
ISO
Mercaptopurine results in decreased expression of PIMREG mRNA
CTD
PMID:23358152
NCBI chr17:6,444,455...6,451,469
Ensembl chr17:6,444,441...6,451,469
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PINLYP
phospholipase A2 inhibitor and LY6/PLAUR domain containing
increases expression
ISO
Mercaptopurine results in increased expression of PINLYP mRNA
CTD
PMID:23358152
NCBI chr19:43,575,509...43,582,098
Ensembl chr19:43,575,801...43,583,964
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PLA2G10
phospholipase A2 group X
decreases expression
ISO
Mercaptopurine results in decreased expression of PLA2G10 mRNA
CTD
PMID:23358152
NCBI chr16:14,672,548...14,701,850
Ensembl chr16:14,672,548...14,694,308
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PLEKHD1
pleckstrin homology and coiled-coil domain containing D1
decreases expression
ISO
Mercaptopurine results in decreased expression of PLEKHD1 mRNA
CTD
PMID:23358152
NCBI chr14:69,467,744...69,531,551
Ensembl chr14:69,484,692...69,531,551
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PRF1
perforin 1
increases expression
ISO
Mercaptopurine results in increased expression of PRF1 mRNA
CTD
PMID:23358152
NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
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PRLR
prolactin receptor
decreases expression
ISO
Mercaptopurine results in decreased expression of PRLR mRNA
CTD
PMID:23358152
NCBI chr 5:35,048,756...35,230,487
Ensembl chr 5:35,048,756...35,230,487
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PTTG1
PTTG1 regulator of sister chromatid separation, securin
decreases expression
ISO
Mercaptopurine results in decreased expression of PTTG1 mRNA
CTD
PMID:23358152
NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
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REC8
REC8 meiotic recombination protein
decreases expression
ISO
Mercaptopurine results in decreased expression of REC8 mRNA
CTD
PMID:23358152
NCBI chr14:24,172,080...24,180,923
Ensembl chr14:24,171,853...24,180,257
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RELA
RELA proto-oncogene, NF-kB subunit
multiple interactions affects localization
EXP
Mercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]] Mercaptopurine affects the localization of RELA protein
CTD
PMID:12697733
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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RETN
resistin
increases expression
ISO
Mercaptopurine results in increased expression of RETN mRNA
CTD
PMID:23358152
NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455
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RFLNB
refilin B
decreases expression
ISO
Mercaptopurine results in decreased expression of RFLNB mRNA
CTD
PMID:23358152
NCBI chr17:439,978...445,940
Ensembl chr17:439,978...445,939
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RGS1
regulator of G protein signaling 1
increases expression
ISO
Mercaptopurine results in increased expression of RGS1 mRNA
CTD
PMID:23358152
NCBI chr 1:192,575,773...192,580,024
Ensembl chr 1:192,575,763...192,580,024
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RHO
rhodopsin
increases expression
ISO
Mercaptopurine results in increased expression of RHO mRNA
CTD
PMID:23358152
NCBI chr 3:129,528,639...129,535,344
Ensembl chr 3:129,528,639...129,535,344
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RRAD
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
decreases expression
ISO
Mercaptopurine results in decreased expression of RRAD mRNA
CTD
PMID:23358152
NCBI chr16:66,921,685...66,925,535
Ensembl chr16:66,921,685...66,925,535
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RTL1
retrotransposon Gag like 1
decreases expression
ISO
Mercaptopurine results in decreased expression of RTL1 mRNA
CTD
PMID:23358152
NCBI chr14:100,879,753...100,903,722
Ensembl chr14:100,879,753...100,903,722
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RTN4RL1
reticulon 4 receptor like 1
increases expression
ISO
Mercaptopurine results in increased expression of RTN4RL1 mRNA
CTD
PMID:23358152
NCBI chr17:1,934,677...2,025,334
Ensembl chr17:1,934,677...2,025,334
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S100A16
S100 calcium binding protein A16
decreases expression
ISO
Mercaptopurine results in decreased expression of S100A16 mRNA
CTD
PMID:23358152
NCBI chr 1:153,606,883...153,613,137
Ensembl chr 1:153,606,886...153,613,145
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S100B
S100 calcium binding protein B
increases expression
ISO
Mercaptopurine results in increased expression of S100B mRNA
CTD
PMID:23358152
NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
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S100Z
S100 calcium binding protein Z
decreases expression
ISO
Mercaptopurine results in decreased expression of S100Z mRNA
CTD
PMID:23358152
NCBI chr 5:76,850,014...76,952,953
Ensembl chr 5:76,850,001...76,921,650
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SATB1
SATB homeobox 1
decreases expression
ISO
Mercaptopurine results in decreased expression of SATB1 mRNA
CTD
PMID:23358152
NCBI chr 3:18,345,377...18,445,592
Ensembl chr 3:18,345,377...18,445,621
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SBSPON
somatomedin B and thrombospondin type 1 domain containing
decreases expression
ISO
Mercaptopurine results in decreased expression of SBSPON mRNA
CTD
PMID:23358152
NCBI chr 8:73,064,543...73,093,172
Ensembl chr 8:73,064,543...73,124,088
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SCAMP5
secretory carrier membrane protein 5
decreases expression
ISO
Mercaptopurine results in decreased expression of SCAMP5 mRNA
CTD
PMID:23358152
NCBI chr15:74,995,563...75,021,495
Ensembl chr15:74,957,219...75,021,495
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SCD
stearoyl-CoA desaturase
decreases expression
ISO
Mercaptopurine results in decreased expression of SCD1 mRNA
CTD
PMID:23358152
NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
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SCG5
secretogranin V
increases expression
ISO
Mercaptopurine results in increased expression of SCG5 mRNA
CTD
PMID:23358152
NCBI chr15:32,641,710...32,697,092
Ensembl chr15:32,641,676...32,697,098
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SCUBE3
signal peptide, CUB domain and EGF like domain containing 3
increases expression
ISO
Mercaptopurine results in increased expression of SCUBE3 mRNA
CTD
PMID:23358152
NCBI chr 6:35,213,956...35,253,079
Ensembl chr 6:35,213,956...35,253,079
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SFTPC
surfactant protein C
increases expression
ISO
Mercaptopurine results in increased expression of SFTPC mRNA
CTD
PMID:23358152
NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
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SHCBP1L
SHC binding and spindle associated 1 like
increases expression
ISO
Mercaptopurine results in increased expression of SHCBP1L mRNA
CTD
PMID:23358152
NCBI chr 1:182,899,865...182,953,166
Ensembl chr 1:182,899,865...182,953,525
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SHISA3
shisa family member 3
increases expression
ISO
Mercaptopurine results in increased expression of SHISA3 mRNA
CTD
PMID:23358152
NCBI chr 4:42,397,488...42,402,487
Ensembl chr 4:42,397,488...42,402,487
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SHISA8
shisa family member 8
decreases expression
ISO
Mercaptopurine results in decreased expression of SHISA8 mRNA
CTD
PMID:23358152
NCBI chr22:41,909,543...41,915,074
Ensembl chr22:41,909,543...41,915,074
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SLC22A3
solute carrier family 22 member 3
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC22A3 mRNA
CTD
PMID:23358152
NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577
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SLC22A8
solute carrier family 22 member 8
increases transport
ISO
SLC22A8 protein results in increased transport of Mercaptopurine
CTD
PMID:15100168
NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
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SLC2A2
solute carrier family 2 member 2
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC2A2 mRNA
CTD
PMID:23358152
NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
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SLC2A3
solute carrier family 2 member 3
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC2A3 mRNA
CTD
PMID:23358152
NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007
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SLC35G1
solute carrier family 35 member G1
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC35G1 mRNA
CTD
PMID:23358152
NCBI chr10:93,893,978...93,909,830
Ensembl chr10:93,893,973...93,956,062
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SLC38A5
solute carrier family 38 member 5
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC38A5 mRNA
CTD
PMID:23358152
NCBI chr X:48,458,544...48,470,260
Ensembl chr X:48,458,537...48,470,260
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SLC5A5
solute carrier family 5 member 5
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC5A5 mRNA
CTD
PMID:23358152
NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174
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SLC7A14
solute carrier family 7 member 14
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC7A14 mRNA
CTD
PMID:23358152
NCBI chr 3:170,459,548...170,586,075
Ensembl chr 3:170,459,548...170,586,075
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SLC9A2
solute carrier family 9 member A2
decreases expression
ISO
Mercaptopurine results in decreased expression of SLC9A2 mRNA
CTD
PMID:23358152
NCBI chr 2:102,619,553...102,711,355
Ensembl chr 2:102,619,553...102,711,355
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SMOC2
SPARC related modular calcium binding 2
decreases expression
ISO
Mercaptopurine results in decreased expression of SMOC2 mRNA
CTD
PMID:23358152
NCBI chr 6:168,441,184...168,667,992
Ensembl chr 6:168,441,151...168,673,445
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SNCG
synuclein gamma
decreases expression
ISO
Mercaptopurine results in decreased expression of SNCG mRNA
CTD
PMID:23358152
NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258
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SOD2
superoxide dismutase 2
increases expression
EXP
Mercaptopurine results in increased expression of SOD2 mRNA
CTD
PMID:18222062
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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SORCS2
sortilin related VPS10 domain containing receptor 2
increases expression
ISO
Mercaptopurine results in increased expression of SORCS2 mRNA
CTD
PMID:23358152
NCBI chr 4:7,192,538...7,742,827
Ensembl chr 4:7,192,538...7,742,827
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SOSTDC1
sclerostin domain containing 1
decreases expression
ISO
Mercaptopurine results in decreased expression of SOSTDC1 mRNA
CTD
PMID:23358152
NCBI chr 7:16,461,481...16,465,738
Ensembl chr 7:16,461,481...16,530,580
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SPINK5
serine peptidase inhibitor Kazal type 5
increases expression
ISO
Mercaptopurine results in increased expression of SPINK5 mRNA
CTD
PMID:23358152
NCBI chr 5:148,063,980...148,137,382
Ensembl chr 5:148,025,683...148,137,382
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SYNM
synemin
increases expression
ISO
Mercaptopurine results in increased expression of SYNM mRNA
CTD
PMID:23358152
NCBI chr15:99,105,080...99,141,767
Ensembl chr15:99,098,217...99,135,593
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TAC3
tachykinin precursor 3
decreases expression
ISO
Mercaptopurine results in decreased expression of TAC2 mRNA
CTD
PMID:23358152
NCBI chr12:57,010,000...57,016,529
Ensembl chr12:57,010,000...57,028,883
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TEX10
testis expressed 10
decreases expression
ISO
Mercaptopurine results in decreased expression of TEX10 mRNA
CTD
PMID:23358152
NCBI chr 9:100,302,084...100,352,942
Ensembl chr 9:100,302,077...100,352,942
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TFCP2L1
transcription factor CP2 like 1
decreases expression
ISO
Mercaptopurine results in decreased expression of TFCP2L1 mRNA
CTD
PMID:23358152
NCBI chr 2:121,216,587...121,285,202
Ensembl chr 2:121,216,587...121,285,202
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TFRC
transferrin receptor
decreases expression
ISO
Mercaptopurine results in decreased expression of TFRC mRNA
CTD
PMID:23358152
NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
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TH
tyrosine hydroxylase
multiple interactions
ISO
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]; Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
CTD
PMID:27435855
NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
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THBS4
thrombospondin 4
increases expression
ISO
Mercaptopurine results in increased expression of THBS4 mRNA
CTD
PMID:23358152
NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287
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THEM5
thioesterase superfamily member 5
increases expression
ISO
Mercaptopurine results in increased expression of THEM5 mRNA
CTD
PMID:23358152
NCBI chr 1:151,847,101...151,853,712
Ensembl chr 1:151,847,101...151,853,712
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TM4SF20
transmembrane 4 L six family member 20
decreases expression
ISO
Mercaptopurine results in decreased expression of TM4SF20 mRNA
CTD
PMID:23358152
NCBI chr 2:227,362,038...227,381,647
Ensembl chr 2:227,362,038...227,381,995
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TMCC2
transmembrane and coiled-coil domain family 2
decreases expression
ISO
Mercaptopurine results in decreased expression of TMCC2 mRNA
CTD
PMID:23358152
NCBI chr 1:205,227,946...205,273,343
Ensembl chr 1:205,227,946...205,285,632
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TMEM100
transmembrane protein 100
decreases expression
ISO
Mercaptopurine results in decreased expression of TMEM100 mRNA
CTD
PMID:23358152
NCBI chr17:55,719,627...55,732,081
Ensembl chr17:55,719,627...55,732,121
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TMPRSS7
transmembrane serine protease 7
increases expression
ISO
Mercaptopurine results in increased expression of TMPRSS7 mRNA
CTD
PMID:23358152
NCBI chr 3:112,034,736...112,081,269
Ensembl chr 3:112,034,736...112,081,269
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TP53
tumor protein p53
affects activity
EXP
Mercaptopurine affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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TPMT
thiopurine S-methyltransferase
affects response to substance affects metabolic processing
EXP
TPMT gene polymorphism affects the susceptibility to Mercaptopurine TPMT protein affects the metabolism of Mercaptopurine
CTD
PMID:12509611 PMID:14505127
NCBI chr 6:18,128,311...18,155,169
Ensembl chr 6:18,128,311...18,155,077
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TRH
thyrotropin releasing hormone
increases expression
ISO
Mercaptopurine results in increased expression of TRH mRNA
CTD
PMID:23358152
NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935
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TRPV6
transient receptor potential cation channel subfamily V member 6
increases expression
ISO
Mercaptopurine results in increased expression of TRPV6 mRNA
CTD
PMID:23358152
NCBI chr 7:142,871,208...142,885,745
Ensembl chr 7:142,871,208...142,885,745
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TSPAN11
tetraspanin 11
decreases expression
ISO
Mercaptopurine results in decreased expression of TSPAN11 mRNA
CTD
PMID:23358152
NCBI chr12:30,926,748...31,016,502
Ensembl chr12:30,926,428...30,996,602
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TYMS
thymidylate synthetase
affects response to substance
EXP
TYMS gene polymorphism affects the susceptibility to Mercaptopurine
CTD
PMID:15713801
NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
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UBD
ubiquitin D
increases expression
ISO
Mercaptopurine results in increased expression of UBD mRNA
CTD
PMID:23358152
NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
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VAV1
vav guanine nucleotide exchange factor 1
increases expression
EXP
Mercaptopurine results in increased expression of VAV1 protein
CTD
PMID:12697733
NCBI chr19:6,772,708...6,857,361
Ensembl chr19:6,772,708...6,857,366
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VDR
vitamin D receptor
affects response to substance
EXP
VDR gene polymorphism affects the susceptibility to Mercaptopurine
CTD
PMID:15713801
NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048
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VGF
VGF nerve growth factor inducible
increases expression
ISO
Mercaptopurine results in increased expression of VGF mRNA
CTD
PMID:23358152
NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569
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VIPR2
vasoactive intestinal peptide receptor 2
decreases expression
ISO
Mercaptopurine results in decreased expression of VIPR2 mRNA
CTD
PMID:23358152
NCBI chr 7:159,028,175...159,144,867
Ensembl chr 7:159,028,175...159,144,867
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WFDC1
WAP four-disulfide core domain 1
increases expression
ISO
Mercaptopurine results in increased expression of WFDC1 mRNA
CTD
PMID:23358152
NCBI chr16:84,294,878...84,329,844
Ensembl chr16:84,294,846...84,329,844
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WFDC2
WAP four-disulfide core domain 2
decreases expression
ISO
Mercaptopurine results in decreased expression of WFDC2 mRNA
CTD
PMID:23358152
NCBI chr20:45,469,753...45,481,532
Ensembl chr20:45,469,753...45,481,532
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WNT10B
Wnt family member 10B
decreases expression
ISO
Mercaptopurine results in decreased expression of WNT10B mRNA
CTD
PMID:23358152
NCBI chr12:48,965,340...48,971,735
Ensembl chr12:48,965,340...48,971,735
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WNT2B
Wnt family member 2B
decreases expression
ISO
Mercaptopurine results in decreased expression of WNT2B mRNA
CTD
PMID:23358152
NCBI chr 1:112,466,541...112,530,165
Ensembl chr 1:112,466,541...112,530,165
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WT1
WT1 transcription factor
increases expression
ISO
Mercaptopurine results in increased expression of WT1 mRNA
CTD
PMID:23358152
NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564
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XDH
xanthine dehydrogenase
increases expression affects expression
ISO
Mercaptopurine results in increased expression of XDH mRNA Mercaptopurine affects the expression of XDH mRNA
CTD
PMID:22688000 PMID:23358152
NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
G
XKRX
XK related X-linked
decreases expression
ISO
Mercaptopurine results in decreased expression of XKRX mRNA
CTD
PMID:23358152
NCBI chr X:100,886,916...100,959,343
Ensembl chr X:100,913,445...100,929,433
G
ZBTB16
zinc finger and BTB domain containing 16
increases expression
ISO
Mercaptopurine results in increased expression of ZBTB16 mRNA
CTD
PMID:23358152
NCBI chr11:114,059,711...114,256,770
Ensembl chr11:114,059,041...114,256,765
G
ZEB2
zinc finger E-box binding homeobox 2
increases expression
ISO
Mercaptopurine results in increased expression of ZEB2 mRNA
CTD
PMID:23358152
NCBI chr 2:144,384,081...144,520,119
Ensembl chr 2:144,364,364...144,521,057
G
ZIC3
Zic family member 3
decreases expression
ISO
Mercaptopurine results in decreased expression of ZIC3 mRNA
CTD
PMID:23358152
NCBI chr X:137,566,127...137,577,691
Ensembl chr X:137,566,127...137,577,691
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all