MIR23A (microRNA 23a) - Rat Genome Database

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Gene: MIR23A (microRNA 23a) Homo sapiens
Analyze
Symbol: MIR23A
Name: microRNA 23a
RGD ID: 1351663
HGNC Page HGNC:31605
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including miRNA-mediated gene silencing by mRNA destabilization; positive regulation of ERK1 and ERK2 cascade; and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Located in extracellular exosome. Biomarker of colorectal cancer; hepatocellular carcinoma; macular degeneration; obesity; and primary pulmonary hypertension.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-23a; mir-23a; MIRN23A; miRNA23A
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,836,587 - 13,836,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,836,587 - 13,836,659 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,947,401 - 13,947,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,400 - 13,808,472 (-)NCBINCBI36Build 36hg18NCBI36
Celera1913,841,149 - 13,841,221 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,518,969 - 13,519,041 (-)NCBIHuRef
CHM1_11913,947,906 - 13,947,978 (-)NCBICHM1_1
T2T-CHM13v2.01913,962,719 - 13,962,791 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
BMP signaling pathway  (ISO)
cell growth involved in cardiac muscle cell development  (ISS)
cellular response to estradiol stimulus  (ISO)
cellular response to phenylalanine  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IGI)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA,IGI,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of gap junction assembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of SMAD protein signal transduction  (IMP)
negative regulation of vascular permeability  (IDA)
ossification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (IDA,IGI)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IGI)
positive regulation of cell migration involved in sprouting angiogenesis  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IGI)
positive regulation of Fas signaling pathway  (IGI)
positive regulation of ferroptosis  (ISO)
positive regulation of gene expression  (IGI,ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of myelination  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
post-embryonic hindlimb morphogenesis  (ISO)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of sprouting angiogenesis  (IDA)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-23a-3p inhibitor decreases osteonecrosis incidence in a rat model. Dong Y, etal., Mol Med Rep. 2017 Dec;16(6):9331-9336. doi: 10.3892/mmr.2017.7808. Epub 2017 Oct 17.
2. Inhibition of long noncoding RNA growth arrest-specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats. Gao S, etal., J Thorac Cardiovasc Surg. 2019 Jan 25:S0022-5223(19)30260-0. doi: 10.1016/j.jtcvs.2019.01.050.
3. Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy. Hirota K, etal., Graefes Arch Clin Exp Ophthalmol. 2015 Mar;253(3):335-42. doi: 10.1007/s00417-014-2692-5. Epub 2014 Jun 27.
4. MicroRNA-23a-3p promotes the perihematomal edema formation after intracerebral hemorrhage via ZO-1. Hu YL, etal., Eur Rev Med Pharmacol Sci. 2018 May;22(9):2809-2816. doi: 10.26355/eurrev_201805_14980.
5. Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats. Kong Y, etal., J Mol Neurosci. 2021 Sep;71(9):1863-1875. doi: 10.1007/s12031-020-01770-x. Epub 2021 Jan 5.
6. Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells. Lin H, etal., Invest Ophthalmol Vis Sci. 2011 Aug 9;52(9):6308-14. doi: 10.1167/iovs.10-6632.
7. Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth in hepatocellular cancer by targeting the VHL/HIF axis. Liu Y, etal., J Physiol Biochem. 2019 Aug;75(3):391-401. doi: 10.1007/s13105-019-00692-6. Epub 2019 Jul 18.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Role of circulating miRNAs as biomarkers in idiopathic pulmonary arterial hypertension: possible relevance of miR-23a. Sarrion I, etal., Oxid Med Cell Longev. 2015;2015:792846. doi: 10.1155/2015/792846. Epub 2015 Feb 25.
10. Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Wang B, etal., Hepatology. 2012 Jul;56(1):186-97. doi: 10.1002/hep.25632. Epub 2012 Jun 5.
11. Cardiac hypertrophy is positively regulated by MicroRNA miR-23a. Wang K, etal., J Biol Chem. 2012 Jan 2;287(1):589-599. doi: 10.1074/jbc.M111.266940. Epub 2011 Nov 14.
12. Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. Yong FL, etal., BMC Cancer. 2013 Jun 8;13:280. doi: 10.1186/1471-2407-13-280.
Additional References at PubMed
PMID:11679670   PMID:11914277   PMID:14573789   PMID:15131085   PMID:15325244   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18766170   PMID:19513126   PMID:20086171   PMID:20698883  
PMID:20815877   PMID:21037258   PMID:21536891   PMID:21593605   PMID:21750350   PMID:22455847   PMID:22634383   PMID:22653319   PMID:22752005   PMID:23019365   PMID:23158364   PMID:23322776  
PMID:23444217   PMID:23450049   PMID:23630040   PMID:23649631   PMID:23865473   PMID:23918807   PMID:23929433   PMID:23977359   PMID:24103454   PMID:24305689   PMID:24417970   PMID:24457242  
PMID:24498188   PMID:24584347   PMID:24659264   PMID:24802236   PMID:24898878   PMID:24981880   PMID:24997345   PMID:25213664   PMID:25264594   PMID:25347474   PMID:25429623   PMID:25445205  
PMID:25461762   PMID:25501015   PMID:25604141   PMID:25619478   PMID:25656948   PMID:25674252   PMID:25701323   PMID:25714010   PMID:25753893   PMID:25829494   PMID:25879432   PMID:25929864  
PMID:26110567   PMID:26115870   PMID:26314966   PMID:26315270   PMID:26342566   PMID:26400397   PMID:26439986   PMID:26646931   PMID:26774446   PMID:26818976   PMID:27028342   PMID:27085964  
PMID:27099864   PMID:27191270   PMID:27197200   PMID:27279136   PMID:27318087   PMID:27411920   PMID:27485599   PMID:27492069   PMID:27509223   PMID:27534887   PMID:27566562   PMID:27737950  
PMID:27741223   PMID:27936459   PMID:27991481   PMID:27993628   PMID:28059053   PMID:28159509   PMID:28193283   PMID:28248456   PMID:28422282   PMID:28453394   PMID:28523344   PMID:28646123  
PMID:28707079   PMID:28740547   PMID:28772220   PMID:28798470   PMID:28847731   PMID:28901474   PMID:28929578   PMID:28981115   PMID:29141872   PMID:29344643   PMID:29377281   PMID:29520105  
PMID:29845275   PMID:29864909   PMID:30078013   PMID:30181004   PMID:30227118   PMID:30246348   PMID:30280185   PMID:30280770   PMID:30342991   PMID:30453069   PMID:30518189   PMID:30583038  
PMID:30606659   PMID:30854665   PMID:30862230   PMID:30867808   PMID:30913118   PMID:30981077   PMID:31020662   PMID:31081097   PMID:31211843   PMID:31270050   PMID:31281935   PMID:31371699  
PMID:31539127   PMID:31570693   PMID:31626694   PMID:31736444   PMID:31769216   PMID:31799657   PMID:31876746   PMID:31884108   PMID:31926946   PMID:31994011   PMID:32096162   PMID:32107941  
PMID:32141657   PMID:32314193   PMID:32492770   PMID:32522566   PMID:32590069   PMID:32772928   PMID:32783743   PMID:32866518   PMID:32881354   PMID:32889404   PMID:32960357   PMID:33049089  
PMID:33107309   PMID:33155364   PMID:33290159   PMID:33389496   PMID:33402976   PMID:33779886   PMID:33784796   PMID:33982771   PMID:34046994   PMID:34126237   PMID:34291333   PMID:34327529  
PMID:34363438   PMID:34559194   PMID:34608568   PMID:34874224   PMID:34937039   PMID:35034562   PMID:35239776   PMID:35537329   PMID:35650643   PMID:35707849   PMID:35909545   PMID:36250827  
PMID:36374403   PMID:36649268   PMID:36809792   PMID:37057923   PMID:37087718   PMID:37191968   PMID:37222952   PMID:37290686   PMID:37995941   PMID:38348790   PMID:38378600   PMID:38836681  


Genomics

Comparative Map Data
MIR23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,836,587 - 13,836,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,836,587 - 13,836,659 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,947,401 - 13,947,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,400 - 13,808,472 (-)NCBINCBI36Build 36hg18NCBI36
Celera1913,841,149 - 13,841,221 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,518,969 - 13,519,041 (-)NCBIHuRef
CHM1_11913,947,906 - 13,947,978 (-)NCBICHM1_1
T2T-CHM13v2.01913,962,719 - 13,962,791 (-)NCBIT2T-CHM13v2.0
Mir23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,935,147 - 84,935,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,935,147 - 84,935,221 (+)EnsemblGRCm39 Ensembl
GRCm38884,208,518 - 84,208,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,518 - 84,208,592 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,732,417 - 86,732,491 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera888,508,624 - 88,508,698 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.58NCBI
Mir23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,859,769 - 40,859,843 (-)NCBIGRCr8
mRatBN7.21923,954,997 - 23,955,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,954,997 - 23,955,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,775,857 - 30,775,931 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,430,266 - 31,430,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,653,035 - 33,653,109 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,318,582 - 25,318,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,318,582 - 25,318,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,294,770 - 36,294,844 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,503,845 - 23,503,919 (-)NCBICelera
Cytogenetic Map19q11NCBI
MIR23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,620,335 - 48,620,386 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,620,323 - 48,620,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,494,255 - 48,494,306 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,138,446 - 49,138,497 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,138,434 - 49,138,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,348,926 - 48,348,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,775,839 - 48,775,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,018,907 - 49,018,958 (+)NCBIUU_Cfam_GSD_1.0
MIR23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,308,117 - 65,308,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,308,117 - 65,308,186 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,581,838 - 65,581,907 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.13-13.12(chr19:13533925-14258833)x1 copy number loss See cases [RCV000051051] Chr19:13533925..14258833 [GRCh38]
Chr19:13644739..14369645 [GRCh37]
Chr19:13505739..14230645 [NCBI36]
Chr19:19p13.13-13.12		 uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12		 pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:13802749-14003761)x3 copy number gain See cases [RCV000239944] Chr19:13802749..14003761 [GRCh37]
Chr19:19p13.2-13.12		 uncertain significance
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:13592592-14717528)x1 copy number loss See cases [RCV000511445] Chr19:13592592..14717528 [GRCh37]
Chr19:19p13.2-13.12		 likely pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12697728-14111313)x1 copy number loss not provided [RCV001834482] Chr19:12697728..14111313 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ATF1hsa-miR-23a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
FOXO3hsa-miR-23a-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22084234
FOXO3hsa-miR-23a-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22095742
CXCL12hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI14697198
G6PC1hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22318941
HES1hsa-miR-23a-3pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//NorFunctional MTI12808467
HES1hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI15066185
POU4F2hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
POU4F2hsa-miR-23a-3pMirtarbaseexternal_infoFlow//GFP reporter assay//Northern blot//qRT-PCR//Functional MTI20609388
CELF1hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20299448
ATAT1hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI15131085
IL6Rhsa-miR-23a-3pMirtarbaseexternal_infoGFP reporter assay//Microarray//qRT-PCR//Western bFunctional MTI20698883
FANCGhsa-miR-23a-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI21750350
MYH1hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22771720
PTENhsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23019365
PTPN11hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23420868
HMGN2hsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23437179
HIVEP1hsa-miR-23a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CXCL12hsa-miR-23a-3pTarbaseexternal_infoReporter GenePOSITIVE
CXCL12hsa-miR-23a-3pMirecordsexternal_infoNANA14697198
HES1hsa-miR-23a-3pMirecordsexternal_infoNANA15066185
ATAT1hsa-miR-23a-3pMirecordsexternal_infoNANA15131085
PTENhsa-miR-23a-3pOncomiRDBexternal_infoNANA23019365
CDH1hsa-miR-23a-3pOncomiRDBexternal_infoNANA22752005
MTSS1hsa-miR-23a-3pOncomiRDBexternal_infoNANA22628407
PPARGC1Ahsa-miR-23a-3pOncomiRDBexternal_infoNANA22318941
IL6Rhsa-miR-23a-3pOncomiRDBexternal_infoNANA20698883
GLShsa-miR-23a-3pOncomiRDBexternal_infoNANA19219026

Predicted Targets
Summary Value
Count of predictions:56781
Count of gene targets:17246
Count of transcripts:40938
Interacting mature miRNAs:hsa-miR-23a-3p, hsa-miR-23a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
1300034BP50_HBlood pressure QTL 50 (human)2.10.00094Blood pressuresystolic191108946337089463Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
43 195 102 76 314 169 430 4 100 300 101 219 838 500 48 134 224 244 306 11

Sequence


Ensembl Acc Id: ENST00000385245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1913,836,587 - 13,836,659 (-)Ensembl
RefSeq Acc Id: NR_029495
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381913,836,587 - 13,836,659 (-)NCBI
GRCh371913,947,401 - 13,947,473 (-)RGD
Celera1913,841,149 - 13,841,221 (-)RGD
HuRef1913,518,969 - 13,519,041 (-)ENTREZGENE
CHM1_11913,947,906 - 13,947,978 (-)NCBI
T2T-CHM13v2.01913,962,719 - 13,962,791 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31605 AgrOrtholog
COSMIC MIR23A COSMIC
Ensembl Genes ENSG00000207980 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385245 ENTREZGENE
GTEx ENSG00000207980 GTEx
HGNC ID HGNC:31605 ENTREZGENE
Human Proteome Map MIR23A Human Proteome Map
miRBase MI0000079 ENTREZGENE
NCBI Gene 407010 ENTREZGENE
OMIM 607962 OMIM
PharmGKB PA164722613 PharmGKB
RNAcentral URS00001CC864 RNACentral
  URS00005070A9 RNACentral
  URS00005540D2 RNACentral