WNT10B (Wnt family member 10B) - Rat Genome Database
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Gene: WNT10B (Wnt family member 10B) Homo sapiens
Analyze
Symbol: WNT10B
Name: Wnt family member 10B
RGD ID: 1312744
HGNC Page HGNC
Description: Predicted to have cytokine activity and frizzled binding activity. Involved in several processes, including hematopoietic stem cell proliferation; negative regulation of fat cell differentiation; and protein stabilization. Predicted to localize to extracellular space. Implicated in obesity; split hand-foot malformation 6; and tooth agenesis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: protein Wnt-10b; SHFM6; STHAG8; wingless-type MMTV integration site family member 10B; wingless-type MMTV integration site family, member 10B; WNT-10B protein; WNT-12
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,965,340 - 48,971,735 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,965,340 - 48,979,587 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371249,359,123 - 49,365,518 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371249,359,123 - 49,365,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,645,390 - 47,651,810 (-)NCBINCBI36hg18NCBI36
Build 341247,645,390 - 47,651,810NCBI
Celera1248,153,932 - 48,160,449 (-)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1246,390,715 - 46,397,232 (-)NCBIHuRef
CHM1_11249,324,923 - 49,331,441 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone trabecula formation  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IDA,ISO)
cell cycle arrest  (IEA,ISO)
cell fate commitment  (IBA)
cellular response to cAMP  (IEA,ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cellular response to parathyroid hormone stimulus  (IEA,ISO)
cellular response to retinoic acid  (ISS)
chondrocyte differentiation  (IEP)
fungiform papilla development  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
hematopoietic stem cell proliferation  (IDA,ISO)
lipid metabolic process  (IEA,ISO)
multicellular organism development  (IEA)
myoblast differentiation involved in skeletal muscle regeneration  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IDA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (IBA,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of epithelial cell differentiation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA,ISO)
positive regulation of timing of anagen  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein stabilization  (IDA)
regulation of fat cell differentiation  (ISO)
regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of protein metabolic process  (ISO)
regulation of skeletal muscle tissue development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
sensory perception of taste  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (ISO)
smoothened signaling pathway  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO,TAS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8167409   PMID:9121776   PMID:9284937   PMID:9441749   PMID:9787155   PMID:10937998   PMID:11350055   PMID:11713588   PMID:12437293   PMID:12477932   PMID:15135146   PMID:15190075  
PMID:15489334   PMID:16344560   PMID:17761539   PMID:18465804   PMID:18515319   PMID:19016593   PMID:19056892   PMID:19075223   PMID:19453261   PMID:19458884   PMID:19913121   PMID:20579865  
PMID:20628086   PMID:20628624   PMID:20635353   PMID:21321991   PMID:21554266   PMID:21873635   PMID:22041457   PMID:22189080   PMID:22890324   PMID:23104151   PMID:23135473   PMID:23307470  
PMID:23325361   PMID:23900840   PMID:24211389   PMID:25995040   PMID:26186194   PMID:26338900   PMID:26370090   PMID:27321946   PMID:27853307   PMID:28071181   PMID:28370659   PMID:28514442  
PMID:28586066   PMID:29150431   PMID:29364501   PMID:29427788   PMID:30149605   PMID:30246922   PMID:30563890   PMID:31050392   PMID:31089877   PMID:31433503   PMID:32694731   PMID:32814053  


Genomics

Comparative Map Data
WNT10B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,965,340 - 48,971,735 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,965,340 - 48,979,587 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371249,359,123 - 49,365,518 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371249,359,123 - 49,365,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,645,390 - 47,651,810 (-)NCBINCBI36hg18NCBI36
Build 341247,645,390 - 47,651,810NCBI
Celera1248,153,932 - 48,160,449 (-)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1246,390,715 - 46,397,232 (-)NCBIHuRef
CHM1_11249,324,923 - 49,331,441 (-)NCBICHM1_1
Wnt10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,668,593 - 98,676,093 (-)NCBIGRCm39mm39
GRCm381598,770,712 - 98,778,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,770,712 - 98,778,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,602,183 - 98,608,581 (-)NCBIGRCm37mm9NCBIm37
MGSCv361598,599,796 - 98,606,184 (-)NCBImm8
Celera15100,921,391 - 100,927,785 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,922,088 - 129,927,892 (-)NCBI
Rnor_6.0 Ensembl7140,448,465 - 140,454,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07140,448,284 - 140,466,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X114,958,456 - 114,976,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,541,197 - 137,547,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17137,617,649 - 137,623,456 (-)NCBI
Celera7126,411,054 - 126,416,855 (-)NCBICelera
Cytogenetic Map7q36NCBI
Wnt10b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,782,782 - 7,788,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,782,782 - 7,800,281 (-)NCBIChiLan1.0ChiLan1.0
WNT10B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,659,106 - 40,665,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBIMhudiblu_PPA_v0panPan3
Wnt10b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365126,768,240 - 6,774,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT10B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,997,381 - 15,013,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,997,377 - 15,013,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,407,596 - 15,422,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT10B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,205,728 - 45,229,050 (-)NCBI
ChlSab1.1 Ensembl1145,205,566 - 45,210,893 (-)Ensembl
Wnt10b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248163,221,573 - 3,227,102 (+)NCBI

Position Markers
RH91791  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,359,196 - 49,359,363UniSTSGRCh37
Build 361247,645,463 - 47,645,630RGDNCBI36
Celera1248,154,005 - 48,154,172RGD
Cytogenetic Map12q13UniSTS
HuRef1246,390,788 - 46,390,955UniSTS
GeneMap99-GB4 RH Map12217.11UniSTS
A009J45  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,359,174 - 49,359,393UniSTSGRCh37
Build 361247,645,441 - 47,645,660RGDNCBI36
Celera1248,153,983 - 48,154,202RGD
Cytogenetic Map12q13UniSTS
HuRef1246,390,766 - 46,390,985UniSTS
GeneMap99-GB4 RH Map12217.11UniSTS
WNT10B_7903  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,359,008 - 49,359,774UniSTSGRCh37
Build 361247,645,275 - 47,646,041RGDNCBI36
Celera1248,153,817 - 48,154,583RGD
HuRef1246,390,600 - 46,391,366UniSTS
G32596  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,359,174 - 49,359,393UniSTSGRCh37
Celera1248,153,983 - 48,154,202UniSTS
Cytogenetic Map12q13UniSTS
HuRef1246,390,766 - 46,390,985UniSTS
Wnt10b  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,360,306 - 49,361,815UniSTSGRCh37
Celera1248,155,115 - 48,156,623UniSTS
HuRef1246,391,898 - 46,393,406UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2654
Count of miRNA genes:806
Interacting mature miRNAs:941
Transcripts:ENST00000301061, ENST00000403957, ENST00000407467, ENST00000413630, ENST00000420388, ENST00000475740
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 66 33 11 4 118 4 37 27 1330 4 26 39 1 12 19
Low 1902 1669 1045 241 1549 95 2847 911 1832 142 1044 1395 155 960 1533 4
Below cutoff 460 1267 614 329 235 317 1441 1236 543 204 371 161 18 1 232 1206 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB070724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC073610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF028700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ970136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA530656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN309554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U81787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000301061   ⟹   ENSP00000301061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,965,340 - 48,971,735 (-)Ensembl
RefSeq Acc Id: ENST00000403957   ⟹   ENSP00000385980
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,965,556 - 48,971,718 (-)Ensembl
RefSeq Acc Id: ENST00000407467   ⟹   ENSP00000384691
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,965,405 - 48,971,498 (-)Ensembl
RefSeq Acc Id: ENST00000413630   ⟹   ENSP00000398473
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,968,296 - 48,970,756 (-)Ensembl
RefSeq Acc Id: ENST00000420388   ⟹   ENSP00000404896
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,970,120 - 48,970,889 (-)Ensembl
RefSeq Acc Id: ENST00000475740
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,970,120 - 48,970,652 (-)Ensembl
RefSeq Acc Id: NM_003394   ⟹   NP_003385
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,965,340 - 48,971,735 (-)NCBI
GRCh371249,359,123 - 49,365,641 (-)ENTREZGENE
Build 361247,645,390 - 47,651,810 (-)NCBI Archive
HuRef1246,390,715 - 46,397,232 (-)ENTREZGENE
CHM1_11249,324,923 - 49,331,441 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538722   ⟹   XP_011537024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,965,340 - 48,970,177 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538724   ⟹   XP_011537026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,966,119 - 48,971,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019919   ⟹   XP_016875408
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,965,340 - 48,969,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449179   ⟹   XP_024304947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,965,340 - 48,979,587 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003385   ⟸   NM_003394
- Peptide Label: precursor
- UniProtKB: O00744 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011537024   ⟸   XM_011538722
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011537026   ⟸   XM_011538724
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016875408   ⟸   XM_017019919
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024304947   ⟸   XM_024449179
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000398473   ⟸   ENST00000413630
RefSeq Acc Id: ENSP00000385980   ⟸   ENST00000403957
RefSeq Acc Id: ENSP00000384691   ⟸   ENST00000407467
RefSeq Acc Id: ENSP00000301061   ⟸   ENST00000301061
RefSeq Acc Id: ENSP00000404896   ⟸   ENST00000420388

Promoters
RGD ID:6814535
Promoter ID:HG_XEF:1860
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001079303,   NM_178219
Position:
Human AssemblyChrPosition (strand)Source
Build 361247,649,806 - 47,650,306 (-)MPROMDB
RGD ID:6789961
Promoter ID:HG_KWN:15533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   NB4
Transcripts:ENST00000403957,   OTTHUMT00000319864,   UC001RST.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361247,651,601 - 47,652,787 (-)MPROMDB
RGD ID:6790665
Promoter ID:HG_KWN:15532
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   NB4
Transcripts:OTTHUMT00000319863,   OTTHUMT00000319867,   OTTHUMT00000319868
Position:
Human AssemblyChrPosition (strand)Source
Build 361247,651,621 - 47,652,121 (-)MPROMDB
RGD ID:7223785
Promoter ID:EPDNEW_H17637
Type:initiation region
Name:WNT10B_1
Description:Wnt family member 10B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17638  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,971,671 - 48,971,731EPDNEW
RGD ID:7223783
Promoter ID:EPDNEW_H17638
Type:initiation region
Name:WNT10B_2
Description:Wnt family member 10B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17637  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,971,853 - 48,971,913EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003394.4(WNT10B):c.458_461dup (p.Asp155fs) duplication Split-hand/foot malformation 6 [RCV000023161] Chr12:48968195..48968196 [GRCh38]
Chr12:49361978..49361979 [GRCh37]
Chr12:12q13.12
pathogenic
NM_003394.4(WNT10B):c.1087C>G (p.Arg363Gly) single nucleotide variant not provided [RCV000520692] Chr12:48966178 [GRCh38]
Chr12:49359961 [GRCh37]
Chr12:12q13.12
uncertain significance
NM_003394.4(WNT10B):c.994C>T (p.Arg332Trp) single nucleotide variant Split-hand/foot malformation 6 [RCV000008069] Chr12:48966271 [GRCh38]
Chr12:49360054 [GRCh37]
Chr12:12q13.12
pathogenic
NM_003394.3(WNT10B):c.699G>A (p.Arg233=) single nucleotide variant Malignant melanoma [RCV000062515] Chr12:48967958 [GRCh38]
Chr12:49361741 [GRCh37]
Chr12:47648008 [NCBI36]
Chr12:12q13.12
not provided
NM_003394.3(WNT10B):c.698G>A (p.Arg233Lys) single nucleotide variant Malignant melanoma [RCV000062516] Chr12:48967959 [GRCh38]
Chr12:49361742 [GRCh37]
Chr12:47648009 [NCBI36]
Chr12:12q13.12
not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p11.21-q13.12(chr12:31886971-50360461)x3 copy number gain See cases [RCV000207454] Chr12:31886971..50360461 [GRCh37]
Chr12:12p11.21-q13.12
pathogenic
NM_003394.4(WNT10B):c.786G>A (p.Trp262Ter) single nucleotide variant Tooth agenesis, selective, 8 [RCV000239472] Chr12:48966479 [GRCh38]
Chr12:49360262 [GRCh37]
Chr12:12q13.12
pathogenic
NM_003394.4(WNT10B):c.632G>A (p.Arg211Gln) single nucleotide variant Tooth agenesis, selective, 8 [RCV000239578] Chr12:48968025 [GRCh38]
Chr12:49361808 [GRCh37]
Chr12:12q13.12
pathogenic
NM_003394.4(WNT10B):c.995G>A (p.Arg332Gln) single nucleotide variant not provided [RCV000585078] Chr12:48966270 [GRCh38]
Chr12:49360053 [GRCh37]
Chr12:12q13.12
uncertain significance
NM_003394.4(WNT10B):c.338-1G>C single nucleotide variant Split-hand/foot malformation 6 [RCV000656339] Chr12:48968320 [GRCh38]
Chr12:49362103 [GRCh37]
Chr12:12q13.12
likely pathogenic
GRCh37/hg19 12q11-13.12(chr12:37857750-49791459)x3 copy number gain See cases [RCV000448835] Chr12:37857750..49791459 [GRCh37]
Chr12:12q11-13.12
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_003394.4(WNT10B):c.676C>T (p.Arg226Ter) single nucleotide variant Split-hand/foot malformation 6 [RCV000625580] Chr12:48967981 [GRCh38]
Chr12:49361764 [GRCh37]
Chr12:12q13.12
likely pathogenic
NM_005430.4(WNT1):c.104+4_104+44del deletion Osteogenesis imperfecta, type xv [RCV000677241] Chr12:48978757..48978797 [GRCh38]
Chr12:49372540..49372580 [GRCh37]
Chr12:12q13.12
likely pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13
uncertain significance
GRCh37/hg19 12q13.12(chr12:49191810-49630201)x3 copy number gain not provided [RCV000683434] Chr12:49191810..49630201 [GRCh37]
Chr12:12q13.12
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_003394.4(WNT10B):c.689_691ACA[2] (p.Asn232del) microsatellite Split-hand/foot malformation 6 [RCV000735854] Chr12:48967960..48967962 [GRCh38]
Chr12:49361743..49361745 [GRCh37]
Chr12:12q13.12
pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:49055179-49466566)x3 copy number gain not provided [RCV000750395] Chr12:49055179..49466566 [GRCh37]
Chr12:12q13.11-13.12
benign
NM_003394.4(WNT10B):c.290T>C (p.Leu97Pro) single nucleotide variant Split-hand/foot malformation 6 [RCV000761463] Chr12:48970136 [GRCh38]
Chr12:49363919 [GRCh37]
Chr12:12q13.12
uncertain significance
NM_005430.4(WNT1):c.105-6C>T single nucleotide variant not provided [RCV000923942] Chr12:48979462 [GRCh38]
Chr12:49373245 [GRCh37]
Chr12:12q13.12
likely benign
NM_003394.4(WNT10B):c.36G>A (p.Ser12=) single nucleotide variant not provided [RCV000903611] Chr12:48970494 [GRCh38]
Chr12:49364277 [GRCh37]
Chr12:12q13.12
benign
NM_003394.4(WNT10B):c.337+7C>T single nucleotide variant not provided [RCV000882249] Chr12:48970082 [GRCh38]
Chr12:49363865 [GRCh37]
Chr12:12q13.12
likely benign
NM_003394.4(WNT10B):c.746G>T (p.Cys249Phe) single nucleotide variant Split-hand/foot malformation 6 [RCV000785181] Chr12:48966519 [GRCh38]
Chr12:49360302 [GRCh37]
Chr12:12q13.12
likely pathogenic
NM_005430.4(WNT1):c.159G>A (p.Leu53=) single nucleotide variant not provided [RCV000923658] Chr12:48979522 [GRCh38]
Chr12:49373305 [GRCh37]
Chr12:12q13.12
likely benign
GRCh37/hg19 12q13.11-13.12(chr12:49034325-49468966)x1 copy number loss Kabuki syndrome 1 [RCV000859976] Chr12:49034325..49468966 [GRCh37]
Chr12:12q13.11-13.12
pathogenic
NM_003394.4(WNT10B):c.498A>C (p.Ala166=) single nucleotide variant not provided [RCV000917430] Chr12:48968159 [GRCh38]
Chr12:49361942 [GRCh37]
Chr12:12q13.12
likely benign
NC_000012.12:g.48978304C>A single nucleotide variant not provided [RCV000831606] Chr12:48978304 [GRCh38]
Chr12:49372087 [GRCh37]
Chr12:12q13.12
benign
NM_003394.4(WNT10B):c.949T>A (p.Phe317Ile) single nucleotide variant Split-hand/foot malformation 6 [RCV000785183] Chr12:48966316 [GRCh38]
Chr12:49360099 [GRCh37]
Chr12:12q13.12
likely pathogenic
NM_003394.4(WNT10B):c.817del (p.Ala273fs) deletion Split-hand/foot malformation 6 [RCV000785180] Chr12:48966448 [GRCh38]
Chr12:49360231 [GRCh37]
Chr12:12q13.12
pathogenic
NM_003394.4(WNT10B):c.817dup (p.Ala273fs) duplication Split-hand/foot malformation 6 [RCV000785182]|Tooth agenesis, selective, 8 [RCV001253087] Chr12:48966447..48966448 [GRCh38]
Chr12:49360230..49360231 [GRCh37]
Chr12:12q13.12
pathogenic|uncertain significance
NM_003394.4(WNT10B):c.901C>T (p.Pro301Ser) single nucleotide variant not provided [RCV000964427] Chr12:48966364 [GRCh38]
Chr12:49360147 [GRCh37]
Chr12:12q13.12
benign
NM_003394.4(WNT10B):c.110C>G (p.Pro37Arg) single nucleotide variant not provided [RCV000912672] Chr12:48970316 [GRCh38]
Chr12:49364099 [GRCh37]
Chr12:12q13.12
benign
NM_003394.4(WNT10B):c.257A>C (p.Gln86Pro) single nucleotide variant Split-hand/foot malformation 6 [RCV001027401] Chr12:48970169 [GRCh38]
Chr12:49363952 [GRCh37]
Chr12:12q13.12
likely pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:49024019-50299974)x3 copy number gain not provided [RCV001259140] Chr12:49024019..50299974 [GRCh37]
Chr12:12q13.11-13.12
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12775 AgrOrtholog
COSMIC WNT10B COSMIC
Ensembl Genes ENSG00000169884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000301061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000384691 UniProtKB/Swiss-Prot
  ENSP00000385980 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000398473 UniProtKB/TrEMBL
  ENSP00000404896 UniProtKB/TrEMBL
Ensembl Transcript ENST00000301061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000403957 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000407467 UniProtKB/Swiss-Prot
  ENST00000413630 UniProtKB/TrEMBL
  ENST00000420388 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot
GTEx ENSG00000169884 GTEx
HGNC ID HGNC:12775 ENTREZGENE
Human Proteome Map WNT10B Human Proteome Map
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot
  Wnt_CS UniProtKB/Swiss-Prot
KEGG Report hsa:7480 UniProtKB/Swiss-Prot
NCBI Gene 7480 ENTREZGENE
OMIM 225300 OMIM
  601906 OMIM
  617073 OMIM
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37377 PharmGKB
PRINTS WNT10PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5MCC8_HUMAN UniProtKB/TrEMBL
  C9J3H3_HUMAN UniProtKB/TrEMBL
  C9JCI2_HUMAN UniProtKB/TrEMBL
  O00744 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R7A5 UniProtKB/Swiss-Prot
  O00747 UniProtKB/Swiss-Prot
  Q4VAJ4 UniProtKB/Swiss-Prot
  Q4VAJ5 UniProtKB/Swiss-Prot
  Q8WZ97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 WNT10B  Wnt family member 10B  WNT10B  wingless-type MMTV integration site family member 10B  Symbol and/or name change 5135510 APPROVED
2015-11-24 WNT10B  wingless-type MMTV integration site family member 10B  WNT10B  wingless-type MMTV integration site family, member 10B  Symbol and/or name change 5135510 APPROVED