WNT10B (Wnt family member 10B) - Rat Genome Database

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Gene: WNT10B (Wnt family member 10B) Canis lupus familiaris
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Symbol: WNT10B
Name: Wnt family member 10B
RGD ID: 12232331
Description: ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cell population proliferation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Neoplasm Recurrence, Local (ortholog); obesity (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein Wnt-10b
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,599,905 - 5,605,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,601,089 - 5,605,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,652,204 - 40,660,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,648,026 - 5,656,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,650,675 - 5,656,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,611,949 - 5,620,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,602,160 - 5,610,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,044,507 - 41,052,994 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone trabecula formation  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
cell fate commitment  (IBA)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to organic substance  (IEA,ISO)
cellular response to parathyroid hormone stimulus  (IEA,ISO)
chondrocyte differentiation  (IEA)
epithelial cell differentiation  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fungiform papilla development  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
myoblast development  (IEA,ISO)
myoblast differentiation involved in skeletal muscle regeneration  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (IBA)
osteoblast differentiation  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of epithelial cell differentiation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA,ISO)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of timing of anagen  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein stabilization  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of fat cell differentiation  (IEA,ISO)
regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of protein metabolic process  (IEA,ISO)
regulation of skeletal muscle tissue development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
sensory perception of taste  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
T cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
WNT10B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,599,905 - 5,605,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,601,089 - 5,605,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,652,204 - 40,660,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,648,026 - 5,656,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,650,675 - 5,656,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,611,949 - 5,620,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,602,160 - 5,610,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,044,507 - 41,052,994 (-)NCBIUU_Cfam_GSD_1.0
WNT10B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,965,340 - 48,971,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1248,965,340 - 48,971,735 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,359,123 - 49,365,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,645,390 - 47,651,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341247,645,390 - 47,651,810NCBI
Celera1248,153,932 - 48,160,449 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,390,715 - 46,397,232 (-)NCBIHuRef
CHM1_11249,324,923 - 49,331,441 (-)NCBICHM1_1
T2T-CHM13v2.01248,927,542 - 48,933,936 (-)NCBIT2T-CHM13v2.0
Wnt10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,668,593 - 98,676,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,668,593 - 98,676,031 (-)EnsemblGRCm39 Ensembl
GRCm381598,770,712 - 98,778,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,770,712 - 98,778,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,602,183 - 98,608,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,599,796 - 98,606,184 (-)NCBIMGSCv36mm8
Celera15100,921,391 - 100,927,785 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,922,088 - 129,927,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,922,088 - 129,927,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,729,217 - 131,735,022 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07133,954,768 - 133,960,573 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07133,867,281 - 133,873,087 (-)NCBIRnor_WKY
Rnor_6.07140,448,284 - 140,466,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,448,465 - 140,454,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,958,456 - 114,976,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,541,197 - 137,547,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,617,649 - 137,623,456 (-)NCBI
Celera7126,411,054 - 126,416,855 (-)NCBICelera
Cytogenetic Map7q36NCBI
Wnt10b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,782,782 - 7,788,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,782,782 - 7,800,281 (-)NCBIChiLan1.0ChiLan1.0
WNT10B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,659,106 - 40,665,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Wnt10b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,386,524 - 66,396,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,768,240 - 6,774,172 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365126,768,240 - 6,774,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT10B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,997,381 - 15,003,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,997,377 - 15,013,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,407,596 - 15,422,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT10B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,205,728 - 45,229,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,205,566 - 45,210,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,931,714 - 200,938,206 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt10b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,210,828 - 3,227,096 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,221,573 - 3,227,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNT10B
39 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 22 6 6 6 6 12 8 10 6
Low 3 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000013935   ⟹   ENSCAFP00000012894
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,601,089 - 5,605,501 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081664   ⟹   ENSCAFP00000059071
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,601,089 - 5,604,747 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039984   ⟹   ENSCAFP00845031309
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl275,650,675 - 5,656,505 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040054   ⟹   ENSCAFP00845031363
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl275,652,095 - 5,656,505 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040097   ⟹   ENSCAFP00845031399
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl275,652,095 - 5,655,751 (+)Ensembl
RefSeq Acc Id: XM_038438305   ⟹   XP_038294233
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0275,648,026 - 5,656,510 (+)NCBI
RefSeq Acc Id: XM_038513017   ⟹   XP_038368945
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1275,611,949 - 5,620,434 (+)NCBI
RefSeq Acc Id: XM_038577525   ⟹   XP_038433453
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02741,044,507 - 41,052,994 (-)NCBI
RefSeq Acc Id: XM_038640779   ⟹   XP_038496707
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0275,602,160 - 5,610,644 (+)NCBI
RefSeq Acc Id: XM_543687   ⟹   XP_543687
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1275,599,905 - 5,605,506 (+)NCBI
Dog10K_Boxer_Tasha2740,652,204 - 40,660,691 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038294233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038368945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038433453 (Get FASTA)   NCBI Sequence Viewer  
  XP_038496707 (Get FASTA)   NCBI Sequence Viewer  
  XP_543687 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_543687   ⟸   XM_543687
- UniProtKB: A0A8C0P6D0 (UniProtKB/TrEMBL),   A0A8C0KK60 (UniProtKB/TrEMBL),   A0A8I3PFR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000012894   ⟸   ENSCAFT00000013935
RefSeq Acc Id: ENSCAFP00000059071   ⟸   ENSCAFT00000081664
RefSeq Acc Id: XP_038368945   ⟸   XM_038513017
RefSeq Acc Id: XP_038496707   ⟸   XM_038640779
RefSeq Acc Id: XP_038294233   ⟸   XM_038438305
- UniProtKB: A0A8C0P6D0 (UniProtKB/TrEMBL),   A0A8C0KK60 (UniProtKB/TrEMBL),   A0A8I3PFR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038433453   ⟸   XM_038577525
RefSeq Acc Id: ENSCAFP00845031363   ⟸   ENSCAFT00845040054
RefSeq Acc Id: ENSCAFP00845031399   ⟸   ENSCAFT00845040097
RefSeq Acc Id: ENSCAFP00845031309   ⟸   ENSCAFT00845039984


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008767 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021563 UniProtKB/TrEMBL
  ENSCAFG00040024744 UniProtKB/TrEMBL
  ENSCAFG00845022647 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000012894.5 UniProtKB/TrEMBL
  ENSCAFP00000059071.1 UniProtKB/TrEMBL
  ENSCAFP00000067697.1 UniProtKB/TrEMBL
  ENSCAFP00030034515.1 UniProtKB/TrEMBL
  ENSCAFP00030034547.1 UniProtKB/TrEMBL
  ENSCAFP00040040228 UniProtKB/TrEMBL
  ENSCAFP00040040246 UniProtKB/TrEMBL
  ENSCAFP00845031309.1 UniProtKB/TrEMBL
  ENSCAFP00845031363 ENTREZGENE
  ENSCAFP00845031363.1 UniProtKB/TrEMBL
  ENSCAFP00845031399.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013935.6 UniProtKB/TrEMBL
  ENSCAFT00000081664.2 UniProtKB/TrEMBL
  ENSCAFT00000095102.1 UniProtKB/TrEMBL
  ENSCAFT00030039557.1 UniProtKB/TrEMBL
  ENSCAFT00030039590.1 UniProtKB/TrEMBL
  ENSCAFT00040046097 UniProtKB/TrEMBL
  ENSCAFT00040046116 UniProtKB/TrEMBL
  ENSCAFT00845039984.1 UniProtKB/TrEMBL
  ENSCAFT00845040054 ENTREZGENE
  ENSCAFT00845040054.1 UniProtKB/TrEMBL
  ENSCAFT00845040097.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt10 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene WNT10B ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT10PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8C0KK60 ENTREZGENE
  A0A8C0P6D0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0P828_CANLF UniProtKB/TrEMBL
  A0A8I3PFR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PFU6_CANLF UniProtKB/TrEMBL
  A0A8I3S382_CANLF UniProtKB/TrEMBL