DKKL1 (dickkopf like acrosomal protein 1) - Rat Genome Database

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Gene: DKKL1 (dickkopf like acrosomal protein 1) Homo sapiens
Analyze
Symbol: DKKL1
Name: dickkopf like acrosomal protein 1
RGD ID: 1350645
HGNC Page HGNC
Description: Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of testosterone biosynthetic process; and penetration of zona pellucida. Predicted to act upstream of or within positive regulation of fat cell differentiation. Predicted to be located in acrosomal vesicle. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 34; CT34; dickkopf-like 1; dickkopf-like protein 1; SGY; SGY-1; SGY1; soggy; soggy-1; testicular secretory protein Li 15
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: DKKL1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,361,783 - 49,375,116 (+)EnsemblGRCh38hg38GRCh38
GRCh381949,360,520 - 49,375,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,867,134 - 49,878,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,558,854 - 54,570,185 (+)NCBINCBI36hg18NCBI36
Build 341954,558,853 - 54,570,183NCBI
Celera1946,733,898 - 46,745,228 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,243,555 - 46,254,943 (+)NCBIHuRef
CHM1_11949,868,966 - 49,880,350 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10570958   PMID:12477932   PMID:12975309   PMID:15489334   PMID:15892050   PMID:17081983   PMID:17207965   PMID:17474147   PMID:19176879   PMID:21833088   PMID:21873635   PMID:21988832  
PMID:22020285   PMID:22817830   PMID:23088713   PMID:24190897   PMID:24909558   PMID:27635108   PMID:27826023   PMID:28514442   PMID:33281184  


Genomics

Comparative Map Data
DKKL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,361,783 - 49,375,116 (+)EnsemblGRCh38hg38GRCh38
GRCh381949,360,520 - 49,375,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,867,134 - 49,878,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,558,854 - 54,570,185 (+)NCBINCBI36hg18NCBI36
Build 341954,558,853 - 54,570,183NCBI
Celera1946,733,898 - 46,745,228 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,243,555 - 46,254,943 (+)NCBIHuRef
CHM1_11949,868,966 - 49,880,350 (+)NCBICHM1_1
Dkkl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,856,949 - 44,861,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl744,856,943 - 44,861,571 (-)Ensembl
GRCm38745,207,525 - 45,212,165 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,207,519 - 45,212,147 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,462,895 - 52,467,253 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,075,567 - 45,079,892 (-)NCBImm8
Celera740,663,416 - 40,667,775 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.19NCBI
Dkkl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,694,010 - 95,699,259 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1101,205,426 - 101,210,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,205,426 - 101,210,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,270,284 - 102,275,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,684,794 - 95,690,043 (-)NCBIRGSC3.4rn4RGSC3.4
Celera189,952,293 - 89,957,542 (-)NCBICelera
Cytogenetic Map1q22NCBI
Dkkl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,445,149 - 1,449,004 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,445,082 - 1,449,167 (-)NCBIChiLan1.0ChiLan1.0
DKKL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11955,300,173 - 55,313,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,301,955 - 55,313,690 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01946,375,301 - 46,389,822 (+)NCBIMhudiblu_PPA_v0panPan3
DKKL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,109,787 - 107,113,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,109,791 - 107,113,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,693,253 - 106,697,206 (-)NCBI
ROS_Cfam_1.01107,630,262 - 107,634,229 (-)NCBI
UMICH_Zoey_3.11107,303,172 - 107,307,137 (-)NCBI
UNSW_CanFamBas_1.01106,945,347 - 106,949,315 (-)NCBI
UU_Cfam_GSD_1.01107,786,470 - 107,790,436 (-)NCBI
Dkkl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,638,880 - 21,645,597 (+)NCBI
SpeTri2.0NW_0049366643,257,744 - 3,263,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKKL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,463,759 - 54,468,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,462,367 - 54,468,363 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DKKL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,544,459 - 42,555,653 (+)NCBI
ChlSab1.1 Ensembl642,547,593 - 42,555,566 (+)Ensembl
Vero_WHO_p1.0NW_02366607322,470,364 - 22,482,443 (+)NCBI
Dkkl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,816,383 - 4,820,082 (-)NCBI

Position Markers
SHGC-56684  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,872,097 - 49,872,192UniSTSGRCh37
Build 361954,563,909 - 54,564,004RGDNCBI36
Celera1946,738,952 - 46,739,047RGD
Cytogenetic Map19q13.33UniSTS
HuRef1946,248,668 - 46,248,763UniSTS
TNG Radiation Hybrid Map1918233.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1894
Count of miRNA genes:462
Interacting mature miRNAs:521
Transcripts:ENST00000221498, ENST00000594268, ENST00000596402, ENST00000597546, ENST00000597873, ENST00000598682
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 5
Medium 1 1 1 8 3 1 4 390 7 3
Low 998 248 169 84 209 75 769 552 401 117 650 425 14 200 397 1
Below cutoff 1372 2316 1406 467 938 317 3216 1371 2798 252 387 1077 156 990 2091 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001197301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001197302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006723142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB047818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC010524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI879324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI826695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI826744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB300285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000221498   ⟹   ENSP00000221498
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,363,877 - 49,375,116 (+)Ensembl
RefSeq Acc Id: ENST00000594268   ⟹   ENSP00000469865
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,361,783 - 49,375,116 (+)Ensembl
RefSeq Acc Id: ENST00000596402   ⟹   ENSP00000470676
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,363,730 - 49,374,899 (+)Ensembl
RefSeq Acc Id: ENST00000597546   ⟹   ENSP00000472056
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,363,934 - 49,374,991 (+)Ensembl
RefSeq Acc Id: ENST00000597873   ⟹   ENSP00000472866
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,363,074 - 49,374,961 (+)Ensembl
RefSeq Acc Id: ENST00000598682   ⟹   ENSP00000471812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,364,655 - 49,375,116 (+)Ensembl
RefSeq Acc Id: NM_001197301   ⟹   NP_001184230
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,363,877 - 49,375,116 (+)NCBI
GRCh371949,866,466 - 49,878,373 (+)NCBI
HuRef1946,243,555 - 46,254,943 (+)ENTREZGENE
CHM1_11949,869,021 - 49,880,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001197302   ⟹   NP_001184231
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,363,877 - 49,375,116 (+)NCBI
GRCh371949,866,466 - 49,878,373 (+)NCBI
HuRef1946,243,555 - 46,254,943 (+)ENTREZGENE
CHM1_11949,868,966 - 49,880,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014419   ⟹   NP_055234
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,363,877 - 49,375,116 (+)NCBI
GRCh371949,866,466 - 49,878,373 (+)NCBI
Build 361954,558,854 - 54,570,185 (+)NCBI Archive
Celera1946,733,898 - 46,745,228 (+)RGD
HuRef1946,243,555 - 46,254,943 (+)ENTREZGENE
CHM1_11949,869,021 - 49,880,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006723142   ⟹   XP_006723205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,364,049 - 49,375,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526724   ⟹   XP_011525026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,362,974 - 49,375,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526725   ⟹   XP_011525027
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,360,520 - 49,375,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526726   ⟹   XP_011525028
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,361,603 - 49,375,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526727   ⟹   XP_011525029
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,362,974 - 49,375,132 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526728   ⟹   XP_011525030
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,362,974 - 49,375,132 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526729   ⟹   XP_011525031
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,363,586 - 49,375,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026593   ⟹   XP_016882082
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,360,525 - 49,375,119 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_055234   ⟸   NM_014419
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UK85 (UniProtKB/Swiss-Prot),   A0A140VK15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001184231   ⟸   NM_001197302
- Peptide Label: isoform 3
- UniProtKB: Q9UK85 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001184230   ⟸   NM_001197301
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UK85 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006723205   ⟸   XM_006723142
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011525027   ⟸   XM_011526725
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011525028   ⟸   XM_011526726
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011525026   ⟸   XM_011526724
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011525029   ⟸   XM_011526727
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011525030   ⟸   XM_011526728
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011525031   ⟸   XM_011526729
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016882082   ⟸   XM_017026593
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSP00000470676   ⟸   ENST00000596402
RefSeq Acc Id: ENSP00000472866   ⟸   ENST00000597873
RefSeq Acc Id: ENSP00000472056   ⟸   ENST00000597546
RefSeq Acc Id: ENSP00000471812   ⟸   ENST00000598682
RefSeq Acc Id: ENSP00000221498   ⟸   ENST00000221498
RefSeq Acc Id: ENSP00000469865   ⟸   ENST00000594268

Promoters
RGD ID:13205109
Promoter ID:EPDNEW_H26135
Type:initiation region
Name:DKKL1_1
Description:dickkopf like acrosomal protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26137  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,361,774 - 49,361,834EPDNEW
RGD ID:13205113
Promoter ID:EPDNEW_H26137
Type:initiation region
Name:DKKL1_2
Description:dickkopf like acrosomal protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26135  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,363,914 - 49,363,974EPDNEW
RGD ID:6795334
Promoter ID:HG_KWN:30532
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562
Transcripts:NM_014419
Position:
Human AssemblyChrPosition (strand)Source
Build 361954,558,571 - 54,559,072 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
NM_001197301.1(DKKL1):c.416G>A (p.Trp139Ter) single nucleotide variant Malignant melanoma [RCV000072255] Chr19:49374808 [GRCh38]
Chr19:49878065 [GRCh37]
Chr19:54569877 [NCBI36]
Chr19:19q13.33
not provided
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.33(chr19:49645600-49891280)x3 copy number gain not provided [RCV000684076] Chr19:49645600..49891280 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_014419.4(DKKL1):c.719G>A (p.Arg240Gln) single nucleotide variant not provided [RCV000959576] Chr19:49375018 [GRCh38]
Chr19:49878275 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.33(chr19:49600909-51366070)x3 copy number gain not provided [RCV000847250] Chr19:49600909..51366070 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_014419.4(DKKL1):c.497G>A (p.Arg166Gln) single nucleotide variant not provided [RCV000961667] Chr19:49374796 [GRCh38]
Chr19:49878053 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16528 AgrOrtholog
COSMIC DKKL1 COSMIC
Ensembl Genes ENSG00000104901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000221498 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000469865 UniProtKB/TrEMBL
  ENSP00000470676 UniProtKB/TrEMBL
  ENSP00000471812 UniProtKB/TrEMBL
  ENSP00000472056 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000472866 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000221498 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000594268 UniProtKB/TrEMBL
  ENST00000596402 UniProtKB/TrEMBL
  ENST00000597546 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000597873 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000598682 UniProtKB/TrEMBL
GTEx ENSG00000104901 GTEx
HGNC ID HGNC:16528 ENTREZGENE
Human Proteome Map DKKL1 Human Proteome Map
InterPro DKK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 27120 ENTREZGENE
OMIM 605418 OMIM
PANTHER PTHR12113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134974559 PharmGKB
UniProt A0A140VK15 ENTREZGENE, UniProtKB/TrEMBL
  DKKL1_HUMAN UniProtKB/Swiss-Prot
  M0QYJ2_HUMAN UniProtKB/TrEMBL
  M0QZP1_HUMAN UniProtKB/TrEMBL
  M0R1E5_HUMAN UniProtKB/TrEMBL
  M0R1Q7_HUMAN UniProtKB/TrEMBL
  M0R2X7_HUMAN UniProtKB/TrEMBL
  Q9UK85 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-18 DKKL1  dickkopf like acrosomal protein 1    dickkopf-like 1  Symbol and/or name change 5135510 APPROVED
2011-09-01 DKKL1  dickkopf-like 1  DKKL1  dickkopf-like 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 DKKL1  dickkopf-like 1  DKKL1  dickkopf-like 1 (soggy)  Symbol and/or name change 5135510 APPROVED