MIR31 (microRNA 31) - Rat Genome Database

Name: MIR31
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MIR31 (microRNA 31) Homo sapiens

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Symbol:

MIR31

Name:

microRNA 31

Description:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Type:

ncrna

RefSeq Status:

PROVISIONAL

Also known as:

hsa-mir-31; miR-31; MIRN31

Orthologs:

Mus musculus (house mouse) : Mir31 (microRNA 31) MGI
Rattus norvegicus (Norway rat) : Mir31 (microRNA 31) Alliance
Canis lupus familiaris (dog) : MIR31 (microRNA mir-31)
Sus scrofa (pig) : MIR31 (microRNA mir-31)

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	21,512,115 - 21,512,185 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	21,512,114 - 21,512,184 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	21,502,113 - 21,502,183 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	9	21,450,429 - 21,450,499 (-)	NCBI
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	21,475,518 - 21,475,588 (-)	NCBI		HuRef
CHM1_1	9	21,511,915 - 21,511,985 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

miRNA Target Status

Confirmed Targets

Gene Target	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
HIF1AN	hsa-miR-31-5p	Mirtarbase	external_info	Northern blot//qRT-PCR//Western blot	Functional MTI	22532441
HIF1AN	hsa-miR-31-5p	Mirtarbase	external_info	CLASH	Functional MTI (Weak)	23622248
RHOA	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19524507
RHOA	hsa-miR-31-5p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	22854067
PPP2R2A	hsa-miR-31-5p	Mirtarbase	external_info	qRT-PCR//Luciferase reporter assay	Functional MTI	20237410
SATB2	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20980827
FOXP3	hsa-miR-31-5p	Mirtarbase	external_info	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	19408243
SELE	hsa-miR-31-5p	Mirtarbase	external_info	Immunocytochemistry//Northern blot//qRT-PCR//Weste	Functional MTI	19949084
CASR	hsa-miR-31-5p	Mirtarbase	external_info	LacZ assay	Functional MTI	20145132
YY1	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR	Non-Functional MTI	19524507
MPRIP	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR	Functional MTI	19524507
DMD	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	21212803
TIAM1	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//Microarray//Northern bl	Functional MTI	20826792
ICAM1	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Non-Functional MTI	19949084
DKK1	hsa-miR-31-5p	Mirtarbase	external_info	Immunoprecipitaion//Luciferase reporter assay//Mic	Functional MTI	21048943
PRKCE	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23364795
RASA1	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23322774
STK40	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23233723
MCM2	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23233736
CREG1	hsa-miR-31-5p	Mirtarbase	external_info	Immunofluorescence//Luciferase reporter assay//qRT	Functional MTI	23518389
MLH1	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23539435
MET	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23552883
MET	hsa-miR-31-5p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	23553486
PRKCE	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	23364795
RASA1	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	23322774
EZH2	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	22948084
MAP3K14	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	22264793
RDX	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	22089331
ITGA2	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21875932
EMP1	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21658006
ITGA5	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21406558
WASF3	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21105030
DKK1	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21048943
TIAM1	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	20826792
LATS2	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	20237410
HIF1AN	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	20145132
E2F6	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	21368878
RHOA	hsa-miR-31-5p	OncomiRDB	external_info	NA	NA	19524507
RHOA	hsa-miR-31-3p	Mirtarbase	external_info	qRT-PCR//Western blot	Functional MTI	22854067
INHBA	hsa-miR-31-3p	Mirtarbase	external_info	CLASH	Functional MTI (Weak)	23622248
LATS2	hsa-miR-31-3p	Mirecords	external_info	{changed}	NA	20237410
CASR	hsa-miR-31-3p	Mirecords	external_info	{changed}	NA	20145132
ITGA5	hsa-miR-31-3p	Mirecords	external_info	{changed}	NA	19524507
FOXP3	hsa-miR-31-3p	Mirecords	external_info	{changed}	NA	19408243
ENY2	hsa-miR-31-3p	Mirecords	external_info	{changed}	NA	20980827
RHOA	hsa-miR-31-3p	OncomiRDB	external_info	NA	NA	22854067

Predicted Targets

	Summary Value
Count of predictions:	20501
Count of gene targets:	8307
Count of transcripts:	16253
Interacting mature miRNAs:	hsa-miR-31-3p, hsa-miR-31-5p
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences

Clinical Variants

Additional Information

External Database Links

More on MIR31
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1343532
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2019-11-26
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar

Imported Annotations - CTD