RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator) - Rat Genome Database

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Gene: RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator) Homo sapiens
Analyze
Symbol: RRAD
Name: RRAD, Ras related glycolysis inhibitor and calcium channel regulator
RGD ID: 736416
HGNC Page HGNC
Description: Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Implicated in type 2 diabetes mellitus. Biomarker of congestive heart failure; INTERACTS WITH (-)-demecolcine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GTP-binding protein RAD; RAD; RAD1; RAS (RAD and GEM) like GTP binding 3; ras associated with diabetes; Ras-related associated with diabetes; REM3; RRAD, Ras related glycolysis inihibitor and calcium channel regulator
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1666,921,679 - 66,925,536 (-)EnsemblGRCh38hg38GRCh38
GRCh381666,921,685 - 66,925,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,955,588 - 66,959,438 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,513,089 - 65,516,920 (-)NCBINCBI36hg18NCBI36
Build 341665,513,088 - 65,516,920NCBI
Celera1651,463,841 - 51,467,698 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1652,829,691 - 52,833,549 (-)NCBIHuRef
CHM1_11668,362,590 - 68,366,447 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (EXP)
diuron  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethanol  (EXP)
fenvalerate  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
haloperidol  (ISO)
Heliotrine  (EXP)
hydrogen chloride  (EXP)
hydroquinone  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
Licochalcone B  (EXP)
lithium chloride  (EXP)
melphalan  (EXP)
mercaptopurine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-Nitrosopyrrolidine  (EXP)
nitrofen  (ISO)
O-methyleugenol  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
propanal  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thimerosal  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triclosan  (EXP)
Tungsten carbide  (EXP)
urethane  (EXP)
vanadyl sulfate  (ISO)
vitamin K  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (TAS)
plasma membrane  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:7859947   PMID:7876254   PMID:8248782   PMID:8557685   PMID:8781531   PMID:8798502   PMID:8810259   PMID:8889549   PMID:9115241   PMID:9677319   PMID:10359610   PMID:10441394  
PMID:10611312   PMID:11280768   PMID:12477932   PMID:15342556   PMID:15489334   PMID:16511212   PMID:16866878   PMID:17195088   PMID:17672918   PMID:20079427   PMID:20460530   PMID:21873635  
PMID:21988832   PMID:22487779   PMID:22658652   PMID:23414517   PMID:23973784   PMID:24222170   PMID:24632303   PMID:24648519   PMID:24992013   PMID:25114038   PMID:25313011   PMID:25893381  
PMID:26344687   PMID:26546438   PMID:28065597   PMID:30391675   PMID:31114854   PMID:31857616  


Genomics

Comparative Map Data
RRAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1666,921,679 - 66,925,536 (-)EnsemblGRCh38hg38GRCh38
GRCh381666,921,685 - 66,925,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,955,588 - 66,959,438 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,513,089 - 65,516,920 (-)NCBINCBI36hg18NCBI36
Build 341665,513,088 - 65,516,920NCBI
Celera1651,463,841 - 51,467,698 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1652,829,691 - 52,833,549 (-)NCBIHuRef
CHM1_11668,362,590 - 68,366,447 (-)NCBICHM1_1
Rrad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,354,702 - 105,357,976 (-)NCBIGRCm39mm39
GRCm39 Ensembl8105,354,702 - 105,357,959 (-)Ensembl
GRCm388104,628,070 - 104,631,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,628,070 - 104,631,327 (-)EnsemblGRCm38mm10GRCm38
MGSCv378107,151,966 - 107,155,221 (-)NCBIGRCm37mm9NCBIm37
MGSCv368107,517,580 - 107,520,044 (-)NCBImm8
Celera8108,860,666 - 108,863,921 (-)NCBICelera
Cytogenetic Map8D3NCBI
Rrad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.219354,184 - 357,424 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl19354,198 - 357,417 (+)Ensembl
Rnor_6.019561,696 - 564,929 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19561,727 - 564,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019555,959 - 559,189 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419272,791 - 275,957 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119272,790 - 275,957 (+)NCBI
Celera19350,432 - 353,630 (+)NCBICelera
Cytogenetic Map19p14NCBI
Rrad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543323,426,643 - 23,438,923 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543323,426,258 - 23,439,094 (-)NCBIChiLan1.0ChiLan1.0
RRAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11666,339,106 - 66,342,396 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01647,236,886 - 47,240,799 (-)NCBIMhudiblu_PPA_v0panPan3
RRAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,392,608 - 82,395,574 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,392,557 - 82,395,561 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,381,299 - 82,384,264 (+)NCBI
ROS_Cfam_1.0582,829,207 - 82,832,176 (+)NCBI
UMICH_Zoey_3.1582,652,397 - 82,655,362 (+)NCBI
UNSW_CanFamBas_1.0582,339,219 - 82,342,172 (+)NCBI
UU_Cfam_GSD_1.0582,978,172 - 82,981,138 (+)NCBI
Rrad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934942,412,632 - 42,415,959 (+)NCBI
SpeTri2.0NW_00493647517,173,170 - 17,176,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,601,692 - 27,605,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,601,692 - 27,605,127 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RRAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,620,846 - 52,626,799 (-)NCBI
ChlSab1.1 Ensembl552,621,231 - 52,624,436 (-)Ensembl
Vero_WHO_p1.0NW_02366604723,285,743 - 23,293,154 (+)NCBI
Rrad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474619,584,061 - 19,587,476 (+)NCBI

Position Markers
RH80345  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,955,619 - 66,955,830UniSTSGRCh37
Build 361665,513,120 - 65,513,331RGDNCBI36
Celera1651,463,878 - 51,464,089RGD
Cytogenetic Map16q22UniSTS
HuRef1652,829,728 - 52,829,939UniSTS
GeneMap99-GB4 RH Map16400.36UniSTS
RH80791  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,955,745 - 66,955,990UniSTSGRCh37
Build 361665,513,246 - 65,513,491RGDNCBI36
Celera1651,464,004 - 51,464,249RGD
Cytogenetic Map16q22UniSTS
HuRef1652,829,854 - 52,830,099UniSTS
GeneMap99-GB4 RH Map16398.51UniSTS
D16S324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,956,530 - 66,956,719UniSTSGRCh37
GRCh37417,610,619 - 17,611,902UniSTSGRCh37
Build 361665,514,031 - 65,514,220RGDNCBI36
Celera418,075,615 - 18,076,898UniSTS
Celera1651,464,789 - 51,464,978RGD
Cytogenetic Map16q22UniSTS
HuRef1652,830,639 - 52,830,828UniSTS
HuRef416,965,208 - 16,966,491UniSTS
RRAD__5528  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,955,592 - 66,956,225UniSTSGRCh37
Build 361665,513,093 - 65,513,726RGDNCBI36
Celera1651,463,851 - 51,464,484RGD
HuRef1652,829,701 - 52,830,334UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1503
Count of miRNA genes:594
Interacting mature miRNAs:686
Transcripts:ENST00000299759, ENST00000420652, ENST00000566577, ENST00000567791, ENST00000568915
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 37 122 137 2 2 1 122
Medium 1747 2174 1005 113 257 40 3556 1981 1209 308 1093 1319 82 1081 2542 3
Low 621 320 672 468 1062 382 465 53 2491 102 326 230 92 1 123 124 1 2
Below cutoff 63 454 48 42 595 42 182 26 34 7 37 57 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000299759   ⟹   ENSP00000299759
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,921,685 - 66,925,535 (-)Ensembl
RefSeq Acc Id: ENST00000420652   ⟹   ENSP00000388744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,921,679 - 66,925,536 (-)Ensembl
RefSeq Acc Id: ENST00000566577   ⟹   ENSP00000462559
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,921,832 - 66,924,952 (-)Ensembl
RefSeq Acc Id: ENST00000567791
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,921,687 - 66,923,898 (-)Ensembl
RefSeq Acc Id: ENST00000568915   ⟹   ENSP00000461995
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,921,750 - 66,924,974 (-)Ensembl
RefSeq Acc Id: NM_001128850   ⟹   NP_001122322
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,921,685 - 66,925,535 (-)NCBI
GRCh371666,955,582 - 66,959,439 (-)ENTREZGENE
HuRef1652,829,691 - 52,833,549 (-)ENTREZGENE
CHM1_11668,362,590 - 68,366,447 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004165   ⟹   NP_004156
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,921,685 - 66,925,535 (-)NCBI
GRCh371666,955,582 - 66,959,439 (-)ENTREZGENE
Build 361665,513,089 - 65,516,920 (-)NCBI Archive
HuRef1652,829,691 - 52,833,549 (-)ENTREZGENE
CHM1_11668,362,590 - 68,366,447 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004156   ⟸   NM_004165
- UniProtKB: P55042 (UniProtKB/Swiss-Prot),   A0A024R6X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001122322   ⟸   NM_001128850
- UniProtKB: P55042 (UniProtKB/Swiss-Prot),   A0A024R6X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000299759   ⟸   ENST00000299759
RefSeq Acc Id: ENSP00000462559   ⟸   ENST00000566577
RefSeq Acc Id: ENSP00000388744   ⟸   ENST00000420652
RefSeq Acc Id: ENSP00000461995   ⟸   ENST00000568915

Promoters
RGD ID:6793429
Promoter ID:HG_KWN:23995
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_001128850,   OTTHUMT00000268830
Position:
Human AssemblyChrPosition (strand)Source
Build 361665,516,639 - 65,517,139 (-)MPROMDB
RGD ID:7232457
Promoter ID:EPDNEW_H21974
Type:multiple initiation site
Name:RRAD_1
Description:RRAD, Ras related glycolysis inhibitor and calcium channel regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21975  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,925,535 - 66,925,595EPDNEW
RGD ID:7232459
Promoter ID:EPDNEW_H21975
Type:initiation region
Name:RRAD_2
Description:RRAD, Ras related glycolysis inhibitor and calcium channel regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21974  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,925,787 - 66,925,847EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2
pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q21-22.1(chr16:62179331-67770414)x1 copy number loss See cases [RCV000053333] Chr16:62179331..67770414 [GRCh38]
Chr16:62213235..67804317 [GRCh37]
Chr16:60770736..66361818 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:64311275-68062011)x1 copy number loss See cases [RCV000053335] Chr16:64311275..68062011 [GRCh38]
Chr16:64345179..68095914 [GRCh37]
Chr16:62902680..66653415 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q22.1(chr16:66694180-67865445)x1 copy number loss See cases [RCV000053336] Chr16:66694180..67865445 [GRCh38]
Chr16:66728083..67899348 [GRCh37]
Chr16:65285584..66456849 [NCBI36]
Chr16:16q22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:66245888-67473023)x1 copy number loss See cases [RCV000134709] Chr16:66245888..67473023 [GRCh38]
Chr16:66279791..67506926 [GRCh37]
Chr16:64837292..66064427 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1
pathogenic
GRCh38/hg38 16q22.1(chr16:66893204-67357178)x3 copy number gain See cases [RCV000137368] Chr16:66893204..67357178 [GRCh38]
Chr16:66927107..67391081 [GRCh37]
Chr16:65484608..65948582 [NCBI36]
Chr16:16q22.1
likely pathogenic|uncertain significance
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q22.1(chr16:66921669-67312444)x3 copy number gain See cases [RCV000142764] Chr16:66921669..67312444 [GRCh38]
Chr16:66955572..67346347 [GRCh37]
Chr16:65513073..65903848 [NCBI36]
Chr16:16q22.1
uncertain significance
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q21-22.1(chr16:66537021-67369281)x3 copy number gain See cases [RCV000510388] Chr16:66537021..67369281 [GRCh37]
Chr16:16q21-22.1
uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q21-22.1(chr16:65669673-70180183)x1 copy number loss not provided [RCV001006797] Chr16:65669673..70180183 [GRCh37]
Chr16:16q21-22.1
pathogenic
GRCh37/hg19 16q22.1(chr16:66797153-67109495)x3 copy number gain not provided [RCV000848721] Chr16:66797153..67109495 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q22.1(chr16:66876199-67150370)x3 copy number gain not provided [RCV000846681] Chr16:66876199..67150370 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3
not provided

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10446 AgrOrtholog
COSMIC RRAD COSMIC
Ensembl Genes ENSG00000166592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000299759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000388744 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000461995 UniProtKB/TrEMBL
  ENSP00000462559 UniProtKB/TrEMBL
Ensembl Transcript ENST00000299759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000420652 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000566577 UniProtKB/TrEMBL
  ENST00000568915 UniProtKB/TrEMBL
GTEx ENSG00000166592 GTEx
HGNC ID HGNC:10446 ENTREZGENE
Human Proteome Map RRAD Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6236 ENTREZGENE
OMIM 179503 OMIM
PANTHER PTHR45775:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34860 PharmGKB
PIRSF GTP-binding_GEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R6X0 ENTREZGENE, UniProtKB/TrEMBL
  J3KRG9_HUMAN UniProtKB/TrEMBL
  J3KSM6_HUMAN UniProtKB/TrEMBL
  P55042 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q96F39 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-19 RRAD  RRAD, Ras related glycolysis inhibitor and calcium channel regulator    Ras-related associated with diabetes  Symbol and/or name change 5135510 APPROVED