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Gene: MVP (major vault protein) Homo sapiens
Symbol: MVP
Name: major vault protein
RGD ID: 732476
Description: Exhibits identical protein binding activity; protein kinase binding activity; and protein phosphatase binding activity. Involved in ERBB signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; and negative regulation of protein phosphorylation. Localizes to several cellular components, including cytoskeleton; cytosol; and perinuclear region of cytoplasm. Implicated in mitral valve prolapse.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: LRP; lung resistance-related protein; testicular secretory protein Li 30; VAULT1
Mus musculus (house mouse) : Mvp (major vault protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mvp (major vault protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mvp (major vault protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MVP (major vault protein)
Canis lupus familiaris (dog) : MVP (major vault protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mvp (major vault protein)
Sus scrofa (pig) : MVP (major vault protein)
Chlorocebus sabaeus (African green monkey) : MVP (major vault protein)
Heterocephalus glaber (naked mole-rat) : Mvp (major vault protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1629,820,394 - 29,848,039 (+)EnsemblGRCh38hg38GRCh38
GRCh381629,820,394 - 29,848,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371629,831,715 - 29,859,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,731,591 - 29,766,842 (+)NCBINCBI36hg18NCBI36
Build 341629,739,288 - 29,766,843NCBI
Celera1672,936,886 - 72,964,474 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,492,353 - 27,519,952 (+)NCBIHuRef
CHM1_11631,047,524 - 31,075,150 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MVP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732476
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.