MEST (mesoderm specific transcript) - Rat Genome Database
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Gene: MEST (mesoderm specific transcript) Homo sapiens
Analyze
Symbol: MEST
Name: mesoderm specific transcript
RGD ID: 1345318
HGNC Page HGNC
Description: Predicted to have hydrolase activity. Predicted to be involved in response to retinoic acid. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686L18234; mesoderm specific transcript homolog; mesoderm-specific transcript homolog protein; MGC111102; MGC8703; paternally expressed gene 1; paternally-expressed gene 1 protein; PEG1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: MESTP1   MESTP2   MESTP3   MESTP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7130,486,171 - 130,506,465 (+)EnsemblGRCh38hg38GRCh38
GRCh387130,486,175 - 130,506,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377130,126,016 - 130,146,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,913,282 - 129,933,369 (+)NCBINCBI36hg18NCBI36
Build 347129,725,123 - 129,740,080NCBI
Celera7124,921,818 - 124,941,908 (+)NCBI
Cytogenetic Map7q32.2NCBI
HuRef7124,488,506 - 124,508,626 (+)NCBIHuRef
CHM1_17130,059,437 - 130,079,559 (+)NCBICHM1_1
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (EXP)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
diosgenin  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethyl methanesulfonate  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
lead diacetate  (EXP)
mercaptopurine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
mitoxantrone  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
purine-6-thiol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8884280   PMID:9158153   PMID:9192843   PMID:9526615   PMID:9781054   PMID:10554015   PMID:10631159   PMID:10679925   PMID:10860668   PMID:10955473   PMID:10958657   PMID:11536368  
PMID:11718568   PMID:11754049   PMID:11821432   PMID:11920156   PMID:12023987   PMID:12095916   PMID:12477932   PMID:12690205   PMID:12754712   PMID:15146197   PMID:15547750   PMID:16338457  
PMID:16344560   PMID:17192395   PMID:17353931   PMID:17450433   PMID:18029348   PMID:18585117   PMID:18644838   PMID:18676680   PMID:19019082   PMID:19170196   PMID:19199708   PMID:19625176  
PMID:19692168   PMID:20301499   PMID:20339302   PMID:20628624   PMID:21575949   PMID:21832049   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22249249   PMID:22456293   PMID:22531794  
PMID:23209187   PMID:23229728   PMID:23343754   PMID:23415968   PMID:23775149   PMID:26119994   PMID:27503909   PMID:27697227   PMID:28052120   PMID:28501506   PMID:28854270   PMID:29157033  
PMID:29721103   PMID:30707743   PMID:30903102   PMID:31067453   PMID:31527615   PMID:31536960   PMID:31574234   PMID:32296183  


Genomics

Comparative Map Data
MEST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7130,486,171 - 130,506,465 (+)EnsemblGRCh38hg38GRCh38
GRCh387130,486,175 - 130,506,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377130,126,016 - 130,146,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,913,282 - 129,933,369 (+)NCBINCBI36hg18NCBI36
Build 347129,725,123 - 129,740,080NCBI
Celera7124,921,818 - 124,941,908 (+)NCBI
Cytogenetic Map7q32.2NCBI
HuRef7124,488,506 - 124,508,626 (+)NCBIHuRef
CHM1_17130,059,437 - 130,079,559 (+)NCBICHM1_1
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
Mest
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,733,505 - 30,783,580 (+)NCBIGRCm39mm39
GRCm39 Ensembl630,723,546 - 30,748,464 (+)Ensembl
GRCm38630,733,506 - 30,748,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,723,547 - 30,748,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv37630,688,063 - 30,698,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv36630,688,073 - 30,698,467 (+)NCBImm8
Celera630,747,989 - 30,758,382 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.53NCBI
Mest
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2459,354,445 - 59,364,919 (+)NCBI
Rnor_6.0 Ensembl458,053,041 - 58,063,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0458,052,786 - 58,063,227 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0457,811,101 - 57,821,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera454,452,983 - 54,463,392 (+)NCBICelera
Cytogenetic Map4q22NCBI
Mest
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547911,122,007 - 11,135,061 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547911,116,705 - 11,135,061 (+)NCBIChiLan1.0ChiLan1.0
MEST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17134,968,531 - 134,988,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7134,968,638 - 134,988,564 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07122,450,524 - 122,470,855 (+)NCBIMhudiblu_PPA_v0panPan3
MEST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl146,436,649 - 6,449,099 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1146,435,693 - 6,454,358 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mest
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365794,782,761 - 4,800,971 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,327,536 - 18,345,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,319,126 - 18,358,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,327,977 - 19,348,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEST
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12199,121,330 - 99,141,861 (+)NCBI
ChlSab1.1 Ensembl2199,127,403 - 99,140,638 (+)Ensembl
Mest
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247835,798,141 - 5,816,595 (-)NCBI

Position Markers
RH12524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377130,145,837 - 130,145,978UniSTSGRCh37
GRCh37329,130,816 - 29,130,956UniSTSGRCh37
Build 36329,105,820 - 29,105,960RGDNCBI36
Celera329,067,704 - 29,067,844RGD
Celera7124,941,612 - 124,941,753UniSTS
Cytogenetic Map7q32UniSTS
HuRef7124,508,325 - 124,508,466UniSTS
HuRef329,072,091 - 29,072,231UniSTS
CRA_TCAGchr7v27129,531,243 - 129,531,384UniSTS
GeneMap99-GB4 RH Map7591.82UniSTS
GDB:3755019  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377130,139,463 - 130,139,547UniSTSGRCh37
Build 367129,926,699 - 129,926,783RGDNCBI36
Celera7124,935,239 - 124,935,323RGD
Cytogenetic Map7q32UniSTS
HuRef7124,501,958 - 124,502,042UniSTS
CRA_TCAGchr7v27129,524,870 - 129,524,954UniSTS
COPG2_4062  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377130,146,013 - 130,146,566UniSTSGRCh37
Build 367129,933,249 - 129,933,802RGDNCBI36
Celera7124,941,788 - 124,942,340RGD
HuRef7124,508,501 - 124,509,053UniSTS
CRA_TCAGchr7v27129,531,419 - 129,531,971UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5266
Count of miRNA genes:928
Interacting mature miRNAs:1103
Transcripts:ENST00000223215, ENST00000341441, ENST00000378576, ENST00000393187, ENST00000399874, ENST00000416162, ENST00000421001, ENST00000427521, ENST00000433159, ENST00000437637, ENST00000437945, ENST00000458161, ENST00000460590, ENST00000462132, ENST00000463263, ENST00000475188, ENST00000488093, ENST00000494868
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 1 7 6 1
Medium 681 332 1468 498 501 361 1576 89 1410 195 1046 1408 150 1 1177 646 3
Low 1710 2386 254 125 1127 103 2535 1825 2310 194 398 185 25 27 1949 2
Below cutoff 46 273 3 1 294 1 230 281 9 25 7 10 193 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA728839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB045582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU118070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG831799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI459412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN425918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR627364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA487705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB454206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC367784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000223215   ⟹   ENSP00000223215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,492,085 - 130,506,465 (+)Ensembl
RefSeq Acc Id: ENST00000341441   ⟹   ENSP00000342749
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,486,171 - 130,506,292 (+)Ensembl
RefSeq Acc Id: ENST00000378576   ⟹   ENSP00000367839
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,486,342 - 130,506,292 (+)Ensembl
RefSeq Acc Id: ENST00000393187   ⟹   ENSP00000376884
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,491,329 - 130,506,296 (+)Ensembl
RefSeq Acc Id: ENST00000399874   ⟹   ENSP00000390589
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,486,971 - 130,498,179 (+)Ensembl
RefSeq Acc Id: ENST00000416162   ⟹   ENSP00000408933
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,486,175 - 130,506,292 (+)Ensembl
RefSeq Acc Id: ENST00000421001   ⟹   ENSP00000407222
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,491,333 - 130,500,807 (+)Ensembl
RefSeq Acc Id: ENST00000427521   ⟹   ENSP00000409505
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,486,336 - 130,506,465 (+)Ensembl
RefSeq Acc Id: ENST00000433159   ⟹   ENSP00000409768
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,487,126 - 130,498,451 (+)Ensembl
RefSeq Acc Id: ENST00000437637   ⟹   ENSP00000393709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,492,472 - 130,500,476 (+)Ensembl
RefSeq Acc Id: ENST00000437945   ⟹   ENSP00000401657
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,492,113 - 130,506,288 (+)Ensembl
RefSeq Acc Id: ENST00000458161   ⟹   ENSP00000396504
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,494,530 - 130,498,477 (+)Ensembl
RefSeq Acc Id: ENST00000462132   ⟹   ENSP00000495770
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,492,395 - 130,506,253 (+)Ensembl
RefSeq Acc Id: ENST00000463263   ⟹   ENSP00000473492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,498,226 - 130,505,298 (+)Ensembl
RefSeq Acc Id: ENST00000475188
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,497,677 - 130,498,801 (+)Ensembl
RefSeq Acc Id: ENST00000488093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,498,380 - 130,501,069 (+)Ensembl
RefSeq Acc Id: ENST00000494868
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7130,498,225 - 130,500,042 (+)Ensembl
RefSeq Acc Id: NM_001253900   ⟹   NP_001240829
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,492,058 - 130,506,297 (+)NCBI
GRCh377130,126,016 - 130,146,138 (+)NCBI
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,065,320 - 130,079,559 (+)NCBI
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001253901   ⟹   NP_001240830
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,486,175 - 130,506,297 (+)NCBI
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,059,437 - 130,079,559 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001253902   ⟹   NP_001240831
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,486,347 - 130,506,297 (+)NCBI
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,059,609 - 130,079,559 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002402   ⟹   NP_002393
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,492,085 - 130,506,465 (+)NCBI
GRCh377130,126,016 - 130,146,138 (+)NCBI
Build 367129,919,174 - 129,933,369 (+)NCBI Archive
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,065,320 - 130,079,559 (+)NCBI
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
Sequence:
RefSeq Acc Id: NM_177524   ⟹   NP_803490
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,486,175 - 130,506,297 (+)NCBI
GRCh377130,126,016 - 130,146,138 (+)NCBI
Build 367129,913,282 - 129,933,369 (+)NCBI Archive
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,059,437 - 130,079,559 (+)NCBI
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
Sequence:
RefSeq Acc Id: NM_177525   ⟹   NP_803491
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,491,329 - 130,506,297 (+)NCBI
GRCh377130,126,016 - 130,146,138 (+)NCBI
Build 367129,918,409 - 129,933,369 (+)NCBI Archive
HuRef7124,488,506 - 124,508,626 (+)NCBI
CHM1_17130,064,591 - 130,079,559 (+)NCBI
CRA_TCAGchr7v27129,511,419 - 129,531,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516222   ⟹   XP_011514524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,492,072 - 130,506,297 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017012218   ⟹   XP_016867707
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,492,707 - 130,506,292 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024446764   ⟹   XP_024302532
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,486,347 - 130,506,292 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024446765   ⟹   XP_024302533
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,491,296 - 130,506,292 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001240829 (Get FASTA)   NCBI Sequence Viewer  
  NP_001240830 (Get FASTA)   NCBI Sequence Viewer  
  NP_001240831 (Get FASTA)   NCBI Sequence Viewer  
  NP_002393 (Get FASTA)   NCBI Sequence Viewer  
  NP_803490 (Get FASTA)   NCBI Sequence Viewer  
  NP_803491 (Get FASTA)   NCBI Sequence Viewer  
  XP_011514524 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867707 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302532 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302533 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH02413 (Get FASTA)   NCBI Sequence Viewer  
  AAH11908 (Get FASTA)   NCBI Sequence Viewer  
  AAH14564 (Get FASTA)   NCBI Sequence Viewer  
  AAH18695 (Get FASTA)   NCBI Sequence Viewer  
  AAH90049 (Get FASTA)   NCBI Sequence Viewer  
  AAP35705 (Get FASTA)   NCBI Sequence Viewer  
  BAA11432 (Get FASTA)   NCBI Sequence Viewer  
  BAA21757 (Get FASTA)   NCBI Sequence Viewer  
  BAC02716 (Get FASTA)   NCBI Sequence Viewer  
  BAG35568 (Get FASTA)   NCBI Sequence Viewer  
  BAG61078 (Get FASTA)   NCBI Sequence Viewer  
  CAA71631 (Get FASTA)   NCBI Sequence Viewer  
  CAA72297 (Get FASTA)   NCBI Sequence Viewer  
  CAG33321 (Get FASTA)   NCBI Sequence Viewer  
  CAH10465 (Get FASTA)   NCBI Sequence Viewer  
  EAL24086 (Get FASTA)   NCBI Sequence Viewer  
  EAL24087 (Get FASTA)   NCBI Sequence Viewer  
  EAW83765 (Get FASTA)   NCBI Sequence Viewer  
  EAW83766 (Get FASTA)   NCBI Sequence Viewer  
  EAW83767 (Get FASTA)   NCBI Sequence Viewer  
  Q5EB52 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_803490   ⟸   NM_177524
- Peptide Label: isoform b precursor
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot),   A4D1L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_803491   ⟸   NM_177525
- Peptide Label: isoform b precursor
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot),   A4D1L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002393   ⟸   NM_002402
- Peptide Label: isoform a
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot),   A0A024R768 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240830   ⟸   NM_001253901
- Peptide Label: isoform d precursor
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240831   ⟸   NM_001253902
- Peptide Label: isoform d precursor
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240829   ⟸   NM_001253900
- Peptide Label: isoform c
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot),   B4DQW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514524   ⟸   XM_011516222
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016867707   ⟸   XM_017012218
- Peptide Label: isoform X1
- UniProtKB: Q5EB52 (UniProtKB/Swiss-Prot),   A4D1L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024302532   ⟸   XM_024446764
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024302533   ⟸   XM_024446765
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000401657   ⟸   ENST00000437945
RefSeq Acc Id: ENSP00000393709   ⟸   ENST00000437637
RefSeq Acc Id: ENSP00000473492   ⟸   ENST00000463263
RefSeq Acc Id: ENSP00000390589   ⟸   ENST00000399874
RefSeq Acc Id: ENSP00000409505   ⟸   ENST00000427521
RefSeq Acc Id: ENSP00000408933   ⟸   ENST00000416162
RefSeq Acc Id: ENSP00000367839   ⟸   ENST00000378576
RefSeq Acc Id: ENSP00000396504   ⟸   ENST00000458161
RefSeq Acc Id: ENSP00000376884   ⟸   ENST00000393187
RefSeq Acc Id: ENSP00000409768   ⟸   ENST00000433159
RefSeq Acc Id: ENSP00000342749   ⟸   ENST00000341441
RefSeq Acc Id: ENSP00000223215   ⟸   ENST00000223215
RefSeq Acc Id: ENSP00000407222   ⟸   ENST00000421001
RefSeq Acc Id: ENSP00000495770   ⟸   ENST00000462132
Protein Domains
AB hydrolase-1

Promoters
RGD ID:6805910
Promoter ID:HG_KWN:59687
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000345184,   OTTHUMT00000345186,   OTTHUMT00000345194,   OTTHUMT00000345195,   OTTHUMT00000345196,   UC003VQD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367129,913,286 - 129,913,967 (+)MPROMDB
RGD ID:6805909
Promoter ID:HG_KWN:59689
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000345183,   OTTHUMT00000345198,   OTTHUMT00000345199,   UC010LMG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367129,918,861 - 129,919,361 (+)MPROMDB
RGD ID:6853416
Promoter ID:EP74533
Type:initiation region
Name:HS_MEST
Description:Mesoderm specific transcript homolog (mouse).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 367129,919,174 - 129,919,234EPD
RGD ID:7211933
Promoter ID:EPDNEW_H11712
Type:initiation region
Name:MEST_2
Description:mesoderm specific transcript
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11713  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,486,333 - 130,486,393EPDNEW
RGD ID:7211935
Promoter ID:EPDNEW_H11713
Type:initiation region
Name:MEST_1
Description:mesoderm specific transcript
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11712  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,492,086 - 130,492,146EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q32.1-33(chr7:128747478-134018250)x3 copy number gain See cases [RCV000051072] Chr7:128747478..134018250 [GRCh38]
Chr7:128387532..133703003 [GRCh37]
Chr7:128174768..133353543 [NCBI36]
Chr7:7q32.1-33
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q31.33-32.3(chr7:126859732-132750936)x1 copy number loss See cases [RCV000054171] Chr7:126859732..132750936 [GRCh38]
Chr7:126499786..132435696 [GRCh37]
Chr7:126287022..132086236 [NCBI36]
Chr7:7q31.33-32.3
pathogenic
NM_177524.2(MEST):c.355G>A (p.Glu119Lys) single nucleotide variant Malignant melanoma [RCV000067637] Chr7:130498181 [GRCh38]
Chr7:130138022 [GRCh37]
Chr7:129925258 [NCBI36]
Chr7:7q32.2
not provided
NM_177524.2(MEST):c.768G>A (p.Trp256Ter) single nucleotide variant Malignant melanoma [RCV000067638] Chr7:130502689 [GRCh38]
Chr7:130142530 [GRCh37]
Chr7:129929766 [NCBI36]
Chr7:7q32.2
not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q32.2(chr7:130282044-130490317)x1 copy number loss See cases [RCV000135732] Chr7:130282044..130490317 [GRCh38]
Chr7:129709120..129917394 [NCBI36]
Chr7:7q32.2
uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q31.33-33(chr7:124170657-134163594)x1 copy number loss See cases [RCV000142552] Chr7:124170657..134163594 [GRCh38]
Chr7:123810711..133848346 [GRCh37]
Chr7:123597947..133498886 [NCBI36]
Chr7:7q31.33-33
pathogenic
NM_002402.4(MEST):c.559C>T (p.Pro187Ser) single nucleotide variant Childhood-Onset Schizophrenia [RCV000202328] Chr7:130499898 [GRCh38]
Chr7:130139739 [GRCh37]
Chr7:7q32.2
likely pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.2-32.3(chr7:130032531-130590540)x3 copy number gain not provided [RCV000848512] Chr7:130032531..130590540 [GRCh37]
Chr7:7q32.2-32.3
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
Single allele complex Renal transitional cell carcinoma [RCV000754611] Chr7:129367205..140482957 [GRCh37]
Chr7:7q32.2-34
likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q32.2-33(chr7:129997717-133355098)x3 copy number gain not provided [RCV001006011] Chr7:129997717..133355098 [GRCh37]
Chr7:7q32.2-33
uncertain significance
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic
GRCh37/hg19 7q32.2-33(chr7:129605827-133093756)x3 copy number gain not provided [RCV001258971] Chr7:129605827..133093756 [GRCh37]
Chr7:7q32.2-33
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7028 AgrOrtholog
COSMIC MEST COSMIC
Ensembl Genes ENSG00000106484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000223215 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000342749 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000367839 UniProtKB/Swiss-Prot
  ENSP00000376884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390589 UniProtKB/TrEMBL
  ENSP00000393709 UniProtKB/TrEMBL
  ENSP00000396504 UniProtKB/TrEMBL
  ENSP00000401657 UniProtKB/TrEMBL
  ENSP00000407222 UniProtKB/TrEMBL
  ENSP00000408933 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000409505 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000409768 UniProtKB/TrEMBL
  ENSP00000473492 UniProtKB/TrEMBL
  ENSP00000495770 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000223215 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000341441 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000378576 UniProtKB/Swiss-Prot
  ENST00000393187 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000399874 UniProtKB/TrEMBL
  ENST00000416162 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000421001 UniProtKB/TrEMBL
  ENST00000427521 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000433159 UniProtKB/TrEMBL
  ENST00000437637 UniProtKB/TrEMBL
  ENST00000437945 UniProtKB/TrEMBL
  ENST00000458161 UniProtKB/TrEMBL
  ENST00000462132 UniProtKB/Swiss-Prot
  ENST00000463263 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000106484 GTEx
HGNC ID HGNC:7028 ENTREZGENE
Human Proteome Map MEST Human Proteome Map
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4232 ENTREZGENE
OMIM 601029 OMIM
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Abhydrolase_6 UniProtKB/TrEMBL
PharmGKB PA30762 PharmGKB
PRINTS EPOXHYDRLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R768 ENTREZGENE, UniProtKB/TrEMBL
  A4D1L9 ENTREZGENE, UniProtKB/TrEMBL
  B4DQW6 ENTREZGENE, UniProtKB/TrEMBL
  C9JCM6_HUMAN UniProtKB/TrEMBL
  C9JG66_HUMAN UniProtKB/TrEMBL
  C9JRA9_HUMAN UniProtKB/TrEMBL
  C9JUD2_HUMAN UniProtKB/TrEMBL
  C9JW74_HUMAN UniProtKB/TrEMBL
  C9JWU9_HUMAN UniProtKB/TrEMBL
  MEST_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  R4GN52_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R6S1 UniProtKB/Swiss-Prot
  O14973 UniProtKB/Swiss-Prot
  O15007 UniProtKB/Swiss-Prot
  Q6AI49 UniProtKB/Swiss-Prot
  Q92571 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-12 MEST  mesoderm specific transcript    mesoderm specific transcript homolog (mouse)  Symbol and/or name change 5135510 APPROVED